Diabetes Mellitus Insulin-Dependent
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Peer Reviewed Scientific Research Reports.
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1. Long- and short-haul travel by air: issues for people with diabetes on insulin.
Match Strength: 11.757
OBJECTIVE: To determine what problems are experienced by people with diabetes mellitus traveling abroad using insulin, whether appropriate and consistent advice is available to them, and if necessary, how this advice could be improved or enhanced. DESIGN: Census study by self-administered questionnaire of patients with diabetes who use insulin attending an outpatient clinic. SETTING: Grampian Diabetes Centre, Woolmanhill Hospital, Aberdeen. PARTICIPANTS: A total of 493 patients using insulin who attended the clinic in Aberdeen over a period of 3 months. MAIN OUTCOME MEASURES: Determination of ... Read More »
» Published in J Travel Med. 2006 Sep-Oct;13(5):255-60.
2. Cardiovascular risk in the spectrum of type 2 diabetes mellitus.
Match Strength: 10.685
The clinical importance of the metabolic syndrome is that this group of risk factors greatly increases the likelihood of cardiovascular events, the major source of disease morbidity and mortality in patients with obesity and type 2 diabetes. Recent studies have helped clarify the mechanisms underlying the vascular dysfunction that leads to cardiovascular outcomes in diabetes. This vascular dysfunction is correlated with visceral adiposity, insulin resistance and alterations in the levels of a variety of circulating factors. The vascular effects of overt hyperglycemia also play an important ... Read More »
» Published in Mt Sinai J Med. 2006 Sep;73(5):759-68.
3. Characterization of alterations in carbohydrate metabolism in children with Prader-Willi syndrome.
Match Strength: 9.803
OBJECTIVE: To study carbohydrate metabolism and insulin sensitivity and secretion in children and adolescents with Prader-Willi syndrome (PWS) compared with multifactorial obesity (MO) controls. PATIENTS AND METHODS: Seventy-five patients with PWS and 395 controls with MO were studied by oral glucose tolerance test. Insulin resistance (IR) and beta-cell function were assessed by homeostasis model assessment (HOMA), insulin glucose index, fasting insulin and insulin sensitivity index. RESULTS: The incidence of diabetes mellitus was 0% in PWS and 1.5% in MO, while carbohydrate intolerance was 9 ... Read More »
» Published in J Pediatr Endocrinol Metab. 2006 Jul;19(7):911-8.
4. Management of diabetes mellitus in hospitalized patients: efficiency and effectiveness of sliding-scale insulin therapy.
Match Strength: 9.625
STUDY OBJECTIVE: To determine the efficiency and effectiveness of current prescribing practices relative to short- and intermediate-acting insulins in the prevention or treatment of acute hyperglycemic episodes in hospitalized patients with diabetes mellitus or hyperglycemia, and to identify clinical findings that influence the effectiveness of insulin therapy in these patients. DESIGN: Retrospective observational study. SETTING: University-affiliated hospital. PATIENTS: Ninety consecutive adult inpatients who had orders placed for as-needed subcutaneous regular or lispro sliding-scale insulin ... Read More »
» Published in Pharmacotherapy. 2006 Oct;26(10):1421-32.
5. Metabolic decompensation in children with type 1 diabetes mellitus associated with increased serum levels of the soluble leptin receptor.
Match Strength: 9.611
OBJECTIVE: Type 1 diabetes mellitus (T1DM) leads to increased serum levels of the soluble leptin receptor (sOB-R) by an as yet unknown cellular mechanism. The aim of our study was to investigate potential metabolic factors that may be associated with the induction of the sOB-R release from its membrane receptor. MATERIALS AND METHODS: Twenty-five children (aged between 1.5 and 17.0 years) were studied at the onset of T1DM. Blood samples were collected before (n = 25), during the first 18 h (mean +/- S.D. 11.1 +/- 4.3 h, n = 16) and 92 h (47.5 +/- 22.5 h; n = 14) after beginning insulin therapy ... Read More »
» Published in Eur J Endocrinol. 2006 Oct;155(4):609-14.
6. Effects of type 2 diabetes mellitus on cochlear structure in humans.
Match Strength: 9.489
OBJECTIVE: To evaluate the effects of type 2 diabetes mellitus on cochlear elements in humans. DESIGN: Comparative study of the histopathologic characteristics of human temporal bones. SETTING: Otopathology laboratory in a tertiary academic medical center. PATIENTS: Temporal bones from 18 patients with type 2 diabetes mellitus were divided into 2 groups according to the method of management of diabetes: insulin in 11 patients (mean age, 51.9 years; age range, 44-65 years) and oral hypoglycemic agents in 7 patients (mean age, 54.4 years; age range, 45-64 years). The diabetic groups and 26 age ... Read More »
» Published in Arch Otolaryngol Head Neck Surg. 2006 Sep;132(9):934-8.
7. Efficacy of a pedometer-based physical activity program on parameters of diabetes control in type 2 diabetes mellitus.
Match Strength: 9.243
The aim of the study was to determine whether a recommendation to walk 10000 steps per day would result in significant improvements in glycemic control, insulin sensitivity, and cardiovascular risk in patients with type 2 diabetes mellitus. The study was a 6-week randomized controlled trial that included 30 patients with type 2 diabetes mellitus. After 10 days of baseline activity, patients were randomized into 2 groups: control and active. The control group (n = 15) was instructed to continue with their baseline activity for 6 weeks. The active group (n = 15) was instructed to walk at least ... Read More »
» Published in Metabolism. 2006 Oct;55(10):1382-7.
8. Short-term suppression of elevated growth hormone concentrations following insulin-like growth factor 1 administration in young adults with type 1 diabetes does not alter glomerular filtration or albumin excretion rates.
Match Strength: 8.845
OBJECTIVE: Young adults with type 1 diabetes mellitus (T1DM) have increased glomerular filtration rate (GFR), which may mediate progressive renal disease and microalbuminuria. This may be secondary to low concentrations of insulin-like growth factor (IGF)-I and GH hypersecretion. We tested the hypothesis that restoration of circulating IGF-I concentrations in young adults with T1DM might suppress GH secretion, GFR and urinary albumin excretion. DESIGN: In a randomized double blind crossover study six young adults with T1DM (three men, 19-24 years) received 7 days treatment with rhIGF-I/insulin ... Read More »
» Published in Clin Endocrinol (Oxf). 2006 Oct;65(4):439-45.
9. The effectiveness of intensive glycemic control for the prevention of vascular complications in diabetes mellitus.
Match Strength: 8.840
Obesity and type 2 diabetes mellitus have reached epidemic proportions in the US, and indeed, globally. While microvascular complications contribute to considerable morbidity, much of the excess mortality (around 70%) is due to macrovascular disease. Hyperglycemia has predictable toxic effects on multiple organs ('glucotoxicity') including the pancreas, where it impairs insulin secretion and insulin gene expression through mechanisms that lead to glucose densensitization and beta-cell exhaustion, eventually resulting in irreversible beta-cell failure. There is robust evidence to suggest that ... Read More »
» Published in Treat Endocrinol. 2006;5(5):273-86.
10. Peripheral insulin resistance during treatment of chronic hepatitis C with peguilated interferon plus ribavirin.
Match Strength: 8.360
Patients with hepatitis C virus (HCV) infection present higher risk of developing type-2 diabetes mellitus (DM). However, the mechanism of this association and the role of antiviral treatment are still unclear. The objective of this study was to investigate the relationship between the use of peguilated interferon and the development of insulin resistance (IR) in these patients. METHODS: HOMA index was evaluated in 30 HCV-infected patients just before and during the first 6 months of treatment with peguilated interferon plus ribavirin. Anthropometrical parameters and glucose/cholesterol ... Read More »
» Published in J Med Virol. 2006 Nov;78(11):1406-10.
11. Succinic acid monoethyl ester, a novel insulinotropic agent: Effect on lipid composition and lipid peroxidation in streptozotocin-nicotin-amide induced type 2 diabetic rats.
Match Strength: 8.112
Succinic acid monoethyl ester (EMS) is recently proposed as an insulinotropic agent for the treatment of non-insulin dependent diabetes mellitus. Oxidative stress has been suggested to be a contributory factor in the development and complications of diabetes. In the present study the effect of EMS and Metformin on plasma glucose, insulin, serum and tissue lipid profile, lipoproteins and lipid peroxidation in streptozotocin-nicotinamide induced type 2 diabetic model was investigated. The carboxylic nutrient EMS was administered intraperitonially (8 micromol/g body weight) to streptozotocin ... Read More »
» Published in Mol Cell Biochem. 2006 Sep 28;
12. Evaluation of the superiority of insulin glargine as basal insulin replacement by continuous glucose monitoring system.
Match Strength: 8.010
To evaluate the superiority of insulin glargine as basal insulin replacement by continuous glucose monitoring system (CGMS). Twenty-four patients with type 2 diabetes mellitus (T2DM) whose blood glucose was not well controlled with sulphanylureas were enrolled. At first, they were treated with extended-release glipizide (glucotrol XL) 5mg/d before breakfast for 2 weeks, then randomized to combination treatment with glargine (16 patients) or NPH (8 patients) and treated for 12 weeks. CGMS were carried in the second week after treatment with glucotrol XL, and in the 12th week after combination ... Read More »
» Published in Diabetes Res Clin Pract. 2006 Sep 13;
13. Relative iron "overload" in offspring of patients with type 2 diabetes mellitus: a new component in the conundrum of insulin resistance syndrome?
Match Strength: 7.568
There are a few reports suggesting that subtle disturbances of iron metabolism are frequently found in patients with type 2 diabetes (DM2), but it is not known if these disturbances precede or accompany the diabetic state. We investigated the serum iron indices in 41 offspring of DM2 parents (group I) with normal glucose tolerance, and in 49 offspring whose parents had no history of DM2 and were matched for sex, age, body mass index (BMI), waist to hip ratio (WHR) and blood pressure (group II). Serum iron, ferritin, total iron binding capacity (TIBC), transferrin saturation, serum ... Read More »
» Published in Hormones (Athens). 2003 Jul-Sep;2(3):161-8.
14. Sleep deprivation as a neurobiologic and physiologic stressor: Allostasis and allostatic load.
Match Strength: 7.350
Sleep has important homeostatic functions, and sleep deprivation is a stressor that has consequences for the brain, as well as many body systems. Whether sleep deprivation is due to anxiety, depression, or a hectic lifestyle, there are consequences of chronic sleep deprivation that impair brain functions and contribute to allostatic load throughout the body. Allostatic load refers to the cumulative wear and tear on body systems caused by too much stress and/or inefficient management of the systems that promote adaptation through allostasis. Chronic sleep deprivation in young healthy volunteers ... Read More »
» Published in Metabolism. 2006 Oct;55(10 Suppl 2):S20-3.
15. Acute thiamine deficiency in diabetic ketoacidosis: Diagnosis and management.
Match Strength: 7.129
OBJECTIVE: Persistent encephalopathy in a patient with diabetic ketoacidosis is often feared as a sign of cerebral edema. Although thiamine deficiency is a rare diagnosis in children, marginal nutritional status and osmotic diuresis may be risk factors. The objective was to describe a heretofore unreported cause of encephalopathy in a child with diabetic ketoacidosis and review the mechanisms and pathophysiology of thiamine deficiency in this clinical scenario. DESIGN: Case report and review of the literature. SETTING: Pediatric intensive care unit of a tertiary care pediatric hospital. ... Read More »
» Published in Pediatr Crit Care Med. 2006 Nov;7(6):595-9.
16. Prevention and Treatment of Type 2 Diabetes in Youth.
Match Strength: 6.694
Parallel to the increase in obesity worldwide, there has been a rise in the prevalence of type 2 diabetes mellitus (T2DM) in children and adolescents. The etiology of T2DM in youth, similar to adults, is multifactorial including genetic and environmental factors, among them obesity, sedentary lifestyle, family history of the disease, high-risk ethnicity and insulin resistance phenotype playing major roles. Treatment of T2DM should not have a glucocentric approach; it should rather target improving glycemia, dyslipidemia, hypertension, weight management and the prevention of short- and long ... Read More »
» Published in Horm Res. 2006 Sep 28;67(1):22-34
17. Drug-eluting stents versus arterial myocardial revascularization in patients with diabetes mellitus.
Match Strength: 6.635
OBJECTIVE: The introduction of drug-eluting stents significantly reduced restenosis and reinterventions in patients undergoing percutaneous coronary interventions. This study compares results of Cypher stenting with those of surgical arterial revascularization in patients with diabetes mellitus. METHODS: From May 2002 through May 2005, 523 consecutive diabetic patients underwent myocardial revascularization: 244 underwent percutaneous coronary interventions incorporating drug-eluting stents, and 279 were treated surgically. All single-vessel patients in the surgical group were treated with the ... Read More »
» Published in J Thorac Cardiovasc Surg. 2006 Oct;132(4):861-6.
18. Genetic screening by DNA technology: a systematic review of health economic evidence.
Match Strength: 5.451
OBJECTIVES: The Human Genome Project has led to a multitude of new potential screening targets on the level of human DNA. The aim of this systematic review is to critically summarize the evidence from health economic evaluations of genetic screening in the literature. METHODS: Based on an extensive explorative search, an appropriate algorithm for a systematic database search was developed. Twenty-one health economic evaluations were identified and appraised using published quality criteria. RESULTS: Genetic screening for eight conditions has been found to be investigated by health economic ... Read More »
» Published in Int J Technol Assess Health Care. 2006 Summer;22(3):327-37.
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