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Peer Reviewed Scientific Research Reports.
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1. Glyburide for the management of gestational diabetes: risk factors predictive of failure and associated pregnancy outcomes.
Match Strength: 8.723
OBJECTIVE: The purpose of this study was to identify characteristics that may predict failure of glyburide therapy for the management of A2 gestational diabetes, and to evaluate whether those that fail are at increased risk for adverse pregnancy outcomes. STUDY DESIGN: This was a retrospective cohort of gestational diabetics requiring medical therapy (A2DM) treated between January 2002 and July 2005. RESULTS: Of the 235 gestational diabetics identified, 79% of the 101 A2DMs were successfully treated with glyburide as first-line therapy. Those that failed had a higher mean glucose value on ... Read More »
» Published in Am J Obstet Gynecol. 2006 Oct;195(4):1090-4.
2. Taurine in women with a history of gestational diabetes.
Match Strength: 7.909
Taurine is the most abundant amino acid in the human body and seems to play an important role in increasing glucose-mediated insulin secretion, as well as in programming beta-cell maturation during the prenatal life in utero. To test the hypothesis that plasma taurine is related to glucose tolerance, insulin sensitivity and insulin secretion in subjects with history of beta-cell dysfunction such as women with history of gestational diabetes (GDM), we studied 72 non-diabetic women with history of GDM (n=43), impaired glucose tolerance (IGT; n=7), and normal glucose tolerance (NGT; n=22) as ... Read More »
» Published in Diabetes Res Clin Pract. 2006 Sep 19;
3. Pre-pregnancy body mass index and pregnancy outcomes.
Match Strength: 6.896
OBJECTIVE: To determine the effect of maternal pre-pregnancy BMI on pregnancy outcomes. METHODS: Pregnancy cohort recruited pregnancies between 16 and 18 weeks. BMI evaluated underweight, BMI<18.5, normal, BMI 18.5-25, overweight BMI 25-30, and obese BMI>30 women. RESULTS: Pre-pregnancy BMI classified 331 women as underweight (11.7%), 1982 normal (69.9%), 326 overweight (11.5%), and 188 as obese (6.6%). Obese women were more likely to develop gestational diabetes (p<0.001), hypertension (p<0.001), preeclampsia (p<0.001), need labor induction (p<0.001), cesarean delivery for ... Read More »
» Published in Int J Gynaecol Obstet. 2006 Dec;95(3):242-7. Epub 2006 Sep 27.
4. Dietary fiber intake, dietary glycemic load, and the risk for gestational diabetes mellitus.
Match Strength: 6.179
OBJECTIVE: We aimed to examine whether pregravid dietary fiber consumptions from cereal, fruit, and vegetable sources and dietary glycemic load were related to gestational diabetes mellitus (GDM) risk. RESEARCH DESIGN AND METHODS: This study was a prospective cohort study among 13,110 eligible women in the Nurses' Health Study II. GDM was self-reported and validated by medical record review in a subsample. RESULTS: We documented 758 incident GDM cases during 8 years of follow-up. After adjustment for age, parity, prepregnancy BMI, and other covariates, dietary total fiber and cereal and fruit ... Read More »
» Published in Diabetes Care. 2006 Oct;29(10):2223-30.
5. Metabolic and polycystic ovary syndromes in indigenous South Asian women with previous gestational diabetes mellitus.
Match Strength: 5.861
OBJECTIVE: To determine the risk of metabolic syndrome (MS) and polycystic ovary syndrome (PCOS) in a cohort of indigenous South Asian women with a recent history of gestational diabetes mellitus (GDM). DESIGN: Case-control study. SETTING: Department of Obstetrics & Gynaecology, University of Colombo, Sri Lanka. SAMPLE: Two hundred and seventy-four indigenous Sri Lankan women with previous GDM and 168 ethnically matched controls. Of these, 147 with previous GDM and 67 controls not taking hormonal contraception participated in an in-depth endocrine study. METHODS: Assessing the prevalence of MS ... Read More »
» Published in BJOG. 2006 Oct;113(10):1182-7.
6. Should diabetic patients be asked to test their blood glucose 90 to 120 minutes after the beginning of their meals?
Match Strength: 5.274
There are three distinct objectives in reducing the post-prandial blood glucose peaks: 1st to reduce the risk of foetal macrosomia in pregnancy, 2nd to reduce cardiovascular morbi-mortality, 3rd to lower the HbA1c. With 6-7 glycaemic controls per day and fractionning their meals, motivated women with gestational diabetes reach this goal. But there is no data today directly proving that post-prandial glycaemia is specifically related to the development of micro and macrovascular complications. So to reduce the cardiovascular risk, there are more arguments in favour of lowering HbA1c or ... Read More »
» Published in Diabetes Metab. 2006 Sep;32(4):377-81.
7. Characterization of differential gene expression profiles in diabetic embryopathy using DNA microarray analysis.
Match Strength: 3.573
OBJECTIVE: The molecular mechanisms by which maternal diabetes impairs embryogenesis are not established. This study aimed to determine the developmental genes and molecular pathways that are involved in diabetic embryopathy, by comparing gene expression profiles in the yolk sacs between the embryos of diabetic and control rats by using DNA microarray analysis. STUDY DESIGN: Diabetes was induced in female rats by injecting streptozotocin (65 mg/kg) intravenously. Glucose levels were controlled by subcutaneously implanting insulin pellets. The female rats were mated with normal male rats. At ... Read More »
» Published in Am J Obstet Gynecol. 2006 Oct;195(4):1075-80.
8. Linear association between maternal pre-pregnancy body mass index and risk of caesarean section in term deliveries.
Match Strength: 3.513
OBJECTIVE: Maternal obesity is a well-known risk factor for caesarean delivery. The aim of this study is to determine whether all the spectrum of pre-pregnancy maternal corpulence (body mass index [BMI]) is associated with the risk of caesarean delivery. DESIGN: Observational study over 4.5 years (2001-05). SETTING: Groupe Hospitalier Sud-Reunion's maternity (island of La Reunion, French overseas department, Indian Ocean). POPULATION: All consecutive singleton live births having delivered at the maternity. METHODS: Data have been analysed according to different risk factors. Maternal ... Read More »
» Published in BJOG. 2006 Oct;113(10):1173-7.
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