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Peer Reviewed Scientific Research Reports.
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1. Uniform resource locator decay in dermatology journals: author attitudes and preservation practices.
Match Strength: 7.037
OBJECTIVES: To describe dermatology journal uniform resource locator (URL) use and persistence and to better understand the level of control and awareness of authors regarding the availability of the URLs they cite. DESIGN: Software was written to automatically access URLs in articles published between January 1, 1999, and September 30, 2004, in the 3 dermatology journals with the highest scientific impact. Authors of publications with unavailable URLs were surveyed regarding URL content, availability, and preservation. MAIN OUTCOME MEASURES: Uniform resource locator use and persistence and ... Read More »
» Published in Arch Dermatol. 2006 Sep;142(9):1147-52.
2. From brown to green: origins of the montagna symposium on the biology of the skin.
Match Strength: 4.592
Recipient of Founding Member Award, Montagna Symposium on The Biology of The SkinJournal of Investigative Dermatology Symposium Proceedings (2006) 11, 4-6. doi:10.1038/sj.jidsymp.5650020 ... Read More »
» Published in J Invest Dermatol. 2006 Sep;126 Suppl:4-6.
3. Management of psoriatic arthritis: the therapeutic interface between rheumatology and dermatology.
Match Strength: 2.954
Psoriatic arthritis is an inflammatory arthritis, which occurs in up to 30% of individuals with psoriasis. Dermatologists and other physicians treating psoriasis are in an ideal position to screen for the condition, and with rheumatologists, strategize optimal therapy. Mild skin and joint manifestations may be treated effectively with topical agents, ultraviolet light therapy, and nonsteroidal anti-inflammatory drugs. More severe manifestations of the disease, including progressive peripheral joint damage, spine disease, enthesitis, dactylitis, and severe skin changes, require systemic therapy ... Read More »
» Published in Curr Rheumatol Rep. 2006 Oct;8(5):348-54.
4. Gender: a possible determinant in dosing of dermatologic drugs--an overview.
Match Strength: 2.908
The role of gender in pharmacokinetics could play a significant role in tailoring HIV and other drug regimens. Here we investigate sex as a factor in saquinavir pharmacokinetics. The HIV-positive women who use saquinavir in combination with other protease inhibitors frequently demonstrate higher saquinavir concentrations than their male counterparts. The majority of the data indicates that the root of women's higher saquinavir concentrations is not inherent to their gender. Rather, extenuating factors associated with HIV play a prominent role in the observed difference between men and women's ... Read More »
» Published in Cutan Ocul Toxicol. 2006;25(3):195-210.
5. Functions of the Peroxisome Proliferator-Activated Receptor (PPAR) alpha and beta in Skin Homeostasis, Epithelial Repair, and Morphogenesis.
Match Strength: 2.744
The three peroxisome proliferator-activated receptors (PPARalpha, PPARbeta, and PPARgamma) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. They are regarded as being sensors of physiological levels of fatty acids and fatty acid derivatives. In the adult mouse skin, they are found in hair follicle keratinocytes but not in interfollicular epidermis keratinocytes. Skin injury stimulates the expression of PPARalpha and PPARbeta at the site of the wound. Here, we review the spatiotemporal program that triggers PPARbeta expression immediately after ... Read More »
» Published in J Invest Dermatol. 2006 Sep;126 Suppl:30-5.
6. Five-year surveillance of nosocomial infections in Ankara Training and Research Hospital.
Match Strength: 2.607
The objective of this study was to assess the rate of nosocomial infections (NIs), frequency of nosocomial pathogens and antimicrobial susceptibility changes in a 530-bed hospital over a five-year period. Hospital-wide laboratory-based NI surveillance was performed prospectively between 1999 and 2003. The Centers for Disease Control and Prevention's definitions were used for NIs and nosocomial surgical site infections, and NI rates were calculated by the number of NIs per number of hospitalized patients on an annual basis. NI rates ranged between 1.4% and 2.4%. Higher rates were observed in ... Read More »
» Published in J Hosp Infect. 2006 Dec;64(4):391-6. Epub 2006 Sep 18.
7. Electrophilic Chemicals but not UV Irradiation or Reactive Oxygen Species Activate Nrf2 in Keratinocytes In Vitro and In Vivo.
Match Strength: 2.597
The NF-E2-related factor 2 (Nrf2) transcription factor is a potent inducer of cytoprotective genes, which encode - among others - enzymes that detoxify reactive oxygen species (ROS). As we demonstrated a crucial role of Nrf2 in the prevention of skin carcinogenesis, it is of interest to identify Nrf2-activating factors in keratinocytes. For this purpose, keratinocytes from mice transgenic for an Nrf2-responsive reporter gene were analyzed. Electrophilic compounds activated the reporter in keratinocytes, and induced nuclear translocation of Nrf2 and the expression of known Nrf2 target genes. ... Read More »
» Published in J Invest Dermatol. 2006 Sep 28;
8. Validation of a quality-of-life instrument for patients with nonmelanoma skin cancer.
Match Strength: 2.548
OBJECTIVE: To validate a disease-specific quality-of-life instrument--the Skin Cancer Index--intended to measure quality-of-life issues relevant to patients with nonmelanoma skin cancer. METHODS: Internal reliability, convergent and divergent validity with existing scales, and factor analyses were performed in a cross-sectional study of 211 patients presenting with cervicofacial nonmelanoma skin cancer to a dermatologic surgery clinic. RESULTS: Factor analyses of the Skin Cancer Index confirmed a multidimensional scale with 3 distinct subscales-emotional, social, and appearance. Excellent ... Read More »
» Published in Arch Facial Plast Surg. 2006 Sep-Oct;8(5):314-8.
9. Lack of Nidogen-1 and -2 Prevents Basement Membrane Assembly in Skin-Organotypic Coculture.
Match Strength: 2.528
Nidogens are considered as classical linkers joining laminin and collagen IV networks in basement membranes (BMs); however, recent genetic approaches have suggested that nidogens function in a tissue-specific and developmental context. Thus, in mice lacking both nidogen-1 and -2 heart and lung were severely affected, causing neonatal death. Furthermore, in various locations, extravasation of erythrocytes was observed implying microvascular defects. Mice expressing solely either isoform, had a functional BM, although nidogen-2 binds with lower affinity to the laminin gamma1 chain. Having ... Read More »
» Published in J Invest Dermatol. 2006 Sep 28;
10. Mechanical Tension and Integrin alpha2beta1 Regulate Fibroblast Functions.
Match Strength: 2.518
The extracellular matrix (ECM) environment in connective tissues provides fibroblasts with a structural scaffold and modulates cell shape, but it also profoundly influences the fibroblast phenotype. Here we studied fibroblasts cultured in a three-dimensional network of native collagen, which was either mechanically stressed or relaxed. Mechanical load induces fibroblasts that synthesize abundant ECM and a characteristic array of cytokines/chemokines. This phenotype is reminiscent of late granulation tissue or scleroderma fibroblasts. By contrast, relaxed fibroblasts are characterized by ... Read More »
» Published in J Invest Dermatol. 2006 Sep;126 Suppl:66-72.
11. Investigation of Mechanisms Underlying the T-Cell Response to the Hapten 2,4-Dinitrochlorobenzene.
Match Strength: 2.516
T-cell mediated contact sensitization by small molecular weight xenobiotics results in significant morbidity and absences from work. To be recognized by T-cells, xenobiotics must act as haptens, becoming protein-bound. At present, the requirement for processing and presentation of xenobiotics, the nature of the T-cell responses to them and the mechanisms that confer individual susceptibility in humans are unclear. We have investigated the T-cell response to the hapten 2,4-dinitrochlorobenzene (DNCB) which can sensitize all immunocompetent people. Fourteen healthy adults were sensitized with ... Read More »
» Published in J Invest Dermatol. 2006 Sep 28;
12. Diagnosis, access and outcomes: Update of a systematic review of telemedicine services.
Match Strength: 2.459
Telemedicine services are being increasingly used. Although insurers and other payers are covering some services in the USA, the rationale for these coverage decisions is not always evidence-based. We reviewed the literature for telemedicine services that substitute for face-to-face medical diagnosis and treatment. We focused on three types of telemedicine services: store-and-forward, home-based and office/hospital-based services. Studies were included if they were relevant to at least one of the three study areas, addressed at least one key question and contained reported results. We excluded ... Read More »
» Published in J Telemed Telecare. 2006;12 Suppl 2:S3-31.
13. CD18 in Monogenic and Polygenic Inflammatory Processes of the Skin.
Match Strength: 2.396
The beta(2) integrin family (CD11/CD18) of leukocyte adhesion molecules plays a key role in inflammation. Absence of the common beta chain (CD18) leads to leukocyte adhesion deficiency-1 (LAD1) in humans. We here summarize data of two genetically defined mice models of beta(2) integrin deficiency, one with a CD18 null mutation (CD18(-/-)), and the other one with a hypomorphic CD18 mutation (CD18(hypo)). Firstly, we focus on the underlying mechanism of a severely impaired wound healing in CD18(-/-) mice, outlining a scenario in which a defective extravasation and phagocytosis of CD18(-/-) ... Read More »
» Published in J Invest Dermatol. 2006 Sep;126 Suppl:7-15.
14. Dermoscopic patterns of acral melanocytic nevi and melanomas in a white population in central Italy.
Match Strength: 2.344
OBJECTIVE: To investigate the dermoscopic features of acral melanocytic lesions in a white population in central Italy. DESIGN: Retrospective review. SETTING: University dermatology department. PATIENTS: Six hundred fifty-one Italian subjects, ranging in age from 6 months to 78 years. MAIN OUTCOME MEASURES: We retrospectively investigated all digital dermoscopic images of acral melanocytic lesions included in our database from January 1996 to May 2005. RESULTS: We retrieved digital images of 723 benign acral melanocytic lesions in 641 patients (235 males and 406 females; mean age, 26.5 years) ... Read More »
» Published in Arch Dermatol. 2006 Sep;142(9):1123-8. Comment in: Arch Dermatol. 2006 Sep;142(9):1211-2.
15. Colocalization of Glial Fibrillary Acidic Protein, Metallothionein, and MHC II in Human, Rat, NOD/SCID, and Nude Mouse Skin Keratinocytes and Fibroblasts.
Match Strength: 2.297
The expression of glial fibrillary acidic protein (GFAP) by perivascular cells of many mammalian organs suggests an as yet unknown function of this intermediate filament protein in the maintenance of homeostasis and vascular permeability at the blood-tissue interface. Although a similar situation may exist at the air-tissue interface, the cellular distribution of GFAP in skin tissue has never been demonstrated. To approach this issue, we have employed immunofluorescence and Western blotting techniques to detect GFAP in skin sections of young and adult humans, normal rodents, and two types of ... Read More »
» Published in J Invest Dermatol. 2006 Sep 28;
16. Contact allergy to topical drugs: prevalence in a clinical setting and estimation of frequency at the population level.
Match Strength: 2.278
OBJECTIVES: To estimate the prevalence of contact allergy (CA) to a set of topical drugs patch tested in the research network IVDK (Information Network of Departments of Dermatology; www.ivdk.org) between 1995 and 2004, and to extrapolate these clinical data to the German population. METHODS: Clinical data comprised results of allergy patch tests with topical drugs in patients with suspected CA. Clinical epidemiology and drug utilization research (CE-DUR) methods were employed to grossly estimate the incidence of CA to these topical drugs during two 5-year periods (1995-1999 and 2000-2005) in ... Read More »
» Published in Pharmacoepidemiol Drug Saf. 2006 Sep 18;
17. A promising method for identifying cross-cultural differences in patient perspective: the use of Internet-based focus groups for content validation of new patient reported outcome assessments.
Match Strength: 1.903
OBJECTIVES: This proof of concept (POC) study was designed to evaluate the use of an Internet-based bulletin board technology to aid parallel cross-cultural development of thematic content for a new set of patient-reported outcome measures (PROs). METHODS: The POC study, conducted in Germany and the United States, utilized Internet Focus Groups (IFGs) to assure the validity of new PRO items across the two cultures--all items were designed to assess the impact of excess facial oil on individuals' lives. The on-line IFG activities were modeled after traditional face-to-face focus groups and ... Read More »
» Published in Health Qual Life Outcomes. 2006 Sep 22;4:64.
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