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Dermatitis
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1. Time course changes of scratching counts, dermatitis symptoms, and levels of cutaneous prostaglandins in NC/Nga mice.
Match Strength: 8.226

NC/Nga (NC) mice are known to develop dermatitis resembling atopic dermatitis (AD) in conventional (Conv) conditions, but not in specific pathogen-free (SPF) conditions. We reported that the ability of skin prostaglandin D(2) (PGD(2)) production, which might be the endogenous inhibitor of itching, was attenuated in skin-lesioned Conv-NC mice. We examined the age-related change in scratching, dermatitis symptoms, and skin PGs of SPF- and Conv-NC mice. In Conv-NC, PGD(2) increased at 7 weeks, at which scratching counts increased, but dermatitis did not develop. PGE(2), PGI(2) and PGF(2alpha) ... Read More »
» Published in Exp Dermatol. 2006 Nov;15(11):875-82.

2. Dermatitis in the mining industry: incidence, sources, and time loss.
Match Strength: 7.646

Occupational skin diseases and disorders are the most commonly reported nontrauma-related category of occupational illness in the United States, and mining has one of the highest incidence rates among all industries. The authors' objective in this study was to describe mining industry dermatitis incidence, sources of exposure, and resultant time lost from work. The authors reviewed Mine Accident, Injury and Illness Reports. From 1983 to 2002, the Mine Safety and Health Administration reported 975 cases of dermatitis in mines across the United States and its territories. Average annual ... Read More »
» Published in Arch Environ Occup Health. 2005 Mar-Apr;60(2):77-85.

3. Rheumatoid neutrophilic dermatitis.
Match Strength: 6.231

Rheumatoid neutrophilic dermatitis (RND) is an infrequent cutaneous manifestation of rheumatoid arthritis (RA). This condition is seen in patients who are both positive and negative for a circulating rheumatoid factor. Histologically, it presents with a neutrophilic dermatosis, characterized by a heavy dermal infiltrate of neutrophils with variable degrees of leukocytoclasis but no vasculitis. We describe the case of a young female with seronegative RA who had concomitant lesions of RND over both elbows. Her lesions appeared as nodules, but RND has been reported as papules and plaques, ... Read More »
» Published in Cutis. 2006 Aug;78(2):133-6.

4. A double-blind, vehicle-controlled clinical study to evaluate the efficacy of MAS065D (XClair), a hyaluronic acid-based formulation, in the management of radiation-induced dermatitis.
Match Strength: 5.891

This study was designed to assess the efficacy and tolerability of MAS065D (Xclair) compared to a vehicle control in the management of radiation dermatitis in patients receiving radiotherapy for breast cancer. Twenty patients were randomized blindly to use the two study substances, three times daily, on separate sections of irradiated skin throughout the duration of radiotherapy and for two weeks afterwards. Patients were monitored before therapy, weekly during therapy, and for 2 weeks after radiotherapy was completed. Skin appearance according to National Cancer Institute (NCI) toxicity ... Read More »
» Published in Cutan Ocul Toxicol. 2006;25(3):165-71.

5. Methicillin-resistant Staphylococcus aureus skin abscesses in a pediatric patient with atopic dermatitis: a case report.
Match Strength: 5.526

Recent trends indicate an increasing incidence of community-acquired methicillin-resistant Staphylococcus aureus (CAMRSA) in the general population, which is especially worrisome for clinicians caring for patients with atopic dermatitis (AD). Patients with AD are heavily colonized with S aureus and have impaired skin integrity and abnormal immune responses, which predisposes them to more invasive cutaneous infections (eg, cellulitis, furuncles, abscesses). In this report, we describe a child with severe AD who presented with CAMRSA skin abscesses. The presence of an atypical skin infection in ... Read More »
» Published in Cutis. 2006 Aug;78(2):113-6.

6. Role of bacterial superantigens in atopic dermatitis : implications for future therapeutic strategies.
Match Strength: 4.460

The role of staphylococcal superantigens in the pathophysiology of atopic dermatitis (AD) has been the focus of intense interest during the past decade. Although the increased prevalence of Staphylococcus aureus and its bacterial toxins in AD skin is well established, exploitation of the known mechanisms of superantigens in this disease for the development of novel therapies remains an active area of research. With the emergence of multi-drug resistant S. aureus, the need for a better understanding of the pathophysiology of bacterial superantigens in AD has become increasingly important. This ... Read More »
» Published in Am J Clin Dermatol. 2006;7(5):273-9.

7. Influence of narrow-band UVB phototherapy on cutaneous microbiota of children with atopic dermatitis.
Match Strength: 4.298

OBJECTIVE: In the present work, the effect of narrow-band ultraviolet B (UVB) phototherapy on a cutaneous microbial population was evaluated in patients with atopic dermatitis (AD) and compared with control patients (vitiligo). METHODS: Count, isolation and identification of cutaneous microbiota from anticubital fossa were performed in 10 controls and 10 AD patients, both submitted to similar levels (P > 0.05) of UVB phototherapy (4.3 +/- 0.9 and 4.3 +/- 0.8 accumulated joules, respectively). Additionally, Staphylococcus aureus isolates were screened for the production of exotoxins. RESULTS ... Read More »
» Published in J Eur Acad Dermatol Venereol. 2006 Oct;20(9):1114-20.

8. Pediatric rosacea.
Match Strength: 4.187

Rosacea is a condition most commonly associated with adults; however, various forms exist in the pediatric population and need to be considered when a child presents with a facial rash. Acne rosacea, steroid rosacea, granulomatous periorificial dermatitis, and other variants of rosacea are presented here and are distinguished from their numerous mimickers. Various topical and systemic therapeutic options exist for the treatment of rosacea with several adjustments and considerations that must be taken into account when treating a child. Publication Types: ... Read More »
» Published in Dermatol Ther. 2006 Jul-Aug;19(4):196-201.

9. What is meant by a "flare" in atopic dermatitis? A systematic review and proposal.
Match Strength: 3.633

OBJECTIVE: To make preliminary recommendations for defining a flare of atopic dermatitis (AD) in clinical research based on a systematic review of the literature and experience in running clinical trials. DATA SOURCES: A sensitive electronic search of MEDLINE biographic database was conducted on April 19, 2005, using the following search terms: flare$, exacerbation$, relaps$, remission$, worse$, and *recurrence. The search was restricted to all prospective studies of AD in humans, using the Cochrane search terms for AD and prospective studies. In addition, we searched the literature on 3 ... Read More »
» Published in Arch Dermatol. 2006 Sep;142(9):1190-6. Comment in: Arch Dermatol. 2006 Sep;142(9):1203-5.

10. Gene expression profiling of skin and draining lymph nodes of rats affected with cutaneous contact hypersensitivity.
Match Strength: 2.942

OBJECTIVES AND DESIGN: The present study aimed at a broad genome expression analysis of rat skin and draining lymph nodes affected with allergic contact dermatitis (ACD). METHODS: ACD was elicited in sensitized SD rats with 0.5% 2,4-dinitrofluorobenzene on skin areas distant from the sensitization sites. Involved skin and lymph nodes were dissected 8 and 24 h after challenge. RNA was hybridized on Affymetrix GeneChips. Expression data were analyzed with the GeneSpring software. RESULTS: Expression of 1,882 out of 8,799 examined genes in skin or lymph nodes was significantly (p < or = 0.01) ... Read More »
» Published in Inflamm Res. 2006 Aug;55(8):322-34.

11. Evaluation of transformation growth factor beta(1), interleukin-10, and interferon-gamma in male symptomatic and asymptomatic dogs naturally infected by Leishmania (Leishmania) chagasi.
Match Strength: 2.513

The aims of this study were to evaluate the immunomodulatory role of TGF-beta(1), IL-10, and INF-gamma in spleen and liver extracts and supernatant cultures of white spleen cells from male symptomatic and asymptomatic dogs, naturally infected by Leishmania (Leishmania) chagasi. Thirty dogs from Aracatuba, Sao Paulo, Brazil, an endemic leishmaniosis area, were selected by positive ELISA serological reaction for Leishmania sp. and divided into two groups: asymptomatic (n=15) and symptomatic (n=15) consisting of animals with at least three characteristic signs (fever, dermatitis, lymphoadenopathy ... Read More »
» Published in Vet Parasitol. 2007 Feb 28;143(3-4):267-74. Epub 2006 Sep 18.

12. CD18 in Monogenic and Polygenic Inflammatory Processes of the Skin.
Match Strength: 2.470

The beta(2) integrin family (CD11/CD18) of leukocyte adhesion molecules plays a key role in inflammation. Absence of the common beta chain (CD18) leads to leukocyte adhesion deficiency-1 (LAD1) in humans. We here summarize data of two genetically defined mice models of beta(2) integrin deficiency, one with a CD18 null mutation (CD18(-/-)), and the other one with a hypomorphic CD18 mutation (CD18(hypo)). Firstly, we focus on the underlying mechanism of a severely impaired wound healing in CD18(-/-) mice, outlining a scenario in which a defective extravasation and phagocytosis of CD18(-/-) ... Read More »
» Published in J Invest Dermatol. 2006 Sep;126 Suppl:7-15.

13. Identification of susceptibility loci for skin disease in a murine psoriasis model.
Match Strength: 2.390

Psoriasis is a frequently occurring inflammatory skin disease characterized by thickened erythematous skin that is covered with silvery scales. It is a complex genetic disease with both heritable and environmental factors contributing to onset and severity. The CD18 hypomorphic PL/J mouse reveals reduced expression of the common chain of beta(2) integrins (CD11/CD18) and spontaneously develops a skin disease that closely resembles human psoriasis. In contrast, CD18 hypomorphic C57BL/6J mice do not demonstrate this phenotype. In this study, we have performed a genome-wide scan to identify loci ... Read More »
» Published in J Immunol. 2006 Oct 1;177(7):4612-9.

14. Pediatric granulomatous arthritis: an international registry.
Match Strength: 2.365

OBJECTIVE: Blau syndrome and its sporadic counterpart, early-onset sarcoidosis, share an identical phenotype featuring the classic triad of arthritis, dermatitis, and uveitis and are associated with mutations of CARD15 in 50-90% of cases. We chose the term "pediatric granulomatous arthritis" to refer to both. An international registry was established in the spring of 2005 to define the phenotype spectrum and establish the mutation frequency and variants. METHODS: Histologically confirmed granuloma and arthritis were required for inclusion. Probands and relatives were genotyped for CARD15. ... Read More »
» Published in Arthritis Rheum. 2006 Oct;54(10):3337-44.

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