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1. Maintenance treatment of bipolar disorder: Applying research to clinical practice.
Match Strength: 8.861

The authors review available controlled trials of bipolar maintenance treatment and discuss the strengths and weaknesses of various study designs. Bipolar maintenance trials are organized according to the features of their designs, such as use of responder-enriched samples; inclusion following an index manic versus an index depressive episode; outcome defined as relapse into mania, depression, or either; and use of survival analysis. Pivotal studies of lithium, divalproex, lamotrigine, olanzapine, aripiprazole, and other medications are reviewed. The directional efficacy of the different ... Read More »
» Published in J Psychiatr Pract. 2006 Sep;12(5):283-99.

2. Comparison of clinical characteristics in episodic and chronic obsessive-compulsive disorder.
Match Strength: 6.611

Our objective in this study was to compare the demographics and clinical characteristics of patients with episodic and chronic obsessive-compulsive disorder (OCD). We recruited 128 outpatients with a primary diagnosis of OCD according to DSM-IV diagnostic criteria. The episodic (n=24) and chronic (n=104) OCD patient groups were compared with respect to demographic variables and scores from various psychiatric rating scales. The severity of compulsions was found to be significantly lower in the episodic OCD group than in the chronic OCD group. When the frequency of Axis I disorders was assessed ... Read More »
» Published in Depress Anxiety. 2006 Sep 27;

3. Bipolar II and anxious reactive "comorbidity": toward better phenotypic characterization suitable for genotyping.
Match Strength: 6.059

OBJECTIVE: In DSM-IV, bipolar II (BP-II) disorder is defined by depression and hypomania. There is little appreciation of affective instability, often associated with anxiety-particularly panic disorder and agoraphobia (PDA)-comorbidity. This association has genetic-familial implications, which we believe must be incorporated in refining the BP-II phenotype suitable for genotyping purposes. METHOD: We examined in a semi-structured format 107 consecutive patients who met DSM-IV criteria for major depressive episode with atypical features and separated them into two subgroups according to the co ... Read More »
» Published in J Affect Disord. 2006 Dec;96(3):239-47. Epub 2006 Sep 14.

4. Screening for serious mental illness in populations with co-occurring substance use disorders: Performance of the K6 scale.
Match Strength: 5.174

Serious mental illnesses (SMIs) such as schizophrenia, bipolar disorder, and major depression are prevalent among individuals with substance use disorders, particularly those in drug treatment programs. No screening tool has yet become the gold standard for identifying SMI among individuals with substance use disorders. One candidate instrument, the K6 screening scale, is brief, easy to administer and score, and has performed well, detecting SMI in studies using general population samples. We used data from the National Survey on Drug Use and Health to examine the K6's psychometric properties ... Read More »
» Published in J Subst Abuse Treat. 2006 Oct;31(3):287-96. Epub 2006 Jul 18.

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