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DNA Virus Infections
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1. Differential signaling networks induced by mild and lethal hemorrhagic fever virus infections.
Match Strength: 6.912

The family Arenaviridae includes several National Institutes of Allergy and Infections Diseases category A select agents which cause hemorrhagic fever. There are few vaccines available, and treatment is limited to ribavirin, which varies in efficacy. Development of new antiviral compounds has been hindered by a lack of understanding of the molecular basis of pathogenesis. We used two variants of Pichinde virus, one attenuated and one virulent in the guinea pig model, to delineate the host determinants which lead to either viral clearance or lethal disease. By analyzing protein level changes ... Read More »
» Published in J Virol. 2006 Oct;80(20):10248-52.

2. Zoonotic infections among veterinarians in Turkey: Crimean-Congo hemorrhagic fever and beyond.
Match Strength: 6.280

OBJECTIVES: We aimed to determine the seroprevalence of Crimean-Congo hemorrhagic fever (CCHF) virus, Brucella spp, and Coxiella burnetii among veterinarians in a highly endemic and a non-endemic region for these infections in Turkey. METHODS: The antibody levels against these three infections were surveyed. Eighty-three veterinarians were included from two distinct geographic regions. RESULTS: CCHF IgG positivity (3% vs. 0%) and Brucella agglutination titer of > or =1/160 (33% vs. 5%) were more common in the endemic region, whereas the rates of Coxiella burnetii antibodies were similar (7% ... Read More »
» Published in Int J Infect Dis. 2006 Nov;10(6):465-9. Epub 2006 Sep 15.

3. Mendelian resistance to human norovirus infections.
Match Strength: 6.195

Noroviruses have emerged as a major cause of acute gastroenteritis in humans of all ages. Despite high infectivity of the virus and lack of long-term immunity, volunteer and authentic studies has suggested the existence of inherited protective factors. Recent studies have shown that histo-blood group antigens (HBGAs) and in particular secretor status controlled by the alpha1,2fucosyltransferase FUT2 gene determine susceptibility to norovirus infections, with nonsecretors (FUT2-/-), representing 20% of Europeans, being highly resistant to symptomatic infections with major strains of norovirus. ... Read More »
» Published in Semin Immunol. 2006 Dec;18(6):375-86. Epub 2006 Sep 14.

4. Comparison of multiplex PCR assays and conventional techniques for the diagnostic of respiratory virus infections in children admitted to hospital with an acute respiratory illness.
Match Strength: 5.659

The performances of four multiplex PCR (m-PCR) were compared to direct immunofluorescence assay (DFA) and HuH7 cell culture for the detection of viruses in 263 children admitted to hospital with an acute respiratory illness. One hundred fifty (57.6%) nasal aspirates were found DFA-positive; 188 (72.3%) were found positive by both DFA and HuH7 cell culture, and 242 (92%) were PCR-positive. The m-PCR detected 124 viruses which were not found by conventional methods: 68 rhinovirus, 17 human metapneumovirus, 15 respiratory syncytial virus (RSV), 8 parainfluenza virus (PIV), 5 coronavirus 229E, 3 ... Read More »
» Published in J Med Virol. 2006 Nov;78(11):1498-504.

5. The role of respiratory viruses in the pathogenesis of pediatric asthma.
Match Strength: 5.346

The role of respiratory viral infection in the development of asthma remains unclear. A number of factors play crucial roles, including the type of virus, the severity of the disease, the time of the infection, and, most important, the host predisposition. On the other hand, there is little doubt that a strong association exists between viral respiratory infections and induction of wheezing illnesses and asthma exacerbations. The underlying mechanisms, although not fully clarified, are likely to be multifactorial, involving inflammation of the bronchial mucosa, which interacts under certain ... Read More »
» Published in Pediatr Ann. 2006 Sep;35(9):637-42.

6. Use of virus vectors for the expression in plants of active full-length and single chain anti-coronavirus antibodies.
Match Strength: 5.340

To extend the potential of antibodies and their derivatives to provide passive protection against enteric infections when supplied orally in crude plant extracts, we have expressed both a small immune protein (SIP) and a full-length antibody in plants using two different plant virus vectors based on potato virus X (PVX) and cowpea mosaic virus (CPMV). The alphaSIP molecule consisted of a single chain antibody (scFv) specific for the porcine coronavirus, transmissible gastroenteritis virus (TGEV) linked to the alpha-CH3 domain from human IgA. To express the full-length IgA, the individual light ... Read More »
» Published in Biotechnol J. 2006 Oct;1(10):1103-11.

7. Noncytopathic bovine viral diarrhea virus can persist in testicular tissue after vaccination of peri-pubertal bulls but prevents subsequent infection.
Match Strength: 5.284

The objectives of this research were to evaluate the risk of prolonged testicular infection as a consequence of vaccination of peri-pubertal bulls with a modified-live, noncytopathic strain of BVDV and to assess vaccine efficacy in preventing prolonged testicular infections after a subsequent acute infection. Seronegative, peri-pubertal bulls were vaccinated subcutaneously with an approximate minimum immunizing dose or a 10x standard dose of modified-live, noncytopathic BVDV or were maintained as unvaccinated controls. Forty-nine days after vaccination, all bulls were intranasally inoculated ... Read More »
» Published in Vaccine. 2007 Jan 15;25(5):867-76. Epub 2006 Sep 20.

8. Postmortem findings and opportunistic infections in HIV-positive patients from a public hospital in Peru.
Match Strength: 5.267

There is a paucity of HIV autopsy data from South America and none that document the postmortem findings in patients with HIV/AIDS in Peru. The purpose of this autopsy study was to determine the spectrum of opportunistic infections and the causes of mortality in HIV-positive patients at a public hospital in Lima. Clinico-epidemiological information regarding HIV infection in Peru is also reviewed. Sixteen HIV-related hospital postmortems, performed between 1999 and 2004, were included in this retrospective analysis. The primary cause of death was established in 12 patients: one died of ... Read More »
» Published in Pathol Res Pract. 2006;202(11):767-75. Epub 2006 Sep 19.

9. Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus.
Match Strength: 5.237

The influenza pandemic of 1918-19 was responsible for about 50 million deaths worldwide. Modern histopathological analysis of autopsy samples from human influenza cases from 1918 revealed significant damage to the lungs with acute, focal bronchitis and alveolitis associated with massive pulmonary oedema, haemorrhage and rapid destruction of the respiratory epithelium. The contribution of the host immune response leading to this severe pathology remains largely unknown. Here we show, in a comprehensive analysis of the global host response induced by the 1918 influenza virus, that mice infected ... Read More »
» Published in Nature. 2006 Oct 5;443(7111):578-81. Epub 2006 Sep 27.

10. An attempt to identify recombinants between two sobemoviruses in doubly infected oat plants.
Match Strength: 5.197

Recombination in RNA viruses is considered to play a major role as a driving force in virus variability to counterbalance loss in fitness that can be due to the accumulation of detrimental mutations. Studies on mixed infections are pertinent for understanding the role of recombination in virus evolution. They also provide important baseline information for studying the biosafety of plants expressing viral sequences. To investigate the possibility of RNA recombination occurrence between two sobemoviruses under little or no selection pressure, we co-infected test plants with Cocksfoot mottle ... Read More »
» Published in Environ Biosafety Res. 2006 Jan-Mar;5(1):47-56. Epub 2006 Sep 19.

11. Serological profiles after consecutive experimental infections of pigs with European H1N1, H3N2, and H1N2 swine influenza viruses.
Match Strength: 5.071

Swine influenza viruses (SIVs) of H1N1, H3N2, and H1N2 subtypes, with antigenically different hemagglutinins, are currently cocirculating in pigs in Europe. This study aimed to determine whether the hemagglutination inhibition (HI) test, which is the primary serological test for SIV, is sufficiently specific to discriminate between infections with the three subtypes. In experiment 1, pigs were consecutively inoculated with European H1N1, H3N2, and H1N2 SIVs by the intranasal route, or with the respective subtypes only. In a second experiment, a commercial, inactivated H1N1- and H3N2- based SIV ... Read More »
» Published in Viral Immunol. 2006 Summer;19(3):373-82. Erratum in: Viral Immunol. 2006 Winter;19(4):775.

12. HIV type 1 inhibition by protein kinase C modulatory compounds.
Match Strength: 5.039

The dichotomous effects of the protein kinase C (PKC) modulatory compounds 12-myristate 13-acetate (PMA), prostratin, and ingenol 3-angelate (I3A) on HIV-1 infection were investigated. PKC modulatory compounds were shown to be potent activators of cells latently infected with HIV-1 (I3A > prostratin). Conversely, PKC modulatory compounds inhibited infection of indicator cells (MAGI) with CXCR4-tropic HIV-1 (PMA > I3A > prostratin), and I3A also inhibited infection with CCR5-tropic virus (AD8-1). Pretreatment with the PKC inhibitors prior to treatment with either I3A or PMA resulted in ... Read More »
» Published in AIDS Res Hum Retroviruses. 2006 Sep;22(9):854-64.

13. Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon.
Match Strength: 4.973

This study demonstrates a unique and crucial role of plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-alpha production following encounter with this cytopathic RNA virus. Furthermore, the particular type I IFN response pattern was not restricted to the murine coronavirus, but was also found in infection with the highly cytopathic ... Read More »
» Published in Blood. 2007 Feb 1;109(3):1131-7. Epub 2006 Sep 19.

14. Chronic rhinoviral infection in lung transplant recipients.
Match Strength: 4.761

RATIONALE: Lung transplant recipients are particularly at risk of complications from rhinovirus, the most frequent respiratory virus circulating in the community. OBJECTIVES: To determine whether lung transplant recipients can be chronically infected by rhinovirus and the potential clinical impact. METHODS: We first identified an index case, in which rhinovirus was isolated repeatedly, and conducted detailed molecular analysis to determine whether this was related to a unique strain or to re-infection episodes. Transbronchial biopsies were used to assess the presence of rhinovirus in the lung ... Read More »
» Published in Am J Respir Crit Care Med. 2006 Dec 15;174(12):1392-9. Epub 2006 Sep 28. Comment in: Am J Respir Crit Care Med. 2006 Dec 15;174(12):1284-5.

15. Novel robust hepatitis C virus mouse efficacy model.
Match Strength: 4.423

The lack of a robust small-animal model for hepatitis C virus (HCV) has hindered the discovery and development of novel drug treatments for HCV infections. We developed a reproducible and easily accessible xenograft mouse efficacy model in which HCV RNA replication is accurately monitored in vivo by real-time, noninvasive whole-body imaging of gamma-irradiated SCID mice implanted with a mouse-adapted luciferase replicon-containing Huh-7 cell line (T7-11). The model was validated by demonstrating that both a small-molecule NS3/4A protease inhibitor (BILN 2061) and human alpha interferon (IFN ... Read More »
» Published in Antimicrob Agents Chemother. 2006 Oct;50(10):3260-8.

16. Polydnavirus genes that enhance the baculovirus expression vector system.
Match Strength: 4.373

The baculovirus expression vector system (BEVS) is a powerful and versatile system for protein expression, which has many advantages. However, a limitation of any lytic viral expression system, including BEVS, is that death and lysis of infected insect cells terminates protein production. This results in interruption of protein production and higher production costs due to the need to set up new infections, maintain uninfected cells, and produce pure viral stocks. Genetic methods to slow or prevent cell death while maintaining high-level, virus-driven protein production could dramatically ... Read More »
» Published in Adv Virus Res. 2006;68:75-90.

17. Interferon and ribavirin treatment results of patients with HBV-HCV co-infection cured of childhood malignancies.
Match Strength: 4.297

OBJECTIVES: We aimed to investigate the virological and clinical characteristics and the results of combination therapy in six oncology patients with hepatitis B virus (HBV)-hepatitis C virus (HCV) co-infection. METHOD: Six patients (five male and one female; age range 8-14 years), diagnosed with HBV-HCV infections during follow-up at the oncology outpatient clinic during 2000-2001 were included in the study. They had received an average of 25.8 units of blood by transfusion per patient during their treatment for malignancies. Positive serological HBV indicators were determined 20-40 months ... Read More »
» Published in Int J Infect Dis. 2006 Nov;10(6):453-7. Epub 2006 Sep 26.

18. The severity of respiratory syncytial virus bronchiolitis in young infants in the United arab emirates.
Match Strength: 4.232

Respiratory syncytial virus (RSV) respiratory infections are very common during infancy and account for the majority of hospitalizations during the fall and winter seasons. Patients vary in the severity of their illnesses, with most hospitalized patients needing oxygen and intravenous fluids. The objective of this study was to assess in hospitalized patients the severity of the disease in relation to age. We compared children who were <90 days old with children who were >90 days old for the duration of oxygen therapy, maximum oxygen concentration used, duration of stay and duration of ... Read More »
» Published in J Trop Pediatr. 2007 Feb;53(1):22-6. Epub 2006 Sep 28.

19. Characterization of drug-resistance mutations in HIV-1 isolates from non-HAART and HAART treated patients in Burkina Faso.
Match Strength: 4.154

Non-B HIV subtypes have been estimated to account for 88% of HIV infections in the world. These subtypes are particularly relevant in view of the availability of antiretroviral (ARV) drugs, since subtype-specific mutations are associated with drug-resistance in developing countries. Therefore, the pol gene sequences in HIV-1 isolates were examined from the three distinct groups of 39 infected patients from Ouagadougou in Burkina Faso: 17 patients who had not received any antiretroviral therapy (ART); 16 patients received ART, and 6 HIV-infected children, from infected mothers, received a ... Read More »
» Published in J Med Virol. 2006 Nov;78(11):1385-91.

20. Detection of hepatitis E virus in liver, mesenteric lymph node, serum, bile and faeces of naturally infected pigs affected by different pathological conditions.
Match Strength: 4.011

The objective of the present study was to detect hepatitis E virus (HEV) in different samples from naturally infected pigs and to characterise genetically the detected strains. Serum, bile, liver, lymph nodes and faeces of 69 animals from 1 week to 4 months of age with different pathological conditions were collected. Reverse transcriptase-polymerase chain reaction (RT-PCR) to detect HEV and histopathology of tissues was conducted. Positive RT-PCR samples were sequenced and phylogenetically analysed. HEV was detected in at least one sample in 26 out of 69 animals (37.7%). Bile was the most ... Read More »
» Published in Vet Microbiol. 2007 Jan 31;119(2-4):105-14. Epub 2006 Sep 25.

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