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Peer Reviewed Scientific Research Reports.
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1. Interstitial cystitis: characterization and management of an enigmatic urologic syndrome.
Match Strength: 14.696
The enigmatic urologic condition known as interstitial cystitis has an estimated prevalence of 0.01% to 0.50% of the female population. Its etiology is unknown but may involve microbiologic, immunologic, mucosal, neurogenic, and/or other, as yet undefined, agents. There is no gold standard for the diagnosis of interstitial cystitis; rather, it is a diagnosis of exclusion. It is impossible to provide a purely evidence-based treatment strategy, but review of available evidence suggests that conservative supportive therapy (including diet modification); oral treatment with pentosan polysulfate, ... Read More »
» Published in Rev Urol. 2002 Summer;4(3):112-21.
2. The role of pentosan polysulfate in treatment approaches for interstitial cystitis.
Match Strength: 10.276
Studies of the mechanisms and causes of interstitial cystitis (IC) and of the properties of pentosan polysulfate have provided a scientific rationale for using pentosan polysulfate to treat IC. In randomized, double-blind studies, patient and investigator evaluations of pentosan polysulfate in the treatment of IC resulted in favorable assessments of the drug. In addition, IC patients in two out of four randomized, prospective trials improved significantly in most variables with treatment by oral pentosan polysulfate; in the two other studies, the IC patients improved in some domains with ... Read More »
» Published in Rev Urol. 2002;4 Suppl 1:S21-7.
3. Complementary and alternative therapies as treatment approaches for interstitial cystitis.
Match Strength: 9.904
The management of interstitial cystitis (IC) is predominantly the reduction of the symptoms of frequency, urgency, and pain. Multimodal treatment approaches for IC are helpful in customizing therapy for individual patients. Complementary and alternative therapies are a quintessential addition to the therapeutic armamentarium and frequently include dietary modification, nutraceuticals, bladder training, neuromodulation, stress reduction, and sex therapy. Dietary modification involves elimination of bladder irritants, fluid regulation, and a bowel regimen. Nutraceuticals studied for the ... Read More »
» Published in Rev Urol. 2002;4 Suppl 1:S28-35.
4. Dysuria at onset of interstitial cystitis/painful bladder syndrome in women.
Match Strength: 9.224
OBJECTIVES: In an ongoing national study of women to identify risk factors for interstitial cystitis/painful bladder syndrome (IC/PBS), dysuria was identified at the onset of IC/PBS in a small majority and the evidence for urinary tract infection was evaluated. METHODS: In women with IC/PBS of 12 months' duration or less, symptoms and pertinent laboratory tests at onset were assessed by telephone interview and medical record review. RESULTS: Of 138 women, 75 (54%) reported that they had started to experience burning or pain on urination at the onset of IC/PBS. Of those with urine cultures, 12 ... Read More »
» Published in Urology. 2006 Sep;68(3):477-81. Epub 2006 Sep 18.
5. Prevalence and correlates for interstitial cystitis symptoms in women participating in a health screening project.
Match Strength: 9.181
OBJECTIVES: To determine the prevalence of interstitial cystitis (IC) symptoms in an urban female population, to study their impact on quality of life and sexual function, and to identify correlates for IC symptoms. METHODS: Women attending a voluntary health survey project in Vienna underwent a detailed health investigation and completed a questionnaire containing the O'Leary-Sant IC questionnaire. Women with high (>/=12) symptom and problem scores including nocturia (>2) and pain were considered most likely to have IC. RESULTS: A total of 981 women, aged 19 to 89 yr (mean, 49.1+/-14.7 ... Read More »
» Published in Eur Urol. 2007 Mar;51(3):803-9. Epub 2006 Aug 30.
6. Pathophysiology of overactive bladder and urge urinary incontinence.
Match Strength: 6.026
Storage symptoms such as urgency, frequency, and nocturia, with or without urge incontinence, are characterized as overactive bladder (OAB). OAB can lead to urge incontinence. Disturbances in nerves, smooth muscle, and urothelium can cause this condition. In some respects the division between peripheral and central causes of OAB is artificial, but it remains a useful paradigm for appreciating the interactions between different tissues. Models have been developed to mimic the OAB associated with bladder instability, lower urinary tract obstruction, neuropathic disorders, diabetes, and ... Read More »
» Published in Rev Urol. 2002;4 Suppl 4:S7-S18.
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