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Cryoglobulinemia
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1. Life-threatening cryoglobulinemia: clinical and immunological characterization of 29 cases.
Match Strength: 6.712

OBJECTIVES: To analyze the etiology, clinical presentation, and outcomes of patients with life-threatening cryoglobulinemic vasculitis. METHODS: We studied 209 consecutive patients with cryoglobulinemic vasculitis. A potentially life-threatening cryoglobulinemia was considered as the development of renal failure, vasculitic abdominal involvement, pulmonary hemorrhage, or central nervous system involvement. RESULTS: Twenty-nine (14%) patients had life-threatening cryoglobulinemic vasculitis. There were 17 women and 12 men, with a mean age of 57 years. In 17 (59%) patients, life-threatening ... Read More »
» Published in Semin Arthritis Rheum. 2006 Dec;36(3):189-96. Epub 2006 Sep 22.

2. Rituximab therapy for mixed cryoglobulinemia in seven renal transplant patients.
Match Strength: 5.704

Systemic B-cell depletion and clinical remission of the systemic effects of cryoglobulins have been achieved in hepatitis C virus-positive immunocompetent patients with rituximab, a human/mouse chimeric monoclonal antibody that specifically reacts with the CD20 antigen. Thus, this provides a rationale for the use of rituximab for type III cryoglobulin-related graft dysfunction in renal-transplant patients. Seven patients, of whom five were hepatitis C positive, developed renal function impairment long after transplantation, as well as de novo nephrotic syndrome (n = 5), severe hypertension (n ... Read More »
» Published in Transplant Proc. 2006 Sep;38(7):2308-10.

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