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Crohn Disease
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1. Novel therapies for Crohn's disease: focus on immunomodulators and antibiotics.
Match Strength: 9.493

OBJECTIVE: To review the literature on novel immunomodulators such as tumor necrosis factor alpha (TNF-alpha)- and interleukin (IL)-related agents, 6-thioguanine (6-TG), tacrolimus, and leflunomide, and antibiotics such as ornidazole, rifaximin, and ciprofloxacin for the treatment of Crohn's disease. DATA SOURCES: Literature was accessed through MEDLINE (1966-January 2006) using the terms Crohn's disease, novel therapies, immunomodulators, and antibiotics. Article references were hand-searched for additional relevant articles and abstracts. STUDY SELECTION AND DATA EXTRACTION: All articles in ... Read More »
» Published in Ann Pharmacother. 2006 Oct;40(10):1804-13. Epub 2006 Sep 19.

2. Long-term outcome after intestinal resection for Crohn's disease.
Match Strength: 9.361

OBJECTIVE: To assess the need for intestinal repeat resection for recurrence of Crohn's disease in patients observed for more than 20 years after the first resection. MATERIAL AND METHODS: Data were gathered retrospectively from the medical records of 53 (28 F) consecutive patients with Crohn's disease from May 1954 to December 2002. Median age at first intestinal resection was 24.5 (range 13-65) years, and median observation time thereafter was 26.5 (20.1-48.6) years. Disease location and behaviour were defined according to the Vienna classification. RESULTS: The 53 patients had an average 2 ... Read More »
» Published in Scand J Gastroenterol. 2006 Oct;41(10):1204-8.

3. Azathioprine as a postoperative prophylaxis reduces symptoms in aggressive Crohn's disease.
Match Strength: 7.392

OBJECTIVE: Recurrence of Crohn's disease (CD) after surgery is common. Azathioprine/6-mercaptopurine (Aza/6-MP) is effective in controlling medically induced remission but, so far, has only been sparsely investigated after surgically induced remission. This study comprises a subset of CD patients considered to have an aggressive disease course and chosen for treatment with Aza postoperatively. MATERIAL AND METHODS: In 1989-2000, a total of 100 patients with CD were given Aza/6-MP as a postoperative prophylaxis. Fourteen Aza/6-MP-intolerant patients were compared with 28 Aza-tolerant patients, ... Read More »
» Published in Scand J Gastroenterol. 2006 Oct;41(10):1190-5.

4. Absence of association between the multidrug resistance (MDR1) gene and inflammatory bowel disease.
Match Strength: 6.524

OBJECTIVE: The multidrug resistance (MDR1) gene encodes for P-glycoprotein, a drug efflux pump. Mice deficient for the MDR1a gene spontaneously develop colitis. In humans, a polymorphism in exon 26 (C3435T) is associated with reduced expression levels and function of MDR1. Currently there are controversial data on the association between MDR1 and inflammatory bowel disease (IBD). The purpose of this study was to examine the involvement of this gene in IBD in a large population of Dutch patients with IBD and family-based controls. MATERIAL AND METHODS: A total of 781 IBD cases and 315 controls ... Read More »
» Published in Scand J Gastroenterol. 2006 Oct;41(10):1174-82.

5. Anti-calreticulin antibodies in patients with inflammatory bowel disease.
Match Strength: 4.646

PURPOSE: Although the pathogenesis of inflammatory bowel disease (IBD) is unclear, autoimmune processes seem to play roles in IBD because several types of autoantibodies have been found in it. Calreticulin (CRT) is a soluble Ca2+ binding protein which is present in a wide variety of cells. CRT is localized mainly in the endoplasmic reticulum and is often a target for autoantibodies. The aim of this study was to evaluate the clinical significance of anti-CRT antibodies measured by enzyme-linked immunosorbent assay (ELISA) using the sera of patients with ulcerative colitis (UC) and Crohn's ... Read More »
» Published in Fukushima J Med Sci. 2006 Jun;52(1):1-11.

6. MRI of complicated pouchitis.
Match Strength: 4.463

OBJECTIVE: The purpose of this study is to assess the ability of MRI to identify the presence of inflammation related to the pouch reservoir in symptomatic patients with an ileal pouch-anal anastomosis who present with clinically suspected complicated pouchitis. CONCLUSION: Initial results suggest that MRI should be considered in patients who have undergone ileal pouch-anal anastomosis and present a clinical impression of complicated pouchitis. MRI showed abnormalities consistent with complicated pouchitis in seven of nine examinations, with findings including pouch wall thickening, abnormal ... Read More »
» Published in AJR Am J Roentgenol. 2006 Oct;187(4):W386-91.

7. Laparoscopic colorectal resection: initial experience in a specialist unit.
Match Strength: 4.186

The adoption of the laparoscopic approach to colorectal resection has been slow amongst colorectal surgeons principally due to concerns regarding oncological safety. Recent randomized controlled trials have confirmed both the safe and some advantage of this procedure have been performing laparoscopic assisted colorectal resection since 2002 and have now performed over 100 cases on non consecutive and selected patients. We have reviewed our experience with the introduction of this technique. 61 patients were operated on for cancer and 39 for benign disease mainly Crohn's and diverticular ... Read More »
» Published in Ir Med J. 2006 Jul-Aug;99(7):211, 213-4.

8. Probiotics and prebiotics in chronic inflammatory bowel diseases.
Match Strength: 3.725

The prokaryotic and eukaryotic cells of the colon exist in a highly complex, but harmonious relationship. Disturbances in this remarkable symbiosis can result in the development of inflammatory bowel diseases (IBD). Although the etiology of IBD is not entirely understood, it is known that the chronic inflammation of Crohn's disease, ulcerative colitis and chronic pouchitis are a result of an overly aggressive immune response to the commensal intestinal flora in genetically susceptible hosts. Recent studies have enhanced our ability to understand the interaction between the host and its ... Read More »
» Published in World J Gastroenterol. 2006 Oct 7;12(37):5941-50.

9. Push-and-pull enteroscopy using the double-balloon technique/double-balloon enteroscopy.
Match Strength: 3.719

Push-and-Pull enteroscopy/Double balloon enteroscopy (PPE/DBE) allows enteroscopy of the entire small bowel, or at least a substantial part of it. The complication rate is acceptably low. Severe complications such as pancreatitis and perforation were encountered in the literature in approximately 1% of all diagnostic PPE/DBEs. It can be expected that the complication rate of therapeutic PPE/DBEs is higher, comparable with the conventional endoscopy. The diagnostic yield is high, at approximately 75%, as is the therapeutic yield. The option of carrying out endoscopic therapy (in approximately ... Read More »
» Published in Dig Liver Dis. 2006 Dec;38(12):932-8. Epub 2006 Sep 15.

10. Multi-detector row CT: spectrum of diseases involving the ileocecal area.
Match Strength: 3.508

The ileocecal area is a relatively short segment of the gastrointestinal tract but may be affected by pathologic conditions that are either common throughout the gastrointestinal system or exclusive to this area. These conditions include benign and malignant tumors, inflammatory processes (appendicitis, diverticulitis, epiploic appendagitis, Crohn disease), infectious diseases, and miscellaneous conditions (cecal ischemia, typhlitis, cecal volvulus, duplication cyst). The various components of the ileocecal area (cecum, appendix, ileocecal valve, terminal ileum) are close to one another, so ... Read More »
» Published in Radiographics. 2006 Sep-Oct;26(5):1373-90.

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