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Peer Reviewed Scientific Research Reports.
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1. Investigations in subjects with cough following upper respiratory tract infection.
Match Strength: 8.492
The study aimed to investigate subjects with cough following acute upper respiratory tract infection (URTI), and to compare those subjects unable to suppress cough ("non-suppressors") with those who were able to suppress cough ("suppressors"). Forty-three URTI subjects participated, 31 with cough associated with acute URTI and 12 healthy controls; 21 of the coughing subjects were "suppressors", 10 were "non-suppressors". We obtained responses to chemical and mechanical stimulation of the nasal cavity or the pharynx using both psychophysical measures and event-related potentials. The study ... Read More »
» Published in Respir Physiol Neurobiol. 2006 Aug 22;
2. Bronchoscopic study on aetiology of chronic cough in HIV-infected adults with negative sputum smears for Mycobacterium tuberculosis at Kenyatta National Hospital, Nairobi.
Match Strength: 7.479
OBJECTIVE: To establish the aetiology of chronic cough in HIV-infected patients with negative sputum smears for Acid Fast Bacilli (AFB). DESIGN: A cross-sectional descriptive study. SETTING: Kenyatta National Hospital, a tertiary referral centre in Kenya SUBJECTS: Sixty five HIV-infected adults presenting with chronic cough and negative sputum smears for AFBs. RESULTS: Sixty-two patients were included in the final analysis. Aetiology of chronic cough was established in 42 (68%) patients. Pneumocystis jiroveci, bacterial pneumonia and Mycobacterium tuberculosis were diagnosed in 22 (35.5%), 17 ... Read More »
» Published in East Afr Med J. 2006 Jun;83(6):295-305.
3. Incidence of chronic obstructive pulmonary disease in a cohort of young adults according to the presence of chronic cough and phlegm.
Match Strength: 7.147
RATIONALE: The few prospective studies aimed at assessing the incidence of chronic obstructive pulmonary disease (COPD) in relation to the presence of chronic cough/phlegm have produced contrasting results. OBJECTIVES: To assess the incidence of COPD in a cohort of young adults and to test whether chronic cough/phlegm and dyspnea are independent predictors of COPD. METHODS: An international cohort of 5,002 subjects without asthma (ages 20-44 yr) with normal lung function (FEV(1)/FVC ratio >/= 70%) from 12 countries was followed from 1991-2002 in the frame of the European Community ... Read More »
» Published in Am J Respir Crit Care Med. 2007 Jan 1;175(1):32-9. Epub 2006 Sep 28.
4. Hypoxemia in children with pneumonia and its clinical predictors.
Match Strength: 5.171
OBJECTIVES: To assess the prevalence of hypoxemia in children, 2 months to 5 years of age, with pneumonia and to identify its clinical predictors. METHODS: Children between 2-60 months of age presenting with a complaint of cough or difficulty breathing were assessed. Hypoxemia was defined as an arterial oxygen saturation of < 90% recorded by a portable pulse oximeter. Patients were categorized into groups: cough and cold, pneumonia, severe pneumonia and very severe pneumonia. RESULTS: The prevalence of hypoxemia (SpO2 of < 90%) in 150 children with pneumonia was 38.7%. Of them 100% of ... Read More »
» Published in Indian J Pediatr. 2006 Sep;73(9):777-81.
5. Imaging of an invasive malignant thymoma on PET Scan: CT and histopathologic correlation.
Match Strength: 3.337
Thymomas are common primary mediastinal neoplasms. They can be benign or malignant. The diagnosis of malignant thymomas is based on capsular invasion, cellular atypia and distant metastases. We present a case of invasive malignant thymoma as diagnosed on PET and CT scan with histologic correlation and review of literature. A seventy year old Asian man presented with cough and dyspnea. A CT scan showed an anterior mediastinal mass, and a PET scan showed a hypermetabolic mass in the corresponding location. Resection of the mass revealed a minimally invasive thymoma based on evidence of capsular ... Read More »
» Published in Clin Nucl Med. 2006 Oct;31(10):614-6.
6. Virtual screening for finding natural inhibitor against cathepsin-L for SARS therapy.
Match Strength: 3.162
Recently Simmons et al. reported a new mechanism for SARS virus entry into target cells, where MDL28170 was identified as an efficient inhibitor of CTSL-meditated substrate cleavage with IC(50) of 2.5 nmol/l. Based on the molecule fingerprint searching method, 11 natural molecules were found in the Traditional Chinese Medicines Database (TCMD). Molecular simulation indicates that the MOL376 (a compound derived from a Chinese medicine herb with the therapeutic efficacy on the human body such as relieving cough, removing the phlegm, and relieving asthma) has not only the highest binding energy ... Read More »
» Published in Amino Acids. 2006 Sep 29;
7. Site-specific acid-base properties of pholcodine and related compounds.
Match Strength: 3.062
The acid-base properties of pholcodine, a cough-depressant agent, and related compounds including metabolites were studied by 1H NMR-pH titrations, and are characterised in terms of macroscopic and microscopic protonation constants. New N-methylated derivatives were also synthesized in order to quantitate site- and nucleus-specific protonation shifts and to unravel microscopic acid-base equilibria. The piperidine nitrogen was found to be 38 and 400 times more basic than its morpholine counterpart in pholcodine and norpholcodine, respectively. The protonation data show that the molecule of ... Read More »
» Published in Anal Bioanal Chem. 2006 Nov;386(6):1709-16. Epub 2006 Sep 27.
8. Chlamydia and Mycoplasma serology in respiratory tract infections of children.
Match Strength: 2.707
One of the challenges in planning the treatment of respiratory tract infection in children is identifying the causative agent. The objective of the present study was to investigate the incidence of Mycoplasma and Chlamydia in the etiology of respiratory tract infections of children. The present study included 100 children, three months to 12 years of age, admitted to the outpatient department of pediatrics with such respiratory symptoms as fever, cough and respiratory distress. Following a detailed clinical history and physical examination, complete blood count, erythrocyte sedimentation rate, ... Read More »
» Published in Tuberk Toraks. 2006;54(3):254-8.
9. Is acute dyspnea related to oxaliplatin administration?
Match Strength: 2.635
The standard adjuvant treatment of colon cancer is fluorouracil plus leucovorin. Oxaliplatin improves the efficacy of this combination in patients with stage III colon cancer and moreover its toxicity is well tolerable. We describe a rare clinical case of acute dyspnoea probably related to oxaliplatin at one month from the end of the adjuvant treatment. A 74-year-old man developed a locally advanced sigmoid carcinoma (pT3N1M0). A port a cath attached to an open-ended catheter was implanted in order to administer primary chemotherapy safely according to the FOLFOX4 schedule. One month following ... Read More »
» Published in World J Gastroenterol. 2006 Sep 28;12(36):5907-8.
10. Randomized Study to Characterize Glycemic Control and Short-Term Pulmonary Function in Patients with Type 1 Diabetes Receiving Inhaled Human Insulin (Exubera(R)).
Match Strength: 2.501
OBJECTIVE: Previous studies with inhaled human insulin (INH; Exubera((R)); (insulin human [rDNA origin]) Inhalation Powder) show comparable efficacy to sc insulin and small declines in pulmonary function in type 1 or 2 diabetes. This is a detailed characterization of efficacy and short-term pulmonary safety profile of INH. RESEARCH DESIGN AND METHODS: In a 24-week multicenter study, 226 nonsmoking patients with type 1 diabetes and normal lung function were randomized to premeal INH or SC insulin for 12 weeks (comparative phase), followed by SC insulin for 12 weeks (washout phase). HbA1c was ... Read More »
» Published in J Clin Endocrinol Metab. 2006 Sep 26;
11. Levofloxacin 750 mg QD for five days versus amoxicillin/clavulanate 875 mg/125 mg BID for ten days for treatment of acute bacterial exacerbation of chronic bronchitis: a post hoc analysis of data from severely ill patients.
Match Strength: 2.467
This post hoc analysis of data from a previous randomized, blinded, multicenter, parallel, noninferiority study assessed the bacterial etiology, symptom resolution, and tolerability of severe acute bacterial exacerbation of chronic bronchitis (ABECB) patients treated with either levofloxacin 750 mg QD for 5 days or amoxicillin/clavulanate 875 mg/125 mg BID for 10 days. Severe ABECB was defined as ABECB and forced expiratory volume in 1 second (FEV(1)) <50% of the predicted value, or (FEV(1)) of 50% to 65% of the predicted value plus comorbidities, or > or =4 exacerbations per year. A ... Read More »
» Published in Clin Ther. 2006 Aug;28(8):1175-80.
12. Tracheobronchial foreign body aspiration in children - diagnostic value of symptoms and signs.
Match Strength: 2.438
OBJECTIVE: Tracheobronchial foreign body (TFB) aspiration is a common cause of respiratory compromise in early childhood. Research indicates that a high number of children are missed with TFB aspiration. The aim of this study was to identify predictors of potential TFB aspiration. STUDY DESIGN: We analysed 370 endoscopic reports of children admitted to our emergency department who underwent explorative rigid bronchoscopy to exclude/remove a TFB (1989-2003). Patient characteristics, history, clinical, radiographic and bronchoscopic findings were noted. Sensitivities and specificities for TFB ... Read More »
» Published in Swiss Med Wkly. 2006 Aug 19;136(33-34):533-8.
13. A Patient-based severity measure of chronic lung disease: evaluating functional health and predicting health services use.
Match Strength: 2.329
Prior research has consistently shown that among patients with chronic lung disease (CLD), health-related quality of life (HRQOL) is tied more to respiratory symptoms than to physiologic measures. However, traditional methods to quantify the severity of CLD have been restricted to physiologic measures (eg, FEV1, FVC, etc) that are often poor predictors of HRQOL and utilization of health services. Using a patient-based measure of symptom severity for CLD developed in the Veterans Health Study (VHS), this article evaluated the impact of the severity of CLD on patients' self-reported HRQOL and ... Read More »
» Published in J Ambul Care Manage. 2006 Oct-Dec;29(4):320-31.
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