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Connective Tissue Diseases
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1. Epidemiology of connective tissue disorders.
Match Strength: 13.762

The reported prevalence and incidence of connective tissue disorders are quite variable, depending on differences in study methodology. Most important differences are the study duration, the classification criteria used for diagnosis and the country in which the study was undertaken. Sjogren's syndrome has the highest prevalence ranging between 0.5 and 3% of a given population. The prevalence of systemic lupus erythematosus (SLE) is estimated between 15 and 50 per 100 000 individuals, with a female:male ratio of 6-10:1 in the age group between 15 and 40 yrs. The prevalence of systemic ... Read More »
» Published in Rheumatology (Oxford). 2006 Oct;45 Suppl 3:iii3-iii4.

2. Pulmonary arterial hypertension and rheumatic diseases--from diagnosis to treatment.
Match Strength: 12.236

Survival rates in pulmonary arterial hypertension (PAH) associated with rheumatic diseases, in particular connective tissue diseases such as systemic sclerosis, are even lower than in idiopathic PAH. These low survival rates highlight the need for early diagnosis and treatment in these patients. Transthoracic Doppler-echocardiography is most often used for diagnostic screening of patients at risk. Other screening tests are serum pro-brain-natriuretic peptide (pro-BNP) and diffusion capacity for carbon monoxide (DLCO), which appear to be changed early in the course of the PAH associated with ... Read More »
» Published in Rheumatology (Oxford). 2006 Oct;45 Suppl 4:iv22-iv25.

3. Pulmonary arterial hypertension (PAH) in connective tissue diseases.
Match Strength: 10.205

Pulmonary arterial hypertension (PAH) is characterized by progressive obliteration of the small pulmonary vascular bed as a result of vascular proliferation and remodelling of the vessel wall leading to permanently increased pulmonary vascular resistance and elevated pulmonary artery pressures, which result in right heart failure and premature death. Pathologic processes behind the complex vascular changes associated with PAH include vasoconstrictor/vasodilator imbalance, thrombosis, misguided angiogenesis and inflammation. Besides idiopathic PAH, it can also occur in association with portal ... Read More »
» Published in Rheumatology (Oxford). 2006 Oct;45 Suppl 3:iii11-iii13.

4. Connective tissue diseases: evaluation of clinical response.
Match Strength: 8.585

Systemic connective tissue diseases (CTDs) are disease entities characterized by a systemic and heterogeneous spectrum of clinical symptoms. The treatment of CDTs has improved substantially, but with the developments of new and probably more expensive targeted therapies, there will be a need of rigorous evaluation in patient-oriented research. Proposed domains for outcome measurement of CTDs are activity, damage by disease and/or medications and quality of life. To evaluate the overall disease activity in CTDs, scores are developed that include typical signs and symptoms. For example, in ... Read More »
» Published in Rheumatology (Oxford). 2006 Oct;45 Suppl 3:iii5-iii7.

5. Nailfold capillaroscopy is useful for the diagnosis and follow-up of autoimmune rheumatic diseases. A future tool for the analysis of microvascular heart involvement?
Match Strength: 8.311

Raynaud's phenomenon (RP) represents the most frequent clinical aspect of cardio/microvascular involvement and is a key feature of several autoimmune rheumatic diseases. Moreover, RP is associated in a statistically significant manner with many coronary diseases. In normal conditions or in primary RP (excluding during the cold-exposure test), the normal nailfold capillaroscopic pattern shows a regular disposition of the capillary loops along with the nailbed. On the contrary, in subjects suffering from secondary RP, one or more alterations of the capillaroscopic findings should alert the ... Read More »
» Published in Rheumatology (Oxford). 2006 Oct;45 Suppl 4:iv43-iv46.

6. Analysis of total work inability in Poland in 2000 and 2001 according to age, disease diagnosis and occupation.
Match Strength: 5.878

This study was to determine the main health-related reasons, age and occupation of those who took early retirement. This was done through an analysis of the data from Poland's Social Insurance Institution (ZUS) from 2000 and 2001. An analysis of these data showed an increase in the number of certificates confirming total inability to work in people over 40 years old. Over 50% of certificates work were issued to workers in 2 age-groups: 45-49 and 50-54. Diseases of the circulatory system, musculoskeletal system and connective tissue as well as mental and behavioural disorders are the main ... Read More »
» Published in Int J Occup Saf Ergon. 2006;12(3):231-40.

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