Common Variable Immunodeficiency
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Peer Reviewed Scientific Research Reports.
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1. Retinitis pigmentosa and hypogammaglobulinemia.
Match Strength: 7.698
This report describes a family demonstrating an unusual association of retinitis pigmentosa and hypogammaglobulinemia. The proband in this family suffered from another rare illness, ie, Sertoli cell only syndrome. The incidence of retinitis pigmentosa is 1 in 5,000 and that of common variable immunodeficiency state is 1 in 100,000, making a chance association of these illnesses very unlikely. Publication Types: Case ... Read More »
» Published in South Med J. 2006 Sep;99(9):989-91. Comment in: South Med J. 2006 Sep;99(9):914.
2. Human immunodeficiency virus type 1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection, and these modifications affect antibody neutralization sensitivity.
Match Strength: 6.318
Over the course of infection, human immunodeficiency virus type 1 (HIV-1) continuously adapts to evade the evolving host neutralizing antibody responses. Changes in the envelope variable loop sequences, particularly the extent of glycosylation, have been implicated in antibody escape. To document modifications that potentially influence antibody susceptibility, we compared envelope variable loops 1 and 2 (V1-V2) from multiple sequences isolated at the primary phase of infection to those isolated around 2 to 3 years into the chronic phase of infection in nine women with HIV-1 subtype A. HIV-1 ... Read More »
» Published in J Virol. 2006 Oct;80(19):9586-98.
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