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Peer Reviewed Scientific Research Reports.
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1. Distinctive cortical articulatory representation in cleft lip and palate: a preliminary functional magnetic resonance imaging study.
Match Strength: 8.474
OBJECTIVE: To investigate cortical representation of articulation of the bilabial plosive in patients with cleft lip and palate. DESIGN: We examined cortical representation for /pa/-articulation in cleft lip and palate patients using blood oxygenation level-dependent functional magnetic resonance imaging. SUBJECTS: Data from four postsurgical adult cleft lip and palate patients were compared with those from six healthy volunteers. RESULTS: Activation foci were found in the bilateral primary sensorimotor cortex in all cleft lip and palate patients, as in the controls. The sensorimotor cortex ... Read More »
» Published in Cleft Palate Craniofac J. 2006 Sep;43(5):620-4.
2. Asian oral-facial cleft birth prevalence.
Match Strength: 8.229
OBJECTIVE: To determine the clefting birth prevalence among Asian populations, specifically Chinese and Japanese, using raw counts from nonoverlapping published studies of Asian populations, and to investigate whether Asian clefting rates have been interpreted accurately as being up to twice the Caucasian rate. DESIGN: A literature review of articles giving raw counts of clefting in Asian populations, primarily Japanese and Chinese. MAIN OUTCOME MEASURES: Where possible, clefts were identified by the patients' ethnicity, country of origin, cleft type, syndromic status, and birth status. ... Read More »
» Published in Cleft Palate Craniofac J. 2006 Sep;43(5):580-9.
3. Self-reports of psychosocial functioning among children and young adults with cleft lip and palate.
Match Strength: 8.146
OBJECTIVE: A cross-sectional study was employed to determine the psychosocial effects of cleft lip and/or palate among children and young adults, compared with a control group of children and young adults without cleft lip and palate. PARTICIPANTS: The study comprised 160 children and young adults with cleft lip and/or palate and 113 children and young adults without cleft lip and/or palate. All participants were between 8 and 21 years of age. OUTCOME MEASURES: Psychological functioning (anxiety, self-esteem, depression, and behavioral problems) was assessed using validated psychological ... Read More »
» Published in Cleft Palate Craniofac J. 2006 Sep;43(5):598-605.
4. Dental age in children with a complete unilateral cleft lip and palate.
Match Strength: 7.913
OBJECTIVE: To assess dental age in children with a complete unilateral cleft lip and palate and to compare this with a noncleft control group. DESIGN: Two-group, mixed-longitudinal cohort study. SETTING: Cleft group from an academic center for cleft lip and palate treatment. Noncleft control group from the same population. PATIENTS: Participants included 70 Caucasian children with a full complement of teeth and a complete unilateral cleft lip and palate (45 boys and 25 girls) from the Cleft Palate Craniofacial Center at the Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands. ... Read More »
» Published in Cleft Palate Craniofac J. 2006 Sep;43(5):612-5.
5. A three-dimensional computed tomographic analysis of the cervical spine in unoperated infants with cleft lip and palate.
Match Strength: 6.812
OBJECTIVE: To investigate anatomical variations and abnormalities of cervical spine morphology in unoperated infants with cleft lip and palate. DESIGN: Retrospective cross-sectional investigation of infants born with nonsyndromic cleft lip and palate using computed tomography scans acquired for investigation of a spectrum of clinical conditions. SETTING: Computed tomography scan data were obtained from 29 unoperated cleft lip and palate infants and 12 noncleft infants of Malay origin, ages 0 to 12 months. METHODS: Observational study of cervical spine computed tomography scans. Heights of ... Read More »
» Published in Cleft Palate Craniofac J. 2006 Sep;43(5):513-8.
6. Defining critical periods for itraconazole-induced cleft palate, limb defects and axial skeletal malformations in the mouse.
Match Strength: 6.415
The main aim of the study was to identify the critical periods of susceptibility for itraconazole-mediated teratogenesis in the mouse. Pregnant ICR (CD-1) mice received a single oral administration of itraconazole at 50 mg/kg b.w., 150 mg/kg b.w. or 250 mg/kg b.w. on gestation day 8, 9, 10, 11 or 12. Control animals were administered with vehicle on gestation days 8-12. The gestational outcome was evaluated near term, on gestation day 18. Treatment-related morphological findings, as they can be evaluated by external, visceral and skeletal examination, mainly included cleft palate, limb defects ... Read More »
» Published in Toxicol Lett. 2006 Nov 1;167(1):8-18. Epub 2006 Aug 24.
7. Hard palate repair timing and facial growth in cleft lip and palate: a systematic review.
Match Strength: 6.376
OBJECTIVE: To evaluate the effect of timing of hard palate repair on facial growth in patients with cleft lip and palate, with special reference to cranial base, maxilla, mandible, jaw relation, and incisor relation. DESIGN: A systematic review. METHODS: The search strategy was based on the key words "facial growth," "cleft lip palate," and "timing of (hard) palate repair." Case reports, case-series, and studies with no control or comparison group in the sample were excluded. RESULTS: Fifteen studies met the selection criteria. All the studies were retrospective and nonrandomized. Five studies ... Read More »
» Published in Cleft Palate Craniofac J. 2006 Sep;43(5):563-70.
8. The changing pattern of analgesic and anti-inflammatory drug use in cleft lip and palate repair.
Match Strength: 5.808
OBJECTIVE: This work aimed at performing a retrospective and comparative investigation of pharmacological therapeutic approach for pain and inflammation control for cleft lip and/or palate repair. STUDY DESIGN: Medical charts from 2000 patients who underwent surgical procedures at the Hospital for Rehabilitation of Craniofacial Anomalies, University of Sao Paulo (HRAC-USP), Brazil, were assessed to obtain information regarding type of cleft, surgical procedure, and analgesic and anti-inflammatory drugs prescribed. The first 1000 consecutive surgeries performed in 1992 and 2002 were assessed. ... Read More »
» Published in Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Oct;102(4):e16-20. Epub 2006 Jul 17.
9. Effects of a long-term volunteer surgical program in a developing country: the case in Vietnam from 1993 to 2003.
Match Strength: 5.680
OBJECTIVE: This study evaluates the activities of the Japanese Cleft Palate Foundation from 1993 to 2003 in southern Vietnam. DESIGN: We assessed trends associated with patient age at first operation for primary lip repair and palate repair by using medical records of the patients. PARTICIPANTS: This study consisted of 790 patients with nonsyndromic cleft lip and/or palate (CL/P). RESULTS: The median patient age for lip repair was reduced from 14.0 years in 1993 to 1.3 years by 2003. For palate repair, the median age was reduced from 13.5 years in 1993 to 5.0 years in 1999 through 2003. The ... Read More »
» Published in Cleft Palate Craniofac J. 2006 Sep;43(5):616-9.
10. An epidemiologic study of orofacial clefts with other birth defects in Victoria, Australia.
Match Strength: 5.622
OBJECTIVE: To describe the epidemiological characteristics of oral clefts occurring with other birth defects in Victoria, Australia. METHODS: Information on infants and fetuses reported to the Victorian Birth Defects Register from 1983 to 2000 was collected. Birth defects were classified as Pierre Robin Sequence, chromosomal anomaly, nonchromosomal syndrome, single-system defect, or multiple-system defect. Pregnancy outcome and associations with selected infant and maternal features was examined. RESULTS: One third of the 2022 oral clefts recorded had other birth defects. There were more ... Read More »
» Published in Cleft Palate Craniofac J. 2006 Sep;43(5):571-6.
11. Alveolar bone graft for patients with cleft lip/palate using bone particles and titanium mesh: A quantitative study.
Match Strength: 5.482
PURPOSE: This study evaluated the bone volume, height, and width that can be obtained in alveolar ridge augmentation using titanium mesh and autogenous bone particles in patients with cleft lip/palate. PATIENTS AND METHODS: Subjects were 15 patients with cleft lip/palate requiring tertiary bone graft for implant therapy. Computed tomography (CT) scans were taken before removing the mesh, from 1 to 21 months after bone grafting. Forty-three reconstructed images corresponding to the positions for implant placement were selected for this study. The percent defect filled with bone (%BONE), defined ... Read More »
» Published in J Oral Maxillofac Surg. 2006 Oct;64(10):1540-5.
12. Reliability of linear measurements on a virtual bilateral cleft lip and palate model.
Match Strength: 5.399
OBJECTIVE: To assess the reliability and validity of measurements performed on three-dimensional virtual models of neonatal bilateral cleft lip and palate patients, compared with measurements performed on plaster cast models. MATERIALS AND METHODS: Ten high-quality plaster cast models of bilateral cleft lip and palate patients were scanned with an LDI-scanner to obtain a three-dimensional virtual model. Linear measurements were performed on the plaster cast models using a digital caliper and also on the three-dimensional virtual model using Viscam RP version 2.1 software. The measurements were ... Read More »
» Published in Cleft Palate Craniofac J. 2006 Sep;43(5):519-23.
13. Hard palate repair timing and facial growth in unilateral cleft lip and palate: a longitudinal study.
Match Strength: 5.367
OBJECTIVE: To investigate whether timing of hard palate repair had a significant effect on facial growth in patients with unilateral cleft lip and palate (UCLP). DESIGN: Retrospective longitudinal study. SETTING: Sri Lankan Cleft Lip and Palate Project. PATIENTS: A total of 104 patients with nonsyndromic UCLP who had hard palate repair by age 13 years, with their 290 cephalometric radiographs taken after lip and palate repair. MAIN OUTCOME MEASURES: Clinical notes were used to record surgical treatment histories. Cephalometry was used to determine facial morphology and growth rate. RESULTS: ... Read More »
» Published in Cleft Palate Craniofac J. 2006 Sep;43(5):547-56.
14. SUMO1 haploinsufficiency leads to cleft lip and palate.
Match Strength: 5.340
The posttranslational modification sumoylation can have multiple effects on its substrate proteins. We studied a patient with isolated cleft lip and palate and a balanced chromosomal translocation that disrupts the SUMO1 (small ubiquitin-related modifier) gene, resulting in haploinsufficiency. In mouse, we found that Sumo1 is expressed in the developing lip and palate and that a Sumo1 hypomorphic allele manifests an incompletely penetrant orofacial clefting phenotype. Products of several genes implicated in clefting are sumoylated, and the Sumo1 hypomorphic allele interacts genetically with a ... Read More »
» Published in Science. 2006 Sep 22;313(5794):1751.
15. Simultaneous hybrid of maxillary Le Fort I halo distraction and mandibular set-back for patients with severe cleft jaw deformity.
Match Strength: 4.950
One of the surgical tactics and retrospective chart review of clinical cases are described for severe maxillo-mandibular discrepancy. The recently developed Le Fort I Halo distraction combined with mandibular sagittal splitting osteotomy is initially carried out simultaneously. Materials include six adult patients revealing severe jaw deformity with mandibular prognathism somehow ranging from 17-19 years of age. The required adjustment of the maxillo-mandibular discrepancy ranged from 14-23 mm to obtain the preferred occlusion. The simultaneous combination of over 10-mm maxillary Le Fort I ... Read More »
» Published in J Craniofac Surg. 2006 Sep;17(5):962-9.
16. The hyoid bone in malay infants with cleft lip and palate.
Match Strength: 4.823
OBJECTIVE: To compare morphological and positional variations of the hyoid bone in unoperated infants with cleft lip and palate (CL/P) with those in noncleft infants. DESIGN: Retrospective, cross sectional. PATIENTS AND METHODS: Three-dimensional computed tomography scans were obtained from 29 unoperated CL/P infants of Malay origin aged between 0 and 12 months and from 12 noncleft infants in the same age range. Observations were made and measurements were obtained with a software package developed at the Australian Craniofacial Unit. The sizes of the hyoid bones and the position of the hyoid ... Read More »
» Published in Cleft Palate Craniofac J. 2006 Sep;43(5):532-8.
17. Cysteine accessibility in the hydrophilic cleft of human organic cation transporter 2.
Match Strength: 4.414
Organic cation transporters (OCTs) are involved in the renal elimination of many cationic drugs and toxins. A hypothetical three-dimensional structure of OCT2 based on a homology model that used the Escherichia coli glycerol 3-phosphate transporter as a template has been described (Zhang, X., Shirahatti, N. V., Mahadevan, D., and Wright, S. H. (2005) J. Biol. Chem. 280, 34813-34822). To further define OCT structure, the accessibility to hydrophilic thiol-reactive reagents of the 13 cysteine residues contained in the human ortholog of OCT2 was examined. Maleimide-PEO2-biotin precipitated ... Read More »
» Published in J Biol Chem. 2006 Nov 17;281(46):35272-80. Epub 2006 Sep 21.
18. Octyl-2-cyanoacrylate tissue glue (Dermabond) versus Monocryl 6 x 0 Sutures in lip closure.
Match Strength: 4.138
OBJECTIVE: To assess the value of octyl-2-cyanoacrylate tissue glue in lip closure versus Monocryl stitches. DESIGN: Closure of a cleft lip can be done using transcutaneous Monocryl 6 x 0 sutures or using octyl-2-cyanoacrylate tissue glue (Dermabond). In 15 consecutive patients, the cleft lip was closed with Monocryl 6 x 0 and in another 15 consecutive patients, Dermabond was applied. Outcome parameters were complications, satisfaction of the parents with the cosmetic result, and the cosmetic result as judged by professionals. Satisfaction of the parents was assessed using a questionnaire and ... Read More »
» Published in Cleft Palate Craniofac J. 2006 Sep;43(5):625-7.
19. Complete unilateral cleft lip and palate: validity of the five-year index and the Goslon yardstick in predicting long-term dental arch relationships.
Match Strength: 3.994
OBJECTIVE: To assess the validity of the 5-year index by subjecting study models at the age of 5 years to both the 5-year index and the Goslon yardstick, and then relating these results to the Goslon ratings at 10 years. DESIGN: Retrospective study. SETTING: Sahlgrenska University Hospital, Gothenburg, Sweden. PATIENTS: Study models of 94 patients with unilateral cleft lip and palate (UCLP) were evaluated at the ages of 5 and 10 years. The dental arch relationships were judged and categorized by using the Goslon yardstick for the 10-year models and both the Goslon yardstick and the 5-year ... Read More »
» Published in Cleft Palate Craniofac J. 2006 Sep;43(5):557-62.
20. Analysis of dental arch relationships in Swedish unilateral cleft lip and palate subjects: 20-year longitudinal consecutive series treated with delayed hard palate closure.
Match Strength: 3.844
OBJECTIVE: To evaluate the dental arch relationships for a consecutive series from Goteborg, Sweden, who had delayed hard palate closure. DESIGN: Retrospective study. SETTING: Sahlgrenska University Hospital, Goteborg, Sweden. PATIENTS: The dental study models of 104 consecutive unilateral cleft lip and palate subjects. The study cohort was born between 1979 and 1994. Longitudinal records were available at ages 5 (n = 94), 10 (n = 97), 16 (n = 59), and 19 years (n = 46). Five assessors rated models according to the GOSLON Yardstick on two separate occasions each. INTERVENTIONS: These patients ... Read More »
» Published in Cleft Palate Craniofac J. 2006 Sep;43(5):606-11.
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