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Peer Reviewed Scientific Research Reports.
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1. Incidence of chronic obstructive pulmonary disease in a cohort of young adults according to the presence of chronic cough and phlegm.
Match Strength: 5.330
RATIONALE: The few prospective studies aimed at assessing the incidence of chronic obstructive pulmonary disease (COPD) in relation to the presence of chronic cough/phlegm have produced contrasting results. OBJECTIVES: To assess the incidence of COPD in a cohort of young adults and to test whether chronic cough/phlegm and dyspnea are independent predictors of COPD. METHODS: An international cohort of 5,002 subjects without asthma (ages 20-44 yr) with normal lung function (FEV(1)/FVC ratio >/= 70%) from 12 countries was followed from 1991-2002 in the frame of the European Community ... Read More »
» Published in Am J Respir Crit Care Med. 2007 Jan 1;175(1):32-9. Epub 2006 Sep 28.
2. Novel tyrosine kinase inhibitors in chronic myelogenous leukemia.
Match Strength: 5.236
PURPOSE OF REVIEW: The successful introduction of the tyrosine kinase inhibitors has initiated a new era in the management of chronic myeloid leukemia. RECENT FINDINGS: Imatinib therapy has significantly improved prognosis of chronic myeloid leukemia. A minority of patients with chronic-phase disease (4% annually) and considerably more in advanced stages develop resistance. This is attributed, in 40-50% of cases, to the development of BCR-ABL (breakpoint cluster region/Abelson oncogene) tyrosine kinase domain mutations that impair imatinib binding. This has led to the development of more ... Read More »
» Published in Curr Opin Oncol. 2006 Nov;18(6):578-83.
3. Mucin overproduction in chronic inflammatory lung disease.
Match Strength: 5.110
Mucus overproduction and hypersecretion are commonly observed in chronic inflammatory lung disease. Mucins are gel-forming glycoproteins that can be stimulated by a variety of mediators. The present review addresses the mechanisms involved in the upregulation of secreted mucins. Mucin induction by neutrophil elastase, bacteria, cytokines, growth factors, smoke and cystic fibrosis transmembrane conductance regulator malfunction are also discussed. Publication Types: Research Support, Non-U.S. Gov't, ... Read More »
» Published in Can Respir J. 2006 Sep;13(6):327-35.
4. The impact of severe exacerbations on quality of life and the clinical course of chronic obstructive pulmonary disease.
Match Strength: 4.729
Severe exacerbations of chronic obstructive pulmonary disease (COPD) are morbid events with slow recovery periods. They consume substantial healthcare resources, and they may cause a more rapid reduction in lung function over time. Quality of life (QOL) deteriorates in patients who experience exacerbations, and the more frequent the exacerbations, the more rapid the decline in QOL. Hospitalizations due to exacerbations account for up to 70% of the cost of medical care for patients with COPD. Patients with more severe COPD have more hospitalizations compared with those with less severe disease. ... Read More »
» Published in Am J Med. 2006 Oct;119(10 Suppl 1):38-45.
5. Restless leg syndrome manifested by iron deficiency from chronic hemoptysis in cystic fibrosis.
Match Strength: 4.639
Restless leg syndrome (RLS) and periodic limb movement disorder (PLMD) are considered to be a continuum of a neurological sleep disorder associated with abnormal iron metabolism or deficiency. I describe a case of RLS and PLMD in a cystic fibrosis patient with iron deficiency from chronic hemoptysis. This is the first case that reports RLS and PLMD manifesting from iron deficiency caused by chronic hemoptysis in advanced cystic fibrosis lung disease ... Read More »
» Published in J Cyst Fibros. 2006 Sep 15;
6. Abnormal vascular tone in infants and children with lung hypoplasia: Findings from cardiac catheterization and the response to chronic therapy.
Match Strength: 4.626
OBJECTIVE: We describe four cases of chronic pulmonary hypertension in infants and children with chronic lung disease and pulmonary hypoplasia due to severe congenital diaphragmatic hernia (CDH) or congenital cystic adenomatoid malformation (CCAM). We report data from cardiac catheterization under various conditions: baseline respiratory support and room air, hyperoxic and inhaled nitric oxide challenge. We further report cardiac catheterization measures after chronic pulmonary vasodilator therapy with sildenafil alone or a combination of sildenafil and inhaled nitric oxide (three patients). ... Read More »
» Published in Pediatr Crit Care Med. 2006 Nov;7(6):589-94.
7. Postencephalitic chronic granulomatous disease.
Match Strength: 4.526
This report details the evolution of a case of herpes simplex encephalitis to chronic granuloma in a 13-year old female who, at the age of 8, suffered herpes simplex virus type 1 encephalitis. Eight months later, she developed an intracranial hypertension syndrome with the onset of a new lesion in the necrosed zone of her right temporal lobe, with no viral presence in the cerebrospinal fluid. The histologic characteristics were those of chronic granuloma with multinucleated giant cells and calcifications. Initially treated for neurosarcoidosis, the patient remained steroid-dependent for 4 ... Read More »
» Published in Pediatr Neurol. 2006 Oct;35(4):297-9.
8. The prevalence of venous insufficiency in patients with chronic obstructive pulmonary disease evaluated by color duplex ultrasonography.
Match Strength: 4.318
OBJECTIVES: We hypothesized that in patients with chronic obstructive pulmonary disease (COPD) some extrapulmonary effects such as increase in intra-abdominal and intra-thoracic pressures, presence of cor pulmonale and pulmonary artery hypertension could cause venous insufficiency (VI) in the lower limbs. Our aim in this study was to assess the prevalence of VI in patients with COPD in comparison with healthy controls. METHODS: Thirty-nine male patients with COPD and 36 healthy male controls were evaluated for VI. All the participants were in the same age group and their smoking intensities ... Read More »
» Published in Wien Klin Wochenschr. 2006 Sep;118(17-18):549-53.
9. Recurrent pyogenic cholangitis due to chronic infestation with Clonorchis sinensis (2006: 8b).
Match Strength: 4.233
Recurrent pyogenic cholangitis is a common disease in Southeast Asia, where an association with the liver fluke Clonorchis sinensis is postulated. It is characterised by repeated attacks of cholangitis with multiple recurrences of bile duct stones and strictures. We present a case of recurrent pyogenic cholangitis due to chronic infestation with Clonorchis sinensis in a young Asian immigrant, describing its radiological appearances and also therapeutic strategies with a review of additional examples from the literature ... Read More »
» Published in Eur Radiol. 2006 Nov;16(11):2612-4. Epub 2006 Sep 16.
10. Composition of calcifications in children with juvenile dermatomyositis: association with chronic cutaneous inflammation.
Match Strength: 4.193
OBJECTIVE: Calcific deposits develop in 20-40% of children with juvenile dermatomyositis (juvenile DM), contributing to disease morbidity and mortality. This study was undertaken to define the structure and composition of these deposits and to characterize their association with chronic inflammation. METHODS: We examined calcific deposits from 5 children with juvenile DM (2 boys and 3 girls). The crystal structure and mineral content of the deposits was analyzed by x-ray diffraction, Fourier transform infrared spectroscopy, and imaging. The protein content of the deposits, following ... Read More »
» Published in Arthritis Rheum. 2006 Oct;54(10):3345-50.
11. Psychological distress and multimorbidity in primary care.
Match Strength: 4.142
PURPOSE: Psychological distress may decrease adherence to medical treatments and lead to poorer health outcomes of chronic diseases. The aim of this study was to evaluate the relationship between psychological distress and multimorbidity among patients seen in family practice after controlling for potential confounding variables and taking into account the severity of diseases. METHODS: We evaluated 238 patients to construct quintiles of increasing multimorbidity based on the Cumulative Illness Rating Scale (CIRS), which is a comprehensive multimorbidity index that takes into account disease ... Read More »
» Published in Ann Fam Med. 2006 Sep-Oct;4(5):417-22.
12. Cardiovascular risk among adults with chronic kidney disease, with or without prior myocardial infarction.
Match Strength: 4.126
OBJECTIVES: This study sought to determine whether chronic kidney disease (CKD) should be considered a coronary heart disease (CHD) risk equivalent for cholesterol treatment. BACKGROUND: It is unclear whether patients with CKD have a risk of CHD events or cardiovascular disease (CVD) mortality equivalent to patients with a prior myocardial infarction (MI). METHODS: Using data from the ARIC (Atherosclerosis Risk in Communities) study, we categorized nondiabetic participants based on their average level of kidney function (estimated glomerular filtration rate > or =60 or 30 to 59 ml/min/1.73 ... Read More »
» Published in J Am Coll Cardiol. 2006 Sep 19;48(6):1183-9. Epub 2006 Aug 28.
13. Sporadic and epidemic community legionellosis: two faces of the same illness.
Match Strength: 4.090
The present study compares the risk factors, presentation and outcome of community-acquired Legionella pneumophila pneumonia in 138 sporadic-case patients (1994-2004) and 113 outbreak-case patients (2002) treated in two hospitals in Catalonia (Spain) since urinary antigen assays were adopted. Univariate and multivariate analysis were performed to compare epidemiological and clinical features, blood chemistry values, radiological findings and outcome of sporadic and epidemic legionnaires' disease. Univariate analysis showed that male sex, chronic lung disease, HIV infection and ... Read More »
» Published in Eur Respir J. 2007 Jan;29(1):138-42. Epub 2006 Sep 27.
14. Influence of chronic cardiovascular disease and hospitalisation due to this disease on quality of life of community-dwelling elderly.
Match Strength: 4.075
The aim of this study was to describe the impact of chronic cardiovascular disease (CVD) and hospitalisation due to this disease on quality-of-life (QOL) in community-dwelling elderly. The study was carried out in the three age- and gender-matched groups of older subjects: 100 elderly without CVD, 100 elderly with CVD and 100 patients actually hospitalised for the cardiologic reasons. The assessment included demographic and social variables, health status, nutritional state, physical activity (PA), physical and cognitive function. QOL was assessed with the Euroqol 5D questionnaire. Presence of ... Read More »
» Published in Qual Life Res. 2006 Sep;15(7):1281-9. Epub 2006 Sep 14.
15. Probiotics and prebiotics in chronic inflammatory bowel diseases.
Match Strength: 4.061
The prokaryotic and eukaryotic cells of the colon exist in a highly complex, but harmonious relationship. Disturbances in this remarkable symbiosis can result in the development of inflammatory bowel diseases (IBD). Although the etiology of IBD is not entirely understood, it is known that the chronic inflammation of Crohn's disease, ulcerative colitis and chronic pouchitis are a result of an overly aggressive immune response to the commensal intestinal flora in genetically susceptible hosts. Recent studies have enhanced our ability to understand the interaction between the host and its ... Read More »
» Published in World J Gastroenterol. 2006 Oct 7;12(37):5941-50.
16. A community model of group therapy for the older patients with chronic obstructive pulmonary disease: a pilot study.
Match Strength: 4.019
OBJECTIVE: A community-based programme for chronic obstructive pulmonary disease (COPD) patients in group sessions is designed, and the feasibility, acceptability and physical and psychosocial outcomes evaluated. METHODS: Patients with COPD discharged from hospital, or those attending specialist outpatient clinic, with a history of hospital admission owing to COPD in the preceding 12 months were recruited. Those who had malignancy or were housebound were excluded. Group sessions were arranged once a week in a Community Centre, and consisted of two hourly sessions. The components of each ... Read More »
» Published in J Eval Clin Pract. 2006 Oct;12(5):523-31.
17. Serum procalcitonin levels in chronic hepatitis C patients under pegylated interferon-alpha plus ribavirin treatment.
Match Strength: 3.978
OBJECTIVES: To evaluate the alterations of serum procalcitonin (PCT) levels in patients with chronic hepatitis C during pegylated interferon-alpha (PEG-IFNa) plus ribavirin (RIB) treatment and to correlate them with clinical and virological outcomes. STUDY DESIGN: Fifty-two consecutive patients (29 males, age=41.2+/-14.7 years) with chronic HCV-related liver disease (six cirrhotics) were evaluated for PCT levels at baseline and during the treatment course (at week 12, 24, 48 and 72) with PEG-IFNa plus RIB. Sustained virological response (SVR) was confirmed by undetectable serum HCV-RNA at the ... Read More »
» Published in J Clin Virol. 2006 Dec;37(4):329-31. Epub 2006 Sep 25.
18. Surgical treatment of chronic atrial fibrillation combined with rheumatic mitral valve disease: Effects of the cryo-maze procedure and predictors for late recurrence.
Match Strength: 3.974
OBJECTIVE: The aim of this study was to evaluate the effects of the modified maze procedure using cryoablation for treating chronic atrial fibrillation (AF) associated with rheumatic mitral valve disease and to assess the risk factors for late failure of sinus rhythm restoration. METHODS: Between March 2000 and June 2004, 170 consecutive patients, who underwent the modified maze procedure using cryoablation concomitant with mitral valve surgery for atrial fibrillation associated with rheumatic mitral valve disease, were divided into two groups based on the type of right-sided maze: the ... Read More »
» Published in Eur J Cardiothorac Surg. 2006 Nov;30(5):728-36. Epub 2006 Sep 26.
19. The genomics of new drugs in sickle cell disease.
Match Strength: 3.933
The quality of life of patients with sickle cell disease in developed countries has improved significantly over the past two decades. Currently available measures to prevent the painful crises and the complications of the disease include the use of penicillin prophylaxis, antipneumonococcal vaccine, folate administration, chronic red cell transfusions in patients with cerebrovascular disease, iron chelating agents, fetal hemoglobin-enhancing agents, such as hydroxyurea, decitabine and butyrate, drugs that augment the endogenous nitric oxide levels and agents that restore red cell dehydration. ... Read More »
» Published in Pharmacogenomics. 2006 Sep;7(6):909-17.
20. The shackles of misfortune: social adversity assessment and representation in a chronic-disease epidemiological setting.
Match Strength: 3.895
Research evidence is accumulating to support an association between social adversity and the development of predisease processes and physical disease outcomes. While methodological advances have been achieved in the assessment of social adversity, significant barriers remain to their adoption in chronic disease epidemiological settings consequent upon the need to limit participant burden and restrictions imposed by cohort size and cost. A large-scale population-based cohort study, as part of the European Prospective Investigation into Cancer, Norfolk, UK, provided an opportunity to include a ... Read More »
» Published in Soc Sci Med. 2007 Jan;64(1):95-111. Epub 2006 Sep 25.
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