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Peer Reviewed Scientific Research Reports.
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1. Could the Chagas disease elimination programme in Venezuela be compromised by reinvasion of houses by sylvatic Rhodnius prolixus bug populations?
Match Strength: 6.610
The Andean Pact Initiative (1997) committed Andean countries to eliminate vectorial transmission of Chagas disease by 2010 via widespread residual insecticide spraying. In Venezuela, this aim could be compromised by reinvasion of houses by palm tree populations of the major vector Rhodnius prolixus. To test this hypothesis, a multivariate logistic regression was undertaken of risk factors for triatomine infestation and colonization in 552 houses and 1068 peri-domestic outbuildings in Barinas State. After adjusting for other risk factors, including palm roofs, R. prolixus infestation and ... Read More »
» Published in Trop Med Int Health. 2006 Oct;11(10):1585-93.
2. Differential transcription profiles in Trypanosoma cruzi associated with clinical forms of Chagas disease: Maxicircle NADH dehydrogenase subunit 7 gene truncation in asymptomatic patient isolates.
Match Strength: 5.947
The majority of individuals in the chronic phase of Chagas disease are asymptomatic (indeterminate form). Every year 2-3% of these individuals develop severe clinical manifestations (cardiac and digestive forms). In this study a Trypanosoma cruzi DNA microarray was used to compare the transcript profiles of six human isolates: three from asymptomatic and three from cardiac patients. Seven signals were expressed differentially between the two classes of isolates, including tryparedoxin, surface protease GP63, cyclophilin, some hypothetical proteins and the pre-edited maxicircle gene NADH ... Read More »
» Published in Mol Biochem Parasitol. 2006 Dec;150(2):236-48. Epub 2006 Sep 15.
3. Interleukin-1 gene cluster polymorphism in chagas disease in a Colombian case-control study.
Match Strength: 5.137
The aim of this study was to assess the possible association between the IL1A, IL1B and IL1RN gene polymorphisms and Chagas disease. Our study population consisted of 130 serologically positive cardiomyopathic patients and 130 seropositive and asymptomatic individuals from a Colombian population where Trypanosoma cruzi infection is endemic. Genotyping of the IL1A (-889C/T, +4845G/T), IL1B (-511C/T, -31T/C, +3954T/C, +5810G/A) and IL1RN (+8006T/C, +8061C/T, +11100T/C) polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism and polymerase chain reaction ... Read More »
» Published in Hum Immunol. 2006 Sep;67(9):741-8. Epub 2006 Jul 26.
4. Peridomestic structure, farming activity and triatomine infestation.
Match Strength: 4.451
The role of peridomestic structure and farming activity on triatomine infestation was studied on two vector species of Chagas disease (Triatoma pseudomaculata and T. brasiliensis) in Bahia State, northeastern Brazil. A randomly selected population issued from 136 farms was divided into four categories according to the householder activity. At regional scale, the dwellings of farmers working on degraded land of irrigated farms are less exposed to T. pseudomaculata infestation. At premises scale, the farmers and casual workers, who have smaller peridomiciles and less cattle, are also less ... Read More »
» Published in Parasite. 2006 Sep;13(3):237-43.
5. Lipid bodies: Structural markers of inflammatory macrophages in innate immunity.
Match Strength: 3.739
OBJECTIVE AND DESIGN: The correlation between innate immune responses and formation of cytoplasmic lipid bodies (LBs) was investigated in vivo in inflammatory macrophages from rats infected with Trypanosoma cruzi, the intracellular parasite which causes Chagas' disease. MATERIAL AND METHODS: We used an experimental model of high-dose irradiation prior to infection, which depletes the humoral and cellular immune responses except for the phagocytic activity of macrophages. Rats, irradiated or not, were infected with T. cruzi and macrophages from different origins (peritoneum, heart, uterus) were ... Read More »
» Published in Inflamm Res. 2006 Aug;55(8):342-8.
6. Long-term protective immunity induced against Trypanosoma cruzi infection after vaccination with recombinant adenoviruses encoding amastigote surface protein-2 and trans-sialidase.
Match Strength: 3.526
Protection against protozoan parasite Trypanosoma cruzi has been shown to be dependent on the induction of type 1 immune responses. Replication-deficient human type 5 recombinant adenoviruses have an unsurpassed ability to induce type 1 immune responses. Thus, we constructed two type 5 recombinant adenoviruses encoding parasite antigens trans-sialidase (rAdTS) and amastigote surface protein-2 (rAdASP2). Both antigens were genetically engineered to secrete recombinant products in order to induce both optimal antibody and T cell responses. Immunizations of mice with rAdASP2 and rAdTS induced ... Read More »
» Published in Hum Gene Ther. 2006 Sep;17(9):898-908.
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