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Cerebral Palsy
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1. Teenage outcome after being born at term with moderate neonatal encephalopathy.
Match Strength: 10.341

The aim of this study was to assess cognitive functions and behavior problems in teenagers who survived moderate neonatal encephalopathy and did not develop cerebral palsy. The study population comprised all 97,468 individuals born in Sweden in 1985. Of these, 684 (0.7%) were born at term and had an Apgar score of <7 at 5 minutes. The obstetric and neonatal records were scrutinized and the individuals were classified according to degree of neonatal encephalopathy. Teenagers with moderate neonatal encephalopathy without cerebral palsy and other major neuro-impairments were subjected to a ... Read More »
» Published in Pediatr Neurol. 2006 Oct;35(4):268-74.

2. The effectiveness of passive stretching in children with cerebral palsy.
Match Strength: 8.104

Passive stretching is widely used for individuals with spasticity in a belief that tightness or contracture of soft tissues can be corrected and lengthened. Evidence for the efficacy of passive stretching on individuals with spasticity is limited. The aim of this review was to evaluate the evidence on the effectiveness of passive stretching in children with spastic cerebral palsy. Seven studies were selected according to the selection criteria and scored against the Physiotherapy Evidence Database scale. Effect size and 95% confidence intervals were calculated for comparison. There was limited ... Read More »
» Published in Dev Med Child Neurol. 2006 Oct;48(10):855-62.

3. Popliteal angle in infants with west syndrome.
Match Strength: 7.506

The aim of this study was to clarify the relationship between neurologic findings and outcome of patients with West syndrome, focusing on the popliteal angle. The complete neurologic examination, including an assessment of the popliteal angle and muscle tone, was performed on 45 patients with West syndrome. A tight popliteal angle was determined when it was 120 degrees or less. In all 45 patients, abnormal muscle tone was not correlated with any variables. A tight popliteal angle was correlated with seizure persistence, cerebral palsy, and abnormality on magnetic resonance imaging (MRI), as ... Read More »
» Published in J Child Neurol. 2006 Oct;21(10):898-900.

4. Comparing functional profiles of children with hemiplegic and diplegic cerebral palsy in GMFCS Levels I and II: Are separate classifications needed?
Match Strength: 7.429

The goal was to compare children with hemiplegia with those with diplegia within Gross Motor Functional Classification System (GMFCS) levels using multiple validated outcome tools. Specifically, we proposed that children with hemiplegia would have better gait and gross motor function within levels while upper extremity function would be poorer. Data were collected on 422 ambulatory children with cerebral palsy: 261 with diplegia and 161 with hemiplegia, across seven centers. Those with hemiplegia in each level performed significantly and consistently better on gait or lower extremity function ... Read More »
» Published in Dev Med Child Neurol. 2006 Oct;48(10):797-803.

5. Postnatal inflammatory rat model for cerebral palsy: too different from humans.
Match Strength: 7.186

OBJECTIVE: In humans, cerebral palsy (CP) may originate from inflammation during the second and third trimesters of gestation when preoligodendrocytes (Pre-OL) are most vulnerable to an inflammatory insult. We studied a postnatal CP model to evaluate injury that would correlate with presence of Pre-OL in human pregnancy. STUDY DESIGN: On postnatal (P) days 2, 3, 4, 5 and 6, pups were treated with (lipopolysaccharide [LPS]) (n = 7; 30, 30, 60, 60, 120 microg/Kg) or saline (n = 7). Neonates were tested for motor and cognitive development. Adult offspring performed beam walking and rotarod for ... Read More »
» Published in Am J Obstet Gynecol. 2006 Oct;195(4):1038-44.

6. The effect of serial casting on gait in children with cerebral palsy: preliminary results from a crossover trial.
Match Strength: 7.037

Serial casting aims to improve an equinus gait pattern in children with spastic cerebral palsy (SCP). We evaluated the effect of short-term stretch casting on gait in children with SCP, compared to the natural history. A crossover trial, consisting of a control phase and a casting phase, was conducted with children randomised into two groups. Both groups were assessed clinically, and using 3D gait analysis, at 0, 5 and 12 weeks. Subjects in one group had the 3 month casting phase first and in the other had the 3 month control period first. Casts were changed weekly and set at maximum available ... Read More »
» Published in Gait Posture. 2006 Sep 26;

7. Neonatal SEP - back to bedside with basic science.
Match Strength: 4.668

Scalp-recorded somatosensory evoked potentials (SEPs) have been successfully used in neonatal assessment for several decades. The current routine SEP paradigm is markedly predictive for future cerebral palsy (CP) or other neurocognitive sequelae in brain-injured babies. Recent advances in basic science have dramatically increased our knowledge about structural-functional development of SEP-related brain mechanisms. It has thereby become apparent that preterm SEP differs from that in more mature counterparts in that it also comprises responses from transient brain structures, and hence being ... Read More »
» Published in Semin Fetal Neonatal Med. 2006 Dec;11(6):464-70. Epub 2006 Sep 14.

8. Long-term outcome of infants with twin-to-twin transfusion syndrome.
Match Strength: 4.527

OBJECTIVE: To clarify the long-term neurodevelopmental outcome of twin-to-twin transfusion syndrome (TTTS) survivors. METHODS: From January 1994 to December 2003, 33 newborns with TTTS who were derived from 18 monochorionic twin gestations were enrolled for the study. The development and growth at 3 or 6 years of age were compared between TTTS survivors and weight-matched singleton controls. RESULTS: The mortality in TTTS (8/33: 24%) was significantly higher than that of the controls (7/80: 9%). Of all 12 TTTS patients who were diagnosed before 25 weeks and born before 28 weeks of gestation, ... Read More »
» Published in Fetal Diagn Ther. 2007;22(1):68-74. Epub 2006 Sep 22.

9. Initial development and validation of the Caregiver Priorities and Child Health Index of Life with Disabilities (CPCHILD).
Match Strength: 4.404

This paper reports the development and validation of a disease-specific measure of health status and well-being of children with severe cerebral palsy (CP). The Caregiver Priorities and Child Health Index of Life with Disabilities (CPCHILD) was constructed from recommendations from caregivers, healthcare providers, and review of other measures. Items spanning six domains are rated on an ordinal scale. Standardized scores (0-100) are reported for each domain and in total. Primary caregivers (n = 77) of 45 males and 32 females between 5 and 18 years of age (mean age 13 y 5 mo [SD 3 y 4 mo]) with ... Read More »
» Published in Dev Med Child Neurol. 2006 Oct;48(10):804-12.

10. Neurodevelopmental outcomes of neonates with medically and surgically treated necrotizing enterocolitis.
Match Strength: 4.266

OBJECTIVES: 1) To characterise neurodevelopmental outcome of neonates with necrotizing enterocolitis (NEC); 2) to define whether NEC increases risk of neurodevelopmental impairment in very low birth weight neonates; 3) to investigate whether stage of disease or need for surgery increase risk of poor outcome. DESIGN: A systematic review was performed. Searches identified 182 relevant papers. Ten studies compared extremely low birth weight neonates with NEC to infants of similar age and gestation who did not develop NEC. Data are reported as odds ratios [95% confidence intervals, p values for ... Read More »
» Published in Arch Dis Child Fetal Neonatal Ed. 2006 Sep 19;

11. The use of complementary and alternative medicine in children with chronic medical conditions.
Match Strength: 4.243

OBJECTIVES: The objectives of this study were to examine whether progressive medical conditions lead to greater use of complementary and alternative medicine (CAM) as compared with more stable conditions, to see whether disease severity influences CAM use, and to identify the main motivations behind CAM use. METHODS: Subjects were selected from outpatient clinics at Hotel Dieu Hospital. Surveys were conducted by mail and telephone. Medical diagnosis and severity were obtained from medical files. Statistical tests included chi, Kruskal-Wallis, and correlations. RESULTS: One hundred ninety-four ... Read More »
» Published in Am J Phys Med Rehabil. 2006 Oct;85(10):842-6.

12. Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation.
Match Strength: 3.985

Recapitulation of tau pathologies in an animal model has been a long-standing goal in neurodegenerative disease research. We generated transgenic (TgTauP301L) mice expressing a frontotemporal dementia with parkinsonism linked to chromosome 17 (FTPD-17) mutation within the longest form of tau (2N, 4R). TgTauP301L mice developed florid pathology including neuronal pretangles, numerous Gallyas-Braak-positive neurofibrillary tangles, and glial fibrillary tangles in the frontotemporal areas of the cerebrum, in the brainstem, and to a lesser extent in the spinal cord. These features were accompanied ... Read More »
» Published in Am J Pathol. 2006 Oct;169(4):1365-75.

13. Analysis of patients with nonambulatory neuromuscular scoliosis surgically treated to the pelvis with intraoperative halo-femoral traction.
Match Strength: 3.315

STUDY DESIGN: Retrospective case-control study. OBJECTIVES: To compare patients treated with and without intraoperative halo-femoral traction to assess neuromuscular spinal deformity correction as well as the safety of the technique. SUMMARY OF BACKGROUND DATA: Optimal sitting balance can be achieved in nonambulatory neuromuscular patients with pelvic obliquity by maneuvering a Galveston-type rod or inserting screws into the iliac wings; however, this is often clinically challenging because of the small, soft bone-stock in the pelvis of these patients. METHODS: A total of 40 patients with ... Read More »
» Published in Spine. 2006 Sep 15;31(20):2381-5.

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