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Cardiovascular System
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1. The role of estrogens in cardiovascular disease in the aftermath of clinical trials.
Match Strength: 5.326

The effects of estrogens on reproductive tissues and climacteric symptoms are unambiguous. However, their effects on other tissues and, in particular, the cardiovascular system remain controversial. In general, premenopausal women are protected from coronary heart disease (CHD) compared with aged-matched men but this ;female protection' appears to be lost after menopause, suggesting beneficial effects of female sex hormones on the cardiovascular system. This view has been supported by observational studies showing that estrogen replacement therapy (ERT) is associated with a 30% to 50% decrease ... Read More »
» Published in Hormones (Athens). 2004 Jul-Sep;3(3):171-83.

2. Efficacy and safety of tamsulosin OCAS.
Match Strength: 4.957

The efficacy and safety of a new tablet formulation of tamsulosin (the oral-controlled absorption system: OCAS(R)) have been assessed in several clinical trials. In a phase IIb and a phase IIIa trial, the appropriate dose of the tamsulosin tablet for clinical practice was determined. All tested doses of tamsulosin OCAS (0.4, 0.8 and 1.2 mg) improved the lower urinary symptoms (LUTS) of benign prostatic enlargement to a statistically significantly greater extent than placebo, with no differences between the doses. However, treatment with tamsulosin OCAS 0.4 mg was associated with a lower ... Read More »
» Published in BJU Int. 2006 Nov;98 Suppl 2:13-7.

3. Gadolinium does not blunt the cardiovascular responses at the onset of voluntary static exercise in cats: a predominant role of central command.
Match Strength: 4.765

The cardiovascular adaptation at the onset of voluntary static exercise is controlled by the autonomic nervous system. Two neural mechanisms are responsible for the cardiovascular adaptation: one is central command descending from higher brain centers, and the other is a muscle mechanosensitive reflex from activation of mechanoreceptors in the contracting muscles. To examine which mechanism played a major role in producing the initial cardiovascular adaptation during static exercise, we studied the effect of intravenous administration of gadolinium (55 micromol/kg), a blocker of stretch ... Read More »
» Published in Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H121-9. Epub 2006 Sep 15.

4. Cardiovascular actions of adrenocorticotropin microinjections into the nucleus tractus solitarius of the rat.
Match Strength: 4.359

The presence of adrenocorticotropin (ACTH) containing cells and melanocortin (MC) receptors has been reported in the nucleus tractus solitarius (NTS) of the rat. The importance of the NTS in the regulation of cardiovascular function is also well established. Based on these reports, it was hypothesized that ACTH acting within the NTS may modulate the central regulation of cardiovascular function. To test this hypothesis, cardiovascular effects of ACTH in the NTS were investigated in intact urethane-anesthetized and unanesthetized decerebrate, artificially ventilated, adult male Wistar rats. ... Read More »
» Published in Neuroscience. 2006 Dec;143(3):863-74. Epub 2006 Sep 25.

5. NADPH oxidases of the brain: distribution, regulation, and function.
Match Strength: 4.293

The NADPH oxidase is a multi-subunit enzyme that catalyzes the reduction of molecular oxygen to form superoxide (O(2)(-)). While classically linked to the respiratory burst in neutrophils, recent evidence now shows that O(2)(-) (and associated reactive oxygen species, ROS) generated by NADPH oxidase in nonphagocytic cells serves myriad functions in health and disease. An entire new family of NADPH Oxidase (Nox) homologues has emerged, which vary widely in cell and tissue distribution, as well as in function and regulation. A major concept in redox signaling is that while NADPH oxidase-derived ... Read More »
» Published in Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1583-96.

6. Gastrointestinal-related complications after major lung surgery.
Match Strength: 3.612

Numerous factors increase the risk for GI complications in patients undergoing lung resection. It seems that the more debilitated the patient and the more extensive the COPD, the higher the risk. The most commonly reported cause of mortality after lung surgery is multi-organ failure accompanying respiratory failure. The trigger site for multi-system failure is often the GI system. Some risk factors cannot be altered, such as diabetes and the cardiovascular effects of long-term smoking. Other factors, such as steroid dose, anemia, hypoxia, narcotics, and other medications, can be modified. In ... Read More »
» Published in Thorac Surg Clin. 2006 Aug;16(3):299-302.

7. Treatment of poisoning caused by beta-adrenergic and calcium-channel blockers.
Match Strength: 3.591

PURPOSE: The toxic effects and treatment of beta-adrenergic blocker and calcium-channel blocker (CCB) overdose are reviewed. SUMMARY: Overdoses with cardiovascular drugs are associated with significant morbidity and mortality. Beta-blockers and CCBs represent the most important classes of cardiovascular drugs. In overdose, beta-blockers and CCBs have similar presentation and treatment overlaps and are often refractory to standard resuscitation measures. The common feature of beta-blocker toxicity is excessive blockade of the beta-receptors resulting in bradycardia and hypotension. Poisoning by ... Read More »
» Published in Am J Health Syst Pharm. 2006 Oct 1;63(19):1828-35.

8. Variability in the efficacy of interferon-alpha in Erdheim-Chester disease by patient and site of involvement: results in eight patients.
Match Strength: 3.585

OBJECTIVE: Erdheim-Chester disease (ECD) is a rare, non-Langerhans form of histiocytosis of unknown origin, characterized by infiltration of tissues by spumous histiocytes. ECD features heterogeneous systemic manifestations, and the general prognosis remains poor despite various treatment options. METHODS: We treated 8 patients with multisystemic ECD with subcutaneous interferon-alpha (IFNalpha) at a dosage of 3-9 x 10(6) units 3 times weekly, for a median duration of 23 months (range 1-46 months). RESULTS: Treatment was generally well tolerated, and side effects remained limited to fever ... Read More »
» Published in Arthritis Rheum. 2006 Oct;54(10):3330-6.

9. Vascular dysfunction in S1P2 sphingosine 1-phosphate receptor knockout mice.
Match Strength: 3.561

There is growing evidence that sphingosine 1-phosphate (S1P) plays an important role in regulating the development, morphology, and function of the cardiovascular system. There is little data, however, regarding the relative contribution of endogenous S1P and its cognate receptors (referred to as S1P(1-5)) to cardiovascular homeostasis. We used S1P(2) receptor knockout mice (S1P(2)(-/-)) to evaluate the role of S1P(2) in heart and vascular function. There were no significant differences in blood pressure between wild-type and S1P(2)(-/-) mice, measured in awake mice. Cardiac function, ... Read More »
» Published in Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R440-6. Epub 2006 Sep 21.

10. Hesr1 knockout mice exhibit behavioral alterations through the dopaminergic nervous system.
Match Strength: 3.491

The basic helix-loop-helix (bHLH) transcriptional factor Hesr1 gene (hairy and enhancer of split-related 1, also called Hey1/HRT1/CHF2/HERP2) has been identified and characterized as a member of the subfamily of hairy/Enhancer of split, and shown to be involved in cardiovascular and neural development. We report that HESR1 binds directly to a part of the 3' non-coding region of the human dopamine transporter (DAT1) gene and represses the endogenous DAT1 gene in HEK293 cells. To investigate functions of the HESR1 gene in the dopaminergic nervous system in vivo, we analyzed the expressions of ... Read More »
» Published in J Neurosci Res. 2006 Nov 15;84(7):1555-63.

11. Common reasons for hospitalization among adult patients with diabetes.
Match Strength: 3.315

OBJECTIVE: To determine reasons for hospitalization among adult patients with diabetes. METHODS: A cross-sectional analysis was conducted of hospital discharges in the state of Georgia for the years 1998 through 2001 that contained either a primary or a coexisting diagnosis of diabetes. With use of the Clinical Classification Software of the Agency for Healthcare Research and Quality, the principal diagnoses among diabetes-related hospital discharges were organized into diagnostic categories. RESULTS: Diabetes was listed as a diagnosis in 14% of all Georgia hospital discharges of adult ... Read More »
» Published in Endocr Pract. 2006 Jul-Aug;12(4):363-70.

12. Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study.
Match Strength: 3.272

The renin-angiotensin system is a key regulator of blood pressure (BP), with inhibitors of angiotensin-converting enzyme (ACE) used clinically to treat hypertension and other cardiovascular conditions. ACE2 is a newly identified member of this system, which converts angiotensin II to angiotensin, and of which the occurrence in plasma has not been investigated. The aim of this study was to determine the heritability of circulating ACE, ACE2, and neprilysin (NEP), which may also be a regulator of BP, in a family study, and to determine covariates that contribute to the variation in plasma ... Read More »
» Published in Hypertension. 2006 Nov;48(5):914-20. Epub 2006 Sep 25.

13. Obstructive sleep apnoea syndrome and genes.
Match Strength: 3.230

Obstructive sleep apnoea (OSA) is a complex disease entity strongly influenced by genetic factors, especially those that affect obesity and fat distribution, upper airway muscle tone, craniofacial morphology, ventilatory control and sleep, giving rise to the OSA phenotype. OSA can also be considered a metabolic syndrome which adversely affects multiple organ systems, especially the cardiovascular system and the brain. The most widely used clinical marker for the diagnosis of OSA is the apnoea-hypopnoea index, calculated by polysomnography. A percentage of 35 to 40% of its variance can be ... Read More »
» Published in Neth J Med. 2006 Sep;64(8):280-9.

14. Some in vitro and in vivo cardiovascular effects of Hypoxis hemerocallidea Fisch & CA Mey (Hypoxidaceae) corm (African potato) aqueous extract in experimental animal models.
Match Strength: 3.193

This study was undertaken to investigate some cardiovascular effects of Hypoxis hemerocallidea Fisch & CA Mey (Hypoxidaceae) corm (African potato) aqueous extract in experimental animal paradigms. The effect of the corm aqueous extract (APE) on myocardial contractile performance was evaluated on guinea-pig isolated atrial muscle strips in vitro; whereas the antihypertensive (hypotensive) effect of the plant extract was examined in hypertensive Dahl salt-sensitive rats in vivo. APE (25-400 mg/ml) produced concentration-dependent, significant (p < 0.05-0.001) negative inotropic and negative ... Read More »
» Published in Cardiovasc J S Afr. 2006 Jul-Aug;17(4):166-71.

15. Capillary microscopy and hemorheology in children during antiepileptic monotherapy with carbamazepine and valproate.
Match Strength: 3.166

The interactions of epilepsy and antiepileptic therapy an one hand and cardiovascular system on the other hand are multiple and complex. Antiepileptic drugs (AEDs) cause alterations of serum lipids and of the fatty acid composition of the membranes. Homocystein, known to induce vascular endothelial damage was found to be elevated in patients on valproate (VPA) and carbamazepine (CBZ) therapy. Marked coronary artherosclerosis and myocardial infarction may already occur in children treated with CBZ. Community based studies corroborated a higher incidence of myocardial infarction, peripheral ... Read More »
» Published in Seizure. 2006 Dec;15(8):606-9. Epub 2006 Sep 25.

16. Physiological responses of skilled players during a competitive wheelchair tennis match.
Match Strength: 3.117

The purpose of this study was to determine heart rate (HR, b.min(-1)) response during competitive match play of 6 men who were skilled wheelchair (WC) tennis players. Each participant completed an arm crank ergometer test that measured HR via a telemetry device and O2 via open circuit spirometry from rest until fatigue (.V(O2)peak). Each athlete participated in 2 competitive singles matches during which HRs were recorded in 5-second intervals and O2 was estimated using the corresponding HR values recorded during the arm ergometer tests. Data analysis revealed an average playing intensity of 69 ... Read More »
» Published in J Strength Cond Res. 2006 Aug;20(3):665-71.

17. Hormone treatments and preventive strategies in the aging male: whom and when to treat?
Match Strength: 3.089

Sex hormones have a broad range of actions in regulating very diverse systems throughout life. Testosterone and other related hormones change with age to varying degrees and may induce pathophysiological changes and the clinical condition known as andropause. Androgen replacement is the accepted but not the only possible treatment for andropause. The presence of clinical symptoms, including a loss of sexual function, intellectual capacity, lean body mass, or bone mineral density; alterations in body hair, skin, or sleep pattern; or increases in visceral fat, together with low levels of serum ... Read More »
» Published in Rev Urol. 2003;5 Suppl 1:S16-21.

18. Erythropoietic and anti-obesity effects of Garcinia cambogia (bitter kola) in Wistar rats.
Match Strength: 3.056

The anti-obesity and erythropoietic effects of crude ethanolic extracts of Garcinia cambogia (bitter kola) seeds on Wistar rats (Rattus norvegicus) were investigated. The rats were divided into three dosage groups: A (0 mg/kg of body weight), B (200 mg/kg) and C (400 mg/kg). Weight changes, plasma lipoprotein levels and the lipid profile of the liver, gastrointestinal system and adipose tissue were monitored as indices for anti-obesity, while the RBC (red blood cell) count (assessed by using a haemocytometer) was monitored as a measure of erythropoiesis. The extract was administered by gavage ... Read More »
» Published in Biotechnol Appl Biochem. 2007 Jan;46(Pt 1):69-72.

19. Myocardial regeneration strategies using human embryonic stem cell-derived cardiomyocytes.
Match Strength: 3.029

Regenerative medicine is a new biomedicine discipline that takes advantage of the recent advancements in the fields of stem cell biology, molecular biology, and tissue engineering to derive tissue substitutes, in an attempt to replace or modify the function of diseased organs. The heart represents an attractive candidate for these emerging technologies since adult cardiac tissue has limited regenerative capacity. Consequentially, myocardial cell replacement therapy has emerged as a novel therapeutic paradigm for restoration of the myocardial electromechanical function. This innovative strategy ... Read More »
» Published in J Control Release. 2006 Nov 28;116(2):211-8. Epub 2006 Jun 29.

20. A pilot investigation of the effect of extremely low frequency pulsed electromagnetic fields on humans' heart rate variability.
Match Strength: 2.902

The question whether pulsed electromagnetic field (PEMF) can affect the heart rhythm is still controversial. This study investigates the effects on the cardiocirculatory system of ELF-PEMFs. It is a follow-up to an investigation made of the possible therapeutic effect ELF-PEMFs, using a commercially available magneto therapeutic unit, had on soft tissue injury repair in humans. Modulation of heart rate (HR) or heart rate variability (HRV) can be detected from changes in periodicity of the R-R interval and/or from changes in the numbers of heart-beat/min (bpm), however, R-R interval analysis ... Read More »
» Published in Bioelectromagnetics. 2007 Jan;28(1):64-8.

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