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Peer Reviewed Scientific Research Reports.
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1. Attenuation of oxidative stress and cardiac dysfunction by bisoprolol in an animal model of dilated cardiomyopathy.
Match Strength: 11.986
Oxidative stress is an important susceptibility factor for dilated cardiomyopathy. We have investigated the effects of bisoprolol, a beta1-selective adrenoceptor blocker, on oxidative stress and the development of cardiac dysfunction in a model of dilated cardiomyopathy. Male TO-2 and control hamsters at 8 weeks of age were treated with bisoprolol (5 mg/kg per day) or vehicle for 4 weeks. Treatment with bisoprolol prevented the progression of cardiac dysfunction in TO-2 hamsters. This drug did not affect the increase in NADPH oxidase activity but prevented the reduction in activity and ... Read More »
» Published in Biochem Biophys Res Commun. 2006 Nov 10;350(1):105-13. Epub 2006 Sep 18.
2. Effects of statin therapy on arrhythmic events and survival in patients with nonischemic dilated cardiomyopathy.
Match Strength: 10.878
OBJECTIVES: We sought to evaluate whether statins were associated with a survival benefit and significant attenuation in life-threatening arrhythmias in patients with nonischemic dilated cardiomyopathy. BACKGROUND: Statins are associated with a reduction in appropriate implantable cardioverter-defibrillator (ICD) therapy in patients with coronary artery disease and improved clinical status in nonischemic dilated cardiomyopathy. METHODS: The effect of statin use on time to death or resuscitated cardiac arrest and time to arrhythmic sudden death was evaluated in 458 patients enrolled in the ... Read More »
» Published in J Am Coll Cardiol. 2006 Sep 19;48(6):1228-33. Epub 2006 Aug 28.
3. Mitral valve surgery for dilated cardiomyopathy with mitral regurgitation.
Match Strength: 9.205
Outcomes of surgery for non-ischemic non-valvular dilated cardiomyopathy with associated mitral regurgitation were assessed in 8 consecutive patients who underwent 9 mitral valve operations between 2001 and 2004. Mitral valve replacement was performed when the coaptation depth exceeded 10 mm. Two patients initially underwent mitral valvuloplasty, and 6 underwent valve replacement. One patient had valve replacement soon after valvuloplasty. Transthoracic echocardiography was performed immediately before surgery, before discharge, and during follow-up. Transesophageal echocardiography was ... Read More »
» Published in Asian Cardiovasc Thorac Ann. 2006 Oct;14(5):371-6.
4. Simultaneous heart and kidney transplantation for combined cardiac and renal failure.
Match Strength: 8.992
Simultaneous heart and kidney transplantation (SHKT) is feasible for combined cardiac and renal failure. Herein we reviewed our 10-year experience in SHKT. Six patients underwent SHKT from June 1995 to December 2004. Their ages ranged from 13 to 63 years old with a mean of 45.5 +/- 15.8 years. They were all men except one girl, who was the youngest (aged 13) who suffered from dilated cardiomyopathy with congestive heart failure and chronic renal failure due to systemic lupus erythematosus. Because of aggravating heart failure, she changed from hemodialysis to peritoneal dialysis. Because of ... Read More »
» Published in Transplant Proc. 2006 Sep;38(7):2135-7.
5. Challenges and opportunities in dystrophin-deficient cardiomyopathy gene therapy.
Match Strength: 8.538
The last decade has evidenced unprecedented progress in gene therapy of Duchenne and Becker muscular dystrophy (DMD and BMD) skeletal muscle disease. Cardiomyopathy is a leading cause of morbidity and mortality in both patients and carriers of DMD, BMD and X-linked dilated cardiomyopathy. However, there is little advance in heart gene therapy. The gene, the vector, vector delivery, the target tissue and animal models are five fundamental components in developing an effective gene therapy. Intensive effort has been made in optimizing gene transfer vectors and methods. Systemic and/or local ... Read More »
» Published in Hum Mol Genet. 2006 Oct 15;15 Spec No 2:R253-61.
6. Grafted skeletal myoblast sheets attenuate myocardial remodeling in pacing-induced canine heart failure model.
Match Strength: 7.473
OBJECTIVE: To overcome problems related to the intramyocardial injection of cells, including cell loss and a limited graft area, we developed a cell delivery system that uses tissue-engineered myoblast grafts grown as sheets. Here, we assessed the feasibility and efficacy of our method in a canine dilated cardiomyopathy model. METHODS: Skeletal myoblasts were incubated on temperature-responsive culture dishes, and the sheets of cells were detached by decreasing the temperature. Twelve dogs were given continuous ventricular pacing at 230 beats/min for 4 weeks; then the myoblast sheets (n = 5) ... Read More »
» Published in J Thorac Cardiovasc Surg. 2006 Oct;132(4):918-24.
7. Case report: inferior vena-cava right atrial anastomotic stenosis after bicaval orthotopic heart transplantation.
Match Strength: 4.853
PURPOSE: This case report describes the occurrence of acute postoperative liver and renal failure after bicaval orthotopic heart transplantation (OHT) due to stenosis of the inferior vena cava (IVC)-right atrial (RA) anastomosis. We also discuss the role of measuring femoral venous pressure and transesophageal echocardiography (TEE) in establishing the diagnosis. CLINICAL FEATURES: A 42-yr-old female patient with idiopathic dilated cardiomyopathy underwent an OHT, using the bicaval anastomotic technique. During the first 12 hr postoperatively she developed unexplained kidney and liver failure. ... Read More »
» Published in Can J Anaesth. 2006 Oct;53(10):1039-43.
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