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Carcinoma Small Cell
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1. Targeted therapy for renal cell carcinoma: a new therapeutic paradigm.
Match Strength: 7.381

Renal cell carcinoma is the most common tumor of the kidney. It has an unpredictable behavior and poor response to systemic therapy. Developing newer therapy for this disease is a priority considering the high recurrence rate and the small subset of patients who benefit from the use of cytokines such as interferon-alpha or interleukin-2. Identifying molecular targets and targeting various biomarkers has revolutionized the therapeutic approach to advanced and metastatic renal cell carcinoma. Although some of the antiangiogenic agents and receptor tyrosine kinase inhibitors appear promising, ... Read More »
» Published in Cancer Invest. 2006 Oct;24(6):640-56.

2. Clinical review - small cell carcinoma of the bladder.
Match Strength: 6.601

OBJECTIVES: To review the published literature on the diagnosis and management of small cell carcinoma of the bladder (SCCB). METHODS: Papers were identified by searches of PubMed using the terms "small cell", "bladder" and "carcinoma". Additional papers were identified from review of references of relevant articles. RESULTS: SCCB comprises less than 1% of bladder malignancies. It is an aggressive tumour that commonly presents at an advanced stage, in an elderly population. Consequently, patients are often not fit for anti-neoplastic therapy. In fit patients, the bedrock of treatment in the ... Read More »
» Published in Cancer Treat Rev. 2006 Dec;32(8):588-93. Epub 2006 Sep 27.

3. Sarcomatoid carcinoma of the prostate: a study of 42 cases.
Match Strength: 6.420

Sarcomatoid carcinoma of the prostate is a rare type of prostatic cancer. With the exception of 1 study, the morphologic features and patient outcomes have been reported only in relatively small case series and individual reports. We examined transurethral resection, needle biopsy, and radical prostatectomy specimens from 42 patients with sarcomatoid carcinoma of the prostate, all of which were received in consultation. Clinical information on 32 patients was obtainable. Five patients were lost to follow-up and information on the 5 remaining patients could not be obtained. Prior prostatic ... Read More »
» Published in Am J Surg Pathol. 2006 Oct;30(10):1316-21.

4. Neuroendocrine cells in the vestibular glands of the genital tract of cows and pigs.
Match Strength: 5.923

The presence of neuroendocrine (NE) cells producing biogenic amines and hormonal peptides has been investigated in the vestibular glands of the genital tracts of cows and pigs using immunohistochemistry. NE cells containing chromogranin A-, serotonin-, cholecystokinin- and somatostatin-immunoreactive material were found in both major and minor vestibular glands. Such cells were numerous, scattered in the acini and excretory duct epithelium, small in size and rounded, triangular or bipolar in shape. The function of the NE vestibular cells has been related to the secretory activity of the glands ... Read More »
» Published in Acta Histochem. 2006;108(5):351-5. Epub 2006 Sep 25.

5. Experience of the treatment with gemcitabine, docetaxel, and carboplatin (GDC) chemotherapy for patients with small-cell carcinoma of the prostate.
Match Strength: 5.769

Small-cell carcinoma of the prostate (SCCP) is a rare entity. Many treatment modalities have been done, but thus far no uniform treatment has been clearly established. We carried out combination chemotherapy with gemcitabine, docetaxel, and carboplatin (GDC) regimen (for two patients with refractory SCCP. Case 1 involved a 53-year-old man diagnosed with SCCP after receiving hormone therapy for prostate cancer (stage D1). Six cycles of GDC chemotherapy was applied. Initially the primary site reduced according with a decline of neuro-specific enolase and with relief of the symptoms; however, ... Read More »
» Published in Int J Urol. 2006 Sep;13(9):1254-8.

6. Targeted approaches for treating advanced clear cell renal carcinoma.
Match Strength: 5.750

The mainstay of any curative treatment in renal cell carcinoma (RCC) is surgery. In the case of metastatic disease at presentation, a radical nephrectomy is recommended to good performance status patients prior to the start of cytokine treatment. Interferon (IFN)-a offers in a small but significant percentage of patients advantage in overall survival. Interleukin (IL)-2-based therapy gives similar survival rates. To date, hormonal therapy and chemotherapy do not have a proven impact on survival. Recent insights demonstrate that the majority of clear cell RCC harbor abnormalities of the von ... Read More »
» Published in Onkologie. 2006 Sep;29(8-9):394-402. Epub 2006 Sep 6.

7. Small interfering RNA targeting epidermal growth factor receptor enhances chemosensitivity to cisplatin, 5-fluorouracil and docetaxel in head and neck squamous cell carcinoma.
Match Strength: 5.651

Overexpression of epidermal growth factor receptor (EGFR) has been found in various epithelial malignancies, including head and neck squamous cell carcinoma (HNSCC), and is associated with increased tumor growth, metastasis, resistance to chemotherapeutic agents and poor prognosis. As such, EGFR is a potential target for antitumor therapy and several EGFR inhibitors have been investigated in preclinical or clinical settings. In the present study, we used small interfering RNA (siRNA) to downregulate EGFR expression while evaluating the effect of EGFR siRNA on cell proliferation, and the ... Read More »
» Published in Cancer Sci. 2006 Oct;97(10):1115-24.

8. Testicular microlithiasis identified ultrasonographically in Japanese adult patients: prevalence and associated conditions.
Match Strength: 5.473

OBJECTIVES: To determine the prevalence of testicular microlithiasis (TM) seen by testicular ultrasonography (US) in Japanese adult men referred for andrologic symptoms and evaluate associations of TM with pathologic conditions. METHODS: For 7 years, US was performed in 969 patients (mean age 40.9 years) at one institution. The patients were divided into groups with infertility (n = 550), unilateral testicular tumor (n = 46), or other andrologic conditions (n = 373). TM was identified as multiple small hyperechogenic foci. In the tumor group, only images of the tumor-free testis were reviewed. ... Read More »
» Published in Urology. 2006 Sep;68(3):636-41. Epub 2006 Sep 18.

9. Epidermal growth factor receptor pathway targeted therapy in patients with aerodigestive malignancies.
Match Strength: 5.338

PURPOSE OF REVIEW: The present review will describe progress in the utilization of epidermal growth factor receptor (EGFR) inhibitors in the treatment of nonsmall-cell lung cancer and the treatment of squamous cell carcinoma of the head and neck. Recent findings regarding clinical activity as well as markers associated with sensitivity to these agents will be reviewed. RECENT FINDINGS: The EGFR pathway plays a crucial role in human carcinogenesis by contributing to relevant processes in tumor development and progression, including cell proliferation, differentiation, regulation of apoptotic ... Read More »
» Published in Curr Opin Oncol. 2006 Nov;18(6):609-14.

10. Combined effects of soluble vascular endothelial growth factor receptor FLT-1 gene therapy and cisplatin chemotherapy in human tongue carcinoma xenografts.
Match Strength: 5.080

The aim of the present study was to assess the anti-tumor effect of a defective adenovirus that expresses soluble vascular endothelial growth factor (VEGF) receptor FLT-1 (AdsFLT-1) in combination with cisplatin (cis-diamminedichloroplatinum, DDP) on human tongue carcinoma Tca8113 cell xenografts that had been pre-established in nude mice. In vitro, Tca8113 cells secreted soluble FLT-1 (sFLT-1) after infection with AdsFLT-1, and the conditioned medium from AdsFLT-1-treated Tca8113 cells seemed to inhibit VEGF-induced proliferation of human umbilical vein endothelial cells. The combined effects ... Read More »
» Published in Oral Oncol. 2006 Sep 22;

11. Pleomorphic giant cell adenocarcinoma of the prostate: report of 6 cases.
Match Strength: 4.928

Pleomorphic tumors with giant cells have been described in a variety of primary sites. However, only a few cases have been described among prostatic carcinomas with only 1 on diagnostic biopsy material. Five cases were retrieved from the consultation files of one of the authors. One of the cases was retrieved from the surgical pathology files at our institute. Patient ranged in age from 59 to 76 years (mean=65.8 y). The diagnosis was made on needle biopsy (n=3), urethral biopsy (n=1), transurethral resection (n=1), or radical prostatectomy (n=1). In all cases, giant, bizarre, anaplastic cells ... Read More »
» Published in Am J Surg Pathol. 2006 Oct;30(10):1254-9.

12. Long-term outcome after resection of non-small cell lung carcinoma complicated by pneumoconiosis.
Match Strength: 4.423

PURPOSE: Lung cancer resection in patients with respiratory complications is associated with a high surgical risk and the operative indications are usually serious. Consequently, the long-term results are unclear. We aimed to clarify the validity of surgery for non-small cell lung cancer (NSCLC) in patients with pneumoconiosis. METHODS: We reviewed the clinical and pathological data of 122 patients undergoing resection of NSCLC with pneumoconiosis (n = 34: group A) or without pneumoconiosis (n = 88: group B) to assess treatment outcomes and prognostic factors. RESULTS: Among the treatment ... Read More »
» Published in Surg Today. 2006;36(10):869-73.

13. Simultaneous chemoradiotherapy compared with radiotherapy alone after induction chemotherapy in inoperable stage IIIA or IIIB non-small-cell lung cancer: study CTRT99/97 by the Bronchial Carcinoma Therapy Group.
Match Strength: 3.890

PURPOSE: The aim of this study was to examine whether, after preceding induction chemotherapy, simultaneous chemoradiotherapy is superior to radiotherapy alone. PATIENTS AND METHODS: Patients with non-small-cell lung cancer in inoperable stage IIIA or IIIB received induction chemotherapy with two cycles of paclitaxel 200 mg/m2 and carboplatin area under the curve 6 every 3 weeks. Patients without progression at restaging after induction chemotherapy were randomly assigned to radiotherapy (60 Gy) or chemoradiotherapy (paclitaxel 60 mg/m2 weekly). The primary end point was overall survival; ... Read More »
» Published in J Clin Oncol. 2006 Sep 20;24(27):4397-404.

14. Transbronchial biopsy guided by low-dose MDCT: a new approach for assessment of solitary pulmonary nodules.
Match Strength: 3.780

OBJECTIVE: The objective of our study was to determine whether transbronchial bronchoscopic biopsy of solitary pulmonary nodules under CT guidance using a low-dose protocol can increase diagnostic yield in patients who had undergone unsuccessful conventional bronchoscopic biopsy. SUBJECTS AND METHODS: We included 33 consecutive patients (25 men; mean age +/- SD, 64 +/- 9.6 years) with solitary pulmonary nodules at different sites and with a lesion-to-pleura distance of at least 2 cm who previously underwent conventional bronchoscopy that did not result in histologic diagnosis. All patients ... Read More »
» Published in AJR Am J Roentgenol. 2006 Oct;187(4):933-9.

15. HATH1 expression in mucinous cancers of the colorectum and related lesions.
Match Strength: 3.231

PURPOSE: Mucinous cancers and signet ring carcinomas are distinct classes of colon cancers characterized by their production of copious quantities of intestinal goblet cell mucin, MUC2. Deletion of transcription factor HATH1 ablates the biogenesis of goblet cells in developing mouse intestine, and forced expression of HATH1 results in elevated expression of MUC2 in colon cancer cells. The aim of this study was to assess the possible role of HATH1 in the development of mucinous cancers and signet ring carcinomas. EXPERIMENTAL DESIGN: Immunohistochemistry and confocal microscopy was used to ... Read More »
» Published in Clin Cancer Res. 2006 Sep 15;12(18):5403-10.

16. Risk of oesophageal cancer by histology among patients hospitalised for gastroduodenal ulcers.
Match Strength: 3.230

OBJECTIVE: The mechanism behind the epidemiologically evident inverse relationship between Helicobacter pylori seropositivity and risk of oesophageal adenocarcinoma (OAC) remains obscure. Severe corpus gastritis is unlikely to be in the causal pathway. With the hypothesis of a uniformly low risk, we aimed to explore the associations of OAC with duodenal ulcer (DU) and gastric ulcer (GU) - both linked to H. pylori infection but with different patterns of bacterial colonization and intragastric acidity. We also addressed possible associations of oesophageal squamous cell carcinoma (OSCC) with ... Read More »
» Published in Gut. 2006 Sep 27;

17. Outcomes of Gleason score 10 prostate carcinoma treated by radical prostatectomy.
Match Strength: 2.976

OBJECTIVES: To evaluate the outcome of radical prostatectomy for the rarest and most poorly differentiated prostate tumors of all: those with Gleason score 10. Controversy exists as to which form of therapy is most effective for high-grade prostate cancer (PCa). METHODS: We retrospectively reviewed the charts of all patients with pathologic Gleason score 10 PCa treated at our institution with radical prostatectomy from 1977 to 1999. All pathology specimens were reviewed by a urologic pathologist, and 13 cases with true Gleason score 10 PCa were identified. The preoperative covariables ... Read More »
» Published in Urology. 2006 Sep;68(3):604-8. Epub 2006 Sep 18.

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