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Peer Reviewed Scientific Research Reports.
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1. Cannulation of the suprachoroidal space: a novel drug delivery methodology to the posterior segment.
Match Strength: 4.231
PURPOSE: To describe, test, and evaluate the pharmacokinetics of a novel posterior drug delivery system (PDS) by means of microcannulation of the suprachoroidal space in both the primate and pig animal model. DESIGN: Animal study. METHODS: A rhesus macaque (Macaca mulatta) (n = 1) and pig model (n = 93) were used to evaluate the PDS, a microcannula that combines a drug delivery channel with a fiber-optic illumination and optimal transition properties. The surgical technique, safety profile, histopathology, retinal and choroidal blood flow, injection of tracer dyes, and triamcinolone ... Read More »
» Published in Am J Ophthalmol. 2006 Nov;142(5):777-87. Epub 2006 Sep 20.
2. Peripheral blood B-cell death compensates for excessive proliferation in lymphoid tissues and maintains homeostasis in bovine leukemia virus-infected sheep.
Match Strength: 3.374
The size of a lymphocyte population is primarily determined by a dynamic equilibrium between cell proliferation and death. Hence, lymphocyte recirculation between the peripheral blood and lymphoid tissues is a key determinant in the maintenance of cell homeostasis. Insights into these mechanisms can be gathered from large-animal models, where lymphatic cannulation from individual lymph nodes is possible. In this study, we assessed in vivo lymphocyte trafficking in bovine leukemia virus (BLV)-infected sheep. With a carboxyfluorescein diacetate succinimidyl ester labeling technique, we ... Read More »
» Published in J Virol. 2006 Oct;80(19):9710-9.
3. Clinical review: alternative vascular access techniques for continuous hemofiltration.
Match Strength: 3.153
Obtaining or maintaining vascular access for continuous hemofiltration can sometimes be problematic, especially in the child or adult in multiple organ failure with edema and/or coagulopathy. Problems commonly encountered include obstruction of the femoral vein by the catheter, insertion difficulties, safety concerns when cannulating the subclavian vein in coagulopathy, and catheter and circuit occlusion due to disseminated intravascular coagulation. For access in infants we describe a technique utilizing two single-lumen thin-walled vascular sheaths. For infants and small children initial ... Read More »
» Published in Crit Care. 2006;10(5):230.
4. Case report: inferior vena-cava right atrial anastomotic stenosis after bicaval orthotopic heart transplantation.
Match Strength: 2.899
PURPOSE: This case report describes the occurrence of acute postoperative liver and renal failure after bicaval orthotopic heart transplantation (OHT) due to stenosis of the inferior vena cava (IVC)-right atrial (RA) anastomosis. We also discuss the role of measuring femoral venous pressure and transesophageal echocardiography (TEE) in establishing the diagnosis. CLINICAL FEATURES: A 42-yr-old female patient with idiopathic dilated cardiomyopathy underwent an OHT, using the bicaval anastomotic technique. During the first 12 hr postoperatively she developed unexplained kidney and liver failure. ... Read More »
» Published in Can J Anaesth. 2006 Oct;53(10):1039-43.
5. Use of a vascular access port for the measurement of pulsatile luteinizing hormone in old broiler breeders.
Match Strength: 2.708
Techniques used to measure circulating hormone concentrations in avian species over extended periods routinely involve cannulation or multiple venipunctures under physical restraint, resulting in sepsis and stress. We adapted a method for serial blood sampling in chickens using a vascular access port (VAP) surgically implanted under the skin of the neck and connected to a catheter inserted in the right jugular vein. The system was used to measure circulating luteinizing hormone (LH) profiles in six, 21-mo-old broiler breeders at the end of their laying period. The VAP were implanted under ... Read More »
» Published in Poult Sci. 2006 Sep;85(9):1632-40.
6. Healthcare-associated infection in pediatric patients on extracorporeal life support: The role of multidisciplinary surveillance.
Match Strength: 2.441
OBJECTIVE: To describe the use of a multidisciplinary approach to sepsis surveillance and evaluate impact on outcome. DESIGN: Prospective clinical study or clinical audit cycle. SETTING: Tertiary pediatric extracorporeal membrane oxygenation (ECMO) center. PATIENTS: Patients were 215 children supported with ECMO January 1999 to December 2004. INTERVENTIONS: A multidisciplinary team met monthly to evaluate cases of bloodstream infection and mediastinitis, review trends, and update unit policies. Changes in practice were made at the end of 2001 in order to address a perceived high rate of sepsis ... Read More »
» Published in Pediatr Crit Care Med. 2006 Nov;7(6):546-50.
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