Cancer of Skin
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Peer Reviewed Scientific Research Reports.
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1. Validation of a quality-of-life instrument for patients with nonmelanoma skin cancer.
Match Strength: 7.686
OBJECTIVE: To validate a disease-specific quality-of-life instrument--the Skin Cancer Index--intended to measure quality-of-life issues relevant to patients with nonmelanoma skin cancer. METHODS: Internal reliability, convergent and divergent validity with existing scales, and factor analyses were performed in a cross-sectional study of 211 patients presenting with cervicofacial nonmelanoma skin cancer to a dermatologic surgery clinic. RESULTS: Factor analyses of the Skin Cancer Index confirmed a multidimensional scale with 3 distinct subscales-emotional, social, and appearance. Excellent ... Read More »
» Published in Arch Facial Plast Surg. 2006 Sep-Oct;8(5):314-8.
2. High-intensity resistance and cardiovascular training improve physical capacity in cancer patients undergoing chemotherapy.
Match Strength: 4.794
The purpose of the study was to examine the effects of a supervised high- and low-intensity structured training program in cancer patients concurrently undergoing chemotherapy. Seventy patients, in different stages of the disease and with different diagnoses (48 females, 22 males), between 18 and 65 years of age (mean age 42.8) participated in a 9-h weekly training program over 6 weeks. The intervention involved physical exercise, relaxation, massage, and body-awareness training. Physical capacity (one-repetition maximum tests (1RM), VO2max) and body composition (weight, skin-fold) were ... Read More »
» Published in Scand J Med Sci Sports. 2006 Oct;16(5):349-57.
3. A double-blind, vehicle-controlled clinical study to evaluate the efficacy of MAS065D (XClair), a hyaluronic acid-based formulation, in the management of radiation-induced dermatitis.
Match Strength: 4.667
This study was designed to assess the efficacy and tolerability of MAS065D (Xclair) compared to a vehicle control in the management of radiation dermatitis in patients receiving radiotherapy for breast cancer. Twenty patients were randomized blindly to use the two study substances, three times daily, on separate sections of irradiated skin throughout the duration of radiotherapy and for two weeks afterwards. Patients were monitored before therapy, weekly during therapy, and for 2 weeks after radiotherapy was completed. Skin appearance according to National Cancer Institute (NCI) toxicity ... Read More »
» Published in Cutan Ocul Toxicol. 2006;25(3):165-71.
4. Anaplastic large-cell non-Hodgkin's lymphoma of the breast in periprosthetic localisation 32 years after treatment for primary breast cancer-a case report.
Match Strength: 4.608
Primary, as well as secondary, lymphomas of the breast are rare diseases and might, in some cases, be misdiagnosed as breast cancer on routine hematoxylin/eosin stainings. We report a case of an anaplastic large cell lymphoma in a 72-year-old woman with a history of breast cancer treated with breast-ablative surgery and a subsequent silicon implant 32 years ago. Clinically, she presented with an ulceration of the skin, which had developed within a few months. On conventional histology, the tumor cells were mimicking poorly differentiated invasive ductal carcinoma with a prominent leukocytic ... Read More »
» Published in Virchows Arch. 2006 Nov;449(5):561-4. Epub 2006 Sep 16.
5. New trends in radiotherapy for breast cancer.
Match Strength: 4.090
PURPOSE OF REVIEW: New radiotherapy techniques are under development to improve tumor control and to decrease the long-term side effects of breast cancer. These include accelerated partial breast irradiation, intensity modulated and image guided radiotherapy. RECENT FINDINGS: Follow-up data of multicatheter brachytherapy accelerated partial breast irradiation and intraoperative electron beam radiotherapy confirm excellent 5-year local control rates in well selected patients. Early side effects seem to be improved, but recent data show increasing skin toxicity in multicatheter and intracavitary ... Read More »
» Published in Curr Opin Oncol. 2006 Nov;18(6):555-62.
6. Development of a keratoacanthoma after topical photodynamic therapy with 5-aminolevulinic acid.
Match Strength: 3.965
Since its FDA approval in 1999, photodynamic therapy (PDT) with topical 5-aminolevulinic acid has become an increasingly popular modality for the treatment of actinic keratosis (AKs). It is hoped that in addition to improving clinical signs and symptoms of AKs, PDT might prevent the development of skin cancer. We present a case of a patient developing a keratoacanthoma immediately following PDT for AKs. Publication Types: Case ... Read More »
» Published in J Drugs Dermatol. 2006 Sep;5(8):804-6.
7. Olive fruit extracts inhibit proliferation and induce apoptosis in HT-29 human colon cancer cells.
Match Strength: 3.634
Olives and their derivatives represent an important component of the Mediterranean diet that has been considered to be protective against cancer. We investigated the effect on cell proliferation and apoptosis in HT-29 cells of an extract from the skin of olives composed of pentacyclic triterpenes with the main components maslinic acid (73.25%) and oleanolic acid (25.75%). Studies of the dose-dependent effects showed antiproliferative activity at an EC50 value of 73.96 +/- 3.19 micromol/L of maslinic acid and 26.56 +/- 2.55 micromol/L of oleanolic acid without displaying necrosis. Apoptosis was ... Read More »
» Published in J Nutr. 2006 Oct;136(10):2553-7.
8. ASSESSMENT OF SUN PROTECTION FOR CHILDREN'S SUMMER 2005 CLOTHING COLLECTION.
Match Strength: 3.301
Overexposure to solar ultraviolet radiation (UVR) in childhood is considered to be a critical factor for developing skin cancer in later life. Clothing may offer a simple and effective means of protection against overexposure to the sun, but its use has often been underrated in public opinion. The Health Protection Agency, in close collaboration with a number of UK retailers, conducted a study to evaluate the UVR protection characteristics of the summer 2005 collection of children's clothing for outdoor activity. The current paper presents a summary of the assessment and the effects of ... Read More »
» Published in Radiat Prot Dosimetry. 2006 Sep 23;
9. Hormone treatments and preventive strategies in the aging male: whom and when to treat?
Match Strength: 3.220
Sex hormones have a broad range of actions in regulating very diverse systems throughout life. Testosterone and other related hormones change with age to varying degrees and may induce pathophysiological changes and the clinical condition known as andropause. Androgen replacement is the accepted but not the only possible treatment for andropause. The presence of clinical symptoms, including a loss of sexual function, intellectual capacity, lean body mass, or bone mineral density; alterations in body hair, skin, or sleep pattern; or increases in visceral fat, together with low levels of serum ... Read More »
» Published in Rev Urol. 2003;5 Suppl 1:S16-21.
10. Gefitinib as front-line treatment in Chinese patients with advanced non-small-cell lung cancer.
Match Strength: 3.050
PURPOSE: This phase II single arm, open label study was designed to evaluate the efficacy and toxicity of oral gefitinib (250mg) daily in previously untreated patients with advanced non-small-cell lung cancer (NSCLC). METHODS: Eligible patients had stage IIIB or IV NSCLC with adequate organ functions, and were chemonaive. All eligible patients were treated with oral administration of 250mg of gefitinib until intolerable toxicity, disease progression or death occurred. Responses were assessed after every 8 weeks of therapy. RESULTS: For a total of 53 patients, the objective response rate (ORR) ... Read More »
» Published in Lung Cancer. 2006 Nov;54(2):193-9. Epub 2006 Sep 22.
11. Novel derivatives of methyl and ethyl 2-(4-oxo-8-aryl-2H-3,4,6,7-tetrahydroimidazo[2,1-c][1,2,4]triazin-3-yl)acetates from biologically active 1-aryl-2-hydrazinoimidazolines: synthesis, crystal structure and antiproliferative activity.
Match Strength: 3.016
The 1-aryl-2-hydrazinoimidazolines (2a-h) were directly obtained from appropriate 1-aryl-2-methylthioimidazolines (1a-h) by condensation reaction with hydrazine hydrate. Antimicrobial activities of two 1-aryl-2-hydrazinoimidazolines (2b and 2e) are presented. Their chemical structures were confirmed by IR, (1)H NMR, EI-MS and elemental analysis. The susceptibility of Gram-positive and Gram-negative bacterial strains, mould and yeast-like fungi strains to synthesized compounds and the MIC values against two reference strains of bacteria were determined. The strongest antibacterial activity for ... Read More »
» Published in Eur J Med Chem. 2006 Dec;41(12):1373-84. Epub 2006 Sep 22.
12. Gender differences in the disposition and toxicity of metals.
Match Strength: 2.368
There is increasing evidence that health effects of toxic metals differ in prevalence or are manifested differently in men and women. However, the database is small. The present work aims at evaluating gender differences in the health effects of cadmium, nickel, lead, mercury and arsenic. There is a markedly higher prevalence of nickel-induced allergy and hand eczema in women compared to men, mainly due to differences in exposure. Cadmium retention is generally higher in women than in men, and the severe cadmium-induced Itai-itai disease was mainly a woman's disease. Gender differences in ... Read More »
» Published in Environ Res. 2006 Sep 20;
13. Testicular function after 131I therapy for hyperthyroidism.
Match Strength: 2.225
OBJECTIVE: Radioiodine-131 is commonly used for treatment of hyperthyroidism but there are few available data on the effects of this treatment on male gonadal function. The untoward effects of (131)I have been mainly studied in male patients treated with high doses for thyroid cancer. In the present work we studied the absorbed radiation dose to the testes and testicular function in hyperthyroid men after (131)I treatment. PATIENTS AND MEASUREMENTS: Nineteen male hyperthyroid patients were enrolled in the study before (131)I therapy. Seventeen of the patients had Graves' disease and two had ... Read More »
» Published in Clin Endocrinol (Oxf). 2006 Oct;65(4):446-52.
14. Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in experimental models.
Match Strength: 2.178
The contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a prototype compound of a whole class of halogenated aromatic hydrocarbons termed 'dioxinlike' contaminants present in food, human tissue, mothers milk, and environmental samples. Among the various adverse effects caused by TCDD in animal experiments, its carcinogenic effects caused particular concern. In rodents, long-term TCDD treatment leads to the development of tumors of the liver, thyroid, lung, skin, oral cavity and other sites. The occurrence of liver tumors mainly observed in female rats has been used as a basis for ... Read More »
» Published in Mol Nutr Food Res. 2006 Oct;50(10):897-907.
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