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Peer Reviewed Scientific Research Reports.
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1. Models of genetic susceptibility to breast cancer.
Match Strength: 4.062
One of the most important risk factors for breast cancer is family history of the disease, indicating that genetic factors are important determinants of breast cancer risk. A number of breast cancer susceptibility genes have been identified, the most important being BRCA1 and BRCA2. However, it is estimated that all the currently known breast cancer susceptibility genes accounts for less than 25% of the familial aggregation of breast cancer. In this paper, we review the evidence for other breast cancer susceptibility genes arising from twin studies, pedigree analysis and studies of phenotypes ... Read More »
» Published in Oncogene. 2006 Sep 25;25(43):5898-905.
2. Human papillomavirus as a risk factor for the increase in incidence of tonsillar cancer.
Match Strength: 3.915
Smoking and alcohol are well-known etiological factors in tonsillar cancer. However, as in cervical cancer, human papillomavirus (HPV) is currently found in a sizable proportion of tonsillar cancer. Recent reports from the U.S. and Finland show an increase in the incidence of tonsillar cancer, without a parallel rise in smoking and alcohol consumption. This study investigates whether the incidence of tonsillar cancer has also changed in Sweden and whether a possible explanation of the increase is a higher proportion of HPV-positive tonsillar cancer. The incidence of tonsillar cancer between ... Read More »
» Published in Int J Cancer. 2006 Dec 1;119(11):2620-3.
3. Assays for complexed prostate-specific antigen and other advances in the diagnosis of prostate cancer.
Match Strength: 3.857
This review discusses advances in the area of serum and tissue markers for prostate cancer. A recently developed assay for complexed prostate-specific antigen (PSA) has been found to have better specificity than that afforded by assay of total PSA. Researchers in Austria have found that lowering the PSA cutoff point for a diagnosis of prostate cancer resulted in a significant increase in identifying men with cancer at a favorable pathologic stage. Difficulties in pathologic interpretation of tissue specimens can result in both under- and over-diagnosis of prostate cancer. When in doubt, ... Read More »
» Published in Rev Urol. 2003;5 Suppl 6:S10-6.
4. Imaging in the diagnosis and management of prostate cancer.
Match Strength: 3.740
The current diagnosis and management of prostate cancer is largely based on the use of serum prostate-specific antigen (PSA) and pathologic risk factors such as Gleason score and clinical stage. The use of serum PSA in clinical practice has resulted in significant stage migration and, as such, imaging modalities historically utilized to stage prostate cancer are no longer able to reliably identify the small amounts of prostate cancer most often found at presentation. Molecular imaging techniques have focused on improving sensitivity and specificity for cancer detection through knowledge of ... Read More »
» Published in Rev Urol. 2004 Summer;6(3):101-13.
5. A community partnership model for developing a Center for Cancer Nursing Education and Research.
Match Strength: 3.735
This article describes a partnership model used to establish the Center for Cancer Nursing Education and Research at the University of Louisville (U of L) School of Nursing. The model was used to bring together area nursing education programs, institutions providing cancer nursing care, and related community groups. The need for the project was directly related to the high cancer morbidity and mortality in the community. The U of L's strategic agenda and strong commitment to cancer prevention and care provided a growth opportunity for the recognition of nurses' role in cancer care. Nurses are ... Read More »
» Published in J Prof Nurs. 2006 Sep-Oct;22(5):273-9.
6. Inflammatory breast cancer: current understanding.
Match Strength: 3.715
PURPOSE OF REVIEW: Inflammatory breast cancer is a highly aggressive variant of locally advanced breast cancer that carries a significantly worse prognosis. The purpose of this review is to highlight recent advances in the molecular modus operandi of this particular form of breast cancer. RECENT FINDINGS: Studies on tumor cell emboli, E-cadherin, chemokine receptors, steroid hormone receptor, angiogenesis, lymphangiogenesis and gene expression all suggest significant differences with noninflammatory breast cancer and are clearly in line with a different pathogenesis of the condition. SUMMARY: ... Read More »
» Published in Curr Opin Oncol. 2006 Nov;18(6):563-71.
7. Analyses and perspectives in cancer immunotherapy.
Match Strength: 3.702
Since the last two decades, rapid progress has been made in the field of cancer immunotherapy relevant to manipulation of adaptative cytotoxic T lymphocytes (CTLs) and innate immunity natural killer (NK) cells as well as antibodies. Many possibilities are now offered for therapeutic purposes contributing to better approaches in treatment of cancer. Publication Types: ... Read More »
» Published in Biomed Pharmacother. 2006 Nov;60(9):621-8. Epub 2006 Aug 28.
8. Legacy of the Pacific Islander cancer control network.
Match Strength: 3.690
The groundwork for the Pacific Islander cancer control network (PICCN) began in the early 1990s with a study of the cancer control needs of American Samoans. The necessity for similar studies among other Pacific Islander populations led to the development of PICCN. The project's principal objectives were to increase cancer awareness and to enhance cancer control research among American Samoans, Tongans, and Chamorros. PICCN was organized around a steering committee and 6 community advisory boards, 2 from each of the targeted populations. Membership included community leaders, cancer control ... Read More »
» Published in Cancer. 2006 Oct 15;107(8 Suppl):2091-8.
9. Risk factors for lung cancer in patients with scleroderma: A nested case-control study.
Match Strength: 3.674
OBJECTIVE: To study potential risk factors for the development of lung cancer in scleroderma patients and explore the chronological relationship between onset of scleroderma symptoms and subtypes of lung cancer. METHOD: Linkage of two population based registers to identify lung cancer cases and gender-matched controls with scleroderma, followed by retrospective case note review for clinical details. RESULTS: Patients with scleroderma who smoke are 7 times more likely to develop lung cancer than non- smokers (p=0.008). Scleroderma smokers with cancer smoke more than scleroderma smokers without ... Read More »
» Published in Ann Rheum Dis. 2006 Sep 19;
10. Second primary oral and pharyngeal cancers in subjects diagnosed with oral and pharyngeal cancer.
Match Strength: 3.661
Patients diagnosed with oral and pharyngeal (OP) cancer have a substantial excess risk of second OP cancer, but risk quantification is still uncertain and scanty information is available on the absolute excess risk of second OP cancer. We considered the risk of second OP primary cancer in a population-based series of 3,092 first primary OP cancers registered between 1974 and 2003 in the Swiss Cantons of Vaud and Neuchatel (total population of about 786,000 inhabitants). A total of 233 second OP cancers were registered, versus 7.4 expected, corresponding to a SIR of 31.7 (95% confidence ... Read More »
» Published in Int J Cancer. 2006 Dec 1;119(11):2702-4.
11. Drug resistance, predictive markers and pharmacogenomics in colorectal cancer.
Match Strength: 3.661
Resistance to chemotherapy limits the effectiveness of current cancer therapies, including those used to treat colorectal cancer, which is the second most common cause of cancer death in Europe and the United States. 5-Fluorouracil-based chemotherapy regimens are the standard treatment for colorectal cancer in both the adjuvant and advanced disease settings. Drug resistance is thought to cause treatment failure in over 90% of patients with metastatic cancer, while drug resistant micrometastic tumour cells may also reduce the impact of adjuvant chemotherapy treatment. The identification of ... Read More »
» Published in Biochim Biophys Acta. 2006 Dec;1766(2):184-96. Epub 2006 Aug 9.
12. Population-based study of the prevalence of family history of cancer: implications for cancer screening and prevention.
Match Strength: 3.656
PURPOSE: Family history assessment is gaining importance as a potential public health tool to help determine susceptibility to common cancers. Population-based data on the prevalence of having a family history of common cancers are scant. METHODS: We queried survey questions from the National Health Interview Survey, an annual nationwide survey of approximately 36,000 households in the United States, to determine the prevalence of persons reporting one or more first-degree relatives with breast, colorectal, lung, prostate, or ovarian cancer. RESULTS: Breast cancer was the most common condition ... Read More »
» Published in Genet Med. 2006 Sep;8(9):571-5.
13. Knowledge and attitude towards risk factors in oral cancer held by dental hygienists in the Autonomous Community of Murcia (Spain): A pilot study.
Match Strength: 3.650
The objective was to study the knowledge and attitude on risk factors in oral cancer held by dental hygienists working in private dental practices in the Autonomous Community of Murcia, Spain. An anonymous phone survey was made after obtaining consent from the interviewee. A simple randomized study was carried out and 240 dental hygienists were selected. The questionnaire was divided into three different parts: (1) professional data and years of practice; (2) knowledge of the risk factors in oral cancer and (3) education and training needs on oral cancer. The response rate was 58.3%. Regarding ... Read More »
» Published in Oral Oncol. 2006 Sep 21;
14. Early diagnosis and staging of prostate cancer.
Match Strength: 3.642
The need for accurate methods of ascertaining the malignant potential of any given man's prostate cancer has never been greater than it is today. The presenters at the session of the 13th International Prostate Cancer Update addressing early diagnosis and staging of disease discussed combined-modality staging of disease; color Doppler imaging for detection of cancer; pelvic lymphadenectomy as a diagnostic tool; and a new, artificial intelligence-based model to predict survival. A summary of these presentations is provided here ... Read More »
» Published in Rev Urol. 2003;5 Suppl 6:S17-22.
15. Histopathological types of breast cancer in Nigerian women: a 12-year review (1993-2004).
Match Strength: 3.583
To determine the commonest histological types of breast cancer in Nigerian women in Edo State and the mean age at diagnosis, we reviewed the histological slides of breast cancer received in the pathology department of University of Benin Teaching Hospital over a twelve-year period (January 1993-December 2004). The clinical data was obtained from the original request form and case notes where necessary. The mean age of the patients was 45.7 (SD= 13.4, SEM = 0.7). Invasive ductal carcinoma (not otherwise specified) constituted the majority of breast cancer accounting for 75.5% while papillary ... Read More »
» Published in Afr J Reprod Health. 2006 Apr;10(1):71-5. Comment in: Afr J Reprod Health. 2006 Apr;10(1):7-12.
16. The 3' untranslated region C > T polymorphism of prohibitin is a breast cancer risk modifier in Polish women carrying a BRCA1 mutation.
Match Strength: 3.563
The variable penetrance of breast cancer in BRCA1 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. The C to T transition in the 3' untranslated region of the prohibitin (PHB) gene alters mRNA function and has been shown to be associated with an increased breast cancer risk among young North-American women who have one first-degree relative with breast cancer. To investigate whether the PHB 3'UTR polymorphism acts as a modifier of hereditary breast cancer risk we performed a case-control study among female BRCA1 mutation carriers, which included ... Read More »
» Published in Breast Cancer Res Treat. 2006 Sep 27;
17. Hormone-refractory prostate cancer: new horizons.
Match Strength: 3.553
The eighth session of the 13th International Prostate Cancer Update focused on the mechanisms of androgen-independent cancer growth and on new therapeutic approaches to the treatment of androgen-independent prostate cancer. Three possible mechanisms that might account for the development of hormone resistance are reviewed here. These are: changes in antigen receptor expression, changes in androgen receptor structure, and changes in androgen receptor function. Therapeutic approaches discussed include the endothelin receptor antagonist astrasentan; PS-341, a boronic acid dipeptide that is highly ... Read More »
» Published in Rev Urol. 2003;5 Suppl 6:S54-8.
18. Prostate cancer pathology, screening, and epidemiology.
Match Strength: 3.539
Recent advances in the understanding of prostate cancer pathology, screening methods, and epidemiology were discussed at the 11th International Prostate Cancer Update. Regarding pathology, Dr. Gary Miller enumerated several factors that lead to the perception of prostate cancer as "unpredictable." These include the disease's multifocal nature, variable progression rates, and the uncertainty regarding the point at which carcinomas metastasize. Screening methods have been the subject of research by the Laval University Prostate Cancer Screening Program since 1988. Dr. Fernand Labrie presented ... Read More »
» Published in Rev Urol. 2001;3 Suppl 2:S2-S10.
19. Cancer incidence in first-degree relatives of a population-based set of cases of early-onset breast cancer.
Match Strength: 3.537
Reliable determination of familial risks for cancer is important for clinical counselling, cancer prevention and understanding cancer aetiology. Family-based gene identification efforts may be targeted if the risks are well characterised and the mode of inheritance is identified. Early-onset breast cancer in a family member is a risk indicator for cancer among first-degree relatives; however, the familial risk pattern has not been assessed fully in population-based incidence studies. We estimated the risks for cancers of the breast, ovary and other sites among the first-degree relatives of ... Read More »
» Published in Eur J Cancer. 2006 Nov;42(17):3034-40. Epub 2006 Sep 22.
20. The potential for prostate cancer chemoprevention.
Match Strength: 3.532
The dramatic international variation in prostate cancer incidence and mortality rates suggests that changeable environmental factors exert an influence. This has prompted a search for ways to prevent the disease. Epidemiologic studies suggest that dietary factors such as the carotenoid lycopene, selenium, vitamin E, and high intake of fat have roles in prostate cancer risk. Several studies show that impairment of androgen synthesis lowers the risk of prostate cancer. 5-alpha-reductase inhibitors such as finasteride have been shown to decrease prostate size by decreasing androgenic stimulation ... Read More »
» Published in Rev Urol. 2002;4 Suppl 5:S11-7.
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