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Bronchopulmonary Dysplasia
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1. Cathepsin K expression is diminished in infants with bronchopulmonary dysplasia.
Match Strength: 13.392

The expression of a potent collagenolytic enzyme, cathepsin K, was measured in repeated tracheal aspirate samples from premature infants with and without a chronic lung disorder, bronchopulmonary dysplasia (BPD). At 9--13 d, but not before, cathepsin K expression was significantly lower in the lungs of premature infants developing BPD. Conclusion: Insufficient pulmonary cathepsin K in BPD may predispose premature lungs to pulmonary fibrosis. Publication Types: Research Support, Non-U.S. Gov ... Read More »
» Published in Acta Paediatr. 2006 Oct;95(10):1298-300.

2. High-resolution CT of the chest in children and young adults who were born prematurely: findings in a population-based study.
Match Strength: 8.509

OBJECTIVE: The purpose of this study was to use a scoring system for high-resolution CT in the evaluation of radiologic findings in young people born extremely preterm and to examine the reproducibility of this scoring system. SUBJECTS AND METHODS: High-resolution CT of the lungs was assessed in 72 children born at a gestational age of < or = 28 weeks or with a birth weight of < or = 1,000 g within a defined region in western Norway in 1982-1985 (n = 40) or in 1991-1992 (n = 32). All images were analyzed by two pediatric radiologists using a scoring system in which a total of 14 features ... Read More »
» Published in AJR Am J Roentgenol. 2006 Oct;187(4):1012-8.

3. Perinatal risk factors altering regional brain structure in the preterm infant.
Match Strength: 7.469

Neuroanatomical structure appears to be altered in preterm infants, but there has been little insight into the major perinatal risk factors associated with regional cerebral structural alterations. MR images were taken to quantitatively compare regional brain tissue volumes between term and preterm infants and to investigate associations between perinatal risk factors and regional neuroanatomical alterations in a large cohort of preterm infants. In a large prospective longitudinal cohort study of 202 preterm and 36 term infants, MR scans at term equivalent were undertaken for volumetric ... Read More »
» Published in Brain. 2006 Sep 28;

4. Amiloride-sensitive nasal potential difference is not changed by estradiol and progesterone replacement but relates to BPD or death in a randomized trial on preterm infants.
Match Strength: 5.700

Postnatal replacement of placental estradiol (E2) and progesterone (P) in preterm infants may improve lung function, possibly mediated through enhanced epithelial Na(+) transport and alveolar fluid clearance. Preterm infants of <29 wk gestational age and <1000 g birth weight requiring mechanical ventilation within 12 h of birth were randomized to receive either 2.5 mg/kg E2 and 22.5 mg/kg P per day (E2/P), or vehicle placebo. Epithelial Na(+) transport was assessed in 29 infants by measuring total nasal potential difference (NPD) and amiloride-sensitive NPD (ASNPD) on postnatal days of ... Read More »
» Published in Pediatr Res. 2006 Nov;60(5):619-23. Epub 2006 Sep 20.

5. The severity of respiratory syncytial virus bronchiolitis in young infants in the United arab emirates.
Match Strength: 4.388

Respiratory syncytial virus (RSV) respiratory infections are very common during infancy and account for the majority of hospitalizations during the fall and winter seasons. Patients vary in the severity of their illnesses, with most hospitalized patients needing oxygen and intravenous fluids. The objective of this study was to assess in hospitalized patients the severity of the disease in relation to age. We compared children who were <90 days old with children who were >90 days old for the duration of oxygen therapy, maximum oxygen concentration used, duration of stay and duration of ... Read More »
» Published in J Trop Pediatr. 2007 Feb;53(1):22-6. Epub 2006 Sep 28.

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