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Bronchiolitis Obliterans Organizing Pneumonia
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1. Macrolides: a treatment alternative for bronchiolitis obliterans organizing pneumonia?
Match Strength: 33.023

Some macrolides have been found to exert anti-inflammatory effects. Lung diseases such as asthma, panbronchiolitis, cystic fibrosis, and bronchiectasis are thought to respond to the immunomodulatory properties of macrolides. We report three cases of idiopathic bronchiolitis obliterans organizing pneumonia, now called cryptogenic organizing pneumonia, and three cases of radiation-related bronchiolitis obliterans organizing pneumonia that responded to macrolide therapy. An explanation of why macrolides may have anti-inflammatory effects in patients with these syndromes is discussed. These cases ... Read More »
» Published in Chest. 2005 Nov;128(5):3611-7.

2. Bronchiolitis obliterans organizing pneumonia: CT features in 14 patients
Match Strength: 29.704

Bronchiolitis obliterans organizing pneumonia is a disease characterized by the presence of granulation tissue within small airways and the presence of areas of organizing pneumonia. We retrospectively reviewed the chest radiographs, CT scans, and biopsy specimens in 14 consecutive patients with proved bronchiolitis obliterans organizing pneumonia. Six patients were immunocompromised because of leukemia or bone-marrow transplantation. In all patients, 10-mm collimation CT scans were available. In 11 of the 14 patients, select 1.5-mm scans were obtained. The CT findings included patchy ... Read More »
» Published in AJR Am J Roentgenol. 1990 May;154(5):983-7.

3. T-cell depletion prevents from bronchiolitis obliterans and bronchiolitis obliterans with organizing pneumonia after allogeneic hematopoietic stem cell transplantation with related donors.
Match Strength: 27.649

Bronchiolitis obliterans (BO) and bronchiolitis obliterans organizing pneumonia (BOOP) are late-onset non-infectious pulmonary complications (LONIPCs) following allogeneic hematopoietic stem cell transplantation (HSCT). In the present study 10 of 197 conventionally prepared stem cell recipients developed BOOP after 365 days and 6 patients developed BO 333 days post-transplant. No BOOP or BO was diagnosed following T-cell depletion (p<0.05). Chronic GVHD was ascertained in all BOOP patients and appeared significantly (p<0,001) more frequent in the conventional transplant group. The data ... Read More »
» Published in Haematologica. 2007 Apr;92(4):558-61.

4. Bronchiolitis Obliterans With Organizing Pneumonia in Rheumatoid Arthritis--A Fatal Case and Short Review of Literature
Match Strength: 27.630

Bronchiolitis obliterans with organizing pneumonia (BOOP) is characterized by excessive proliferation of granulation tissue within small airways (proliferative bronchiolitis) and alveolar ducts associated with chronic inflammation in the surrounding alveoli. It is generally idiopathic but may occur during the resolution of viral or mycoplasmic pneumonia. It is also associated with a variety of systemic illnesses and clinical settings. Complete resolution occurs in 65-85% of patients treated with corticosteroid therapy, and recurrence is not uncommon. Although rapidly fatal BOOP is rare, ... Read More »
» Published in Rheumatol Int. 2005 Jun;25(5):391-3. Epub 2004 Sep 18.

5. Bronchiolitis obliterans organizing pneumonia simulating progression in bronchioloalveolar carcinoma.
Match Strength: 27.160

Bronchiolitis obliterans organizing pneumonia (BOOP) is a clinicopathologic syndrome with characteristic features. The diagnosis of BOOP requires the presence of a combination of pathological, clinical, and radiological features. We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor. Publication Types: Case ... Read More »
» Published in Clin Transl Oncol. 2006 Feb;8(2):133-5.

6. Bronchiolitis obliterans organizing pneumonia.
Match Strength: 27.152

Bronchiolitis obliterans with organizing pneumonia (BOOP) is a pathological syndrome common to a variety of pulmonary inflammatory disorders. It is defined by the presence of buds of granulation tissue consisting of fibroblasts and collagen within the lumen of the distal airspaces. BOOP may be secondary to lung injury resulting especially from infection or drug toxicity or may develop in the context of connective tissue diseases or after lung or bone marrow transplantation. BOOP may also be idiopathic (and then preferentially called cryptogenic organizing pneumonia) and then is the hallmark of ... Read More »
» Published in Semin Respir Crit Care Med. 2000;21(2):135-46.

7. Bronchiolitis obliterans organizing pneumonia associated with Pneumocystis jiroveci infection in orthotopic liver transplantation.
Match Strength: 27.032

We report a patient who presented 6 months after orthotopic liver transplantation (OLT) with fever, dyspnea, and pulmonary infiltrates with biopsy-confirmed Pneumocystis jiroveci infection associated with a process of bronchiolitis obliterans organizing pneumonia (BOOP). We present this second case of BOOP associated with P. carinii pneumonia after OLT to highlight the risk of such disease combination in all transplant patients as well as discuss the protective effect of post-transplant prednisolone with trimethoprim-sulfamethoxazole prophylaxis and the possible duration of prophylaxis ... Read More »
» Published in Transpl Infect Dis. 2008 Feb 3

8. Organizing pneumonia: cryptogenic and disease associated.
Match Strength: 26.884

Organizing pneumonia is defined by the presence of buds of granulation tissue (fibroblastic cells and connective matrix) within the alveolar lumen, usually associated with proliferative bronchiolitis obliterans. It may result from several causes, but cryptogenic organizing pneumonia is a distinct clinicopathologic entity with characteristic clinical and imaging features. Typical COP is thus easily recognized by the clinician, and the diagnosis is made by the finding of organizing pneumonia on lung biopsy specimen. The response to corticosteroids is rapid and complete usually without sequelae, ... Read More »
» Published in Semin Respir Crit Care Med. 2003 Oct;24(5):595-606.

9. Bronchiolitis Obliterans Organizing Pneumonia Associated With Sulfasalazine in a Patient With Rheumatoid Arthritis
Match Strength: 26.558

Pulmonary toxicity and blood dyscrasias are rare side effects of sulfasalazine. Pulmonary pathology is variable, the most common being eosinophilic pneumonia with peripheral eosinophilia, and interstitial inflammation with or without fibrosis. We here present the case of a 68-year-old female patient treated for 6 months with sulfasalazine for rheumatoid arthritis. On laboratory examination, eosinophil count was 97 x 10(3) mm(3). Thorocoscopic biopsy was performed. Histopathologic diagnosis was bronchiolitis obliterans organizing pneumonia (BOOP). This is the first case in the literature to ... Read More »
» Published in Clin Rheumatol. 2004 Jun;23(3):249-51. Epub 2004 Feb 24.

10. Bronchiolitis obliterans and other late onset non-infectious pulmonary complications in hematopoietic stem cell transplantation.
Match Strength: 26.297

Pulmonary complications develop in 30-60% of hematopoietic stem cell transplants (HSCT). The main, late onset, non-infectious complications include Bronchiolitis obliterans (BO), Bronchiolitis obliterans organizing pneumonia (BOOP), and idiopathic pneumonia syndrome (IPS). BO and BOOP occur almost exclusively in allogeneic HSCT, and have 61% and 21% mortality rates, respectively. BOOP responds favorably to corticosteroids. IPS has less than 15% 1-year survival. Publication Types: ... Read More »
» Published in Bone Marrow Transplant. 2001 Sep;28(5):425-34.

11. Bronchiolitis Obliterans Syndrome (BOS), Bronchiolitis Obliterans Organizing Pneumonia (BOOP), and Other Late-Onset Noninfectious Pulmonary Complications following Allogeneic Hematopoietic Stem Cell Transplantation.
Match Strength: 25.695

Pulmonary dysfunction is a significant complication following allogeneic hematopoietic stem cell transplantation (HSCT), and is associated with significant morbidity and mortality. Effective antimicrobial prophylaxis and treatment strategies have increased the incidence of noninfectious lung injury, which can occur in the early posttransplant period or in the months and years that follow. Late-onset noninfectious pulmonary complications are frequently encountered, but diagnostic criteria and terminology for these disorders can be confusing and therapeutic approaches are suboptimal. As a ... Read More »
» Published in Biol Blood Marrow Transplant. 2007 Jul;13(7):749-59.

12. A Comparison of Bronchiolitis Obliterans with Organizing Pneumonia, Usual Interstitial Pneumonia, and Small Airways Disease
Match Strength: 25.590

This report is based on 43 cases where a diagnosis of either bronchiolitis obliterans with organizing pneumonia (BOOP), usual interstitial pneumonia (UIP), or small airways disease (SAD) was established by lung biopsy. The severity of histologic abnormalities in the peripheral airways and interstitial spaces were measured on these biopsies using semiquantitative techniques and compared with the clinical data available in 42 of 43 cases, preoperative chest radiographs in 31 of 43, and preoperative pulmonary function tests in 29 of 43. The data show that when a diagnosis of BOOP was made, there ... Read More »
» Published in Am Rev Respir Dis. 1987 Mar;135(3):705-12.

13. Radiographic appearance of bronchiolitis obliterans organizing pneumonia (BOOP) developing during Bucillamine treatment for rheumatoid arthritis.
Match Strength: 25.441

Bucillamine, a disease-modifying antirheumatic drug, can have adverse effects, including lung injury. Development of interstitial pneumonia during treatment for patients with rheumatoid arthritis (RA) can pose a difficult differential diagnosis between a direct manifestation of RA and a drug effect. Our review of previous reports suggested bucillamine-induced interstitial pneumonia in the patient described here, visualized by chest radiography and computed tomography based on patchy ground-glass opacities in a peribronchial or peripheral distribution, suggesting the appearance of bronchiolitis ... Read More »
» Published in Am J Med Sci. 2006 Jul;332(1):39-42.

14. Oleic Acid-Associated Bronchiolitis Obliterans-Organizing Pneumonia in Beagle Dogs
Match Strength: 25.225

Accidental intra-airway exposure of dogs with pure oleic acid produced bronchiolitis obliterans and bronchopneumonia. Pulmonary changes included multifocal to coalescing necrosis of bronchioles and adjacent alveoli, hemorrhage, inflammation, and exudation of fibrin. Hyperplasia of bronchiolar and alveolar epithelial cells and proliferation of loose fibrovascular connective tissue formed polyps or plugs of variable size and shape. Polyps in the airways primarily consisted of fibroblasts with loose or myxoid stroma and were variably covered with attenuated epithelial cells. Some polyps had ... Read More »
» Published in Vet Pathol. 2006 Mar;43(2):183-5.

15. Oleic acid-associated bronchiolitis obliterans-organizing pneumonia in beagle dogs.
Match Strength: 25.225

Accidental intra-airway exposure of dogs with pure oleic acid produced bronchiolitis obliterans and bronchopneumonia. Pulmonary changes included multifocal to coalescing necrosis of bronchioles and adjacent alveoli, hemorrhage, inflammation, and exudation of fibrin. Hyperplasia of bronchiolar and alveolar epithelial cells and proliferation of loose fibrovascular connective tissue formed polyps or plugs of variable size and shape. Polyps in the airways primarily consisted of fibroblasts with loose or myxoid stroma and were variably covered with attenuated epithelial cells. Some polyps had ... Read More »
» Published in Vet Pathol. 2006 Mar;43(2):183-5.

16. Bronchiolitis obliterans organizing pneumonia (BOOP) after thoracic radiotherapy for breast carcinoma.
Match Strength: 24.695

ABSTRACT: Common complications of thoracic radiotherapy include esophagitis and radiation pneumonitis. However, it is important to be aware of uncommon post-radiotherapy complications such as bronchiolitis obliterans organizing pneumonia (BOOP). We report on two patients with carcinoma of the breast who developed an interstitial lung disease consistent with BOOP. BOOP responds to treatment with corticosteroids and the prognosis is generally good despite of the need for long-term administration of corticosteroids as relapses can occur during tapering of steroids. This report provides guidelines ... Read More »
» Published in Radiat Oncol. 2007 Jan 3;2(1):2

17. Bronchiolitis Obliterans Organizing Pneumonia in a Patient with Chronic Myelogenous Leukemia Developing After Initiation of Interferon and Cytosine Arabinoside
Match Strength: 24.238

A 59-yr-old man developed fevers, shortness of breath, persistent cough and weight loss, shortly after initiation of therapy with interferon-alpha 2a and cytosine arabinoside for treatment of chronic myelogenous leukemia. Radiologic pulmonary infiltrates and lung tissue biopsy were consistent with bronchiolitis obliterans organizing pneumonia (BOOP). After discontinuation of the chemotherapeutic drugs, the pneumonic symptoms and chest roentgenogram infiltrates resolved. This report suggests that treatment with interferon-alpha, in combination with cytosine arabinoside, may produce the rare ... Read More »
» Published in Eur J Haematol. 2001 Nov-Dec;67(5-6):318-21.

18. A case of bronchiolitis obliterans organizing pneumonia syndrome with preceding radiation pneumonitis after breast-conserving therapy.
Match Strength: 23.784

Recent case series have demonstrated that bronchiolitis obliterans organizing pneumonia (BOOP) after radiation therapy to the breast is a distinct clinicopathological entity. Most of the investigators speculated that radiation may prime the development of BOOP through an unidentified immunological process; however, none of them showed the relationship between direct radiation injury and BOOP. We report herein a case of a 67-year-old female with BOOP following direct radiation damage confined to the irradiated area after breast-conserving therapy. This is the first case demonstrating that BOOP ... Read More »
» Published in Jpn J Clin Oncol. 2004 Dec;34(12):755-8.

19. Cryptogenic organizing pneumonia with atypical histopathological features.
Match Strength: 23.769

A case report of cryptogenic organizing pneumonia (COP); also known as bronchiolitis obliterans organizing pneumonia (BOOP) is presented. The histopathologic findings of COP are well documented in the literature and typically consist of organizing pneumonia of uniform appearance. This case report describes, in addition to the classic findings, more acute exudative inflammation not usually associated with this condition. Variation in the evolution of the pneumonic process is one of the reasons for reporting this case. The promotion of awareness of this treatable condition is the other reason ... Read More »
» Published in Australas Radiol. 1994 Feb;38(1):41-5.

20. Bronchiolitis obliterans. Organizing pneumonia
Match Strength: 22.648

Bronchiolitis obliterans combined organizing pneumonia (BOOP), now called organizing pneumonia, is a multi-etiologic disease. It can present as a solitary lesion, or as multinodular or diffuse interstitial lung disease. It is speculated if solitary BOOP may evolve into inflammatory pseudotumor of the lung. BOOP can be seen after non-resolving infectious bronchopneumonia as well as acute interstitial pneumonia with diffuse alveolar damage. BOOP can be the early morphologic pattern in toxic inhalation, especially water-soluble substances, but also in drug induced lung disease. BOOP can be the ... Read More »
» Published in Verh Dtsch Ges Pathol. 2002;86:101-6.

21. Crescentic and ring-shaped opacities. CT features in two cases of bronchiolitis obliterans organizing pneumonia (BOOP).
Match Strength: 22.395

Two cases of idiopathic bronchiolitis obliterans organizing pneumonia (BOOP) with unusual CT findings are presented. On CT both cases exhibited crescentic and ring-shaped opacities, surrounding areas of groundglass attenuation, and associated with a nodular pattern in one patient and airspace consolidations in the second patient. CT-pathologic correlation disclosed that the central areas of groundglass attenuation corresponded to alveolar septal inflammation, in contrast to the denser periphery where granulomatous tissue in peripheral airspaces predominated. In the broad spectrum of CT ... Read More »
» Published in Acta Radiol. 1996 Nov;37(6):889-92.

22. Bronchiolitis obliterans with organizing pneumonia associated with scleroderma and scleroderma spectrum diseases.
Match Strength: 22.063

Systemic sclerosis (SSc) is an autoimmune disorder with a high mortality rate from pulmonary manifestations, such as interstitial lung disease and pulmonary hypertension, seen at autopsy in 90% and 75% of patients, respectively. Bronchiolitis obliterans with organizing pneumonia (BOOP) has numerous causes, but it has only been reported in three patients with SSc. We present three cases of biopsy-proven BOOP in patients with scleroderma spectrum disease, including diffuse cutaneous SSc, mixed connective tissue disease with SSc features, and limited cutaneous SSc that later evolved to ... Read More »
» Published in J Clin Rheumatol. 2003 Aug;9(4):239-45.

23. Improvement of chronic pulmonary graft-vs-host disease manifesting as bronchiolitis obliterans organizing pneumonia following extracorporeal photopheresis.
Match Strength: 21.257

Despite use of combined immunosuppressive agents, prognosis of patients developing pulmonary manifestations of chronic graft-vs-host disease (cGVHD) following allogeneic stem cell transplantation (SCT) still remains poor. We present a male patient who developed pulmonary cGVHD in the form of bronchiolitis obliterans organizing pneumonia (BOOP) following allogeneic SCT for acute myelogenous leukemia. The patient developed progressive course despite use of a combination of immunosuppressive agents including high-dose prednisone, cyclosporin-A, and mycophenolate mofetil in addition to steroid ... Read More »
» Published in Med Oncol. 2006;23(1):125-9.

24. Mast cells in bronchiolitis obliterans organizing pneumonia. Mast cell hyperplasia and evidence for extracellular release of tryptase.
Match Strength: 21.138

Idiopathic bronchiolitis obliterans organizing pneumonia (BOOP) is characterized by air space inflammation and fibrosis of unknown origin. The pathogenesis of the inflammatory reaction and fibrosis in fibrotic lung disorders remains unclear; however, recent attention has focused on the potential role of the mast cell in the genesis of fibrosis. To determine whether mast cells are implicated in the pathogenesis of BOOP, mast cells were identified in BAL fluid and in transbronchial lung biopsy specimens from 11 patients affected by BOOP and 17 control subjects. Mast cells and tryptase were ... Read More »
» Published in Chest. 1996 Aug;110(2):383-91.

25. Bronchiolitis obliterans with organizing pneumonia after rituximab therapy for non-Hodgkin's lymphoma.
Match Strength: 20.887

Rituximab is a chimeric, anti-CD20 monoclonal antibody initially approved for relapsed, refractory indolent B-cell non-Hodgkin's lymphoma (NHL), and is being applied in an increasing variety of clinical scenarios. Most adverse events are due to an infusion-related symptom complex, and severe pulmonary complications are rare. We describe a case of an NHL patient who received rituximab and developed symptomatic, biopsy-proven multinodular bronchiolitis obliterans with organizing pneumonia (BOOP). This is the first reported case of BOOP associated with single-agent rituximab, and along with two ... Read More »
» Published in Hematol Oncol. 2006 Dec;24(4):234-7.

26. Interstitial lung disease.
Match Strength: 20.684

Because the list of interstitial lung diseases is so extensive, encompassing more than 180 chronic lung diseases in which the interstitium is altered by inflammation and/or fibrosis, this chapter focuses on several inflammatory lung diseases of unknown etiology: usual interstitial pneumonitis, respiratory bronchiolitis, idiopathic bronchiolitis obliterans with organizing pneumonia, pulmonary Langerhans' cell granulomatosis, hypersensitivity pneumonitis, and lymphangioleiomyomatosis ... Read More »
» Published in Pathology (Phila). 1996;4(1):1-21.

27. CT of bronchial and bronchiolar diseases.
Match Strength: 20.546

Computed tomography (CT) is useful in evaluating bronchial and bronchiolar abnormalities. Common bronchial and bronchiolar abnormalities include bronchiectasis, asthma, bronchial obstruction, and various forms of bronchiolitis. Causes of bronchiectasis include cystic fibrosis, childhood viral infection, allergic bronchopulmonary aspergillosis, and pulmonary fibrosis. On CT scans, cystic fibrosis may manifest with bronchial wall thickening, bronchiectasis (usually cylindrical, with varicose and cystic forms seen in advanced cases), and mucus plugs in the bronchi. Allergic bronchopulmonary ... Read More »
» Published in Radiographics. 1994 Sep;14(5):991-1003.

28. Bronchiolitis obliterans organizing pneumonia: experience at three hospitals in Riyadh.
Match Strength: 20.505

BACKGROUND: Because reports of bronchiolitis obliterans organizing pneumonia (BOOP) are lacking from the Middle East, we conducted a retrospective review of of all histopathologically proven cases of BOOP over a 10-year period at three tertiary care hospitals in Riyadh and describe the clinical features and outcome. METHODS: Charts at the three hospitals were searched using a specific code for BOOP or cryptogenic organizing pneumonia (COP). Lung specimens had to show histological proof of BOOP with a compatible clinical picture. Chest radiographs and high-resolution CT scans were reviewed. ... Read More »
» Published in Ann Saudi Med. 2007 Jan-Feb;27(1):32-5.

29. Bronchiolitis obliterans.
Match Strength: 20.351

Bronchiolitis obliterans (BO) is a fibrotic lung disease involving the small conducting airways. BO may be classified by etiology and underlying disease or, more commonly, by histopathological pattern. The two major histopathological categories are (1) BO organizing pneumonia (BOOP) and proliferative bronchiolitis and (2) constrictive bronchiolitis. The former is often idiopathic in nature and may also be associated with connective tissue diseases and inhalation injury. Characteristic findings on chest imaging include alveolar infiltrates and ground glass opacities and pulmonary function tests ... Read More »
» Published in Semin Respir Crit Care Med. 2000;21(2):123-34.

30. Bronchiolitis obliterans organizing pneumonia after bone marrow transplantation: association with human leukocyte antigens.
Match Strength: 20.344

This is the first study reporting the relationship between the development of bronchiolitis obliterans organizing pneumonia (BOOP) and human leukocyte antigen (HLA) in patients with bone marrow transplantation (BMT).The HLA B35 was significantly higher in patients with BOOP than in patients without BOOP after BMT (P = 0.0069). The HLA B35 is important as a host factor for the generation of BOOP after BMT. OBJECTIVE: To assess the relationship between the development of BOOP after BMT and HLA. METHODS: We retrospectively reviewed clinical features and chest computed tomographic scans in 64 ... Read More »
» Published in J Comput Assist Tomogr. 2007 January/February;31(1):132-137.

31. Idiopathic Bronchiolitis Obliterans Organizing Pneumonia. Definition of Characteristic Clinical Profiles in a Series of 16 Patients
Match Strength: 20.164

Bronchiolitis obliterans organizing pneumonia (BOOP) is a pathologic finding common to various injuries to the lung of either definite or idiopathic etiology. Since the presentation of patients with idiopathic BOOP varies, we studied 16 patients with BOOP on pulmonary histology to define more distinct and homogeneous clinical and imaging profiles of idiopathic BOOP. We distinguished three groups of patients: group 1 (n = 4), with multiple patchy migratory pulmonary involvement of the pneumonia type. Their clinical course was subacute, with cough, fever, weight loss, mild dyspnea, and increased ... Read More »
» Published in Chest. 1989 Nov;96(5):999-1004.

32. Bronchiolitis obliterans organizing pneumonia after bone marrow transplantation: high-resolution computed tomography findings in 4 patients.
Match Strength: 19.881

OBJECTIVE: To assess the high-resolution computed tomography (HRCT) appearances of bronchiolitis obliterans organizing pneumonia (BOOP) after bone marrow transplantation (BMT). METHODS: The HRCT scans obtained in 4 patients (2 men and 2 women, age range: 20-50 years, mean age = 36 years) with biopsy-proven BOOP after BMT were reviewed retrospectively by 2 observers for the presence, extent, and distribution of parenchymal abnormalities. RESULTS: All patients demonstrated consolidation and ground-glass opacity. The consolidation was bilateral, patchy, and asymmetric in all patients and was ... Read More »
» Published in J Comput Assist Tomogr. 2005 Jul-Aug;29(4):540-3.

33. Respiratory reovirus 1/L induction of intraluminal fibrosis, a model of bronchiolitis obliterans organizing pneumonia, is dependent on T lymphocytes
Match Strength: 19.787

Bronchiolitis obliterans organizing pneumonia (BOOP) is a clinical syndrome characterized by perivascular/peribronchiolar leukocyte infiltration leading to the development of intraalveolar fibrosis. We have developed an animal model of BOOP where CBA/J mice infected with 1 x 10(6) plaque-forming units (PFU) reovirus 1/L develop follicular bronchiolitis and intraalveolar fibrosis similar to human BOOP. In this report, we demonstrate a role for T cells in the development of intraluminal fibrosis associated with BOOP. Corticosteroid treatment of reovirus 1/L-infected mice both inhibited the ... Read More »
» Published in Am J Pathol. 2003 Oct;163(4):1467-79.

34. Pulmonary disease due to aspiration of food and other particulate matter: a clinicopathologic study of 59 cases diagnosed on biopsy or resection specimens.
Match Strength: 19.558

Aspiration of particulate matter is a well-recognized complication in debilitated patients at autopsy but is not widely recognized in surgical pathology material. We have encountered a surprising number of cases on biopsy or resection specimens, and most were unsuspected clinically and pathologically. This study was undertaken to clarify clinical and pathologic features that facilitate the diagnosis of food/particulate matter aspiration pneumonia. Fifty-nine patients were identified with an average age of 57 (range 26 to 85), and a male/female ratio of 2:1. Common presenting symptoms ... Read More »
» Published in Am J Surg Pathol. 2007 May;31(5):752-9.

35. Cryptogenic organizing pneumonia.
Match Strength: 19.267

The terms cryptogenic organizing pneumonia (COP) and idiopathic bronchiolitis obliterans with organizing pneumonia (BOOP) are synonymous. Typical COP should be viewed as a clinicopathological syndrome, consisting of respiratory and systemic symptoms (usually low-grade), patchy consolidation on chest radiography and computed tomography, a restrictive defect on pulmonary function testing, and the presence of buds of granulation tissue within the distal airways and alveolar spaces. In the correct clinical context, the diagnosis can be secured by transbronchial biopsy, with typical bronchoalveolar ... Read More »
» Published in Semin Respir Crit Care Med. 2001 Aug;22(4):449-60.

36. Bronchiolitis obliterans organizing pneumonia: clinicopathologic review of a series of 45 Korean patients including rapidly progressive form
Match Strength: 19.003

Bronchiolitis obliterans organizing pneumonia (BOOP) is a clinicopathological syndrome associated with a variety of disease entities. The aim of this study was to review cases with initial diagnosis of BOOP applying uniform histopathologic criteria, and analyze the clinical characteristics of proven cases of BOOP including rapidly progressive form. A total of 81 cases, initially diagnosed as BOOP and with available tissue sections, was collected. Thirty six cases (44.4%) were excluded from the study, more than two thirds of which were given a revised diagnosis of interstitial pneumonitis ... Read More »
» Published in J Korean Med Sci. 2002 Apr;17(2):179-86.

37. Rapidly progressive bronchiolitis obliterans with organizing pneumonia.
Match Strength: 18.819

Bronchiolitis obliterans with organizing pneumonia (BOOP) is a distinct clinical pathologic syndrome. Most patients experience a good response to therapy, and death from progressive BOOP is uncommon. This report describes the clinical features, etiologic factors, pathologic findings, and outcome of 10 patients with rapidly progressive BOOP that was characterized by severe respiratory failure. The major clinical manifestations were dyspnea, cough, fever, crackles on chest examination, and hypoxemia at rest. Underlying conditions or exposures included connective-tissue disease, exposure to birds ... Read More »
» Published in Am J Respir Crit Care Med. 1994 Jun;149(6):1670-5.

38. Pulmonary complications in adult blood and marrow transplant recipients: autopsy findings.
Match Strength: 18.728

STUDY OBJECTIVE: To describe the pulmonary findings at autopsy of blood and bone marrow transplant (BMT) recipients. DESIGN: Retrospective. SETTING: An academic medical center. PATIENTS: Seventy-one deceased adult BMT recipients. INTERVENTIONS: None. MEASUREMENTS: Antemortem and postmortem pulmonary findings. RESULTS: The transplants were allogeneic in 39 patients (55%), with a peripheral stem cell source in 43 patients (61%). Death occurred at a median of 1.30 months after transplant. Ninety-six pulmonary complications were noted in 63 patients (89%): 27 infectious (bacterial bronchopneumonia ... Read More »
» Published in Chest. 2005 Sep;128(3):1385-92. Comment in: Chest. 2006 Feb;129(2):498; author reply 498.

39. ARDS and diffuse alveolar damage: a pathologist's perspective.
Match Strength: 18.433

Diffuse alveolar damage (DAD) is the histologic correlate of most patients with adult respiratory distress syndrome (ARDS). It is a relatively straight forward diagnosis and the main differential diagnosis clinically is acute pneumonia and histologically is bronchiolitis obliterans and organizing pneumonia (BOOP). The histologic progression of DAD includes 3 phases (exudative, proliferative, and fibrotic) that correlate with the time rather than its specific cause. The factors that govern which patients will do well and which will develop a fulminant course is not known. Publication Types: ... Read More »
» Published in Semin Thorac Cardiovasc Surg. 2006 Spring;18(1):13-9.

40. Bronchiolitis obliterans-organizing pneumonia (BOOP)-like variant of Wegener's granulomatosis. A clinicopathologic study of 16 cases.
Match Strength: 18.416

The classic histologic features of Wegener's granulomatosis (WG) in lung include necrotizing granulomatous inflammation and necrotizing vasculitis. Recently, several histologic variants have been recognized, including cases characterized by bronchocentric inflammation, a marked eosinophil infiltrate, alveolar hemorrhage, and capillaritis or interstitial fibrosis. We report 16 cases of another variant in which bronchiolitis obliterans-organizing pneumonia (BOOP)-like fibrosis represents the main histologic finding. The extensive geographic necrosis characteristic of Wegener's granulomatosis was ... Read More »
» Published in Am J Surg Pathol. 1996 Jul;20(7):794-801.

41. Bronchiolar complications of connective tissue diseases.
Match Strength: 18.231

Inflammatory and fibrotic processes can involve the small airways (i.e., respiratory and terminal bronchioles) in several connective tissue disorders (CTDs). Obliterative (constrictive) bronchiolitis (OB) as well cryptogenic organizing pneumonia (COP), previously termed bronchiolitis obliterans with organizing pneumonia (BOOP), are well-recognized, albeit rare, complications of rheumatoid arthritis and other CTDs. Bronchiectasis has also been described in patients with CTDs. Among the various pathologic conditions, clinical, radiographic, and histologic features and prognosis differ markedly. ... Read More »
» Published in Semin Respir Crit Care Med. 2003 Oct;24(5):543-66.

42. Brief communication: sirolimus-associated pneumonitis: 24 cases in renal transplant recipients.
Match Strength: 18.042

BACKGROUND: Interstitial pneumonitis is an ill-defined side effect of sirolimus, a new immunosuppressant drug recently introduced for patients having organ transplantation. OBJECTIVE: To evaluate clinical and laboratory features of sirolimus-associated pneumonitis. DESIGN: Case series. SETTING: 1 transplantation center in Paris, France. PATIENTS: 24 patients who had renal transplantation and developed sirolimus-associated pneumonitis, including 8 patients previously reported. MEASUREMENTS: Symptoms; laboratory tests, including bronchoalveolar fluid analysis; and computed tomography (CT) of the ... Read More »
» Published in Ann Intern Med. 2006 Apr 4;144(7):505-9. Summary for patients in: Ann Intern Med. 2006 Apr 4;144(7):I45.

43. Drug-induced lung disease: a pragmatic classification incorporating HRCT appearances.
Match Strength: 17.813

Drug-induced lung disease frequently poses a diagnostic challenge. Knowledge of common radiological patterns of lung involvement and corresponding histopathologic diagnoses can facilitate management of individual patients. We outline a framework for understanding radiological and histologic patterns of drug-induced lung disease. Diffuse forms of drug-induced lung disease include processes that mimic acute respiratory distress syndrome (ARDS) and diffuse alveolar hemorrhage. These patterns of drug-induced lung disease are especially common in patients receiving cytotoxic chemotherapeutic agents ... Read More »
» Published in Semin Respir Crit Care Med. 2003 Aug;24(4):445-54.

44. Pulmonary complications after T-cell-depleted allogeneic stem cell transplantation: low incidence and strong association with acute graft-versus-host disease.
Match Strength: 17.320

Lung injury limits the success of allogeneic stem cell transplantation (SCT). The overall incidence varies from 30 to 50% and non-infectious causes occur in one-third to one-half of these. We reviewed pulmonary complications in 369 consecutive patients who received a partially T-cell-depleted myeloablative allogeneic hematopoietic SCT at our institution between 1993 and 2003. All patients were treated uniformly with cyclophosphamide followed by total body irradiation. Control subjects were matched on sex, underlying diagnosis, age, type of transplantation and cytomegalovirus (CMV)-serostatus. ... Read More »
» Published in Bone Marrow Transplant. 2006 Oct;38(8):561-6. Epub 2006 Sep 4.

45. Case report of a kidney transplant recipient converted to everolimus due to malignancy: resolution of bronchiolitis obliterans organizing pneumonia without everolimus discontinuation.
Match Strength: 17.290

The use of proliferative signal inhibitors (PSIs) in immunosuppression-related malignancies opens new roads for increasing the survival and quality of life in patients with solid organ transplantation. A 56-year-old female recipient of a living donor renal allograft (1990), who was immunosuppressed with cyclosporine (CsA; Neoral), azathioprine, and steroids, did initially well with acceptable renal function. During the last 5 years she required local therapy due to posterior vaginal lip human papillomavirus (HPV) lesions. In 2000, she discontinued azathioprine and the CsA doses were reduced to ... Read More »
» Published in Transplant Proc. 2007 Apr;39(3):594-5.

46. Nodular pulmonary lesions in children after autologous stem cell transplantation: a source of misinterpretation.
Match Strength: 17.222

In children with malignant disorders, autologous haematopoietic stem cell transplantation (HSCT) represents a therapeutic option, but several possible complications, such as life-threatening pulmonary disease, make appropriate diagnostic procedures essential. We describe two cases with bronchiolitis obliterans with organizing pneumonia after HSCT, with a brief review of important differential diagnoses ... Read More »
» Published in Br J Haematol. 2008 Feb;140(4):429-32. Epub 2007 Dec 19.

47. A case of non-specific interstitial pneumonia effectively treated with a combination of prednisolone and colchicine, in which granulation tissue was extensive.
Match Strength: 16.805

A 56-year-old woman was admitted for interstitial pneumonia, and subsequently diagnosed with idiopathic non-specific interstitial pneumonia with a bronchiolitis obliterans organizing pneumonia pattern, on the basis of clinical and surgical lung biopsy findings. Histological findings revealed diffuse thickness of alveolar walls accompanied by lymphocyte infiltration and fibrosis in the lobules. In addition to those findings, granulation tissue was extensive. Although initial symptom and CT improvement occurred following high-dose prednisolone therapy, the CT did not show further improvement and ... Read More »
» Published in Respirology. 2005 Sep;10(4):541-4.

48. Polymyositis-dermatomyositis-associated interstitial lung disease.
Match Strength: 16.363

We report findings in 70 patients with both diffuse interstitial lung disease and either polymyositis (PM) or dermatomyositis (DM). Initial presentations were most commonly either musculoskeletal (arthralgias, myalgias, and weakness) or pulmonary (cough, dyspnea, and fever) symptoms alone; in only 15 patients (21.4%) did both occur simultaneously. Pulmonary disease usually took the form of acute to subacute antibiotic-resistant community-acquired pneumonia. Chest radiographs and computed tomography most commonly demonstrated bilateral irregular linear opacities involving the lung bases; ... Read More »
» Published in Am J Respir Crit Care Med. 2001 Oct 1;164(7):1182-5.

49. Anti-inflammatory treatment of acute and chronic pneumonia
Match Strength: 16.217

The inflammatory response to infection is necessary for host defense but can contribute to the systemic toxicity and lung injury that may result from pneumonia. In some settings, adjunctive treatment of lower respiratory infections with anti-inflammatory agents can reduce morbidity. Corticosteroids have a well-documented role in the management of Pneumocystis carinii pneumonia complicating human immunodeficiency virus (HIV) infection. Corticosteroids also were found to reduce systemic symptoms of tuberculosis in a number of older studies, but their role as adjuncts to contemporary ... Read More »
» Published in Semin Respir Infect. 2001 Mar;16(1):76-84.

50. Interstitial pneumonitis associated with sirolimus in liver transplantation: a case report.
Match Strength: 15.969

Sirolimus is a powerful immunosuppressive drug initially used in kidney transplant patients but now increasingly employed in recipients of other types of solid organ transplants, such as liver, heart, lung, or pancreas. Sirolimus is indicated for rescue therapy and to reduce the toxic side effects of calcineurin inhibitors. However, its use has been associated with an uncommon but important pulmonary toxicity. Reports have described interstitial pneumonitis, bronchiolitis obliterans, organizing pneumonia, and alveolar proteinosis. We present the case of a liver transplant patient with ... Read More »
» Published in Transplant Proc. 2007 Dec;39(10):3498-9.

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