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Brain Pathology
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1. Pathogenesis of prion diseases: current status and future outlook.
Match Strength: 5.216

The prion, a conformational variant of a host protein, is the infectious particle responsible for transmissible spongiform encephalopathy (TSE), a fatal neurodegenerative disease of humans and animals. The principal target of prion pathology is the brain, yet most TSEs also display prion replication at extra-cerebral locations, including secondary lymphoid organs and sites of chronic inflammation. Despite significant progress in our understanding of this infectious agent, many fundamental questions relating to the nature of the prion, including the mechanism of replication and the molecular ... Read More »
» Published in Nat Rev Microbiol. 2006 Oct;4(10):765-75.

2. Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.
Match Strength: 4.718

Protein aggregation is an established pathogenic mechanism in Alzheimer's disease, but little is known about the initiation of this process in vivo. Intracerebral injection of dilute, amyloid-beta (Abeta)-containing brain extracts from humans with Alzheimer's disease or beta-amyloid precursor protein (APP) transgenic mice induced cerebral beta-amyloidosis and associated pathology in APP transgenic mice in a time- and concentration-dependent manner. The seeding activity of brain extracts was reduced or abolished by Abeta immunodepletion, protein denaturation, or by Abeta immunization of the ... Read More »
» Published in Science. 2006 Sep 22;313(5794):1781-4.

3. Cathepsin D-mediated proteolysis of apolipoprotein E: possible role in Alzheimer's disease.
Match Strength: 4.297

Proteolysis of apolipoprotein E (apoE) may be involved in the pathogenesis of Alzheimer's disease (AD). We previously identified aspartic protease(s) as possibly contributing to the proteolysis of apoE in human brain homogenates. The current study used biochemical and immunohistochemical methods to examine whether cathepsin D (catD) and cathepsin E (catE), candidate aspartic proteases, may be involved in apoE proteolysis. CatD was found to proteolyze both lipid-free recombinant full-length human apoE and lipidated human plasma full-length apoE (apoE4/dipalmitoylphosphatidylcholine ... Read More »
» Published in Neuroscience. 2006 Dec;143(3):689-701. Epub 2006 Sep 25.

4. Biphasic cytoarchitecture and functional changes in the BBB induced by chronic inflammatory pain.
Match Strength: 4.265

The blood-brain barrier (BBB) is a dynamic system which maintains brain homeostasis and limits CNS penetration via interactions of transmembrane and intracellular proteins. Inflammatory pain (IP) is a condition underlying several diseases with known BBB perturbations, including stroke, Parkinson's, multiple sclerosis and Alzheimer's. Exploring the underlying pathology of chronic IP, we demonstrated alterations in BBB paracellular permeability with correlating changes in tight junction (TJ) proteins: occludin and claudin-5. The present study examines the IP-induced molecular changes leading to ... Read More »
» Published in Brain Res. 2006 Nov 20;1120(1):172-82. Epub 2006 Sep 27.

5. Multiple sclerosis: an infectious syndrome involving Chlamydophila pneumoniae.
Match Strength: 4.178

The concept of autoimmune myelinopathy as the primary pathology in multiple sclerosis (MS) is problematic. Vasculitis is seen in the MS brain, both within lesions and in adjacent normal-appearing white matter. The first observation in acute relapse is the sudden, orderly death of oligodendrocytes; inflammatory removal of unsupported myelin seems to be a secondary process. An alternative explanation for these findings is that oligodendrocyte infection might trigger an inflammatory response. Many pathogens, including Chlamydophila (Chlamydia) pneumoniae, have been associated with MS. MS might be ... Read More »
» Published in Trends Microbiol. 2006 Nov;14(11):474-9. Epub 2006 Sep 25.

6. The full bibliography of Ernst Ludwig Wynder.
Match Strength: 3.614

The chronology of lifetime publications authored and/or co-authored by Dr. Ernst L. Wynder spans a rich assortment of topics relating to the etiology and prevention of chronic diseases. Dr. Wynder's interdisciplinary approach to research in cancer and heart disease embraces the disciplines of epidemiology, biology, pathology, chemistry, biochemistry, tobacco sciences, and nutrition as well as health behavior, and health education. His works reflect his attention to diverse subjects from methodology in scientific endeavors, to mechanisms in carcinogenesis, brain development, alternative ... Read More »
» Published in Prev Med. 2006 Oct;43(4):274-90. Epub 2006 Sep 27.

7. A spectroscopic study of some of the peptidyl radicals formed following hydroxyl radical attack on beta-amyloid and alpha-synuclein.
Match Strength: 3.201

There is clear evidence implicating oxidative stress in the pathology of many neurodegenerative diseases. Reactive oxygen species (ROS) are the primary mediators of oxidative stress, and hydrogen peroxide, a key ROS, is generated during aggregation of the amyloid proteins associated with some of these diseases. Hydrogen peroxide is catalytically converted to the aggressive hydroxyl radical in the presence of Fe(II) and Cu(I), which renders amyloidogenic proteins such as beta-amyloid and alpha-synuclein (implicated in Alzheimer's disease (AD) and Parkinson's disease (PD), respectively) ... Read More »
» Published in Free Radic Res. 2006 Jul;40(7):731-9.

8. Radiation dose and long term risk of cardiac pathology following radiotherapy and anthracyclin for a childhood cancer.
Match Strength: 3.131

PURPOSE: To determine the cardiac status in children 15 years (yrs) or more after a solid tumour treatment. PATIENTS AND METHODS: Of the 447 patients, 229 were fully studied and 218 were not. The following cardiac evaluation was proposed to all the 447 consecutive patients: (1) cardiac Doppler US by one of two expert cardiologists; (2) cardiac rhythm and conduction abnormalities including 24-h holter ECG; (3) (131)I-mIBG myocardial scintigraphy; (4) serum brain natriuretic peptide levels at rest; (5) an exercise test with VO(2)max measurement. The radiation dose delivered to 7 points in the ... Read More »
» Published in Radiother Oncol. 2006 Oct;81(1):47-56. Epub 2006 Sep 20.

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