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Peer Reviewed Scientific Research Reports.
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1. Cardiac arrest due to a vagal reflex potentiated by thoracic epidural analgesia.
Match Strength: 6.591
Reflex bradycardia and cardiac arrest may be the result of a vagal reflex, which can occur during a variety of surgical procedures. We report a patient who developed cardiac arrest as a result of a vagal reflex that was potentiated by thoracic epidural analgesia during general anaesthesia. A 53-year-old man was scheduled for subtotal gastrectomy because of an early gastric adenocarcinoma. After an epidural catheter had been inserted, general anaesthesia was induced. During surgery, an abdominal self-retaining retractor was set up but bradycardia and cardiac arrest developed. The patient ... Read More »
» Published in J Int Med Res. 2006 Jul-Aug;34(4):433-6.
2. Treatment of poisoning caused by beta-adrenergic and calcium-channel blockers.
Match Strength: 5.961
PURPOSE: The toxic effects and treatment of beta-adrenergic blocker and calcium-channel blocker (CCB) overdose are reviewed. SUMMARY: Overdoses with cardiovascular drugs are associated with significant morbidity and mortality. Beta-blockers and CCBs represent the most important classes of cardiovascular drugs. In overdose, beta-blockers and CCBs have similar presentation and treatment overlaps and are often refractory to standard resuscitation measures. The common feature of beta-blocker toxicity is excessive blockade of the beta-receptors resulting in bradycardia and hypotension. Poisoning by ... Read More »
» Published in Am J Health Syst Pharm. 2006 Oct 1;63(19):1828-35.
3. Ablation of NK1 receptor bearing neurons in the nucleus of the solitary tract blunts cardiovascular reflexes in awake rats.
Match Strength: 5.282
The nucleus of the solitary tract (NTS) receives primary afferents involved in cardiovascular regulation. We investigated the role of NK(1)-receptor bearing neurons in the NTS on cardiovascular reflexes in awake rats fitted with chronic venous and arterial cannulae. These neurons were lesioned selectively with saporin conjugated with substance P (SP-SAP, 2 microM, bilateral injections of 20 nL in the subpostremal NTS, or 200 nL in both the subpostremal and the commissural NTS). Before, and 7 and 14 days after injection of SP-SAP, we measured changes in blood pressure and heart rate induced by ... Read More »
» Published in Brain Res. 2006 Nov 13;1119(1):165-73. Epub 2006 Sep 18.
4. Incidence of and factors associated with meconium staining of the amniotic fluid in a Nigerian University Teaching Hospital.
Match Strength: 3.285
This study was conducted to determine the incidence of meconium staining of the amniotic fluid (MSAF) and its associated factors in a Nigerian teaching hospital. Perinatal data on 80 consecutive live, singleton infants of booked mothers born through meconium-stained liquor from March - June 2003 were analysed and compared with babies born through clear liquor. The incidence of MSAF was 20.4% for 393 deliveries. The rate increased with gestational age: no case was found below 37 weeks (p = 0.001). Primiparity, prolonged rupture of fetal membranes and obstructed labour were more often associated ... Read More »
» Published in J Obstet Gynaecol. 2006 Aug;26(6):518-20.
5. Parametric evaluation of methotrimeprazine-midazolam-ketamine and methotrimeprazine-midazolam-ketamine-xylazine combination in dogs.
Match Strength: 2.937
PURPOSE: To evaluate the parameters of dogs anesthetized by different dissociative drugs protocols through continuous intravenous infusion. METHODS: Thirty healthy dogs of both sexes were assigned randomly to three groups (G1, G2, and G3). G1 was administered with methotrimeprazine as a pre-anesthetic medication, intravenously midazolam-ketamine as bolus for induction and midazolam-ketamine by continuous intravenous infusion for a 60 minute-period of maintenance. G2: the same as for G1. plus an increase in the midazolam dose during maintenance. G3: the same treatment as for G2, plus the ... Read More »
» Published in Acta Cir Bras. 2006 Sep-Oct;21(5):304-9.
6. Human Environmental/Exercise: The effects of face cooling during hyperthermic exercise in man: evidence for an integrated thermal, neuroendocrine and behavioural response.
Match Strength: 2.665
The present study investigated whether face cooling reduced both the perceived exertion (RPE) and prolactin (PRL) release during hyperthermic exercise. Ten, non-heat-acclimated males (23 +/- 2 years; maximal oxygen consumption, 56 +/- 7 ml kg(-1) min(-1) [mean +/- s.d.]) exercised for 40 min on a cycle ergometer at 65% of their peak aerobic power, at an ambient temperature of 33 degrees C (27% relative humidity) with (FC) and without face cooling as a control (CON). With FC, forehead temperature was maintained approximately 6 degrees C lower than CON, while other skin sites were similar or ... Read More »
» Published in Exp Physiol. 2007 Jan;92(1):187-95. Epub 2006 Sep 14.
7. In silico assessment of Y1795C and Y1795H SCN5A mutations: implication for inherited arrhythmogenic syndromes.
Match Strength: 2.562
The effects of two SCN5A mutations (Y1795C, Y1795H), previously identified in one Long QT syndrome type 3 (LQT3) and one Brugada syndrome (BrS) families, were investigated by means of numerical modeling of ventricular action potential (AP). A Markov model capable of reproducing a wild-type as well as a mutant sodium current (I(Na)) was identified and was included into the Luo-Rudy ventricular cell model for action potential (AP) simulation. The characteristics of endocardial, midmyocardial, and epicardial cells were reproduced by differentiating the transient outward current (I(TO)) and the ... Read More »
» Published in Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H56-65. Epub 2006 Sep 15.
8. Cardiovascular actions of adrenocorticotropin microinjections into the nucleus tractus solitarius of the rat.
Match Strength: 2.499
The presence of adrenocorticotropin (ACTH) containing cells and melanocortin (MC) receptors has been reported in the nucleus tractus solitarius (NTS) of the rat. The importance of the NTS in the regulation of cardiovascular function is also well established. Based on these reports, it was hypothesized that ACTH acting within the NTS may modulate the central regulation of cardiovascular function. To test this hypothesis, cardiovascular effects of ACTH in the NTS were investigated in intact urethane-anesthetized and unanesthetized decerebrate, artificially ventilated, adult male Wistar rats. ... Read More »
» Published in Neuroscience. 2006 Dec;143(3):863-74. Epub 2006 Sep 25.
9. The A2a/A2b receptor antagonist ZM-241385 blocks the cardioprotective effect of adenosine agonist pretreatment in in vivo rat myocardium.
Match Strength: 2.442
There is increasing evidence for interactions among adenosine receptor subtypes in the brain and heart. The purpose of this study was to determine whether the adenosine A(2a) receptor modulates the infarct size-reducing effect of preischemic administration of adenosine receptor agonists in intact rat myocardium. Adult male rats were submitted to in vivo regional myocardial ischemia (25 min) and 2 h reperfusion. Vehicle-treated rats were compared with rats pretreated with the A(1) agonist 2-chloro-N(6)-cyclopentyladenosine (CCPA, 10 mug/kg), the nonselective agonist 5'-N ... Read More »
» Published in Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H426-31. Epub 2006 Sep 15.
10. The impact of hypoxia on in vivo glucose uptake in a hypoglycemic fish, Myoxocephalus scorpius.
Match Strength: 2.436
The mechanisms controlling carbohydrate utilization in teleost fish are poorly understood, particularly in the heart. Tissue glucose uptake and cardiovascular characteristics were measured in the short-horned sculpin, Myoxocephalus scorpius, a species exhibiting low blood glucose levels, during normoxia and hypoxia to assess the role of adenosine receptors in the control of glucose uptake and anaerobic metabolism. As expected, hypoxia exposure (300 min at 2 mg/l dissolved oxygen) resulted in a bradycardia and plasma lactate accumulation, but glucose uptake rates did not change in heart, brain, ... Read More »
» Published in Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R1033-42. Epub 2006 Sep 28.
11. Feeding and digestion in low salinity in an osmoconforming crab, Cancer gracilis. I. Cardiovascular and respiratory responses.
Match Strength: 2.128
The osmoregulatory physiology of decapod crustaceans has received extensive attention. Within this field there is a growing body of literature on cardiovascular and respiratory responses to low salinity. Most species exhibit a tachycardia coupled with an increase in ventilation rate and oxygen uptake. However, these previous experiments were conducted on animals that were starved prior to experimentation in order to avoid increases in metabolism associated with digestive processes. Because organisms are not necessarily starved prior to experiencing environmental perturbations, results from ... Read More »
» Published in J Exp Biol. 2006 Oct;209(Pt 19):3766-76.
12. Some in vitro and in vivo cardiovascular effects of Hypoxis hemerocallidea Fisch & CA Mey (Hypoxidaceae) corm (African potato) aqueous extract in experimental animal models.
Match Strength: 2.031
This study was undertaken to investigate some cardiovascular effects of Hypoxis hemerocallidea Fisch & CA Mey (Hypoxidaceae) corm (African potato) aqueous extract in experimental animal paradigms. The effect of the corm aqueous extract (APE) on myocardial contractile performance was evaluated on guinea-pig isolated atrial muscle strips in vitro; whereas the antihypertensive (hypotensive) effect of the plant extract was examined in hypertensive Dahl salt-sensitive rats in vivo. APE (25-400 mg/ml) produced concentration-dependent, significant (p < 0.05-0.001) negative inotropic and negative ... Read More »
» Published in Cardiovasc J S Afr. 2006 Jul-Aug;17(4):166-71.
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