Bone Loss Age-Related
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Peer Reviewed Scientific Research Reports.
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1. Distraction osteogenesis.
Match Strength: 8.264
The treatment of bone loss resulting from acute trauma has traditionally been a complex surgical problem. Numerous procedures have been devised to reconstitute bone stock, obtain fracture union, and provide a stable functional limb. Traditional internal bone transport has been used successfully for bony reconstruction for both acute and reconstructive bone loss. Potential complications are primarily related to the complexity of the external device, prolonged time in the frame, and nonunion of the docking and regenerate segments. Recent advances in fixator and pin design have reduced the ... Read More »
» Published in J Am Acad Orthop Surg. 2006 Oct;14(10 Suppl):S168-74.
2. Simulation of impact test for determining "health" of percutaneous bone anchored implants.
Match Strength: 7.661
There is an ongoing requirement for a clinically relevant, noninvasive technique to monitor the integrity of percutaneous implants used for dental restorations, bone-anchored hearing aids, and to retain extra-oral prostheses (ear, eye, nose, etc). Because of the limitations of conventional diagnostic techniques (CT, MRI), mechanical techniques that measure the dynamic response of the implant-abutment system are being developed. This paper documents a finite element analysis that simulates a transient response to mechanical impact testing using contact elements. The detailed model allows for a ... Read More »
» Published in J Biomech Eng. 2006 Oct;128(5):647-53.
3. Bone fragility: failure of periosteal apposition to compensate for increased endocortical resorption in postmenopausal women.
Match Strength: 7.446
The increase in bone fragility after menopause results from reduced periosteal bone formation and increased endocortical resorption. Women with highest remodeling had greatest loss of bone mass and estimated bone strength, whereas those with low remodeling lost less bone and maintained estimated bone strength. INTRODUCTION: Bone loss from the inner (endocortical) surface contributes to bone fragility, whereas deposition of bone on the outer (periosteal) surface is believed to be an adaptive response to maintain resistance to bending. MATERIALS AND METHODS: To test this hypothesis, changes in ... Read More »
» Published in J Bone Miner Res. 2006 Dec;21(12):1856-63.
4. Bone mineral density loss and recovery during 48 months in first-time users of depot medroxyprogesterone acetate.
Match Strength: 7.382
OBJECTIVE: To compare changes in bone mineral density (BMD) during 48 months between first-time depot medroxyprogesterone acetate (MPA) users, during use and after discontinuation, to controls. DESIGN: Longitudinal study. SETTING: Academic community. PATIENT(S): Women 18-35 years, newly initiating depot MPA (n = 178) and controls (n = 145) not using hormonal contraception. MAIN OUTCOME MEASURE(S): The BMD of the hip and spine, measured at 3-month intervals, by dual energy roentgen absorptiometry. RESULTS: Hip and spine BMD declined during 48 months of depot MPA use by 7.7% +/- 0.11% (mean +/- ... Read More »
» Published in Fertil Steril. 2006 Nov;86(5):1466-74. Epub 2006 Sep 25.
5. Conjugated linoleic acid protects against age-associated bone loss in C57BL/6 female mice.
Match Strength: 7.321
Osteoporosis is one of the major causes of morbidity in the elderly. Inflammation exerts a significant influence on bone turnover, inducing the chronic form of osteoporosis. Dietary nutrition has the capacity to modulate inflammatory response. Therefore, nutritional strategies and lifestyle changes may prevent age-related osteoporosis, thereby improving the quality of life of the elderly population. Conjugated linoleic acid (CLA) has been shown to positively influence calcium and bone metabolism. Hence, this study was undertaken to examine the effect of CLA on bone mineral density (BMD) in ... Read More »
» Published in J Nutr Biochem. 2006 Sep 21;
6. Bone mineral density in long-term Chinese heart transplant recipients: a cross-sectional study.
Match Strength: 7.098
Osteoporosis, which usually peaks during 6 to 12 months after transplantation, remains an important concern after heart transplantation. Immunosuppressants contribute to this phenomenon. Glucocorticoids are well documented to cause bone loss, but the role of cyclosporine (CsA) remains controversial, especially among long-term recipients on low doses of steroid. We herein report a cross-sectional study of bone mineral density (BMD) among long-term Chinese heart transplant recipients. We enrolled 41 patients of mean age 50.15 +/- 13.58 years with a mean follow-up of 57.02 months. Lumbar spine ... Read More »
» Published in Transplant Proc. 2006 Sep;38(7):2141-4.
7. Aromatase inhibitors and bone loss.
Match Strength: 7.088
The aromatase inhibitors (AIs) anastrozole (Arimidex), letrozole (Femara), and exemestane (Aromasin) are significantly more effective than the selective estrogen-receptor modulator (SERM) tamoxifen in preventing recurrence in estrogen receptor-positive early breast cancer. Aromatase inhibitors are likely to replace SERMs as first-line adjuvant therapy for many patients. However, AIs are associated with significantly more osteoporotic fractures and greater bone mineral loss. As antiresorptive agents, oral and intravenous bisphosphonates such as alendronate (Fosamax), risedronate (Actonel), ... Read More »
» Published in Oncology (Williston Park). 2006 Aug;20(9):1029-39; discussion 1039-40, 1042, 1048.
8. Tissue engineering solutions for traumatic bone loss.
Match Strength: 6.285
Tissue engineering strategies for the repair, replacement, or augmentation of bone defects involves the use of cells, matrices, and bioregulatory factors. The source (endogenous, exogenous) and character of these factors, however, may vary greatly among the many approaches taken by current investigators. Although the results of current tissue engineering methods for regenerating bone have shown great promise, the extent of damage to extremities associated with war injuries may require the development of techniques that differ substantially from current practice ... Read More »
» Published in J Am Acad Orthop Surg. 2006 Oct;14(10 Suppl):S152-6.
9. Accentuated ovariectomy-induced bone loss and altered osteogenesis in heterozygous N-cadherin null mice.
Match Strength: 6.123
Ovariectomy-induced bone loss is accentuated in mice with germline Cdh2 haploinsufficiency, the result of a decreased osteoblastogenesis in the face of normal osteoclast number. Reduced N-cadherin abundance in these mice decreases cell-cell adhesion and alters signaling pathways important for osteoblast commitment and differentiation, thus providing in vivo evidence that N-cadherin-mediated cell-cell interactions are involved in homeostatic responses to increased bone remodeling. INTRODUCTION: We have shown that targeted expression of a dominant negative truncated form of N-cadherin (Cdh2) ... Read More »
» Published in J Bone Miner Res. 2006 Dec;21(12):1897-906.
10. The prevention of periodontal bone loss at the osteotomy site after anterior segmental and dento-osseous osteotomy.
Match Strength: 6.085
PURPOSE: Degeneration of the gingival margin and periodontal bone loss between segments can occur in various segmental osteotomies. However, treatment and management of these problems have not yet been resolved; improvement of the conventional method is necessary. The purpose of this retrospective study is to evaluate the usefulness and advantage of orthodontic devices in osteotomies. PATIENTS AND METHODS: Forty Japanese adults presented with jaw deformities diagnosed as mandibular prognathism with maxillary protrusion, bimaxillary protrusion, and anterior crowding. Of these 40 patients, 20 ... Read More »
» Published in J Oral Maxillofac Surg. 2006 Oct;64(10):1526-31.
11. Bone density changes in women who receive thromboprophylaxis in pregnancy.
Match Strength: 6.076
OBJECTIVE: The purpose of this study was to compare unfractionated heparin therapy to the low molecular weight heparin, enoxaparin sodium, and their effects on bone mineral density over the course of pregnancy. STUDY DESIGN: Pregnant patients whose condition required thromboprophylaxis were recruited in this prospective randomized controlled trial and were assigned to receive either unfractionated heparin therapy or low molecular weight heparin therapy. Bone mineral density was measured by dual energy x-ray absorptiometry at the proximal femur on enrollment and again shortly after delivery. ... Read More »
» Published in Am J Obstet Gynecol. 2006 Oct;195(4):1109-13.
12. Hearing improvement after stapedotomy using teflon loop prosthesis.
Match Strength: 6.007
Objective: To assess hearing improvement after stapedotomy for otosclerosis using teflon loop prosthesis. Design: Quasy experimental study. Place and Duration of Study: January 2001 to May 2003 in the Otorhinolaryngology Department, CMH, Rawalpindi. Patients and Methods: Thirty diagnosed cases of otosclerosis were included in the study. Ear with greater air-bone gap was selected and stapedotomy was done using teflon loop prosthesis (size 4 - 4.5 mm). Mild vertigo occurred during immediate postoperative period, which subsided with Inj. Prochlorperazine. Patients were followed-up postsurgically ... Read More »
» Published in J Coll Physicians Surg Pak. 2006 Oct;16(10):659-61.
13. RANK ligand inhibition with denosumab for the management of osteoporosis.
Match Strength: 5.958
Receptor activator of nuclear factor-kappaB ligand (RANKL) is a cytokine member of the tumour necrosis factor family that is the principal final mediator of osteoclastic bone resorption. It plays a major role in the pathogenesis of postmenopausal osteoporosis, as well bone loss associated with rheumatoid arthritis, metastatic cancer, multiple myeloma, aromatase inhibitor therapy and androgen deprivation therapy. Denosumab (AMG 162) is an investigational fully human monoclonal antibody with a high affinity and specificity for RANKL. By inhibiting the action of RANKL, denosumab reduces the ... Read More »
» Published in Expert Opin Biol Ther. 2006 Oct;6(10):1041-50.
14. Total knee arthroplasty with modular rotating-platform hinge.
Match Strength: 5.474
Third-generation modular rotating hinged knee systems are now widely available. The S-ROM rotating hinge features slotted and splined stems for torsional stability, and metaphyseal filling and loading sleeves for the bony defects encountered in revision total knee arthroplasty (TKA). Primary indications for a hinge include medial or lateral collateral loss, massive bone loss, and metaphysis and cortical shell, which includes collateral origins or insertions, and severe flexion gap imbalance requiring a link system for stability. Indications for a hinge in primary TKA include patients with ... Read More »
» Published in Orthopedics. 2006 Sep;29(9 Suppl):S80-2.
15. Fitting range of the BAHA Cordelle.
Match Strength: 5.307
The performance of the most powerful Bone-Anchored Hearing Aid (BAHA) currently available, the BAHA Cordelle, was evaluated in 25 patients with severe to profound mixed hearing loss. Patients showed bone conduction thresholds at 500, 1000 and 2000 Hz, ranged between 30 and 70 dB HL, and an additional air-bone gap of about at least 30 dB. With the BAHA Cordelle, free-field thresholds improve relative to bone-conduction thresholds with 1.5, 5.0, 17.8, and 4.3 dB at 500, 1000, 2000, and 4000 Hz, respectively, with substantial inter-individual variability. The differences in unaided air conduction ... Read More »
» Published in Int J Audiol. 2006 Aug;45(8):429-37.
16. Auditory function in patients with surgically treated superior semicircular canal dehiscence.
Match Strength: 5.148
OBJECTIVE: To characterize preoperative and postoperative audiologic findings in patients with superior semicircular canal dehiscence syndrome. STUDY DESIGN: Retrospective case review. SETTING: Tertiary referral center. PATIENTS: Patients with documented superior semicircular canal dehiscence syndrome (according to history, vestibular testing, and high-resolution computed tomography imaging) who underwent surgical repair of their dehiscence. INTERVENTION: Middle fossa craniotomy for superior semicircular canal plugging and/or resurfacing. MAIN OUTCOME MEASURES: Audiologic testing both before ... Read More »
» Published in Otol Neurotol. 2006 Oct;27(7):969-80.
17. IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis.
Match Strength: 5.144
OBJECTIVE: The IKK complex regulates NF-kappaB activation, an important pathway implicated in the rheumatoid arthritis (RA) disease process. This study was undertaken to assess the efficacy of N-(6-chloro-7-methoxy-9H-beta-carbolin-8-yl)-2-methylnicotinamide (ML120B), a potent and selective small molecule inhibitor of IKKbeta. METHODS: Polyarthritis was induced in rats by injection of Freund's complete adjuvant into the hind footpad. ML120B was administered orally twice daily, either prophylactically or therapeutically. Paw volumes and body weights were measured every 2-3 days throughout the ... Read More »
» Published in Arthritis Rheum. 2006 Oct;54(10):3163-73.
18. Glenoid bone grafting with a reverse design prosthesis.
Match Strength: 4.887
The purpose of this study was to evaluate the outcome of patients who underwent glenoid bone grafting and implantation of a reverse design prosthesis in 1 or 2 stages for the treatment of glenoid bone loss and rotator cuff insufficiency. Indications for the reverse prosthesis in this series included cuff tear arthropathy and revision arthroplasty. Nine patients were reviewed clinically and radiographically with a minimum 2-year follow-up (range, 24-41 months). Despite a low postoperative functional score (mean Constant score, 53 points [range, 22-79 points]), most patients were satisfied with ... Read More »
» Published in J Shoulder Elbow Surg. 2006 Sep 19;
19. Preliminary study on vestibular-evoked myogenic potential induced by bone-conducted stimuli.
Match Strength: 4.559
OBJECTIVE: To study the relationship between vestibular-evoked myogenic potential evoked by air-conducted stimuli (A-VEMP) and those evoked by bone-conducted stimuli (B-VEMP). STUDY DESIGN: Prospective study. SETTING: University Hospital. PATIENTS: To determine the optimum stimulus conditions for B-VEMP, 40 ears of 20 healthy volunteers were used. To compare results of A-VEMP and B-VEMP, 60 ears of 30 healthy volunteers and 70 ears of 35 patients with unilateral vestibular disorder without conductive hearing loss were used. MAIN OUTCOME MEASURE: A-VEMP and B-VEMP were measured. Both ... Read More »
» Published in Otol Neurotol. 2006 Dec;27(8):1110-4.
20. The shape of the inferior part of the glenoid: a cadaveric study.
Match Strength: 4.365
Previously, the shape of the inferior glenoid has been described as a circle with a bare spot being the center of that circle. This cadaveric study was done to test that statement. Forty cadaveric scapulae were used in this study. Two researchers used a digital image analysis program to assess the shape of the inferior glenoid and measured the distances from the bare spot to the anterior, inferior, and posterior cartilage and the bone rim. In 39 of 40 scapulae, the inferior glenoid had the shape of a true circle. Statistical analysis showed that the center of the bare spot is not the ... Read More »
» Published in J Shoulder Elbow Surg. 2006 Nov-Dec;15(6):759-63. Epub 2006 Sep 20.
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