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Peer Reviewed Scientific Research Reports.
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1. Mechanisms of pathologic new bone formation.
Match Strength: 8.182
Pathologic new bone formation occurs in response to a variety of stimuli. Heterotopic and orthotopic bone formation can interfere with the normal function of the joint and can contribute to disability in inflammatory joint diseases. Syndesmophyte formation and progressive ankylosis are characteristic features of spondyloarthropathies, including psoriatic arthritis and ankylosing spondylitis, and they can be regarded as abnormal bone remodeling. Successful blocking of inflammation in patients with spondyloarthropathy apparently fails to halt progression of ankylosis in cohort studies. This ... Read More »
» Published in Curr Rheumatol Rep. 2006 Oct;8(5):332-7.
2. Genetic regulation of bone mass and susceptibility to osteoporosis.
Match Strength: 6.598
Osteoporosis is a common disease with a strong genetic component characterized by reduced bone mass and increased risk of fragility fractures. Twin and family studies have shown that the heritability of bone mineral density (BMD) and other determinants of fracture risk-such as ultrasound properties of bone, skeletal geometry, and bone turnover-is high, although heritability of fracture is modest. Many different genetic variants of modest effect size are likely to contribute to the regulation of these phenotypes by interacting with environmental factors such as diet and exercise. Linkage ... Read More »
» Published in Genes Dev. 2006 Sep 15;20(18):2492-506.
3. In vitro analysis of multipotent mesenchymal stromal cells as potential cellular therapeutics in neurometabolic diseases in pediatric patients.
Match Strength: 5.569
Multipotent mesenchymal stromal cells (MSCs) play an important role in stromal support for hematopoietic stem cells, immune modulation, and tissue regeneration. We investigated their potential as cellular therapeutic tools in neurometabolic diseases as a growing number of affected children undergo to bone marrow transplantation. MSCs were isolated from bone marrow aspirates and expanded ex vivo under various culture conditions. MSCs under optimal good medical practice (GMP)-conform culture conditions showed the typical morphology, immunophenotype, and plasticity. Biochemically, the activities ... Read More »
» Published in Exp Hematol. 2006 Oct;34(10):1413-9.
4. Pulsed electromagnetic fields accelerate apoptotic rate in osteoclasts.
Match Strength: 4.501
Selective control of cell function by applying specifically configured, low-energy, time-varying electromagnetic fields (EMF) has added a new, exciting dimension to biology and medicine. However, the mechanism involved is less clear. In our study, we investigated the effect of pulsed electromagnetic fields (PEMF) on induction of osteoclasts apoptosis. A statistically significant increase of apoptotic rate in osteoclasts (48 hr after isolation) was found when exposed to 7.5 Hz PEMF with induced electric fields intensity of 3.0 muv/cm for 8 (105%, p < 0.001) and 16 hr (30%, p < 0.05). ... Read More »
» Published in Connect Tissue Res. 2006;47(4):222-8.
5. Alemtuzumab in T-cell lymphoproliferative disorders.
Match Strength: 3.438
The humanized monoclonal antibody alemtuzumab binds to the CD52 antigen, a glycoprotein which is widely expressed on normal and malignant B and T lymphocytes. Recently it has been demonstrated in a number of clinical trials that alemtuzumab has clinical activity in mature T-cell diseases such as T-prolymphocytic leukaemia and cutaneous T-cell lymphoma, inducing responses in up to two thirds of heavily pre-treated relapsed/refractory patients. Response was associated with improved survival. The toxicity profile for the antibody is manageable. The major complications are infusional reactions ... Read More »
» Published in Best Pract Res Clin Haematol. 2006;19(4):795-810.
6. TCR zeta down-regulation under chronic inflammation is mediated by myeloid suppressor cells differentially distributed between various lymphatic organs.
Match Strength: 2.982
T cell AgR zeta chain down-regulation associated with T cell dysfunction has been described in cancer, infectious, and autoimmune diseases. We have previously shown that chronic inflammation is mandatory for the induction of an immunosuppressive environment leading to this phenomenon. To identify the key immunosuppressive components, we used an in vivo mouse model exhibiting chronic inflammation-induced immunosuppression. Herein, we demonstrate that: 1) under chronic inflammation secondary lymphatic organs display various immunological milieus; zeta chain down-regulation and T cell dysfunction ... Read More »
» Published in J Immunol. 2006 Oct 1;177(7):4763-72.
7. Epidemiologic, clinical, and imaging findings in brucellosis patients with osteoarticular involvement.
Match Strength: 2.866
OBJECTIVE: The aim of this study was to assess the epidemiologic and clinical features, complications, imaging findings, and outcomes for brucellosis patients with osteoarticular involvement. SUBJECTS AND METHODS: This prospective study was performed over 4 years (December 2000-December 2004). The subjects were 251 Turkish patients (age range, 2-77 years) who were diagnosed with brucellosis during that period. Joint sonography, radiography, radionuclide bone scintigraphy, and MRI were performed in all patients with osteoarticular and spinal manifestations. RESULTS: The disease was acute in 92 ... Read More »
» Published in AJR Am J Roentgenol. 2006 Oct;187(4):873-80.
8. Early markers of acute respiratory distress syndrome development in severe trauma patients.
Match Strength: 2.609
PURPOSE: The aim of the study was to identify early risk factors for development of acute respiratory distress syndrome (ARDS) in severe trauma patients. MATERIALS AND METHODS: This was a prospective observational study of 693 severe trauma patients (Injury Severity Score >or=16 and/or Revised Trauma Score
» Published in J Crit Care. 2006 Sep;21(3):253-8.
9. Mutations of TGFbeta signaling molecules in human disease.
Match Strength: 2.470
The transforming growth factor beta (TGFbeta) signaling pathway regulates several biological processes including cellular proliferation, differentiation, apoptosis, migration, and extracellular matrix deposition. Ligand and receptor family members signal through two main Smad signaling branches, TGFbeta/activin to Smad2/3 (Sma and MAD-related proteins) and bone morphogenetic protein (BMP) to Smad1/5. At the molecular level, TGFbeta acts by modifying cytoskeletal organization and ultimately regulating expression of specific target genes. Germline disruption of TGFbeta signaling leads to several ... Read More »
» Published in Ann Med. 2006;38(6):403-14.
10. Update on the biology of the chondrocyte and new approaches to treating cartilage diseases.
Match Strength: 2.467
Osteoarthritis (OA) is a joint disease that involves degeneration of articular cartilage, limited intraarticular inflammation manifested by synovitis and changes in the subchondral bone. The aetiology of OA is largely unknown, but since it may involve multiple factors, including mechanical, biochemical and genetic factors, it has been difficult to identify unique targets for therapy. Chondrocytes, which are the unique cellular component of adult articular cartilage, are capable of responding to structural changes in the surrounding cartilage matrix. Since the initial stages of OA involve ... Read More »
» Published in Best Pract Res Clin Rheumatol. 2006 Oct;20(5):1003-25.
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