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1. Pulse wave analysis and pulse wave velocity: a review of blood pressure interpretation 100 years after Korotkov.
Match Strength: 9.090

The pulsatile component of blood pressure (ie, pulse pressure) has received considerable attention as an important risk factor for cardiovascular disease. In particular, central blood pressure measurements in the ascending aorta or in the carotid artery are expected to be more useful than conventional brachial pressure measurements for predicting cardiovascular events because central pressure, not the brachial pressure, is the pressure that target organs encounter. Due to wave reflection, the blood pressure in the upper limb does not represent the central blood pressure; therefore, leading ... Read More »
» Published in Circ J. 2006 Oct;70(10):1231-9.

2. Importance of salt in determining blood pressure in children: meta-analysis of controlled trials.
Match Strength: 6.733

To assess the effect of reducing salt intake on blood pressure in children, we carried out a meta-analysis of controlled trials. Trials were included if participants were children (< or = 18 years), and duration of salt reduction must have been for > or = 2 weeks. Mean effect size was calculated using a fixed-effect model, because there was no significant heterogeneity. Ten trials of children and adolescents with 966 participants were included (median age: 13 years; range: 8 to 16 years; median duration: 4 weeks; range: 2 weeks to 3 years). Salt intake was reduced by 42% (interquartile ... Read More »
» Published in Hypertension. 2006 Nov;48(5):861-9. Epub 2006 Sep 25. Comment in: Hypertension. 2006 Nov;48(5):818-9., Hypertension. 2007 Feb;49(2):e10; author reply e11.

3. Altered 24-hour blood pressure profiles in children and adolescents with classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
Match Strength: 6.692

OBJECTIVE: Children and adolescents with classical congenital adrenal hyperplasia have been shown to be at risk for obesity associated with higher insulin and leptin levels. Because these factors are also known to cause hypertension, the aim of this study was to analyze 24-h blood pressure profiles and their relation to different clinical and laboratory parameters. DESIGN: Fifty-five subjects, aged between 5.3 and 19.0 yr, were enrolled in a prospective, cross-sectional study. All patients had genetically proven 21-hydroxylase deficiency and underwent ambulatory 24-h blood pressure monitoring ... Read More »
» Published in J Clin Endocrinol Metab. 2006 Dec;91(12):4888-95. Epub 2006 Sep 26.

4. Altered skin blood perfusion in areas with non blanchable erythema: an explorative study.
Match Strength: 6.526

Non blanchable erythema, i.e. stage I pressure ulcer, is common in patients in acute and geriatric care and in nursing homes. Research has shown that this type of lesions is prone to develop into more severe pressure ulcers. The peripheral skin blood perfusion is of major importance for the development of pressure ulcers. The aim of this study was to explore the peripheral skin blood perfusion over time, in areas with non blanchable erythema and in corresponding undamaged areas on the opposite side of the body. A total of 19 measurements were performed, over time, using a laser Doppler ... Read More »
» Published in Int Wound J. 2006 Sep;3(3):215-23.

5. R-wave amplitude in lead II of an electrocardiograph correlates with central hypovolemia in human beings.
Match Strength: 6.329

OBJECTIVES: Previous animal and human experiments have suggested that reduction in central blood volume either increases or decreases the amplitude of R waves in various electrocardiograph (ECG) leads depending on underlying pathophysiology. In this investigation, we used graded central hypovolemia in adult volunteer subjects to test the hypothesis that moderate reductions in central blood volume increases R-wave amplitude in lead II of an ECG. METHODS: A four-lead ECG tracing, heart rate (HR), estimated stroke volume (SV), systolic blood pressure, diastolic blood pressure, and mean arterial ... Read More »
» Published in Acad Emerg Med. 2006 Oct;13(10):1003-10. Epub 2006 Sep 13.

6. The vascular endothelium in hypertension.
Match Strength: 6.082

The vascular endothelium plays a fundamental role in the basal and dynamic regulation of the circulation. Thus, it has a crucial role in the pathogenesis of hypertension. A spectrum of vasoactive substances is synthesised in the endothelium; of these, nitric oxide (NO), prostacyclin (PGI2) and endothelin (ET)-1 are the most important. There is a continuous basal release of NO determining the tone of peripheral blood vessels. Systemic inhibition of NO synthesis or scavenging of NO through oxidative stress causes an increase in arterial blood pressure. Also, the renin-angiotensin-aldosterone ... Read More »
» Published in Handb Exp Pharmacol. 2006;(176 Pt 2):249-83.

7. Immediate changes in blood-gas tensions during chest physiotherapy with positive expiratory pressure and oscillating positive expiratory pressure in patients with cystic fibrosis.
Match Strength: 6.080

OBJECTIVE: To assess and compare immediate effects of chest physiotherapy with positive expiratory pressure (PEP) versus oscillating PEP on transcutaneously measured blood-gas tensions in patients with cystic fibrosis. METHODS: Fifteen patients (mean age 12.5 y, range 6.9-21.5 y) participated. The treatments were randomized and performed on 2 separate occasions, 8 weeks apart. Spirometry was conducted before and after each treatment. We transcutaneously measured oxygen tension (P(tO2). RESULTS: There were no changes in spirometry values. During PEP, different trends in blood-gas tension were ... Read More »
» Published in Respir Care. 2006 Oct;51(10):1154-61.

8. Uterine blood flow during supine rest and exercise after 28 weeks of gestation.
Match Strength: 5.829

OBJECTIVE: To test the null hypothesis that, after 28 weeks of gestation, uterine blood flow during supine rest and supine exercise is no different than uterine blood flow at left-lateral rest. DESIGN: In vivo experimental study in pregnant women. SETTING: Department of Obstetrics, MetroHealth Medical Center, Cleveland, OH, USA. POPULATION: Fourteen, physically active, late-pregnant women who continued supine exercise throughout gestation. METHODS: Studies were carried out between 29 and 38 weeks of gestation. Maternal blood pressure, maternal heart rate, and ultrasound estimates of volume ... Read More »
» Published in BJOG. 2006 Nov;113(11):1239-47. Epub 2006 Sep 15.

9. Workplace-based cardiovascular risk management by community pharmacists: impact on blood pressure, lipid levels, and weight.
Match Strength: 5.805

STUDY OBJECTIVE: To assess the effectiveness of a community pharmacist-delivered cardiovascular case-management program by comparing body mass index (weight), systolic and diastolic blood pressure, and full lipid profile at the beginning of the program with these outcome measures at the end of the program. DESIGN: Retrospective data analysis using billing data submitted between July 1, 2001, and October 31, 2004, with a pre-post design in which subjects served as their own controls. SETTING: Manufacturing workplace in rural Iowa. PARTICIPANTS: Fifty-six workers with risk factors for ... Read More »
» Published in Pharmacotherapy. 2006 Oct;26(10):1511-7.

10. Diabetes guidelines: easier to preach than to practise?
Match Strength: 5.574

OBJECTIVE: To review the management of glycaemia, blood pressure and serum lipids in a hospital outpatient diabetes clinic, the director of which co-authored the current national diabetes management guidelines. DESIGN: Retrospective audit. SETTING: Outpatient diabetes clinic in a tertiary referral teaching hospital, Sydney, NSW. STUDY POPULATION: 96 patients with type 1 diabetes (mean age, 44.4 [SD, 12.8] years) and 509 patients with type 2 diabetes (mean age, 64.4 [SD, 12.0] years) attending the clinic in 2003, who had undergone formal review of complications. MAIN OUTCOME MEASURES: Weight, ... Read More »
» Published in Med J Aust. 2006 Sep 18;185(6):305-9. Comment in: Med J Aust. 2006 Sep 18;185(6):301-2.

11. Microvascular blood flow during cardiopulmonary resuscitation is predictive of outcome.
Match Strength: 5.512

There is growing evidence that microcirculatory blood flow is the ultimate determinant of the outcome in circulatory shock states. We therefore examined changes in the microcirculation accompanying the most severe form of circulatory failure, namely cardiac arrest and the effects of subsequent cardiopulmonary resuscitation. Ventricular fibrillation was electrically induced in nine pigs and untreated for 5min prior to beginning closed chest cardiac compression and attempting electrical defibrillation. Orthogonal polarization spectral imaging was utilized for visualization of the sublingual ... Read More »
» Published in Resuscitation. 2006 Nov;71(2):248-53. Epub 2006 Sep 20.

12. Melatonin reduces night blood pressure in patients with nocturnal hypertension.
Match Strength: 5.341

PURPOSE: Nocturnal hypertension is associated with a high risk of morbidity and mortality. A blunted nocturnal surge in melatonin excretion has been described in nondipping hypertensive patients. We therefore studied the potency of melatonin to reduce nighttime blood pressure (BP) in treated hypertensive patients with nocturnal hypertension. PATIENTS AND METHODS: Thirty-eight treated hypertensive patients (22 males, mean age 64+/-11 years) with confirmed nocturnal hypertension (mean nighttime systolic BP >125 mm Hg), according to repeated 24-hour ambulatory blood pressure monitoring (ABPM), ... Read More »
» Published in Am J Med. 2006 Oct;119(10):898-902.

13. Subclinical thyroid dysfunction and blood pressure: a community-based study.
Match Strength: 5.269

OBJECTIVE: Overt hypothyroidism and hyperthyroidism are associated with hypertension, but it is uncertain whether the same is true of subclinical hypothyroidism and hyperthyroidism. DESIGN, SUBJECTS AND MEASUREMENTS: Cross-sectional study of 2033 participants (aged 17-89 years) in the Busselton Thyroid Study who did not have a history of thyroid disease. Systolic blood pressure (SBP), diastolic blood pressure (DBP) and the prevalence of hypertension (defined as SBP >or=140 mmHg, DBP >or=90 mmHg or on treatment for hypertension) in subjects with thyroid dysfunction and euthyroid subjects ... Read More »
» Published in Clin Endocrinol (Oxf). 2006 Oct;65(4):486-91.

14. Extensive genetic analysis of 10 candidate genes for hypertension in Japanese.
Match Strength: 5.232

The identification of genes that contribute to essential hypertension has been hampered because of a lack of statistical power and problems with multiple testing. In the present study, we performed association analyses between the 161 single nucleotide polymorphisms of 10 candidate genes and hypertension in a Japanese population recruited from the Suita Study (n=3654). We found that 5 polymorphisms in the 3 genes (SLC9A2, UMOD, and ELN) were associated with hypertension status, and 4 of these 5 polymorphisms were also associated with blood pressure values with a classical criterion of P<0 ... Read More »
» Published in Hypertension. 2006 Nov;48(5):901-7. Epub 2006 Sep 18.

15. Intraoperative identification and effective "blood patch" prevention of persistent air leak in lung resections.
Match Strength: 5.099

Persistent air leak (PAL) is the most common complication after lung resection, requiring additional treatments and hospital stay. Intraoperative prevention of PAL is usually left to the surgeon's subjective judgement, with inconsistent results. The aim of the study was to establish systematic, reproducible quantification of air leaks at thoracotomy in order to identify those which are potentially persistent, to be preventively treated by intraoperative "blood patch" pneumo-stasis. In a consecutive series of 570 lung resections, parenchymal suture air tightness was tested intraoperatively at ... Read More »
» Published in Chir Ital. 2006 Jul-Aug;58(4):413-21.

16. Effects of L-arginine oral supplements in pregnant spontaneously hypertensive rats.
Match Strength: 5.078

PURPOSE: To evaluate the effects of L-arginine oral supplementation in spontaneously hypertensive pregnant rats (SHR). METHODS: Thirty SHR and ten Wistar-EPM-1 virgin female rats were used in the study. Before randomization, females were caged with males of the same strain (3:1). Pregnancy was confirmed by sperm-positive vaginal smear (Day 0). Wistar-EPM-1 rats served as counterpart control (C-1). SHR rats were randomized in 4 groups (n=10): Group Control 2, non-treated rats; Group L-Arginine treated with L-arginine 2%; Group Alpha-methyldopa treated with Alpha-methyldopa 33 mg/Kg; Group L ... Read More »
» Published in Acta Cir Bras. 2006 Sep-Oct;21(5):291-5.

17. Increase in renal vascular resistance after intake of cyclosporin A and tacrolimus and reversal by nitroglycerin spray: a study in patients with stable renal allograft function.
Match Strength: 5.058

PURPOSE: Acute effects of drug administration on renal arterial resistance index (RI) are still discussed controversially. In our study we investigated the immediate effects of cyclosporin A (CyA) and tacrolimus (FK-506) on renal arterial resistance indices in patients with stable graft function after renal transplantation. Additionally we studied the effects of nitroglycerin spray on resistance indices. METHODS: RI was measured by color Doppler sonography at baseline, at 1 and 2 hours after intake of medication and 30 minutes after administration of nitroglycerin spray which followed the 2 ... Read More »
» Published in Int J Clin Pharmacol Ther. 2006 Sep;44(9):422-7.

18. Risk factors for vascular complications in patients on peritoneal dialysis.
Match Strength: 5.037

The major cause of death in patients on peritoneal dialysis (PD) is vascular complications, including congestive heart failure, cerebrovascular disease, and myocardial infarction. To clarify the risk factors for vascular complications in patients on PD, we investigated the clinical course of PD in patients with and without cardiovascular and cerebrovascular complications. From among 327 end-stage renal disease (ESRD) patients initiated onto PD from April 1995 to March 2005 in the Kidney and Dialysis Center, Saitama Medical School, 8 developed de novo cardiovascular and cerebrovascular ... Read More »
» Published in Adv Perit Dial. 2006;22:192-7.

19. Role of prostanoids in the regulation of cerebral blood flow during normoxia and hypoxia in the fetal sheep.
Match Strength: 5.034

The fetal cardiovascular responses to hypoxia include decreased peripheral blood flow and increased cerebral, cardiac, and adrenal blood flow. Prostanoids, metabolites of cyclooxygenase enzyme activity, have potent effects on vascular tone in both the adult and the fetus. To examine the role of prostanoids in the regulation of fetal cerebral blood flow (CBF) during acute hypoxic stress, eight near term fetal sheep were studied after infusing vehicle or diclofenac, a cyclooxygenase inhibitor, followed by a 30-min period of hypoxia (arterial Po(2) 12 Torr). In the control experiments, CBF, ... Read More »
» Published in Pediatr Res. 2006 Nov;60(5):524-9. Epub 2006 Sep 20.

20. Mycophenolate mofetil (Cellcept) in pediatric renal transplantation.
Match Strength: 5.007

Mycophenolate mofetil (MMF) was introduced in pediatric renal transplantation almost 10 years ago. In several pediatric studies, MMF has been associated with improved graft survival and improved renal function with standard immunosuppression of steroids and calcineurin inhibitors (CNI). Both drugs are associated with significant negative effects including influence on growth, blood pressure, glucose metabolism, and also cosmetic side effects. Reduction of CNI was possible with MMF without increased rejection, improving blood pressure and renal function. Information is accumulating that steroid ... Read More »
» Published in Transplant Proc. 2006 Sep;38(7):2038-40.

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