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Peer Reviewed Scientific Research Reports.
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1. An exploratory open-label trial of ziprasidone for the treatment of behavioral and psychological symptoms of dementia.
Match Strength: 7.401
OBJECTIVE: To evaluate the efficacy and tolerability of ziprasidone in behavioral and psychological symptoms of dementia. METHOD: A 7-week open-label trial of ziprasidone. RESULTS: Of the 25 patients who participated, 15 completed the study. The main reason for discontinuation was adverse events. The mean total Neuropsychiatric Inventory (NPI) score fell significantly from 47.1 +/- 17.1 (baseline) to 25.8 +/- 17.9 (day 49) (p < 0.01). The NPI caregiver burden showed a significant improvement from 22.6 +/- 8.3 at baseline to 11.8 +/- 7.3. The most frequent adverse events were somnolence, ... Read More »
» Published in Dement Geriatr Cogn Disord. 2006;22(5-6):445-8. Epub 2006 Sep 15.
2. Episodic vestibular disruption following ablation of the inferior olive in rats: behavioral correlates.
Match Strength: 6.474
The experiments herein investigate whether the behavioral responses to transient and episodic vestibular disruption and permanent ablation are distinct in the absence of climbing fiber input. Subjects in group 1 received an IP injection of PBS followed by an IP injection of niacinamide. Seven days later these rats received the first of 3 serial transtympanic injections of TTX on the same side with 7 days between each injection. Following each TTX injection rats displayed unilateral vestibular symptoms that persisted beyond 48h. Spontaneous barrel rolling behavior was not observed. Group 2 ... Read More »
» Published in Behav Brain Res. 2006 Nov 25;175(1):128-38. Epub 2006 Sep 18.
3. Study of behavioral and psychological symptoms of dementia in Taiwan.
Match Strength: 6.143
The behavioral and psychological symptoms of dementia (BPSD) are common serious problems that affect the quality of life for both the patients with such symptoms as well as their caregivers. BPSD present a major challenge in the medical management of patients and are the major cause of institutionalization. Alzheimer's Disease (AD) is the most common type of dementia in Taiwan. I performed a systematic literature review on BPSD studies and found that Taiwanese patients with AD exhibit many of the BPSD. Studies showed that between 30% and 63% of Taiwan's AD patients experienced delusion. ... Read More »
» Published in Acta Neurol Taiwan. 2006 Sep;15(3):154-60.
4. Effects of continuous activity programming on behavioral symptoms of dementia.
Match Strength: 5.641
OBJECTIVES: To describe the effect of continuous activity programming on behavioral symptoms of dementia. DESIGN: Observational study based on quality improvement data. SETTING: Two Dementia Special Care Units in different locations. PARTICIPANTS: Ninety veterans with dementia provided with long-tem care. INTERVENTION: Continuous activity programming. MEASUREMENTS: Data were extracted from the MDS files and obtained by questionnaires filled out by staff members not involved in activity programming. RESULTS: Two settings of continuous activity programming, requiring no additional staffing, ... Read More »
» Published in J Am Med Dir Assoc. 2006 Sep;7(7):426-31. Epub 2006 May 11.
5. Time course of alterations after olfactory bulbectomy in mice.
Match Strength: 5.569
Olfactory bulbectomy in rodents causes behavioral alterations, which result in a model of depression, validated for pharmacological screening of antidepressant drugs. To unravel the appearance and time course of the major behavioral effects which follow surgery, mice underwent olfactory bulb ablation or sham operation, and were analyzed after 1, 2, or 4 weeks. Bulbectomized (BX) mice were anosmic, and hyperactive when tested under stressful situations in the forced swimming test. Predatory aggression was upregulated in a time-dependent way: only after 4 weeks BX mice were faster than controls ... Read More »
» Published in Physiol Behav. 2006 Dec 30;89(5):637-43. Epub 2006 Sep 12.
6. Assessment of home-based behavior modification programs for autistic children: reliability and validity of the behavioral summarized evaluation.
Match Strength: 5.102
Since the publication of Lovaas' (1987) impressive findings, there has been a proliferation of home-based behavior modification programs for autistic children. Parents and other paraprofessionals often play key roles in the implementation and monitoring of these programs. The Behavioral Summarized Evaluation (BSE) was developed for professionals and paraprofessionals to use in assessing the severity of autistic symptoms over the course of treatment. This paper examined the psychometric properties of the BSE (inter-item consistency, factorial composition, convergent validity, and sensitivity to ... Read More »
» Published in J Prev Interv Community. 2006;32(1-2):25-39.
7. Randomized trial of a brief depression prevention program: An elusive search for a psychosocial placebo control condition.
Match Strength: 5.065
This trial compared a brief group cognitive-behavioral (CBT) depression prevention program to a waitlist control condition and four placebo or alternative interventions. High-risk adolescents with elevated depressive symptoms (N=225, M age=18, 70% female) were randomized to CBT, supportive-expressive group intervention, bibliotherapy, expressive writing, journaling, or waitlist conditions and completed assessments at baseline, termination, and 1- and 6-month follow-up. All five active interventions showed significantly greater reductions in depressive symptoms at termination than waitlist ... Read More »
» Published in Behav Res Ther. 2006 Sep 26;
8. Fatigue representations in women with heart failure.
Match Strength: 4.806
Self-care management of symptoms for persons with heart failure (HF) may only be successful when their representations regarding their symptoms are accurate and linked to appropriate behavioral strategies. The purpose of this secondary data analysis (N = 169 women with HF) was to describe representations of one HF-related symptom, fatigue, and examine whether representations were related to physical health status, health care utilization, and psychological well-being and whether they differed by age. Overall, women agreed that fatigue was chronic, caused by HF, and had serious consequences. ... Read More »
» Published in Res Nurs Health. 2006 Oct;29(5):452-64.
9. Systemic lupus erythematosus and the brain: what mice are telling us.
Match Strength: 4.259
Neuropsychiatric symptoms occur in systemic lupus erythematosus (SLE), a complex, autoimmune disease of unknown origin. Although several pathogenic mechanisms have been suggested to play a significant role in the etiology of the disease, the exact underlying mechanisms still remain elusive. Several inbred strains of mice are used as models to study SLE, which exhibit a diversity of central nervous system (CNS) manifestations similar to that observed in patients. This review will attempt to give a brief overview of the CNS alterations observed in these models, including biochemical, structural ... Read More »
» Published in Neurochem Int. 2007 Jan;50(1):5-11. Epub 2006 Sep 20.
10. Preclinical research into cognition enhancers.
Match Strength: 4.114
The preclinical development of drugs to treat the cognitive symptoms of neuropsychiatric and neurological disorders is a formidable challenge. Evidence from a wide range of preclinical behavioral and neuropharmacological tests has formed the basis for predicting drug-induced cognition enhancement in normal volunteers and in patients with cognitive impairments. However, the limited validity of preclinical predictions of this enhancement in humans indicates that conventional screening for "broadly active" compounds represents a below-optimal research strategy. This article conceptualizes the ... Read More »
» Published in Trends Pharmacol Sci. 2006 Nov;27(11):602-8. Epub 2006 Sep 25.
11. Self-reports on mental health problems of youth with moderate to borderline intellectual disabilities.
Match Strength: 4.049
OBJECTIVE: To determine the extent to which the Youth Self-Report (YSR) can be used to assess emotional and behavioral problems in adolescents with intellectual disabilities (IDs). METHOD: In 2003, 281 11- to 18-year-olds with IDs (IQ > or =48) completed the YSR in an interview, and in 1993, 1,047 non-ID adolescents completed the YSR themselves. Parents completed the Child Behavior Checklist (CBCL). The ID sample was split into lower (IQ 48-69) and higher (IQ > or =70) IQ groups. Cronbach's alpha values of the YSR scales and (intraclass) correlation coefficients between and within YSR ... Read More »
» Published in J Am Acad Child Adolesc Psychiatry. 2006 Oct;45(10):1224-31.
12. Self-reports of psychosocial functioning among children and young adults with cleft lip and palate.
Match Strength: 3.953
OBJECTIVE: A cross-sectional study was employed to determine the psychosocial effects of cleft lip and/or palate among children and young adults, compared with a control group of children and young adults without cleft lip and palate. PARTICIPANTS: The study comprised 160 children and young adults with cleft lip and/or palate and 113 children and young adults without cleft lip and/or palate. All participants were between 8 and 21 years of age. OUTCOME MEASURES: Psychological functioning (anxiety, self-esteem, depression, and behavioral problems) was assessed using validated psychological ... Read More »
» Published in Cleft Palate Craniofac J. 2006 Sep;43(5):598-605.
13. Cognitive-behavioral therapy for PANDAS-related obsessive-compulsive disorder: findings from a preliminary waitlist controlled open trial.
Match Strength: 3.913
OBJECTIVE: To provide preliminary estimates of the effectiveness of cognitive-behavioral therapy (CBT) in treating pediatric obsessive-compulsive disorder (OCD) of the pediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS) subtype. METHOD: Seven children with OCD of the PANDAS subtype (range 9-13 years) were treated in a 3-week intensive CBT program conducted at a university clinic. Six of seven children were taking selective serotonin reuptake inhibitor medication(s) upon presentation. Assessments were conducted at four time points: baseline, pretreatment ... Read More »
» Published in J Am Acad Child Adolesc Psychiatry. 2006 Oct;45(10):1171-8.
14. Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior.
Match Strength: 3.489
Secretin is a peptide hormone released from the duodenum to stimulate the secretion of digestive juice by the pancreas. Secretin also functions as a neuropeptide hormone in the brain, and exogenous administration has been reported to alleviate symptoms in some patients with autism. We have generated secretin receptor-deficient mice to explore the relationship between secretin signaling in the brain and behavioral phenotypes. Secretin receptor-deficient mice are overtly normal and fertile; however, synaptic plasticity in the hippocampus is impaired and there are slightly fewer dendritic spines ... Read More »
» Published in Hum Mol Genet. 2006 Nov 1;15(21):3241-50. Epub 2006 Sep 28.
15. Treatment of the overactive bladder: where we stand in 2003.
Match Strength: 3.285
The understanding and management of overactive bladder (OAB) continue to evolve. However, argument persists as to the exact incidence of the disease and the underlying pathophysiology of the symptom complex. Individual differences in symptomatic impact and, more importantly, personal coping partially account for the disparity noted among demographic estimates currently extant. Likewise, the underlying pathophysiology that leads to overt OAB syndrome is, as yet, incompletely characterized. Muscarinic receptor behavior provides partial explanation, but other complex underlying receptor and ... Read More »
» Published in Rev Urol. 2003;5 Suppl 8:S11-7.
16. Efficacy of cognitive-behavioral interventions targeting personality risk factors for youth alcohol misuse.
Match Strength: 3.245
Sensation seeking, anxiety sensitivity, and hopelessness are personality risk factors for alcohol use disorders, each associated with specific risky drinking motives in adolescents. We developed a set of interventions and manuals that were designed to intervene at the level of personality risk and associated maladaptive coping strategies, including alcohol misuse. Manuals contained psychoeducational information on the target personality risk factor and how it is associated with maladaptive coping, as well as exercises targeting maladaptive cognitions and behaviors specific to each personality ... Read More »
» Published in J Clin Child Adolesc Psychol. 2006 Dec;35(4):550-63.
17. Assessment of cognitive function in the heterozygous reeler mouse.
Match Strength: 3.007
RATIONALE: The heterozygous reeler mouse has been proposed as a genetic mouse model of schizophrenia based on several neuroanatomical and behavioral similarities between these mice and patients with schizophrenia. However, the effect of reelin haploinsufficiency on one of the cardinal symptoms of schizophrenia, the impairment of prefrontal-cortex-dependent cognitive function, has yet to be determined. OBJECTIVE: Here, we investigated multiple aspects of cognitive function in heterozygous reeler mice that are known to be impaired in schizophrenic patients. METHODS: Heterozygous reeler mice were ... Read More »
» Published in Psychopharmacology (Berl). 2006 Nov;189(1):95-104. Epub 2006 Sep 15.
18. The utility of the Rey Word Recognition Test in the detection of suspect effort.
Match Strength: 2.948
The Rey Word Recognition Test potentially represents an underutilized tool for clinicians to use in the detection of suspect effort. The present study examined the predictive accuracy of the test by examining the performance of three groups of participants: (a) 92 noncredible patients (as determined by failed psychometric and behavioral criteria and external motive to feign), (b) 51 general clinical patients with no motive to feign, and (c) 31 learning disabled college students. Results demonstrated gender differences in performance that necessitated separate cutoff scores for men and women. ... Read More »
» Published in Clin Neuropsychol. 2006 Dec;20(4):873-87.
19. Peri-pubertal maturation after developmental disturbance: a model for psychosis onset in the rat.
Match Strength: 2.940
Schizophrenia is thought to be associated with abnormalities during neurodevelopment although those disturbances usually remain silent until puberty; suggesting that postnatal brain maturation precipitates the emergence of psychosis. In an attempt to model neurodevelopmental defects in the rat, brain cellular proliferation was briefly interrupted with methylazoxymethanol (MAM) during late gestation at embryonic day 17 (E17). The litters were explored at pre- and post-puberty and compared with E17 saline-injected rats. We measured spontaneous and provoked locomotion, working memory test, social ... Read More »
» Published in Neuroscience. 2006 Dec 1;143(2):395-405. Epub 2006 Sep 14.
20. Consumption of soft drinks and hyperactivity, mental distress, and conduct problems among adolescents in Oslo, Norway.
Match Strength: 2.896
OBJECTIVES: We examined whether high levels of consumption of sugar-containing soft drinks were associated with mental distress, hyperactivity, and conduct problems among adolescents. METHODS: A cross-sectional population-based survey was conducted with 10th-grade students in Oslo, Norway (n = 5498). We used the Hopkins Symptom Checklist and the Strengths and Difficulties Questionnaire to assess mental health outcomes. RESULTS: There was a J-shaped dose-response relationship between soft drink consumption and mental distress, conduct problems, and total mental health difficulties score; that ... Read More »
» Published in Am J Public Health. 2006 Oct;96(10):1815-20.
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