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Avian Influenza
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1. Outbreak of avian influenza H7N3 on a turkey farm in the Netherlands.
Match Strength: 14.798

This case report describes the course of an outbreak of avian influenza on a Dutch turkey farm. When clinical signs were observed their cause remained unclear. However, serum samples taken for the monitoring campaign launched during the epidemic of highly pathogenic avian influenza in 2003, showed that all the remaining turkeys were seropositive against an H7 strain of avian influenza virus, and the virus was subsequently isolated from stored carcases. The results of a reverse-transcriptase pcr showed that a H7N3 strain was involved, and it was characterised as of low pathogenicity. However, ... Read More »
» Published in Vet Rec. 2006 Sep 23;159(13):403-5.

2. Comment on "Large-scale sequence analysis of avian influenza isolates".
Match Strength: 10.492

Obenauer et al. (Research Articles, 17 March 2006, p. 1576) reported that the influenza A virus PB1-F2 gene is evolving under strong positive selection, as documented by an extremely high ratio of the number of nonsynonymous nucleotide substitutions to the number of synonymous substitutions (dN/dS). However, we show that this observation is likely to be an artifact related to the location of PB1-F2 in the +1 reading frame of the PB1 gene. Publication Types: ... Read More »
» Published in Science. 2006 Sep 15;313(5793):1573; author reply 1573. Comment on: Science. 2006 Mar 17;311(5767):1576-80.

3. Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus.
Match Strength: 8.978

The influenza pandemic of 1918-19 was responsible for about 50 million deaths worldwide. Modern histopathological analysis of autopsy samples from human influenza cases from 1918 revealed significant damage to the lungs with acute, focal bronchitis and alveolitis associated with massive pulmonary oedema, haemorrhage and rapid destruction of the respiratory epithelium. The contribution of the host immune response leading to this severe pathology remains largely unknown. Here we show, in a comprehensive analysis of the global host response induced by the 1918 influenza virus, that mice infected ... Read More »
» Published in Nature. 2006 Oct 5;443(7111):578-81. Epub 2006 Sep 27.

4. Bioterrorism with zoonotic disease: public health preparedness lessons from a multiagency exercise.
Match Strength: 8.489

Responding to agricultural bioterrorism with pathogenic agents that are communicable from animals to humans (zoonotic diseases) requires effective coordination of many organizations, both inside and outside of government. Action must be simultaneously taken to address public health concerns, respond to the agricultural dimensions of the event, and carry out the necessary law enforcement investigation. As part of a project focused on examining public health preparedness in Georgia, an exercise was carried out in July 2005 examining the intentional introduction of avian influenza (H5N1) in ... Read More »
» Published in Biosecur Bioterror. 2006;4(3):287-92.

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