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Attention Deficit Disorder with Hyperactivity
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1. Semax, an analogue of adrenocorticotropin (4-10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome.
Match Strength: 14.976

Psychostimulants, such as methylphenidate, are currently the most common used drug therapy for children with attention-deficit hyperactivity disorder (ADHD). However, a number of patients with ADHD either fail to respond to these drugs or experience side effects that preclude their use. The heptapeptide Semax is an analogue of the N-terminal fragment (4-10) of adrenocorticotropic hormone, but is completely devoid of any hormonal activity. It has been found to stimulate memory and attention in rodents and humans after intranasal application. Evidence from animal studies revealed that Semax can ... Read More »
» Published in Med Hypotheses. 2006 Sep 21;

2. Psychopathological rating scales for diagnostic use in adults with attention-deficit/hyperactivity disorder (ADHD).
Match Strength: 14.642

The diagnosis of attention-deficit hyperactivity disorder (ADHD) in adults is a complex procedure which should include retrospective assessment of childhood ADHD symptoms either by patient recall or third party information, diagnostic criteria according to DSM-IV, current adult ADHD psychopathology including symptom severity and pervasiveness, functional impairment, quality of life and comorbidity. In order to obtain a systematic database for the diagnosis and evaluation of the course ADHD rating scales can be very useful. This article reviews rating instruments that have found general ... Read More »
» Published in Eur Arch Psychiatry Clin Neurosci. 2006;256 Suppl 1:i3-i11.

3. Attention-deficit hyperactivity disorder involves differential cortical processing in a visual spatial attention paradigm.
Match Strength: 13.695

OBJECTIVE: Inattention is undoubtedly one of the main characteristics of Attention-deficit hyperactivity disorder (ADHD). Nevertheless, a growing corpus of evidence shows that not all attentional processes are affected in this condition. This study aimed to explore the distribution of attentional resources in children with ADHD via a spatially shifted double-oddball visual task. METHODS: We recorded event-related potentials (ERPs) for all visual stimuli. Subjects were instructed to allocate attention in a specific area of visual space while ignoring all stimuli presented outside. Ten male ... Read More »
» Published in Clin Neurophysiol. 2006 Nov;117(11):2540-8. Epub 2006 Sep 26.

4. The parent interview for child symptoms: a situation-specific clinical research interview for attention-deficit hyperactivity and related disorders.
Match Strength: 12.999

OBJECTIVE: To describe the properties of a semistructured research interview of parents designed to evaluate attention-deficit hyperactivity disorder (ADHD) and related psychopathology. METHOD: We examined interrater reliability in 48 videotaped interviews randomly selected from a large clinic sample. We examined convergence of the Parent Interview for Child Symptoms (PICS) and Conners' Parent Rating Scale (CPRS) scores in 594 clinic-referred cases and 26 control subjects, comparing the groups generated by cross-tabulation on measures of intelligence, academic achievement, and inhibitory ... Read More »
» Published in Can J Psychiatry. 2006 Apr;51(5):325-8.

5. Atomoxetine for hyperactivity in autism spectrum disorders: placebo-controlled crossover pilot trial.
Match Strength: 12.673

OBJECTIVE: To explore placebo-controlled efficacy and safety of atomoxetine (ATX) for attention-deficit/hyperactivity disorder (ADHD) symptoms in children with autism spectrum disorders (ASD). METHOD: Children ages 5 to 15 with ASD and prominent ADHD symptoms were randomly assigned to order in a crossover of clinically titrated ATX and placebo, 6 weeks each, separated by 1-week washout. Slopes for each condition were compared by paired t test. RESULTS: In 2004-2005, 12 boys and 4 girls (7 with autistic disorder, 1 Asperger's, 8 pervasive developmental disorder not otherwise specified) all ... Read More »
» Published in J Am Acad Child Adolesc Psychiatry. 2006 Oct;45(10):1196-205.

6. Volumetric MRI differences in treatment-naive vs chronically treated children with ADHD.
Match Strength: 12.425

OBJECTIVE: To determine if there are differences in the volume of the caudate and anterior cingulate cortex (ACC) between children with attention deficit hyperactivity disorder (ADHD) and controls, and if such differences are related to the subjects' history of stimulant treatment. METHODS: We performed a case-control study in an academic medical center. Twenty-one healthy controls, 16 children with ADHD, combined type with a history of stimulant treatment, and 14 children with ADHD, combined type treatment naive, underwent structural MRI. All children with ADHD were medication-free at the ... Read More »
» Published in Neurology. 2006 Sep 26;67(6):1023-7. Erratum in: Neurology. 2006 Dec 12;67(11):2091.

7. Relationship of childhood behavior disorders to weight gain from childhood into adulthood.
Match Strength: 11.214

OBJECTIVE: Obesity and behavior disorders are important conditions that affect the health of children and adolescents; some evidence suggests that they are associated. However, these relationships have not been studied longitudinally from childhood to adulthood. We investigated childhood to adulthood weight change associated with attention-deficit and disruptive behavior disorders. METHODS: We analyzed data from a prospective cohort study in which 655 individuals observed before age 16.6 years, and assessed in 1983 (when aged 9.1 to 16.6 years), 1985-1986 (when 11.1 to 20.8 years), 1991-1994 ... Read More »
» Published in Ambul Pediatr. 2006 Sep-Oct;6(5):297-301.

8. Persistent tobacco use during pregnancy and the likelihood of psychiatric disorders.
Match Strength: 11.193

OBJECTIVES: We examined the association between psychiatric disorders and tobacco use during pregnancy. METHODS: Data were derived from a population-based cohort of 744 pregnant African American and White low-income women living in urban and rural areas. The Diagnostic Interview Schedule was used to assess women for 20 different psychiatric disorders. RESULTS: In comparison with nonusers, persistent tobacco users (women who had used tobacco after confirmation of their pregnancy) and nonpersistent users (women who had used tobacco but not after pregnancy confirmation) were 2.5 and 2 times as ... Read More »
» Published in Am J Public Health. 2006 Oct;96(10):1799-807.

9. Childhood ADHD predicts risky sexual behavior in young adulthood.
Match Strength: 11.188

This study compared young adults (ages 18 to 26) with and without childhood attention deficit hyperactivity disorder (ADHD) on self-reported risky sexual behaviors. Participants were 175 men with childhood ADHD and 111 demographically similar men without ADHD in the Pittsburgh ADHD Longitudinal Study (PALS). Childhood ADHD predicted earlier initiation of sexual activity and intercourse, more sexual partners, more casual sex, and more partner pregnancies. Although childhood conduct problems did contribute significantly to risky sexual behaviors among participants with ADHD, there was also an ... Read More »
» Published in J Clin Child Adolesc Psychol. 2006 Dec;35(4):571-7.

10. Psychological and Neurobehavioral Comparisons of Children with Asperger's Disorder Versus High-Functioning Autism.
Match Strength: 10.861

This study investigated personality and neurobehavioral differences between 16 children with Asperger's Disorder, 15 children with High-Functioning Autism (HFA), and 31 controls, all ranging in age from 5-17 years, M age = 10.7 years, SD = 3.0. Parents rated their children's behaviors on a 44-item autistic symptoms survey and on the 200-item Coolidge Personality and Neuropsychological Inventory (Coolidge, Thede, Stewart, & Segal (2002a). The Coolidge Personality and Neuropsychological Inventory for Children (CPNI): Preliminary psychometric characteristics. Behavior Modification, 26, 550-566). ... Read More »
» Published in J Autism Dev Disord. 2006 Sep 15;

11. Multitasking performance of Chinese children with ADHD.
Match Strength: 10.047

The aim of this study was to explore multitasking skills in a Chinese sample of 22 children with attention deficit-hyperactivity disorder (ADHD) compared with 22 healthy controls matched by gender, age, and IQ. All of the participants completed the children's version of the Six Elements Test (C-SET) and neuropsychological tests that captured specific domains of attention, memory, and executive function. Children with ADHD performed significantly worse than the healthy controls in all domains except the number of rules broken in the C-SET. The majority of the C-SET domain scores correlated ... Read More »
» Published in J Int Neuropsychol Soc. 2006 Jul;12(4):575-9.

12. Inattention, hyperactivity, and impulsivity in teenagers with intellectual disabilities, with and without autism.
Match Strength: 9.995

OBJECTIVE: To explore inattentive, hyperactive, and impulsive behaviours in teenagers with intellectual disabilities (ID), with and without autism. METHOD: We identified teenagers with ID, with and without autism, in a single geographic area. Those with autism were matched for age, sex, and nonverbal IQ to those with ID only. We compared inattentive, hyperactive, and impulsive (IHI) behaviours in the 2 groups, along with adaptive functioning and medical circumstances. We further subdivided the autism group into those with IHI behaviours (autism IHI) and those without (autism non-IHI) and ... Read More »
» Published in Can J Psychiatry. 2006 Aug;51(9):598-606.

13. Stimulant medications: a trade-off? The lived experience of adolescents with ADHD.
Match Strength: 9.482

PURPOSE: The purpose of this study was to gain information and insight about prescription stimulant medication use among children and adolescents with attention deficit-hyperactivity disorder (ADHD) across developmental stages. DESIGN AND METHODS: Investigators conducted semistructured qualitative interviews with 15 college students with ADHD. Follow-up interviews confirmed and validated information obtained during initial interviews. RESULTS: Qualitative data analysis resulted in three global categories related to the use of prescription stimulant medication from childhood to late adolescence ... Read More »
» Published in J Spec Pediatr Nurs. 2006 Oct;11(4):214-26.

14. Sleep disturbances and correlates of children with autism spectrum disorders.
Match Strength: 9.305

This study examined sleep patterns, sleep problems, and their correlates in children with autism spectrum disorders (ASD). Subjects consisted of 167 ASD children, including 108 with autistic disorder, 27 with Asperger's syndrome, and 32 with other diagnoses of ASD. Mean age was 8.8 years (SD = 4.2), 86% were boys. Parents completed a self-administered child sleep questionnaire. Results showed that average night sleep duration was 8.9 h (SD = 1.8), 16% of children shared a bed with parent. About 86% of children had at least one sleep problem almost every day, including 54% with bedtime ... Read More »
» Published in Child Psychiatry Hum Dev. 2006 Winter;37(2):179-91.

15. Influence of the antipsychotic drug pipamperone on the expression of the dopamine D4 receptor.
Match Strength: 7.933

The dopamine D4 receptor is a G protein-coupled receptor that binds with high affinity various antipsychotics. The receptor may be involved in attention/cognition, and in genetic studies a polymorphic repeat sequence in its coding sequence has been associated with attention deficit/hyperactivity disorder. We developed an inducible episomal expression system based on the reverse tetracycline transactivator and Epstein-Barr viral sequences. In HEK293rtTA cells expressing the dopamine D4 receptor from this episomal expression vector, addition of doxycycline in combination with sodium butyrate and ... Read More »
» Published in Life Sci. 2006 Dec 3;80(1):74-81. Epub 2006 Aug 25.

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