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Peer Reviewed Scientific Research Reports.
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1. Respiratory sinus arrhythmia as a function of state anxiety in healthy individuals.
Match Strength: 5.911
Respiratory sinus arrhythmia (RSA) was examined in relation to state and trait anxiety in healthy individuals. Time-frequency analyses of HR-power spectrum in the high frequency region (0.12-0.40 Hz), related to RSA, were examined in 43 women and 39 men. Based on median split, the participants were divided into high and low state and trait anxiety groups. The main result showed that high state anxious individuals had higher RSA-magnitude (HF-power) than low state anxious individuals. The higher RSA-magnitude in the former group was interpreted as reflecting increased attention or vigilance ... Read More »
» Published in Int J Psychophysiol. 2007 Jan;63(1):48-54. Epub 2006 Sep 20.
2. Prevalence of life-threatening arrhythmias in ED patients transported to the radiology suite while monitored by telemetry.
Match Strength: 5.739
OBJECTIVE: The aim of this study was to determine the prevalence of life-threatening arrhythmias in monitored ED patients while in the radiology suite. METHODS: This is a retrospective analysis at a tertiary care hospital with an ED census of 52,000 visits. The patient population consisted of 3,051 adult ED patients with a chief complaint of chest pain, who were monitored with telemetry while they were sent to the radiology suite, and who were ultimately admitted to the hospital. RESULTS: Of a total of 3,051 consecutive patients with a cardiac presentation who received a nonportable chest x ... Read More »
» Published in Am J Emerg Med. 2006 Oct;24(6):655-7.
3. Drug evaluation: dronedarone, a novel non-iodinated anti-arrhythmic agent.
Match Strength: 4.261
sanofi-aventis (formerly Sanofi-Synthelabo) is developing the oral class III anti-arrhythmic agent dronedarone (Multaq) for the potential treatment and prevention of atrial fibrillation. In June 2005, sanofi-aventis submitted EU and US filings for atrial fibrillation. In October 2002, phase I trials for arrhythmia were reported to be ongoing in Japan. Publication Types: ... Read More »
» Published in Curr Opin Investig Drugs. 2006 Sep;7(9):842-9.
4. Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation.
Match Strength: 4.188
Pharmacological management of cardiac arrhythmias has been a long and widely sought goal. One of the difficulties in treating arrhythmia stems, in part, from incomplete understanding of the mechanisms of drug block and how intrinsic properties of channel gating affect drug access, binding affinity, and unblock. In the last decade, a plethora of genetic information has revealed that genetics may play a critical role in determining arrhythmia susceptibility and in efficacy of pharmacological therapy. In this context, we present a theoretical approach for investigating effects of drug-channel ... Read More »
» Published in Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H66-75. Epub 2006 Sep 22.
5. The renin-angiotensin system: a therapeutic target in atrial fibrillation.
Match Strength: 3.665
There is growing evidence to suggest a role for the renin-angiotensin system (RAS) in the pathogenesis of atrial fibrillation (AF). Experimental animal data suggest RAS-dependent mechanisms for the development of a structural and electrophysiologic substrate for AF. This is consistent with clinical data demonstrating the effectiveness of RAS blockade in preventing new-onset or recurrent AF in a variety of patient populations including patients with hypertension and left ventricular hypertrophy, congestive heart failure, and those undergoing electrical cardioversion for AF. This review ... Read More »
» Published in Pacing Clin Electrophysiol. 2006 Sep;29(9):1006-12.
6. Non-compacted cardiomyopathy: clinical-echocardiographic study.
Match Strength: 2.870
The aim of the present study was to describe the clinical and echocardiographic findings of ventricular noncompaction in adult patients. Fifty-three patients underwent complete clinical history, electrocardiogram, Holter and transthoracic echocardiogram. Forty patients (75%) were in class I/II of the New York Heart Association, and 13 (25%) in class III/IV. Ventricular and supraventricular escape beats were found in 40% and 26.4%, respectively. Holter showed premature ventricular contractions in 32% and sustained ventricular tachycardia in 7.5%. Ventricular noncompaction was an isolated ... Read More »
» Published in Cardiovasc Ultrasound. 2006 Sep 26;4:35.
7. Takotsubo cardiomyopathy--transient left ventricular apical ballooning mimicking acute myocardial infarction.
Match Strength: 2.860
Takotsubo cardiomyopathy is characterized by transient left ventricular dysfunction with clinical symptoms of chest pain, electrocardiographic changes of ST-segment elevation or T wave inversion, which mimics acute myocardial infarction in patients without angiographically significant coronary artery stenosis. We report a 75-year-old woman with a history of chest tightness who presented with typical pictures of takotsubo cardiomyopathy. Acute myocardial infarction was initially diagnosed based on the electrocardiographic changes and elevated troponin. Apical akinesis and ballooning with basal ... Read More »
» Published in J Formos Med Assoc. 2006 Oct;105(10):839-43.
8. The natural history of Noonan syndrome: a long-term follow-up study.
Match Strength: 2.702
OBJECTIVE: To define better the adult phenotype and natural history of Noonan syndrome. DESIGN: A prospective observational study of a large cohort. RESULTS: Data are presented for 112 individuals with Noonan syndrome (mean age 25.3 (range 12-71) years), who were followed up for a mean of 12.02 years. Mutations in PTPN11 were identified in 35% of probands. Ten subjects died during the study interval; three of these deaths were secondary to heart failure associated with hypertrophic cardiomyopathy. Pulmonary stenosis affected 73 (65%) subjects; 42 (58%) required no intervention, nine underwent ... Read More »
» Published in Arch Dis Child. 2007 Feb;92(2):128-32. Epub 2006 Sep 21.
9. Gastric arrhythmia and nausea of motion sickness induced in healthy Japanese subjects viewing an optokinetic rotating drum.
Match Strength: 2.675
The purpose of this study was to investigate whether nausea or gastric dysrhythmia, including tachygastria, which was determined by electrogastrography (EGG), were observed during optokinetic motion sickness in healthy Japanese volunteers. Twelve volunteers (9 men and 3 women) participated in the study. The subjects were asked to sit in a chair with their heads positioned in the center of a drum whose inside had been painted with black and white stripes. After a 15 min resting period, the drum was rotated at a speed of 60 degree/sec for 15 min. The EGG was continuously recorded for a total of ... Read More »
» Published in J Physiol Sci. 2006 Oct;56(5):341-5. Epub 2006 Sep 28.
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