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Peer Reviewed Scientific Research Reports.
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1. Identifying hospitalized infants who have bronchiolitis and are at high risk for apnea.
Match Strength: 9.408
STUDY OBJECTIVE: Young infants with bronchiolitis are at risk for apnea. We seek to determine the rate of apnea in young infants with bronchiolitis and evaluate the performance of a predefined set of risk criteria for identifying infants at high risk for the development of apnea. METHODS: We identified a retrospective cohort study of patients treated in the emergency department (ED) of an urban pediatric tertiary care hospital from November 1995 to June 2000. All infants younger than 6 months who met our study definition of bronchiolitis and were admitted to the hospital were included. We ... Read More »
» Published in Ann Emerg Med. 2006 Oct;48(4):441-7. Epub 2006 May 18.
2. Occult cardiac dysfunction in patients with obstructive sleep apnea syndrome revealed by tissue Doppler imaging.
Match Strength: 9.151
Obstructive sleep apnea syndrome has been linked to cardiovascular complications. The diagnosis of effects of sleep apnea on heart may be difficult before apparent examination findings. The aim of the present study was to evaluate changes of myocardial contractile properties in patients affected by sleep apnea showing tissue Doppler imaging, in the face of quite normal myocardial contractility on standard echocardiography. Shortly, tissue Doppler imaging may represent an early stage of myocardial abnormality despite a preserved global function ... Read More »
» Published in Int J Cardiol. 2006 Sep 21;
3. A prospective study to determine the incidence of atopy in children undergoing adenotonsillectomy for obstructive sleep apnea.
Match Strength: 7.811
OBJECTIVES: To investigate the relationship between adenotonsillar hypertrophy seen in pediatric obstructive sleep apnea and upper airway allergy to airborne allergens. METHODS: A prospective study of Radioallergosorbent (RAST) tests to common airborne allergens in children (<16 years old) undergoing adenotonsillectomy for obstructive sleep apnea in a London Teaching Hospital. RESULTS: 20.9% of patients had a positive RAST result to house dust mite, 2.8% to cat hair, 0% to mixed feather, 7.8% to mixed grass pollen and 3.8% to dog hair. CONCLUSIONS: This study does not support the hypothesis ... Read More »
» Published in Int J Pediatr Otorhinolaryngol. 2007 Jan;71(1):19-22. Epub 2006 Sep 18.
4. Neuromechanical control of upper airway patency during sleep.
Match Strength: 7.382
Obstructive sleep apnea is caused by pharyngeal occlusion due to alterations in upper airway mechanical properties and/or disturbances in neuromuscular control. The objective of the study was to determine the relative contribution of mechanical loads and dynamic neuromuscular responses to pharyngeal collapse during sleep. Sixteen obstructive sleep apnea patients and sixteen normal subjects were matched on age, sex, and body mass index. Pharyngeal collapsibility, defined by the critical pressure, was measured during sleep. The critical pressure was partitioned between its passive mechanical ... Read More »
» Published in J Appl Physiol. 2007 Feb;102(2):547-56. Epub 2006 Sep 28.
5. Obstructive sleep apnea and hypertension: epidemiology, mechanisms and treatment effects.
Match Strength: 4.514
Obstructive sleep apnea (OSA) is a highly prevalent disorder of breathing during sleep. A growing body of evidence suggests that OSA is independently associated with an increased risk of cardiovascular disease, although the extent of this risk and underlying mechanisms remain to be elucidated. However, there is clearer evidence from epidemiological and pathophysiological research of a causal link between OSA and hypertension. The acute hemodynamic and autonomic perturbations that accompany obstructive apneas during sleep, with associated repeated arousals and intermittent hypoxemia, appear to ... Read More »
» Published in Minerva Med. 2006 Aug;97(4):299-312.
6. Activation of glycogen synthase in myocardium induced by intermittent hypoxia is much lower in fasted than in fed rats.
Match Strength: 4.471
Obstructive sleep apnea is characterized by intermittent obstruction of the upper airway, which leads to intermittent hypoxia. Myocardial glycogen is a major energy resource for heart during hypoxia. Previous studies have demonstrated that intermittent hypoxia rapidly degrades myocardial glycogen and activates glycogen synthase (GS). However, the underlying mechanisms remain undefined. Because sleep apnea/intermittent hypoxia usually happens at night, whether intermittent hypoxia leads to GS activation in the postabsorptive state is not known. In the present study, male adult rats were studied ... Read More »
» Published in Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E469-75. Epub 2006 Sep 26.
7. Plasma leptin levels in patients with floppy eyelid syndrome.
Match Strength: 3.049
PURPOSE: To determine the range of plasma leptin levels in patients with floppy eyelid syndrome (FES). METHODS: This was a retrospective, noninterventional case series of 11 patients with FES. Charts were reviewed for patient age, sex, plasma leptin level, body mass index (BMI), presence or absence of obstructive sleep apnea (OSA) and diabetes mellitus, and any treatments for OSA. RESULTS: Charts of 11 patients were reviewed (10 male, 1 female). Plasma leptin levels were elevated in 7 of 11 patients (64%). Mean plasma leptin concentration was 49.5 ng/ml in male patients (range, 5 to 120 ng/ml) ... Read More »
» Published in Ophthal Plast Reconstr Surg. 2006 Sep-Oct;22(5):375-7.
8. Radiofrequency tongue reduction through a cervical approach: a pilot study.
Match Strength: 2.601
OBJECTIVE/HYPOTHESIS: The objective of this prospective cohort study was to determine the feasibility, safety, and efficacy of radiofrequency tongue base reduction through a cervical approach in patients with obstructive sleep apnea syndrome (OSAS). METHODS: Patients with moderate to severe OSAS and predominant tongue base obstruction by physical examination were included at our institution from 1999 to 2003. A sonogram was obtained to identify the lingual arteries, and an electrode was inserted through the neck and into the tongue under fluoroscopic guidance. Adverse events were recorded as ... Read More »
» Published in Laryngoscope. 2006 Oct;116(10):1887-93.
9. Ampakines alleviate respiratory depression in rats.
Match Strength: 2.403
RATIONALE: There is a need for improved therapeutic interventions to treat both drug- and sleep-induced respiratory depression. Increased understanding of the neurochemical control of respiration will help identify a basis for advances. Activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors positively modulates respiratory drive and rhythmogenesis in several brain regions including the pre-Botzinger complex. Ampakines are a diverse group of small molecules that activate subsets of these receptors. OBJECTIVE: We determined whether the ampakine ... Read More »
» Published in Am J Respir Crit Care Med. 2006 Dec 15;174(12):1384-91. Epub 2006 Sep 14.
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