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Aphasia
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1. Pharmacotherapy of aphasia: Myth or reality?
Match Strength: 10.815

Pharmacotherapy of aphasia had been discussed for the last twenty years with first bromocriptine and amphetamine and then serotoninergic, GABAergic and cholinergic agents. Here, we reviewed the MEDLINE available reports of drug therapy for aphasia. So far, proofs of efficiency were found indubitable for none of the studied molecules. However, some of them showed limited efficiency (piracetam and amphetamine). Moreover, drug therapies for aphasia were less efficient alone than when they were associated with speech therapy ... Read More »
» Published in Brain Lang. 2006 Sep 16;

2. Loss and hope: strategies for coping with aphasia.
Match Strength: 10.149

Speaking from almost 30 years of experience living with aphasia, the author offers suggestions for health care professionals who relate to persons with this disorder. Persons with aphasia should be involved in meaningful activities, learn to accept limitations, build trusting relationships, strengthen social support, and find tools that facilitate communication ... Read More »
» Published in Top Stroke Rehabil. 2006 Summer;13(3):84-6.

3. Different patterns of Mini Mental Status Examination responses in primary progressive aphasia and Alzheimer's disease.
Match Strength: 5.639

Primary progressive aphasia (PPA) syndrome is frequently misdiagnosed--particularly in favour of Alzheimer's disease (AD). Misdiagnosis is related to the heterogeneity of language disorders at onset, variability in the rate of clinical progression and the low prevalence of PPA syndrome, compared with AD. The aim of this study was to determine whether a patient's first Mini Mental Status Examination (MMSE) might provide insight into differentiating between PPA and AD. We compared item scores for the first, complete MMSE in consecutive patients with PPA versus matched patients with AD. Word ... Read More »
» Published in Eur J Neurol. 2006 Oct;13(10):1124-7.

4. A study of syntactic processing in aphasia II: Neurological aspects.
Match Strength: 5.089

This paper presents the results of a study of the effects of left hemisphere strokes on syntactically-based comprehension in aphasic patients. We studied 42 patients with aphasia secondary to left hemisphere strokes and 25 control subjects for the ability to assign and interpret three syntactic structures (passives, object extracted relative clauses, and reflexive pronouns) in enactment, sentence-picture matching and grammaticality judgment tasks. We measured accuracy, RT and self-paced listening times in SPM and GJ. We obtained magnetic resonance (MR) and 5-deoxyglucose positron emission ... Read More »
» Published in Brain Lang. 2006 Sep 22;

5. A study of syntactic processing in aphasia I: Behavioral (psycholinguistic) aspects.
Match Strength: 4.345

This paper presents the results of a study of syntactically based comprehension in aphasic patients. We studied 42 patients with aphasia secondary to left hemisphere strokes and 25 control participants. We measured off-line, end-of-sentence, performance (accuracy and reaction time) in two tasks that require comprehension-enactment and sentence-picture matching-and in grammaticality judgment, with whole sentence auditory presentation. We also used sentence-picture matching and grammaticality judgment as tasks in two self-paced listening studies with the same patients to measure on-line ... Read More »
» Published in Brain Lang. 2006 Sep 22;

6. The validity of the repeatable battery of neuropsychological status in acute stroke.
Match Strength: 2.821

The construct validity of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was investigated in a sample of 210 acute ischemic stroke patients seen on an inpatient rehabilitation unit. Intercorrelations between the six index scores were found to be relatively consistent with previously published work. A principal components analysis yielded a two-factor (Language/Verbal Memory and Visuospatial/Visual Memory) solution that accounted for 61% of the variance. Correlations generated between the resulting factor scores, the Controlled Oral Word Association Test (COWA), ... Read More »
» Published in Clin Neuropsychol. 2006 Dec;20(4):702-15.

7. Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage.
Match Strength: 2.739

The efficacy and safety of fasudil hydrochloride, a novel protein kinase inhibitor, were evaluated for the treatment of cerebral vasospasm and associated cerebral ischemic symptoms in patients with ruptured cerebral aneurysm. This randomized open trial with nimodipine as the control included 72 patients who underwent subarachnoid hemorrhage surgery for ruptured cerebral aneurysm of Hunt and Hess grades I to IV. For 14 days following surgery, patients were administered either 30 mg of fasudil hydrochloride by intravenous injection over a period of 30 minutes three times a day or 1 mg/hr of ... Read More »
» Published in Neurol Med Chir (Tokyo). 2006 Sep;46(9):421-8.

8. Traces of vocabulary acquisition in the brain: Evidence from covert object naming.
Match Strength: 2.583

One of the strongest predictors of the speed with which adults can name a pictured object is the age at which the object and its name are first learned. Age of acquisition also predicts the retention or loss of individual words following brain damage in conditions like aphasia and Alzheimer's disease. Functional Magnetic Resonance Imaging (fMRI) was used to reveal brain areas differentially involved in naming objects with early or late acquired names. A baseline task involved passive viewing of non-objects. The comparison between the silent object naming conditions (early and late) with ... Read More »
» Published in Neuroimage. 2006 Nov 15;33(3):958-68. Epub 2006 Sep 20.

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