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Aortic Valve Stenosis
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1. Acute improvement in myocardial function assessed by myocardial strain and strain rate after aortic valve replacement for aortic stenosis.
Match Strength: 13.373

OBJECTIVES: We investigated whether Doppler tissue imaging (tissue velocity, strain, and strain rate) could be useful to detect subtle left ventricular (LV) dysfunction in patients with aortic stenosis and changes in regional myocardial function after aortic valve replacement (AVR). METHODS: We studied 34 patients (age 69.2 +/- 10.4 years) with severe aortic stenosis, 21 of whom underwent AVR. Tissue velocity, systolic strain, strain rate, time to peak strain, and time to peak systolic and diastolic strain rates of basal and midsegments were measured in the apical 4-, 3-, and 2-chamber views ... Read More »
» Published in J Am Soc Echocardiogr. 2006 Oct;19(10):1238-44.

2. Analysis and study of the variation of splitting in the second heartbeat sound of wavelet transform.
Match Strength: 13.331

The second heart sound, S2, consists of two acoustic components, A2 and P2. The former is due to the closure of the aortic valve and the latter is due to the closure of the pulmonary valve. The aortic valve usually closes before the pulmonary valve, introducing a time delay known as the 'split'. A technique based on discrete wavelet transform (DWT) and continuous wavelet transform (CWT) is developed in this paper to measure the split. To quantify splitting, two components in S2 (i.e. A2 and P2) are identified, and the delay between the two components can be estimated. One normal case and three ... Read More »
» Published in J Med Eng Technol. 2006 Sep-Oct;30(5):298-305.

3. Intravalvular implantation technique for a modified Bentall's procedure in aortitis syndrome.
Match Strength: 11.993

Surgical treatments of aortic root involvement in aortitis syndrome are frequently complicated by valve detachment and pseudoaneurysmal formation during active inflammation. A 40-year-old woman with aortitis syndrome complicating the ascending aortic aneurysm, severe aortic regurgitation (AR), and left coronary ostial stenosis was successfully treated by aortic root replacement and concomitant coronary artery bypass grafting (CABG) during acute inflammation. We devised an intravalvular implantation between the fragile aortic annulus and Teflon felt to a modified Bentall's procedure, which ... Read More »
» Published in Ann Thorac Cardiovasc Surg. 2006 Aug;12(4):290-2.

4. Apicoaortic valved conduit: potential for progress?
Match Strength: 10.774

OBJECTIVE: The number of elderly patients who require aortic valve replacement is growing, as is the increase of complicating factors, such as previous coronary bypass grafting and atherosclerotic disease of the ascending aorta. An uncommon surgical option to aortic valve replacement is the apicoaortic valved conduit. In this article the techniques and outcomes of 13 cases of apicoaortic valved conduit insertions in high-risk patients are described. METHODS: From 2002 through 2005, 13 patients (mean age, 75 +/- 8.7 years; 8 men) with severe calcific aortic stenosis had insertions of an ... Read More »
» Published in J Thorac Cardiovasc Surg. 2006 Oct;132(4):796-801.

5. Correlations with operative anatomy of real time three-dimensional echocardiographic imaging of congenital aortic valvar stenosis.
Match Strength: 8.891

OBJECTIVE: To define the anatomic characteristics of the congenitally malformed and severely stenotic aortic valve using trans-thoracic real time three-dimensional echocardiography, and to compare and contrast this with the valvar morphology as seen at surgery. DESIGN: Prospective cross-sectional observational study. SETTING: Tertiary centre for paediatric cardiology. METHODS: All patients requiring aortic valvotomy between December 2003 and July 2004 were evaluated prior to surgery with three-dimensional echocardiography. Full volume loop images were acquired using the Phillips Sonos 7500 ... Read More »
» Published in Cardiol Young. 2006 Oct;16(5):490-4.

6. Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis.
Match Strength: 8.104

The avascularity of cardiac valves is abrogated in several valvular heart diseases (VHDs). This study investigated the molecular mechanisms underlying valvular avascularity and its correlation with VHD. Chondromodulin-I, an antiangiogenic factor isolated from cartilage, is abundantly expressed in cardiac valves. Gene targeting of chondromodulin-I resulted in enhanced Vegf-A expression, angiogenesis, lipid deposition and calcification in the cardiac valves of aged mice. Echocardiography showed aortic valve thickening, calcification and turbulent flow, indicative of early changes in aortic ... Read More »
» Published in Nat Med. 2006 Oct;12(10):1151-9. Epub 2006 Sep 17. Comment in: Nat Med. 2006 Oct;12(10):1118-9.

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