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Peer Reviewed Scientific Research Reports.
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1. Abnormal personality and the mood and anxiety disorders: Implications for structural models of anxiety and depression.
Match Strength: 10.961
Substantial overlap exists between the mood and anxiety disorders. Previous research has suggested that their comorbidity can be explained by a shared factor (negative emotionality), but that they may also be distinguished by other unique components. The current study explicated these relations using an abnormal personality framework. Current diagnoses of major depression and several anxiety disorders were assessed in 563 Gulf War veterans. Participants also completed the schedule for nonadaptive and adaptive personality (SNAP) to determine how these disorders relate to abnormal personality ... Read More »
» Published in J Anxiety Disord. 2006 Sep 13;
2. Somatic symptoms in children and adolescents with anxiety disorders.
Match Strength: 10.783
OBJECTIVE: To evaluate the prevalence of somatic symptoms (SSs) in children and adolescents with anxiety disorders; the relationship between SSs and anxiety severity, impairment, and child global functioning; and the impact of fluvoxamine (FLV) versus pill placebo (PBO) on reducing SSs. METHOD: As part of a double-blind, placebo-controlled trial, 128 children (mean age, 10.8 years; range, 6-17) with DSM-IV anxiety disorders (i.e., social, separation, and generalized anxiety) were assessed by expert clinicians on 16 SSs using the Pediatric Anxiety Rating Scale. RESULTS: The most common SSs at ... Read More »
» Published in J Am Acad Child Adolesc Psychiatry. 2006 Oct;45(10):1179-87.
3. The association of insomnia with anxiety disorders and depression: exploration of the direction of risk.
Match Strength: 10.241
The purpose of this study is to explore the direction of the association between insomnia and anxiety disorders and major depression among a community-based sample of adolescents to better understand their potential etiologic relationships. Data come from a community-based sample of 1,014 youth aged 13-16. Structured interviews were conducted to assess DSM-IV diagnoses. Retrospectively reported ages of onset were used in Proportional Hazards models to estimate increased risk of one disorder associated with prior onset of the others. The lifetime associations of DSM-IV insomnia with each ... Read More »
» Published in J Psychiatr Res. 2006 Dec;40(8):700-8. Epub 2006 Sep 15.
4. Prevalence and incidence studies of anxiety disorders: a systematic review of the literature.
Match Strength: 9.928
OBJECTIVE: To present the results of a systematic review of literature published between 1980 and 2004 reporting findings of the prevalence and incidence of anxiety disorders in the general population. METHOD: A literature search of epidemiologic studies of anxiety disorders was conducted, using Medline and HealthSTAR databases, canvassing English-language publications. Eligible publications were restricted to studies that examined age ranges covering the adult population. A set of predetermined inclusion and exclusion criteria were used to identify relevant studies. Prevalence and incidence ... Read More »
» Published in Can J Psychiatry. 2006 Feb;51(2):100-13. Comment in: Evid Based Ment Health. 2006 Nov;9(4):115.
5. A functional analysis of danger and safety signals in anxiety disorders.
Match Strength: 8.397
Research in experimental psychopathology indicates that predictability and controllability of threatening events mediate the development, maintenance, and modification of anxiety disorders. We propose that a more thorough analysis of predictability and controllability requires the explication of danger and safety, and those events that provide such signal functions. Although most research is concerned with the identification of signals that predict danger, relatively little attention has been given to the identification of signals that predict safety. The current manuscript outlines the ... Read More »
» Published in Clin Psychol Rev. 2007 Jan;27(1):114-26. Epub 2006 Sep 25.
6. Concurrent validity of the Geriatric Anxiety Inventory in late-life depression.
Match Strength: 8.131
The Geriatric Anxiety Inventory (GAI) is a newly developed instrument specifically designed to measure common symptoms of anxiety in older adults (Pachana et al., 2006). It contains 20 items with a dichotomous response format "agree/disagree". The GAI can be self-rating or administered by a trained health professional. Pachana et al. reported the GAI to have sound psychometric properties in both normal older people and in a sample of geriatric psychiatry patients. The geriatric psychiatry patients consisted of 46 older people attending a community geriatric psychiatric service and were free of ... Read More »
» Published in Int Psychogeriatr. 2006 Sep 28;:1-3
7. Epidemiological Associations between Gambling Behavior, Substance Use & Mood and Anxiety Disorders.
Match Strength: 7.833
OBJECTIVE: To compare gambling behaviors in a random sample of community residents with and without mental disorders identified by the Composite International Diagnostic Interview (CIDI). METHOD: A large national community survey conducted by Statistics Canada included questions about problems arising from gambling activities as per the Canadian Problem Gambling Index (CPGI). We compared respondents within three gambling severity categories (non-problem, low severity and moderate/high severity gambling) across three diagnostic groupings (mood/anxiety disorders, substance dependence/harmful ... Read More »
» Published in J Gambl Stud. 2006 Fall;22(3):275-87.
8. Defining response and remission in anxiety disorders: toward an integrated approach.
Match Strength: 7.827
Response and remission rates are commonly used to evaluate the efficacy of treatments for anxiety disorders and other psychiatric illnesses. Response is generally regarded as a clinically meaningful improvement in symptoms, while remission, the goal of treatment, is generally thought of as the absence or near absence of symptoms following illness, accompanied by a return to premorbid levels of functioning. Response and remission are often defined using psychiatric rating scales, based on score cutoffs or the magnitude of score changes from baseline. While no universally accepted criteria exist ... Read More »
» Published in CNS Spectr. 2006 Oct;11(10 Suppl 12):21-8.
9. Anxious-depressive comorbidity: effects on HPA axis and CNS noradrenergic functions.
Match Strength: 7.810
Psychiatric comorbidity is all too common. An important example is the high comorbidity frequency of depressive and anxiety disorders, 25%-50%, much higher than the 5% or less expected by chance. Possible reasons for this comorbidity include definitional, environmental, and biological factors. Few previous studies have assessed, with proper methodology, potential biological changes associated with this co-occurrence. We assessed both hypothalamic-pituitary-adrenocortical axis (HPA) responses to the Trier Social Stress Test and growth hormone (GH) responses to clonidine, a centrally active ... Read More »
» Published in Essent Psychopharmacol. 2006;7(1):24-34.
10. Clinicians on the front line: active management of depression and anxiety in primary care.
Match Strength: 7.005
Primary-care practitioners confront myriad issue in managing their patients with depression and/or anxiety. Understanding the scope and epidemiology of these disorders is essential to understanding their shared characteristics. Do we always recognize these patients in practice? What are the barriers to diagnosis and treatment, and how can they overcome? What are the treatment options of these sometimes life-altering conditions, and how do we choose from among the many that exist? Publication Types: Case Reports, ... Read More »
» Published in JAAPA. 2006 Jul;Suppl:4-21; quiz 22.
11. Client similarities and differences in two childhood anxiety disorders research clinics.
Match Strength: 6.831
Some evidence suggests that research and service clinics differ on treatment-relevant dimensions, but no study has examined whether research clinics (RCs) themselves differ. We compared 2 samples of children and adolescents (ages 7 to 17 years) with anxiety disorders treated in 2 different university-based child anxiety RCs, one in Philadelphia (n = 184) and one in Miami (n = 64), on child symptom and diagnostic measures, family characteristics (e.g., income), and level of maternal depression. The samples were not significantly different on any youth symptom and diagnostic measures except 1 ... Read More »
» Published in J Clin Child Adolesc Psychol. 2006 Dec;35(4):528-38.
12. Emotion recognition patterns in patients with panic disorder.
Match Strength: 6.375
Recognition of facially expressed emotions is essential in social interaction. For patients with social phobia, general anxiety disorders, and comorbid anxiety, deficits in their emotion recognition and specific biases have already been reported. This is the first study to investigate facial emotion recognition patterns in patients with panic disorder [PD]. We assumed a general performance deficit in patients with PD. Exploratory analyses should have revealed recognition patterns and specific types of errors. Additionally, we checked the influence of depression and anxiety symptoms, per se, on ... Read More »
» Published in Depress Anxiety. 2006 Sep 14;
13. Common mental disorders in the workforce: recent findings from descriptive and social epidemiology.
Match Strength: 6.200
OBJECTIVE: To review the recent descriptive and social epidemiology of common mental disorders in the workplace, including prevalence, participation, work disability, and impact of quality of work, as well as to discuss the implications for identifying targets for clinical and preventive interventions. METHOD: We conducted a structured review of epidemiologic studies in community settings (that is, in the general population or in workplaces). Evidence was restricted to the peer-reviewed, published, English-language literature up to the end of June 2005. We further restricted evidence to ... Read More »
» Published in Can J Psychiatry. 2006 Feb;51(2):63-75. Comment in: Can J Psychiatry. 2006 Feb;51(2):61-2.
14. Persistent tobacco use during pregnancy and the likelihood of psychiatric disorders.
Match Strength: 6.181
OBJECTIVES: We examined the association between psychiatric disorders and tobacco use during pregnancy. METHODS: Data were derived from a population-based cohort of 744 pregnant African American and White low-income women living in urban and rural areas. The Diagnostic Interview Schedule was used to assess women for 20 different psychiatric disorders. RESULTS: In comparison with nonusers, persistent tobacco users (women who had used tobacco after confirmation of their pregnancy) and nonpersistent users (women who had used tobacco but not after pregnancy confirmation) were 2.5 and 2 times as ... Read More »
» Published in Am J Public Health. 2006 Oct;96(10):1799-807.
15. Cellular and molecular alterations in mice with deficient and reduced serotonin transporters.
Match Strength: 5.098
The function of serotonin transporters (SERTs) is related to mood regulation. Mice with defi- cient or reduced SERT function (SERT knockout mice) show several behavioral changes, including increased anxiety-like behavior, increased sensitivity to stress, and decreases in aggressive behavior. Some of these behavioral alterations are similar to phenotypes found in humans with short alleles of polymorphism in the 5-hydroxytryptamine (5-HT) transporter-linked promoter region (5-HTTLPR). Therefore, SERT knockout mice can be used as a tool to study 5-HTTLPRrelated variations in personality and may ... Read More »
» Published in Mol Neurobiol. 2006 Aug;34(1-2):51-66.
16. Activation, internalization, and recycling of the serotonin 2A receptor by dopamine.
Match Strength: 4.590
Serotonergic and dopaminergic systems, and their functional interactions, have been implicated in the pathophysiology of various CNS disorders. Here, we use recombinant serotonin (5-HT) 2A (5-HT2A) receptors to further investigate direct interactions between dopamine and 5-HT receptors. Previous studies in Xenopus oocytes showed that dopamine, although not the cognate ligand for the 5-HT2A receptor, acts as a partial-efficacy agonist. At micromolar concentrations, dopamine also acts as a partial-efficacy agonist on 5-HT2A receptors in HEK293 cells. Like 5-HT, dopamine also induces receptor ... Read More »
» Published in Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15248-53. Epub 2006 Sep 27.
17. Sleep deprivation as a neurobiologic and physiologic stressor: Allostasis and allostatic load.
Match Strength: 4.465
Sleep has important homeostatic functions, and sleep deprivation is a stressor that has consequences for the brain, as well as many body systems. Whether sleep deprivation is due to anxiety, depression, or a hectic lifestyle, there are consequences of chronic sleep deprivation that impair brain functions and contribute to allostatic load throughout the body. Allostatic load refers to the cumulative wear and tear on body systems caused by too much stress and/or inefficient management of the systems that promote adaptation through allostasis. Chronic sleep deprivation in young healthy volunteers ... Read More »
» Published in Metabolism. 2006 Oct;55(10 Suppl 2):S20-3.
18. Cognitive-behavioral therapy for PANDAS-related obsessive-compulsive disorder: findings from a preliminary waitlist controlled open trial.
Match Strength: 4.382
OBJECTIVE: To provide preliminary estimates of the effectiveness of cognitive-behavioral therapy (CBT) in treating pediatric obsessive-compulsive disorder (OCD) of the pediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS) subtype. METHOD: Seven children with OCD of the PANDAS subtype (range 9-13 years) were treated in a 3-week intensive CBT program conducted at a university clinic. Six of seven children were taking selective serotonin reuptake inhibitor medication(s) upon presentation. Assessments were conducted at four time points: baseline, pretreatment ... Read More »
» Published in J Am Acad Child Adolesc Psychiatry. 2006 Oct;45(10):1171-8.
19. From systems biology to dynamical neuropharmacology: proposal for a new methodology.
Match Strength: 4.232
The concepts and methods of systems biology are extended to neuropharmacology in order to test and design drugs for the treatment of neurological and psychiatric disorders. Computational modelling by integrating compartmental neural modelling techniques and detailed kinetic descriptions of pharmacological modulation of transmitter-receptor interaction is offered as a method to test the electrophysiological and behavioural effects of putative drugs. Even more, an inverse method is suggested as a method for controlling a neural system to realise a prescribed temporal pattern. In particular, as ... Read More »
» Published in Syst Biol (Stevenage). 2006 Jul;153(4):299-308.
20. Dimensions underlying outcome criteria in bipolar I disorder.
Match Strength: 4.117
OBJECTIVE: Various subjective and objective criteria are used to assess outcome in bipolar disorder. In this study, we explored to what extent they reflect distinct categories and whether underlying dimensions can be identified. PATIENTS AND METHODS: One-hundred and twenty-one subjects with at least three episodes of bipolar I disorder (DSM-IV) were assessed on average 4.8 years after hospitalization. We assessed 14 variables reflecting different outcome criteria including subjective quality of life (SQOL), self-rated and observer-rated psychopathology, and functioning and disability. A ... Read More »
» Published in J Affect Disord. 2006 Sep 20;
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