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Anoxic Encephalopathy
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1. Follow-up of neuropsychological function recovery in a 9-year-old girl with anoxic encephalopathy: a window on the brain re-organization processes.
Match Strength: 12.320

OBJECTIVE: To investigate comprehensive neuropsychological outcome, disabilities in daily life and individual recovery processes in a case of anoxic encephalopathy. DESIGN: A 9-year-old child's functional outcome after anoxic coma was evaluated in a follow-up study with assessments at 5, 9 and 12 months post-injury. A comprehensive neuropsychological protocol was administered. Qualitative methods of analysis and ecological observation were associated with standard and non-standard quantitative measures. RESULTS: The child presented pervasive functional deficits with prevalence of gnosic, ... Read More »
» Published in Brain Inj. 2005 May;19(5):371-88.

2. Secondary mania in a patient with delayed anoxic encephalopathy after carbon monoxide intoxication.
Match Strength: 11.239

Mania is a rare clinical manifestation of delayed anoxic encephalopathy (DAE). Prior case reports on mania after hypoxic injury involved patients with a previous history of mania or depression, potentially reflecting a recurrence of premorbid mood disorders after hypoxia rather than pure secondary mania. Herein, we report a 55-year-old woman with no past history of neurological or psychiatric illness, who developed mania as a symptom of DAE after carbon monoxide intoxication. Brain magnetic resonance imaging showed diffuse white matter lesions, particularly visible in the frontal white matter. ... Read More »
» Published in J Clin Neurosci. 2006 Oct;13(8):860-2. Epub 2006 Aug 28.

3. Rapid recovery from coma with multifocal PLEDs in a patient with severe dementia and transient hypoxemia.
Match Strength: 10.518

We report a patient with severe dementia who acutely developed transient coma following possible acute anoxic encephalopathy, and presented multifocal periodic lateralized epileptiform discharges (PLEDs) on EEG, who had a good recovery from the acute state. Two EEGs were recorded from this patient. In the first EEG taken immediately after admission, multifocal PLEDs were prominent, and the background activity consisted of low voltage, continuous and irregular theta activity (4-6 Hz). The patient recovered from coma (GCS-3) to the conscious state (GCS-15) within 14 hours and was not associated ... Read More »
» Published in Intern Med. 2006;45(13):823-6. Epub 2006 Aug 1.

4. Acute stimulus-sensitive postanoxic myoclonus: description of a case.
Match Strength: 10.497

We describe the clinical and electroencephalographic features of a comatose patient with severe anoxic encephalopathy who experienced acute reflex myoclonus precipitated by passive eye opening/closure and painful stimulation. Acute stimulus-sensitive postanoxic myoclonus is an underdiagnosed epileptic condition. Shortly after the anoxic insult, the diagnosis should be based on EEG evaluation and various types of stimulation. These should include passive eye opening/closure and painful stimuli. Publication Types: Case ... Read More »
» Published in Clin EEG Neurosci. 2005 Jul;36(3):199-201.

5. Predicting coma and other low responsive patients outcome using event-related brain potentials: A meta-analysis.
Match Strength: 10.150

OBJECTIVE: A meta-analysis was performed to estimate the predictive power (odd ratio, OR) for awakening of auditory event-related potential (ERP) components in low responsive patients with stroke or hemorrhage, trauma, anoxic, post-operative, and metabolic encephalopathy etiologies. METHODS: We reviewed MEDLINE and analyzed citations for retrieved articles. Logistic regressions were applied on patient samples (Glasgow Coma Scale <12) across and for separate etiologies. RESULTS: For stroke and hemorrhage the ORs with 95% confidence intervals were: 2.05 [1.12-3.75] (N100), 4.47 [1.92-10.44] ... Read More »
» Published in Clin Neurophysiol. 2007 Jan 4;

6. Predicting coma and other low responsive patients outcome using event-related brain potentials: A meta-analysis.
Match Strength: 10.150

OBJECTIVE: A meta-analysis was performed to estimate the predictive power (odd ratio, OR) for awakening of auditory event-related potential (ERP) components in low responsive patients with stroke or hemorrhage, trauma, anoxic, post-operative, and metabolic encephalopathy etiologies. METHODS: We reviewed MEDLINE and analyzed citations for retrieved articles. Logistic regressions were applied on patient samples (Glasgow Coma Scale <12) across and for separate etiologies. RESULTS: For stroke and hemorrhage the ORs with 95% confidence intervals were: 2.05 [1.12-3.75] (N100), 4.47 [1.92-10.44] ... Read More »
» Published in Clin Neurophysiol. 2007 Jan 4;

7. Mortality after a first episode of status epilepticus in the United States and Europe.
Match Strength: 9.656

OBJECTIVE: In the last decade several studies have been published on incidence, etiology, and prognosis of status epilepticus (SE) with population-based data from the United States and Europe. The aim of this review is to summarize the available information on the epidemiology of SE and to outline the sources of the variability in reported mortality after SE. METHODS: Comparison of mortality studies in SE from the United States and Europe. RESULTS: The incidence of SE is lower in Europe (9.9-15.8/10,000) than in the United States (18.3-41/100,000). The overall mortality after SE is similar in ... Read More »
» Published in Epilepsia. 2005;46 Suppl 11:46-8.

8. State of the art of magnetic resonance (MR) in neonatal hypoxic-ischemic encephalopathy.
Match Strength: 8.319

Magnetic resonance (MR) has begun to play an important role in neonatal neurology. Several MRI techniques have been applied to the diagnosis of hypoxic ischemic encephalopathy. Cerebral perfusion examined by intravoxel incoherent motion, a non-invasive tool, seems to be opening new inroads for detecting variations (neurophysiological modifications) in cerebral flows during hypoxic ischemic encephalopathy. MR spectroscopy allows identification of specific biochemical alteration of spectra patterns at various moments of hypoxic ischemic distress, including: (1) primary expression of metabolic ... Read More »
» Published in Childs Nerv Syst. 1989 Dec;5(6):350-5.

9. Hypoalbuminemia Is a Poor Predictor of Survival After Percutaneous Endoscopic Gastrostomy in Elderly Patients with Dementia
Match Strength: 7.819

OBJECTIVE: Percutaneous endoscopic gastrostomy (PEG) is widely used for long-term enteral nutrition in patients with dementia and inadequate oral intake, although its benefit in prolonging the survival of the patient is not clear. Patients are often referred for PEG placement after a significant weight loss or fall in serum albumin. It is not known whether this delay in referral adversely affects the survival. Our aim was to determine the survival after PEG placement in patients with inadequate oral intake secondary to cognitive impairment and to determine whether-the nutritional parameters at ... Read More »
» Published in Am J Gastroenterol. 2000 Jan;95(1):133-6.

10. Acute lymphoblastic leukemia presenting in fulminant hepatic failure.
Match Strength: 7.061

A previously healthy 4-year-old boy was admitted because of acute liver failure. He was icteric, lethargic, had elevated ammonia and abnormal liver function tests. Serology was negative for viral hepatitis. There was no history of hepatotoxic drugs. Family history was unremarkable. The child was taken to the operating room for a living-related hepatic transplant. Frozen section showed massive hepatic leukemic infiltration and hepatocellular necrosis. Bone marrow aspiration confirmed the diagnosis of acute lymphoblastic leukemia (ALL). Transplant was withheld and chemotherapy was attempted. He ... Read More »
» Published in Pediatr Blood Cancer. 2006 Nov;47(6):842-5.

11. Changes in intracranial pressure associated with chest physiotherapy.
Match Strength: 6.758

INTRODUCTION: Management of intracranial hypertension is pivotal in the care of brain-injured patients. We report the case of a patient with both a closed head injury and anoxic encephalopathy, who subsequently experienced episodes of refractory intracranial hypertension. The patient's care was complicated by the development of a pneumonia, which required frequent turning of the patient and chest physiotherapy. Conventional wisdom suggests that these interventions may stimulate the patient and worsen intracranial pressure, and therefore should be avoided. RESULTS: Our observations on this ... Read More »
» Published in Neurocrit Care. 2007;6(2):100-3.

12. Myoclonic status in nonprogressive encephalopathies: study of 29 cases.
Match Strength: 6.547

Purpose: Myoclonic status in nonprogressive encephalopaties (MSNE) is characterized by recurrence of long-lasting myoclonic status appearing in infants and young children with nonprogressive encephalopathy. Here, we describe the electroclinical features and evolution of MSNE. Methods: Between February 1, 1990 and July 31, 2005, 29 patients who met diagnostic criteria of MSNE were enrolled in the study at our department and have been followed up to the present time. Results: Three main subgroups could be identified. The first subgroup of 18 patients presented myoclonic absences and rhythmic ... Read More »
» Published in Epilepsia. 2007 Jan;48(1):107-13.

13. Vascular dementia: potential of antiplatelet agents in prevention.
Match Strength: 6.415

The term 'vascular dementia' (VaD) corresponds to a clinicoradiological syndrome that can be defined with more or less restriction. VaD can result from: (1) cortical or subcortical ischemic lesions related to the occlusion of large vessels, (2) lacunar infarcts with or without white-matter lesions at the subcortical level related to small-vessel diseases, (3) ischemic lesions related to hypoperfusion or anoxic-ischemic encephalopathy or (4) hemorrhagic lesions. The prevention of VaD is based on stroke prevention which implies risk factor manipulation and use of antithrombotic drugs among which ... Read More »
» Published in Eur Neurol. 2006;55(2):61-9. Epub 2006 Mar 10.

14. Life-threatening bradyarrhythmia after massive azithromycin overdose.
Match Strength: 6.275

9-month-old infant was inadvertently administered azithromycin 50 mg/kg, taken from floor stock, instead of the prescribed ceftriaxone. Shortly thereafter, she became unresponsive and pulseless. The initial heart rhythm observed when cardiopulmonary resuscitation was started was a widecomplex bradycardia, with a prolonged rate-corrected QT interval and complete heart block. The baby was resuscitated with epinephrine and atropine, but she suffered severe anoxic encephalopathy. Torsade de pointes and QT-interval prolongation have been reported after administration of macrolide antibiotics, ... Read More »
» Published in Pharmacotherapy. 2006 Jan;26(1):147-50.

15. Symptomatic myoclonus.
Match Strength: 5.884

A huge number of neurological disorders are associated with myoclonus. This paper describes these disorders whose diagnosis partly relies on the presence of myoclonus. The diagnostic approach is related to certain clinical features of myoclonus, which, after their integration in the clinical context, help orientate towards diagnosis. Myoclonus is frequent during dementia. Although its presence is well-known to take part in the diagnosis of Creutzfeldt-Jakob disease (CJD), myoclonus can also be present to a significant degree in Alzheimer's disease and Lewy body dementia (LBD), which raises a ... Read More »
» Published in Neurophysiol Clin. 2006 Sep-Dec;36(5-6):309-18. Epub 2007 Jan 17.

16. Unusually rapid and severe cognitive deterioration after mild traumatic brain injury.
Match Strength: 5.795

A 56-year-old man (AB) presented with dramatic cognitive deterioration following a mild traumatic brain injury. There was no indication of severe brain injury or significant anoxic encephalopathy. Detailed history indicated no significant pre-morbid cognitive deficits. His pre-injury psychosocial and occupational functioning was intact. Cognition functioning was impaired immediately post-injury and remained impaired. Neuropsychological examination at 8 months post-injury showed severe cognitive deficits. The cognitive profile was consistent with Alzheimer's disease. MRI at 1-year post-injury ... Read More »
» Published in Brain Inj. 2005 Dec 20;19(14):1269-76.

17. Comparison of management patterns and clinical outcomes in patients with atrial fibrillation in Canada and the United States (from the analysis of the Atrial Fibrillation Follow-up Investigation of Rhythm Management [AFFIRM] database).
Match Strength: 5.375

Little is known about differences in practice patterns or outcomes in the management of patients who have atrial fibrillation in Canada compared with those in the United States (US). We evaluated the effect that the country of enrollment may have on the management patterns and clinical outcomes in patients who participated in the AFFIRM study. Three thousand four hundred patients came from the US and 660 from Canada. In the US, patients were more likely to have a history of coronary artery disease (39% vs 35%, p = 0.03), hypertension (72% vs 67%, p = 0.01), or congestive heart failure (24% vs ... Read More »
» Published in Am J Cardiol. 2005 Sep 15;96(6):815-21.

18. Patterns of damage in the mature neonatal brain.
Match Strength: 5.346

Patterns of damage in the mature neonatal brain can be subdivided into focal, multifocal and diffuse. The main cause of diffuse brain damage in the term newborn is hypoxic-ischaemic encephalopathy (HIE). HIE is still the major recognized perinatal cause of neurological morbidity in full-term newborns. MRI offers today the highest sensitivity in detecting acute anoxic injury of the neonatal brain. Conventional acquisition techniques together with modern diffusion techniques can identify typical patterns of HIE injury, even in the early course of the disease. However, even though highly ... Read More »
» Published in Pediatr Radiol. 2006 May 18;

19. Impact of treatment on the short-term prognosis of status epilepticus in two population-based cohorts.
Match Strength: 5.312

PURPOSE : Epidemiological surveys on status epilepticus (SE) in adults in two Italian areas (Bologna and Lugo di Romagna) disclosed a major difference in 30-day case fatality (33% versus 7 %). Since suboptimal management was hypothesised in the first site, we compared the quality of treatment in the two cohorts and examined its contribution to prognosis. METHODS : The Bologna and Lugo di Romagna cohorts of adults with incident SE were included. Patients with post-anoxic encephalopathy were excluded. Quality of treatment was independently classified by two experts. Clinical and treatment ... Read More »
» Published in J Neurol. 2008 Jan 23

20. Patterns of damage in the mature neonatal brain.
Match Strength: 5.279

Patterns of damage in the mature neonatal brain can be subdivided into focal, multifocal and diffuse. The main cause of diffuse brain damage in the term newborn is hypoxic-ischaemic encephalopathy (HIE). HIE is still the major recognized perinatal cause of neurological morbidity in full-term newborns. MRI offers today the highest sensitivity in detecting acute anoxic injury of the neonatal brain. Conventional acquisition techniques together with modern diffusion techniques can identify typical patterns of HIE injury, even in the early course of the disease. However, even though highly ... Read More »
» Published in Pediatr Radiol. 2006 Jul;36(7):608-20. Epub 2006 May 18.

21. Endoscopic management of early upper gastrointestinal hemorrhage following laparoscopic roux-en-y gastric bypass.
Match Strength: 5.216

BACKGROUND AND AIMS: Upper gastrointestinal hemorrhage (UGIH) is an infrequent complication (1-3.8%) following laparoscopic Roux-en-Y gastric bypass (LRYGB). The safety and efficacy of endoscopic management of immediate postoperative bleeding is unknown. We sought to determine how frequently UGIH complicates LRYGB and whether endoscopic management is successful in controlling hemorrhage. METHODS: Retrospective chart review of all patients who developed UGIH following LRYGB from November 2001 to July 2005 at a large suburban teaching hospital. RESULTS: Of 933 patients who underwent LRYGB, 30 (3 ... Read More »
» Published in Am J Gastroenterol. 2008 Jan;103(1):86-91. Epub 2007 Oct 17.

22. Asymptomatic atrial fibrillation: demographic features and prognostic information from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study.
Match Strength: 5.133

BACKGROUND: Atrial fibrillation (AF) may occur without symptoms. Little is known about demographic features and prognostic information in patients with asymptomatic AF. METHODS: In the AFFIRM study, 4060 patients were randomized to either rhythm or rate control. At baseline, patients were identified as asymptomatic if they answered "no" to a 15-item questionnaire related to cardiac symptoms during AF in the 6 months before study entry. RESULTS: There were 481 (12%) asymptomatic patients at baseline. Compared with symptomatic patients, asymptomatic patients were more often men and had a lower ... Read More »
» Published in Am Heart J. 2005 Apr;149(4):657-63.

23. International differences in end-of-life attitudes in the intensive care unit: results of a survey.
Match Strength: 5.097

BACKGROUND: Important international differences exist in attitudes toward end-of-life issues in the intensive care unit. METHODS: A simple questionnaire survey was sent by e-mail to participants at an international meeting on intensive care medicine. Respondents were asked to choose 1 of 3 to 5 possible answers for each of 4 questions related to the treatment of a hypothetical patient in a vegetative state due to anoxic encephalopathy after cardiac arrest with no family and no advance directives. RESULTS: From 3494 valid addresses, 1961 complete questionnaires (56%) were received from 21 ... Read More »
» Published in Arch Intern Med. 2005 Sep 26;165(17):1970-5.

24. Acute motor and sensory neuronopathy associated with small-cell lung cancer: a clinicopathological study.
Match Strength: 5.038

A 48-year-old Chinese woman developed ascending motor paralysis while visiting Japan, leading to tetraplegia and respiratory failure over 2 weeks. The patient's course was complicated by anoxic encephalopathy. Nerve conduction studies revealed a severely decreased amplitude of compound muscle action potentials and a sural nerve biopsy specimen showed findings consistent with axonal-form Guillain-Barr6 syndrome. An autopsy, excluding the brain, demonstrated small-cell lung cancer that was not detected clinically, axonal-dominant degeneration in the nerve roots and distal peripheral nerves, and ... Read More »
» Published in Neuropathology. 2006 Aug;26(4):329-37.

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