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Peer Reviewed Scientific Research Reports.
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1. Brief review: angiotensin converting enzyme inhibitors and angioedema: anesthetic implications.
Match Strength: 9.067
PURPOSE: Angiotensin converting enzyme inhibitors (ACEIs) are a group of drugs used to treat hypertension and heart failure, with additional benefits, such as cardiovascular and renal protection, in patients with diabetes. However, angioedema as a complication of ACEI therapy is under-recognized. As there are important implications for anesthesiologists and emergency medicine physicians, a review was undertaken to document the scope of the problem of ACEI-induced angioedema.. METHODS: A review of the published literature (identified by searching Medline, EMBASE and CINAHL) was undertaken, ... Read More »
» Published in Can J Anaesth. 2006 Oct;53(10):994-1003.
2. Negative regulation of VEGF-induced vascular leakage by blockade of angiotensin II type 1 receptor.
Match Strength: 3.771
OBJECTIVE: Permeability of blood vessels is essential for tissue homeostasis. However, disorganized hyperpermeability leads to progression of diseases. Vascular endothelial growth factor-A (VEGF) is a key regulator for leakiness of blood vessels and it has been reported that VEGF-mediated hyperpermeability was suppressed by angiopoietin-1 (Ang1). We found that Angiotensin-converting enzyme (ACE) was downregulated in endothelial cells by Ang1. ACE converts angiotensin I to angiotensin II (AII). Here, we studied the relationship between VEGF and AII relative to vascular permeability. METHODS AND ... Read More »
» Published in Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2673-80. Epub 2006 Sep 14.
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