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1. Supernumerary marker chromosomes detected in 100,000 prenatal diagnoses: molecular cytogenetic studies and clinical significance.
Match Strength: 5.171
OBJECTIVE: To evaluate the clinical significance of the supernumerary marker chromosomes (SMCs) detected during prenatal diagnosis. METHODS: We retrospectively studied cytogenetic/fluorescence in situ hybridization (FISH) results and clinical evaluation of 110 marker cases identified from approximately 100,000 cases referred for prenatal diagnosis. The clinical follow-up performed was focused on cases with de novo markers not derived from chromosome 15. RESULTS: Among the 110 SMCs, 79 (71.8%) were de novo, 24 (21.8%) were familial, and the origin was undetermined in 7 cases. Fifty-eight of the ... Read More »
» Published in Prenat Diagn. 2006 Dec;26(12):1142-50.
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