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Peer Reviewed Scientific Research Reports.
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1. Recurrent anemia in kidney transplant recipients with parvovirus B19 infection.
Match Strength: 8.450
Parvovirus B19 (PV B19) infection is known to cause acute anemia in solid organ transplant recipients. Intravenous immunoglobulin combined with reduction of immunosuppression may be of benefit to clear the infection. However, PV B19-associated anemia can be recurrent. We describe three renal transplant recipients with a PV B19 infection. These patients showed recurrent anemia with episodes separated by as much as several months ... Read More »
» Published in Transplant Proc. 2006 Sep;38(7):2321-3.
2. Adjusting i.v. iron and EPO doses in patients on hemodialysis prior to continuing surgery: can we protect our patients education from iron-deficiency anemia?
Match Strength: 7.232
Ongoing blood loss and iron-deficiency anemia are common problems in patients on hemodialysis; therefore, nephrology clinicians are particularly concerned with their patients who are scheduled for surgery Surgery can cause significant blood and iron losses, thereby worsening their preexisting anemia. However, patients on hemodialysis can be effectively treated preoperatively by adjusting their continued doses of intravenous (i.v.) iron and recombinant human erythropoietin (EPO) therapy, based on expected blood and iron losses. This valuable strategy can help improve surgical and anemia ... Read More »
» Published in Nephrol Nurs J. 2006 Jul-Aug;33(4):430-7; quiz 438.
3. Prevalence and treatment of anemia with once-weekly epoetin alfa in patients with diabetes and chronic kidney disease.
Match Strength: 7.012
OBJECTIVE: To describe the characteristics and prevalence of anemia in patients with diabetes and chronic kidney disease (CKD) not receiving dialysis and to evaluate the efficacy and safety of once-weekly (QW) epoetin alfa for the treatment of anemia in these patients. METHODS: Post hoc subset analyses were conducted for 2 studies: a prospective, multicenter survey evaluating the prevalence of anemia in patients with CKD (the Prevalence of Anemia in Early Renal Insufficiency [PAERI] study) and a prospective, multicenter, open-label trial evaluating the efficacy and safety of QW epoetin alfa ... Read More »
» Published in Endocr Pract. 2006 Sep-Oct;12(5):506-13.
4. Ifn/Rbv treatment induced anemia and its correction with epoetin alpha in patients with hepatitis C.
Match Strength: 6.990
The aim of the 18 months follow up study was to assess the frequency of anemia during IFN/RBV therapy in patients with chronic hepatitis C; to manage anemia either with recombinant human erythropoietin (rHuEPO)--epoetin alpha or with RBV dose reduction and to compare the rate of SVR in patients with RBV dose reduction and with administration of epoetin alpha. Study enrolled 61 patients with chronic active hepatitis C aged 33-61 years. All patients had HCV genotype 1b. Out of them 41 were male and 20 female. Anemia (Hb <10 or >2 g/dL Hgb drop from baseline) developed in 41 patients out of ... Read More »
» Published in Georgian Med News. 2006 Aug;(137):62-5.
5. The KDOQI clinical practice guidelines and clinical practice recommendations for treating anemia in patients with chronic kidney disease: implications for nurses.
Match Strength: 5.634
The National Kidney Foundation Kidney Disease Outcomes Quality Initiative recently published revised clinical practice guidelines and recommendations for the treatment of anemia. This article provides an overview of the new guidelines and recommendations, with a focus on the hemoglobin treatment range, iron status, use of erythropoiesis-stimulating agents, and adjuvant therapies. Publication Types: Practice Guideline, Research Support, Non-U.S. Gov ... Read More »
» Published in Nephrol Nurs J. 2006 Jul-Aug;33(4):423-6, 445; quiz 427-8.
6. Nutritional status and anemia in Surui Indian children, Brazilian Amazon.
Match Strength: 5.468
OBJECTIVE: To assess the nutritional status of Surui Indian children aged less than 10 years by means of anthropometric measurements and determination of hemoglobin concentration levels. METHODS: The study was carried out from February to March 2005 in the Sete de Setembro Indian Reservation, located on the boundary between the states of Rondonia and Mato Grosso, Amazonia, Brazil. Height and weight were measured according to standard procedures and then compared with the National Center for Health Statistics reference values (n = 284). Hemoglobin concentration was determined by a portable Beta ... Read More »
» Published in J Pediatr (Rio J). 2006 Sep-Oct;82(5):383-8. Epub 2006 Sep 19.
7. A case of alpha-thalassemia-2 associated with pulmonary infarction.
Match Strength: 5.458
Pulmonary infarction is an entity of medical significance that develops concurrently in beta-thalassemia but not in alpha-thalassemia. The reason for this difference is yet to be elucidated. We have evaluated a 21-year-old male alpha-thalassemia-2 patient who had profound microcytic anemia and pulmonary infarction. Analysis of the alpha-globin gene revealed -alpha3.7/alpha alpha genotype. His mother also had the same heterozygous gene deletion, though she had neither anemia nor pulmonary infarction. Since the patient had no other predisposition to pulmonary infarction, it is suggested that ... Read More »
» Published in Lung. 2006 Jul-Aug;184(4):223-7.
8. Low testosterone and high C-reactive protein concentrations predict low hematocrit in type 2 diabetes.
Match Strength: 5.350
OBJECTIVE: After the demonstration that one-third of male patients with type 2 diabetes have hypogonadotrophic hypogonadism, we have shown that patients with hypogonadotrophic hypogonadism also have markedly elevated C-reactive protein (CRP) concentrations. We have now hypothesized that type 2 diabetic subjects with hypogonadotrophic hypogonadism may have a lower hematocrit because testosterone stimulates, whereas chronic inflammation suppresses, erythropoiesis. RESEARCH DESIGN AND METHODS: Seventy patients with type 2 diabetes at a tertiary referral center were included in this study. RESULTS ... Read More »
» Published in Diabetes Care. 2006 Oct;29(10):2289-94.
9. Intravenous iron alone for the treatment of anemia in patients with chronic heart failure.
Match Strength: 5.148
OBJECTIVES: This study was undertaken to assess the hematologic, clinical, and biochemical response to intravenous iron in patients with chronic heart failure (CHF) and anemia. BACKGROUND: Anemia is common in patients with CHF and is associated with higher morbidity and mortality. The combination of erythropoietin (EPO) and iron increases hemoglobin (Hb) and improves symptoms and exercise capacity in anemic CHF patients. It is not known whether intravenous iron alone is an effective treatment for anemia associated with CHF. METHODS: Sixteen anemic patients (Hb < or =12 g/dl) with stable CHF ... Read More »
» Published in J Am Coll Cardiol. 2006 Sep 19;48(6):1225-7. Epub 2006 Aug 28.
10. Preclinical evaluation of Hematide, a novel erythropoiesis stimulating agent, for the treatment of anemia.
Match Strength: 5.010
OBJECTIVE: To evaluate the preclinical erythropoiesis stimulating properties of Hematide, a novel, PEGylated, synthetic peptide for the treatment of anemia associated with chronic kidney disease and cancer. METHODS: The in vitro activity of Hematide was assessed in competitive binding, proliferation, signal transduction, and apoptosis assays, and in erythroid colony-forming assays with CD34(+) cells purified from human bone marrow. Erythropoiesis and pharmacokinetics were evaluated in rat, monkey, and a rat chronic renal insufficiency (CRI) model following single administration. Erythropoiesis ... Read More »
» Published in Exp Hematol. 2006 Oct;34(10):1303-11.
11. Evidence for downregulation of erythropoietin receptor in bone marrow erythroid cells of patients with chronic idiopathic neutropenia.
Match Strength: 4.696
OBJECTIVE: The aim of this study is to probe the mechanisms underlying anemia in patients with chronic idiopathic neutropenia (CIN) by evaluating parameters of bone marrow (BM) erythropoiesis. PATIENTS AND METHODS: Ten CIN patients fulfilling the criteria of anemia of chronic disease, 27 nonanemic CIN patients, and 30 healthy volunteers were enrolled in the study. Reserves and survival characteristics of BM erythroid cells were evaluated using flow cytometry and clonogenic assays. Serum erythropoietin (EPO) was measured with ELISA. Expression of EPO receptors (EPORs) on BM erythroid cells was ... Read More »
» Published in Exp Hematol. 2006 Oct;34(10):1312-22.
12. Increased plasma transferrin, altered body iron distribution, and microcytic hypochromic anemia in ferrochelatase-deficient mice.
Match Strength: 4.518
Patients with deficiency in ferrochelatase (FECH), the last enzyme of the heme biosynthetic pathway, experience a painful type of skin photosensitivity called erythropoietic protoporphyria (EPP), which is caused by the excessive production of protoporphyrin IX (PPIX) by erythrocytes. Controversial results have been reported regarding hematologic status and iron status of patients with EPP. We thoroughly explored these parameters in Fechm1Pas mutant mice of 3 different genetic backgrounds. FECH deficiency induced microcytic hypochromic anemia without ringed sideroblasts, little or no hemolysis, ... Read More »
» Published in Blood. 2007 Jan 15;109(2):811-8. Epub 2006 Sep 26.
13. Association of necrotizing enterocolitis with elective packed red blood cell transfusions in stable, growing, premature neonates.
Match Strength: 4.292
The purpose of this study was to determine an association between packed red blood cell (PRBC) transfusions for anemia and necrotizing enterocolitis (NEC) in a subset of stable, growing, premature neonates. As part of a survey of current clinical practices over a 17-month period from June 1999 to October 2000, a chart review was performed to determine the relationship between elective PRBC transfusions and the occurrence of NEC. Demographic data were tabulated and compared between the NEC patients with a prior history of immediate blood transfusion (within 48 hours of onset of symptoms) and ... Read More »
» Published in Am J Perinatol. 2006 Nov;23(8):451-8. Epub 2006 Sep 28.
14. Gender differences in renal nuclear receptors and aryl hydrocarbon receptor in 5/6 nephrectomized rats.
Match Strength: 3.639
This study was aimed at delineating molecular pathways essential in gender-different pathogenesis of chronic kidney diseases (CKD). Renal transcripts of nuclear receptors and metabolic enzymes in male and female kidneys from 5/6 nephrectomized (Nx) rats 7 weeks post-Nx were examined using branched DNA signal amplification assay. Nx-males had marked kidney injury coupled with anemia and malnutrition. Nx-females had moderate renal injury, and were free of albuminuria, anemia, and malnutrition. Nx-males had systemic and renal inflammation, which were largely absent in Nx-females. Blood 17beta ... Read More »
» Published in Kidney Int. 2006 Dec;70(11):1920-8. Epub 2006 Sep 20. Comment in: Kidney Int. 2006 Dec;70(11):1889-90.
15. Colitis due to Ancylostoma duodenale.
Match Strength: 3.571
The larva of hookworm matures into the adult stage in the small intestine, causing chronic intestinal blood loss and iron-deficiency anemia. Hookworm infestation of colon has not been reported previously. We report a 35-year-old man who presented with diarrhea with blood and mucus in stools. Colonoscopy revealed several hookworms in the colon firmly adherent to the mucosa, with oozing of blood and surrounding mucosal erosions. He was treated with mebendazole and symptoms recovered completely. Publication Types: Case ... Read More »
» Published in Indian J Gastroenterol. 2006 Jul-Aug;25(4):210-1.
16. Evaluation of liposomal clodronate in experimental spontaneous autoimmune hemolytic anemia in dogs.
Match Strength: 3.562
OBJECTIVES: Liposomal clodronate (dichloromethylene diphosphonate) has been used to deplete macrophages and block clearance of opsonized cells in mouse models of autoimmune disease. However, liposomal clodronate (LC) has not been previously evaluated in a large-animal spontaneous autoimmune disease model. Therefore, the safety and efficacy of LC treatment was assessed in normal dogs and in dogs with spontaneous autoimmune hemolytic anemia (AIHA). METHODS: LC was administered intravenously first to healthy dogs and then to dogs with spontaneous, severe AIHA to determine if the treatment was ... Read More »
» Published in Exp Hematol. 2006 Oct;34(10):1393-402.
17. Care outcomes in long-term care facilities in British Columbia, Canada. Does ownership matter?
Match Strength: 3.555
OBJECTIVES: This study investigated whether for-profit (FP) versus not-for-profit (NP) ownership of long-term care facilities resulted in a difference in hospital admission and mortality rates among facility residents in British Columbia, Canada. RESEARCH DESIGN: This retrospective cohort study used administrative data on all residents of British Columbia long-term care facilities between April 1, 1996, and August 1, 1999 (n = 43,065). Hospitalizations were examined for 6 diagnoses (falls, pneumonia, anemia, dehydration, urinary tract infection, and decubitus ulcers and/or gangrene), which are ... Read More »
» Published in Med Care. 2006 Oct;44(10):929-35.
18. Sporotrichosis: the main differential diagnosis with tegumentary leishmaniosis in dogs from Rio de Janeiro, Brazil.
Match Strength: 3.470
Seventy-four dogs from the State of Rio de Janeiro with ulcerated cutaneous lesions were submitted to clinical, dermatological, parasitological, mycological, histopathological and cytopathological exams, a leishmanin skin test, an indirect immunofluorescence (IIF) test for leishmaniosis, and nonspecific laboratory tests such as blood count and serum biochemistry. Sporothrix schenckii was isolated from 41 dogs and Leishmania (Viannia) braziliensis was isolated from 33 animals. Most dogs with sporotrichosis were from the municipality of Rio de Janeiro (53.7%) and presented ulcerated cutaneous ... Read More »
» Published in Vet Parasitol. 2007 Jan 19;143(1):1-6. Epub 2006 Sep 12.
19. Once-weekly epoetin-beta improves hemoglobin levels in cancer patients with chemotherapy-induced anemia: A randomized, double-blind, dose-finding study.
Match Strength: 3.386
OBJECTIVE: To determine a recommended dose of once-weekly epoetin-beta administration for anemic cancer patients receiving myelosuppressive chemotherapy, we conducted a multicenter, randomized, double-blind trial. METHODS: A total of 86 patients with malignant lymphoma or lung cancer who received chemotherapy containing platinum, taxanes or anthracyclines were enrolled in the study. Patients were randomly assigned into groups that received three dose levels of epoetin-beta (9000, 18,000 or 36,000 IU) administered subcutaneously once a week for 12 weeks. The primary endpoint was change in ... Read More »
» Published in Jpn J Clin Oncol. 2006 Oct;36(10):655-61. Epub 2006 Sep 20.
20. Gastrointestinal-related complications after major lung surgery.
Match Strength: 2.765
Numerous factors increase the risk for GI complications in patients undergoing lung resection. It seems that the more debilitated the patient and the more extensive the COPD, the higher the risk. The most commonly reported cause of mortality after lung surgery is multi-organ failure accompanying respiratory failure. The trigger site for multi-system failure is often the GI system. Some risk factors cannot be altered, such as diabetes and the cardiovascular effects of long-term smoking. Other factors, such as steroid dose, anemia, hypoxia, narcotics, and other medications, can be modified. In ... Read More »
» Published in Thorac Surg Clin. 2006 Aug;16(3):299-302.
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