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Peer Reviewed Scientific Research Reports.
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1. MRI in evaluating atrophy of the external anal sphincter in patients with fecal incontinence.
Match Strength: 7.773
OBJECTIVE: External anal sphincter atrophy seen at endoanal MRI may predict poor outcome of surgical anal sphincter repair for an external anal sphincter defect. The purposes of this study were to compare external phased-array MRI to endoanal MRI for depicting external anal sphincter atrophy in patients with fecal incontinence and to evaluate observer reproducibility in detecting external anal sphincter atrophy with these techniques. SUBJECTS AND METHODS: Thirty patients with fecal incontinence (23 women, seven men; mean age, 58.7 years; age range, 37-78 years) underwent both endoanal and ... Read More »
» Published in AJR Am J Roentgenol. 2006 Oct;187(4):991-9.
2. Effect of Simotang oral liquid on anal exhaust in patients after abdominal gynecological operation.
Match Strength: 6.502
OBJECTIVE: To study the effect of Simotang oral liquid and glycerin enema on the patients' bowel sound (BS) restoration and anal exhaust after abdominal gynecological operation. METHOD: Ninety patients with benign tumor who had undergone gynecological operation were randomly divided into the Simotang group, treated after operation with Simotang oral liquid; the enema group, treated with glycerin enema, and the control group, non-treated. The restoration time of BS and anal exhaust were observed. RESULTS: Compared with the control group, the restoration time of BS and anus exhaust were both ... Read More »
» Published in Chin J Integr Med. 2006 Sep;12(3):221-3.
3. Bowel symptoms in women planning surgery for pelvic organ prolapse.
Match Strength: 6.218
OBJECTIVE: The objective of the study was to measure associations between bowel symptoms and prolapse. STUDY DESIGN: Baseline data were analyzed from 322 women in the Colpopexy And Urinary Reduction Efforts trial of sacrocolpopexy with or without Burch colposuspension. Women completed the Colorectal-Anal Distress Inventory and Colorectal-Anal Impact Questionnaire and underwent Pelvic Organ Prolapse Quantification. Associations between symptoms and questionnaire scores and Pelvic Organ Prolapse Quantification measures were assessed. RESULTS: Mean age was 61 +/- 10 years. Pelvic Organ Prolapse ... Read More »
» Published in Am J Obstet Gynecol. 2006 Dec;195(6):1814-9. Epub 2006 Sep 25.
4. Histological features of human papilloma virus 16 and its association with the development and progression of anal squamous cell carcinoma.
Match Strength: 6.046
PURPOSE: To investigate the development of anal squamous cell carcinoma (SCC) and the expression patterns of human papillomavirus (HPV). METHODS: We performed typing of HPV-DNA using a polymerase chain reaction (PCR), and amplified the Duchenne muscular dystrophy (DMD) genes simultaneously, to investigate the tumor DNA state. The expression patterns of HPV in the cancer cell nuclei was investigated by in situ hybridization (ISH) using HPV probes. RESULTS: Amplification of DMD genes was confirmed in 8 of 20 patients with anal SCC, suggesting that tumor DNA was preserved in these patients. In ... Read More »
» Published in Surg Today. 2006;36(10):885-91.
5. Efficacy of anal fistula plug in closure of Crohn's anorectal fistulas.
Match Strength: 6.035
PURPOSE: The efficacy of Surgisis anal fistula plug in closure of Crohn's anorectal fistula was studied. METHODS: Patients with Crohn's anorectal fistulas were prospectively studied. Diagnosis was made by histologic, radiographic, or endoscopic criteria. Variables recorded were: number of fistula tracts (primary openings), presence of setons, and current antitumor necrosis factor therapy. Under general anesthesia and in prone jackknife position, patients underwent irrigation of the fistula tract by using hydrogen peroxide. Each primary opening was occluded by using a Surgisis anal fistula plug ... Read More »
» Published in Dis Colon Rectum. 2006 Oct;49(10):1569-73.
6. Three-dimensional anal endosonography may improve detection of recurrent anal cancer.
Match Strength: 6.003
PURPOSE: In our center since 2001, follow-up examination has included three-dimensional endosonography in all patients with suspicion of local recurrence of anal cancer. This study was designed to investigate whether three-dimensional endosonography surpassed two-dimensional endosonography as a diagnostic tool for patients with suspected local recurrence. METHODS: This prospective study included 38 consecutive patients who have had anal carcinoma and were investigated using three-dimensional endosonography in combination with anoscopy and digital rectal examination at Rigshospitalet from July ... Read More »
» Published in Dis Colon Rectum. 2006 Oct;49(10):1527-32.
7. Randomized clinical trial of botulinum toxin plus glyceryl trinitrate vs. botulinum toxin alone for medically resistant chronic anal fissure: overall poor healing rates.
Match Strength: 5.660
PURPOSE: This study was designed to assess whether addition of glyceryl trinitrate to botulinum toxin improves the healing rate of glyceryl trinitrate-resistant fissures over that achieved with botulinum toxin alone. METHODS: Patients were randomized between botulinum toxin plus glyceryl trinitrate (Group A) and botulinum toxin plus placebo paste (Group B). Patients were seen at baseline, four and eight weeks, and six months. The primary end point was fissure healing at eight weeks. Secondary end points were symptomatic relief, need for surgery, side effects, and reduction in maximum resting ... Read More »
» Published in Dis Colon Rectum. 2006 Oct;49(10):1574-80.
8. MRI of complicated pouchitis.
Match Strength: 5.332
OBJECTIVE: The purpose of this study is to assess the ability of MRI to identify the presence of inflammation related to the pouch reservoir in symptomatic patients with an ileal pouch-anal anastomosis who present with clinically suspected complicated pouchitis. CONCLUSION: Initial results suggest that MRI should be considered in patients who have undergone ileal pouch-anal anastomosis and present a clinical impression of complicated pouchitis. MRI showed abnormalities consistent with complicated pouchitis in seven of nine examinations, with findings including pouch wall thickening, abnormal ... Read More »
» Published in AJR Am J Roentgenol. 2006 Oct;187(4):W386-91.
9. A systematic review of the efficacy of cesarean section in the preservation of anal continence.
Match Strength: 5.293
PURPOSE: Elective primary cesarean section is performed largely to avoid maternal pelvic trauma that may result in anal incontinence, although its efficacy in this regard has not been thoroughly assessed. We perform a systematic review of published reports that compare anal incontinence risk by mode of delivery. METHODS: PubMed was searched from 1966 through August 2005. Authors were contacted for missing data or analyses. Both randomized and nonrandomized reports were included. Eligible studies included females having vaginal delivery or cesarean section, fecal and/or flatal incontinence was ... Read More »
» Published in Dis Colon Rectum. 2006 Oct;49(10):1587-95.
10. Defining pelvic factors in sphincter-preservation of low rectal cancer with a three-dimensional digital model of pelvis.
Match Strength: 4.949
PURPOSE: Surgeons often can contribute failure of sphincter-preserving procedure to a limitation of pelvis anatomy; however, they cannot determine definitely which anatomic diameter or spatial factor actually affected the success of the procedure. METHODS: Colorectal surgeons, radiologists, and research fellows collaborated closely to establish a three-dimensional digital model of the pelvis with spiral computerized tomography scanning data of patients with rectal cancer. Retrospective analysis on data of 97 patients with low rectal cancer was performed with this model to identify geometric ... Read More »
» Published in Dis Colon Rectum. 2006 Oct;49(10):1517-26.
11. Unprotected anal intercourse and substance use among men who have sex with men with recent HIV infection.
Match Strength: 4.901
OBJECTIVES: To examine within-subjects and combined between- and within-subjects associations between substance use and unprotected anal intercourse (UAI) among men who have sex with men (MSM) with recent HIV infection. METHODS: One hundred ninety-four MSM who were recently infected with HIV completed a computer-assisted questionnaire regarding sexual behaviors and substance use with their last 3 partners. Associations between UAI and substance use were assessed using conditional logistic regression (CLR) to assess associations among the 116 MSM reporting UAI with some but not all partners and ... Read More »
» Published in J Acquir Immune Defic Syndr. 2006 Nov 1;43(3):344-50.
12. Restorative proctocolectomy and ileal pouch-anal anastomosis for familial adenomatous polyposis revisited.
Match Strength: 4.584
Since restorative proctocolectomy (RPC) with ileal-pouch anal anastomosis (IPAA) removes the entire diseased mucosa, it has become firmly established as the standard operative procedure of choice for familial adenomatous polyposis (FAP). Many technical controversies still persist, such as mesenteric lengthening techniques, close rectal wall proctectomy, endoanal mucosectomy vs. double stapled anastomosis, loop ileostomy omission and a laparoscopic approach. Despite the complexity of the operation, IPAA is safe (mortality: 0.5-1%), it carries an acceptable risk of non-life-threatening ... Read More »
» Published in Fam Cancer. 2006;5(3):241-60; discussion 261-2.
13. Relative efficacy of a multisession sexual risk-reduction intervention for young men released from prisons in 4 states.
Match Strength: 4.443
OBJECTIVES: We compared the effects of an enhanced multisession intervention with a single-session intervention on the sexual risk behavior of young men released from prison. METHODS: Young men, aged 18 to 29 years, were recruited from US prisons in 4 states and systematically assigned to the prerelease single-session intervention or the pre- and postrelease enhanced intervention. Both interventions addressed HIV, hepatitis, and other sexually transmitted infections; the enhanced intervention also addressed community reentry needs (e.g., housing, employment). Assessment data were collected ... Read More »
» Published in Am J Public Health. 2006 Oct;96(10):1854-61.
14. Translocation of AT1- and AT2-receptors by higher concentrations of angiotensin II in the smooth muscle cells of rat internal anal sphincter.
Match Strength: 4.082
Previous studies have reported bimodal effects by angiotensin II (Ang II) in the rat internal anal sphincter (IAS), a concentration-dependent contraction (at lower concentrations) and relaxation (at higher concentrations). The experiments suggest the above-mentioned responses are the result of Ang II subtype I receptor(s) (AT(1)-R) and subtype II receptor(s) (AT(2)-R) activation, respectively. These studies determined the role and mechanism of AT(2)-R-induced relaxation of the smooth muscle cells (SMCs) from the IAS in response to Ang II. Laser confocal microscopy showed that in the basal ... Read More »
» Published in J Pharmacol Exp Ther. 2006 Dec;319(3):1088-95. Epub 2006 Sep 19.
15. Prevalence of perianal intraepithelial neoplasia in HIV-infected patients referred for high-resolution anoscopy.
Match Strength: 3.793
PURPOSE: This study was designed to describe perianal disease in a cohort of HIV-infected patients referred for high-resolution anoscopy. METHODS: A retrospective chart review was performed on 52 HIV-infected patients referred for high-resolution anoscopy from 2001 to 2005. All patients underwent anal canal and perianal high-resolution anoscopy in the office with biopsy of suspicious areas. Patients with high-grade intraepithelial perianal lesions underwent multiple biopsies under general anesthesia in the operating room to rule out malignancy. RESULTS: Of the 52 patients, 19 (37 percent) had ... Read More »
» Published in Dis Colon Rectum. 2006 Oct;49(10):1581-6.
16. MR imaging of the pelvic floor.
Match Strength: 3.692
Pelvic floor disorders are a common clinical problem. Clinical evaluation frequently underestimates the extent of the disease. Fluoroscopic colpocystodefecography (CCD) is an established tool for diagnosing disorders of the rectum and recto- anal junction. It is however less performant when it comes to evaluate the complex pelvic floor mechanism in all its aspects. MR defecography allows to evaluate all the compartments of the pelvis without being invasive.This article describes the clinical setting, the MR technique and provides guidelines for interpretation of a MR defecography study. ... Read More »
» Published in JBR-BTR. 2006 Jul-Aug;89(4):182-9.
17. Non-cavernomatous superior mesenteric thrombosis successfully recanalized with interventional radiological procedures carried out with a combination transmesenteric and transjugular approaches.
Match Strength: 3.271
This is the study of a 52-year-old man with oesophageal, rectal and anal varices caused by portal hypertension with complete obstruction of the superior mesenteric vein. Treatment by two sessions of interventional radiological procedures was successful. The first was a catheter-directed thrombolysis using the transmesenteric approach. The second was percutaneous transluminal angioplasty and stent implantation for the obstructed segment of the superior mesenteric vein and the creation of a transjugular intrahepatic portosystemic shunt. In the second session, devices were advanced over a ... Read More »
» Published in Australas Radiol. 2006 Oct;50(5):495-9.
18. Disintegration mechanisms of charged aqueous nanodroplets studied by simulations and analytical models.
Match Strength: 2.652
The mechanism of fragmentation processes in aqueous nanodroplets charged with ions is studied by molecular dynamics (MD) simulations. By using constant-temperature MD, the evaporation of the water is naturally taken into account and sequences of ion fragmentation events are observed. The size of the critical radius of the charged droplet just before the fragmentation and the distribution of the sizes of the fragments are estimated. Comparison of the Rayleigh critical radius for fragmentation and simulation data is within 0.23 nm. This seemingly small difference arises from a large difference ... Read More »
» Published in J Phys Chem B Condens Matter Mater Surf Interfaces Biophys. 2006 Oct 5;110(39):19168-75.
19. Experience of the treatment with gemcitabine, docetaxel, and carboplatin (GDC) chemotherapy for patients with small-cell carcinoma of the prostate.
Match Strength: 2.604
Small-cell carcinoma of the prostate (SCCP) is a rare entity. Many treatment modalities have been done, but thus far no uniform treatment has been clearly established. We carried out combination chemotherapy with gemcitabine, docetaxel, and carboplatin (GDC) regimen (for two patients with refractory SCCP. Case 1 involved a 53-year-old man diagnosed with SCCP after receiving hormone therapy for prostate cancer (stage D1). Six cycles of GDC chemotherapy was applied. Initially the primary site reduced according with a decline of neuro-specific enolase and with relief of the symptoms; however, ... Read More »
» Published in Int J Urol. 2006 Sep;13(9):1254-8.
20. Mucosal stimulation activates secretomotor neurons via long myenteric pathways in guinea pig ileum.
Match Strength: 2.194
This study examined whether mucosal stimulation activates long secretomotor neural reflexes and, if so, how they are organized. The submucosa of in vitro full thickness guinea pig ileal preparations was exposed in the distal portion and intracellular recordings were obtained from electrophysiologically identified secretomotor neurons. Axons in the intact mucosa of the oral segment were stimulated by a large bipolar stimulating electrode. In control preparations, a single stimulus pulse evoked a fast excitatory postsynaptic potential (EPSP) in 86% of neurons located 0.7-1.0 cm anal to the ... Read More »
» Published in Am J Physiol Gastrointest Liver Physiol. 2007 Feb;292(2):G608-14. Epub 2006 Sep 28.
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