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1. Shroom2 (APXL) regulates melanosome biogenesis and localization in the retinal pigment epithelium.
Match Strength: 5.270
Shroom family proteins have been implicated in the control of the actin cytoskeleton, but so far only a single family member has been studied in the context of developing embryos. Here, we show that the Shroom-family protein, Shroom2 (previously known as APXL) is both necessary and sufficient to govern the localization of pigment granules at the apical surface of epithelial cells. In Xenopus embryos that lack Shroom2 function, we observed defects in pigmentation of the eye that stem from failure of melanosomes to mature and to associate with the apical cell surface. Ectopic expression of ... Read More »
» Published in Development. 2006 Oct;133(20):4109-18. Epub 2006 Sep 20.
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