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Airway Obstruction
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1. Neuromechanical control of upper airway patency during sleep.
Match Strength: 9.405

Obstructive sleep apnea is caused by pharyngeal occlusion due to alterations in upper airway mechanical properties and/or disturbances in neuromuscular control. The objective of the study was to determine the relative contribution of mechanical loads and dynamic neuromuscular responses to pharyngeal collapse during sleep. Sixteen obstructive sleep apnea patients and sixteen normal subjects were matched on age, sex, and body mass index. Pharyngeal collapsibility, defined by the critical pressure, was measured during sleep. The critical pressure was partitioned between its passive mechanical ... Read More »
» Published in J Appl Physiol. 2007 Feb;102(2):547-56. Epub 2006 Sep 28.

2. Case of the month: A case of airway obstruction following tenecteplase administration.
Match Strength: 9.062

The value of thrombolysis in the treatment of acute myocardial infarction is well established. Haemorrhage into subcutaneous tissues is fortunately a rare complication of fibrinolytic administration. However, if as a result of trauma a haematoma develops within the neck following thrombolysis, it can lead to rapid airway compromise. This is the first reported case of tenecteplase administration leading to subcutaneous haemorrhage and consequent airway compromise. It is also the first reported case where the antecedent trauma was a jaw thrust ... Read More »
» Published in Emerg Med J. 2006 Oct;23(10):815-6.

3. Analysis of outcomes after functional rhinoplasty using a disease-specific quality-of-life instrument.
Match Strength: 8.593

OBJECTIVE: To measure the efficacy of functional rhinoplasty techniques with a validated quality-of-life instrument. DESIGN: Prospective observational outcomes study of patients with severe nasal obstruction owing to septal deviation, internal or external valve collapse, and turbinate hypertrophy who subsequently underwent functional rhinoplasty. Preoperative and postoperative evaluations were performed using the Nasal Obstruction Symptoms Evaluation scale. RESULTS: Forty-one patients completed preoperative and postoperative evaluations. No complications occurred. There was a significant ... Read More »
» Published in Arch Facial Plast Surg. 2006 Sep-Oct;8(5):306-9.

4. How competent are obstetric and gynaecology trainees in managing maternal cardiac arrests?
Match Strength: 8.592

The recent Confidential Enquiry (2000-2002) has emphasised 'emergency drills for maternal resuscitation should be regularly practised in clinical areas in all maternity units'. It was therefore planned to assess the knowledge of airway management and ventilation among obstetrics and gynaecology trainees in the Yorkshire Deanery (Training Region). Questionnaires were given to trainees attending the Modular Training Programme and were collected on the same day. A total of 71 questionnaires were collected which represents 62% of the 113 trainees in Yorkshire region. Replies were received from 39 ... Read More »
» Published in J Obstet Gynaecol. 2006 Aug;26(6):507-8.

5. Comparison of the antioxidant status in tracheal and bronchoalveolar epithelial lining fluids in recurrent airway obstruction.
Match Strength: 7.465

REASONS FOR PERFORMING STUDY: Following a period of airway inflammation the clearance of inflammatory cells along the mucociliary escalator may impose a considerable oxidant load on the trachea. OBJECTIVES: To determine the degree of oxidative stress in tracheal epithelial lining fluid (ELF) in comparison to that present in peripheral airways after an acute exposure to organic dust. METHODS: Tracheal wash fluid and bronchoalveolar lavage fluid (BALF) were collected for cytology and antioxidant analyses from 6 recurrent airway obstruction (RAO)-affected horses and 6 healthy control horses ... Read More »
» Published in Equine Vet J. 2006 Sep;38(5):417-22.

6. Alar expansion and reinforcement: a new technique to manage nasal valve collapse.
Match Strength: 5.309

OBJECTIVE: To describe the new technique of alar expansion and reinforcement as a comprehensive approach to the surgical management of nasal valve collapse. METHODS: Alar expansion and reinforcement expands the narrow nasal valve and reinforces the floppy nasal sidewall. Forty-one patients underwent rhinoplastic surgery for nasal valve collapse between May 1, 2002, and April 30, 2005, using an external rhinoplasty approach; of these, 32 responded to our postoperative questionnaire. Twenty-four patients (75%) underwent primary surgery and 8 (25%) had undergone previous rhinoplasty. All patients ... Read More »
» Published in Arch Facial Plast Surg. 2006 Sep-Oct;8(5):293-9.

7. Single dose of tiotropium improves the 6-minute walk distance in chronic obstructive pulmonary disease.
Match Strength: 4.102

The aim of this study was to evaluate the effect of a single dose of tiotropium on the exercise capacity of stable chronic obstructive pulmonary disease (COPD) patients. The study was a randomized, placebo-controlled, double-blind, cross-over study. Forty-four stable COPD patients with moderate to severe airway obstruction were selected according to the GOLD criteria. The regular anticholinergic therapies of the patients were interrupted one week before the test. In the morning hours of the first day, half the group was given one capsule (18 mcg) of tiotropium and the other half was given ... Read More »
» Published in Lung. 2006 Jul-Aug;184(4):201-4.

8. Complement in asthma: sensitivity to activation and generation of C3a and C5a via the different complement pathways.
Match Strength: 3.885

Studies in rodent models suggested that complement may play a critical role in susceptibility to airway hyperresponsiveness (AHR) and as a mediator of bronchial obstruction and inflammation in asthma. Complement may participate in susceptibility to asthma because of an intrinsic abnormality in complement activation and generation of C3a, C5a, or other products that affect cellular responses, resulting in T(H)2 predominance and asthma susceptibility. Alternatively, an intrinsic abnormality in the cellular response to complement activation products could determine susceptibility to asthma. In ... Read More »
» Published in Transl Res. 2006 Oct;148(4):157-63.

9. Activation of glycogen synthase in myocardium induced by intermittent hypoxia is much lower in fasted than in fed rats.
Match Strength: 3.846

Obstructive sleep apnea is characterized by intermittent obstruction of the upper airway, which leads to intermittent hypoxia. Myocardial glycogen is a major energy resource for heart during hypoxia. Previous studies have demonstrated that intermittent hypoxia rapidly degrades myocardial glycogen and activates glycogen synthase (GS). However, the underlying mechanisms remain undefined. Because sleep apnea/intermittent hypoxia usually happens at night, whether intermittent hypoxia leads to GS activation in the postabsorptive state is not known. In the present study, male adult rats were studied ... Read More »
» Published in Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E469-75. Epub 2006 Sep 26.

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