Adenomatous Polyposis Coli
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Peer Reviewed Scientific Research Reports.
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1. The genetics of FAP and FAP-like syndromes.
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The presence of multiple adenomatous polyps in the large bowel confers a high lifetime risk of colorectal cancer. Although many cases of classical familial adenomatous polyposis (> 100 polyps) can be accounted for by mutations in the adenomatous polyposis coli (APC) gene, a large group of patients remains with multiple (5-100) adenomas and in whom there is no detectable APC mutation. Recently two new genetic variants have been found to be associated with multiple colorectal adenomas and cancer, MYH/MUTYH on chromosome 1p and the HMPS/CRAC1 locus on chromosome 15q13-q14. New information also ... Read More »
» Published in Fam Cancer. 2006;5(3):221-6.
2. Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.
Match Strength: 13.009
The tumor suppressor gene Apc (adenomatous polyposis coli) is a member of the Wnt signaling pathway that is involved in development and tumorigenesis. Heterozygous knockout mice for Apc have a tumor predisposition phenotype and homozygosity leads to embryonic lethality. To understand the role of Apc in development we generated a floxed allele. These mice were mated with a strain carrying Cre recombinase under the control of the human Keratin 14 (K14) promoter, which is active in basal cells of epidermis and other stratified epithelia. Mice homozygous for the floxed allele that also carry the ... Read More »
» Published in PLoS Genet. 2006 Sep 15;2(9):e146. Epub 2006 Jul 28.
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