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Acne
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1. Defining criteria used to evaluate response to treatment of acne vulgaris.
Match Strength: 7.401

Results from controlled studies form the basis of overall perceptions regarding the efficacy and safety of specific treatments. In acne vulgaris, determining statistical significance related to mean percentage reduction in inflammatory and noninflammatory lesion counts, investigator global assessment, and patient (subject) global assessment have formed the basis of most studies. Results may be impacted by several mitigating factors related to inclusion and exclusion criteria and variations in study "power." Recently, standards for evaluation of response to acne treatment have been reconsidered ... Read More »
» Published in Cutis. 2006 Aug;78(2):117-21.

2. Pharmacological management of SAPHO syndrome.
Match Strength: 5.520

The SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome (SaS) includes different skeletal manifestations such as recurrent multifocal osteomyelitis, osteitis and arthritis, which are frequently associated with different forms of skin pustulosis (palmoplantar pustulosis, pustular psoriasis and severe acne). This syndrome is strictly related to the spondyloarthopathies (particularly to psoriatic arthritis) and many SaS cases fulfil the classification criteria for the spondyloarthopathies. Because SaS is an uncommon disease, current knowledge regarding its therapy is based on ... Read More »
» Published in Expert Opin Investig Drugs. 2006 Oct;15(10):1229-33.

3. Pediatric rosacea.
Match Strength: 4.848

Rosacea is a condition most commonly associated with adults; however, various forms exist in the pediatric population and need to be considered when a child presents with a facial rash. Acne rosacea, steroid rosacea, granulomatous periorificial dermatitis, and other variants of rosacea are presented here and are distinguished from their numerous mimickers. Various topical and systemic therapeutic options exist for the treatment of rosacea with several adjustments and considerations that must be taken into account when treating a child. Publication Types: ... Read More »
» Published in Dermatol Ther. 2006 Jul-Aug;19(4):196-201.

4. Diagnosis and management of the dermatologic manifestations of the polycystic ovary syndrome.
Match Strength: 3.634

Polycystic ovary syndrome (PCOS) is a complex phenotypic spectrum of primarily hyperandrogenic signs and symptoms. PCOS is the most common endocrine disturbance to affect women of reproductive years. Although patients affected are often very disturbed by the cutaneous manifestations, including acne, hirsutism, alopecia, obesity, and acanthosis nigricans, the clinical manifestations of PCOS ramify far beyond the skin. PCOS frequently causes menstrual abnormalities and infertility. Insulin resistance is both pathogenic and a cause of numerous serious health consequences. The accurate diagnosis ... Read More »
» Published in Dermatol Ther. 2006 Jul-Aug;19(4):210-23.

5. 5alpha-reductase: history and clinical importance.
Match Strength: 3.552

The treatment of men with symptomatic benign prostatic hyperplasia (BPH) has shifted dramatically from surgery to drug therapy over the past decade. The revolution in BPH treatment began with the discovery of congenital 5alpha-reductase (5AR) deficiency, leading to the appreciation of 2 different androgenic hormones: testosterone, which mediates overt masculinization in the adult male, and dihydrotestosterone (DHT), which mediates prostatic growth, acne, facial beard, and male pattern baldness. Inhibition of DHT in adults results in prostatic shrinkage and symptomatic relief in many men, ... Read More »
» Published in Rev Urol. 2004;6 Suppl 9:S11-21.

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