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Peer Reviewed Scientific Research Reports.

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1. The impact of time aids on independence and autonomy in adults with developmental disabilities.
Match Strength: 6.693

The aim of this study was to describe how people with developmental disabilities experienced the use of time aids one year after their introduction by an occupational therapist. Data were obtained through semi-structured interviews. The analysis was performed using a phenomenographic qualitative approach. The results showed that independence and autonomy should be considered as two separate phenomena. Increased independence did not always lead to increased autonomy or vice versa. Four different relationships between these two phenomena were found. They all illustrate the different priorities ... Read More »
» Published in Occup Ther Int. 2006;13(3):160-75.

2. Relationship between knowledge of HIV/AIDS and sexual behaviour among in-school adolescents in Delta State, Nigeria.
Match Strength: 6.069

OBJECTIVE: To determine if there is any correlation between the knowledge of HIV/AIDS among in-school adolescents in Delta state of Nigeria and their sexual behaviour. METHOD: A questionnaire based descriptive study of randomly selected secondary school students in Asaba. Delta state. RESULTS: A total of 437 students were recruited for the study. About 47% of respondents had good knowledge of HIV/AIDS. The electronic media were their main sources of information. Fifty-eight percent had been sexually initiated but only 10% were currently sexually active. About 73% of the males and 58% of the ... Read More »
» Published in Niger J Clin Pract. 2006 Jun;9(1):37-9.

3. The HIV Landscape in a Managed Care Environment: Current Challenges and Potential Solutions.
Match Strength: 6.061

OBJECTIVE: To review the current impact of human immunodeficiency virus (HIV)/ acquired immunodeficiency syndrome (AIDS) and its treatment on the population and on managed care. SUMMARY: In 2006, HIV/AIDS remains as big a problem as ever, with many countries reporting an incidence of 40% or higher among intravenous drug users. While daunting, this does not detract from the many victories that have occurred over the HIV/AIDS landscape. Mortality has declined dramatically since 1995. Treatment with highly active antiretroviral therapy (HAART) has been simplified and offers substantial survivor ... Read More »
» Published in J Manag Care Pharm. 2006 Sep;12(7 Suppl B):2-5.

4. Effects of ice massage on neuropathic pain in persons with AIDS.
Match Strength: 5.808

Peripheral neuropathic pain is a unique form of chronic pain that afflicts up to 50% of persons with AIDS. The purpose of this pilot study was to examine the effects of ice massage to reduce neuropathic pain and improve sleep quality and to determine the feasibility of a larger study. A repeated measures design was used. The three treatments consisted of ice massage, dry-towel massage, and presence. Consecutive sampling was used to select 33 persons with AIDS who had neuropathic pain. Although the results of the study were negative, there was a decrease in pain intensity over time with both ... Read More »
» Published in J Assoc Nurses AIDS Care. 2006 Sep-Oct;17(5):15-22.

5. Pediatric nursing in the context of the HIV/AIDS epidemic in resource-poor settings--balancing the "art and the science".
Match Strength: 5.663

Pediatric wards in South Africa are largely occupied by children with AIDS-related illnesses. This study uses qualitative inquiry involving focus groups with nurses into the needs of children, caregivers, and healthcare providers. The findings indicate changes to the nature of nursing practice, knowledge of nursing, and ethics of nursing care. Publication Types: Research Support, Non-U.S. Gov ... Read More »
» Published in Holist Nurs Pract. 2006 Sep-Oct;20(5):247-54.

6. Polymorphous hemangioendothelioma in a child with acquired immunodeficiency syndrome (AIDS).
Match Strength: 5.139

Polymorphous hemangioendotheliomas (PH) are rare and borderline malignant tumors that are among the wide range of vascular tumors. We report here a 13-year-old male presenting with a history of weight loss, opportunistic infections, and lymphadenopathy. He was determined to be HIV positive and to have acquired immunodeficiency syndrome (AIDS). A biopsy of a femoral node was diagnostic of PH. His systemic lymphadenopathy appeared to resolve with anti-retroviral therapy. This tumor should be considered within the differential diagnoses of pediatric and immunocompromised patients. Pediatr Blood ... Read More »
» Published in Pediatr Blood Cancer. 2006 Sep 21;

7. Cultural influences on the physician-patient encounter: The case of shared treatment decision-making.
Match Strength: 5.091

OBJECTIVE: In this paper we discuss the influence of culture on the process of treatment decision-making, and in particular, shared treatment decision-making in the physician-patient encounter. We explore two key issues: (1) the meaning of culture and the ways that it can affect treatment decision-making; (2) cultural issues and assumptions underlying the development and use of treatment decision aids. METHODS: This is a conceptual paper. Based on our knowledge and reading of the key literature in the treatment decision-making field, we looked for written examples where cultural influences ... Read More »
» Published in Patient Educ Couns. 2006 Nov;63(3):262-7. Epub 2006 Sep 26.

8. Building collaborative networks for HIV/AIDS vaccine development: the AVIP experience.
Match Strength: 4.927

The need for an effective HIV/AIDS vaccine is imperative to halt a pandemic that involves more than 40 million individuals worldwide as of 2005 and is causing enormous socio-economic losses, especially in developing countries (DC). The overall failure of more than two decades of HIV vaccine research justifies the demands for a concerted effort for the rapid development of new and efficacious vaccines against HIV/AIDS. In this context, building international collaborative networks is a must for speeding up scientific research and optimizing the use of funding in a synergistic fashion, as ... Read More »
» Published in Springer Semin Immunopathol. 2006 Nov;28(3):289-301. Epub 2006 Sep 16.

9. Attitude of health-care workers to HIV/AIDS.
Match Strength: 4.836

The current 5% prevalence rate of HIV in Nigeria represents a significant population of people living with HIV/AIDS (PLWHA). Discrimination against PLWHA has profound impact on the care and support required for their optimal management particularly in resource-constrained settings. The study sought to assess the knowledge of health-care providers about HIV/AIDS, determine the potential for discrimination in the provision of services based on patients' HIV sero-status and review the factors that may contribute to such attitude. Self-administered semi-structured questionnaires were administered ... Read More »
» Published in Afr J Reprod Health. 2006 Apr;10(1):39-46.

10. Cardiac isoform of alpha 2 macroglobulin, an early diagnostic marker for cardiac manifestations in AIDS patients.
Match Strength: 4.778

This study investigated the possible role of the cardiac isoform of alpha 2-macroglobulin (CA2M) as an early diagnostic marker for HIV-associated cardiovascular manifestations. A total of 349 samples were analysed by Western blot and quantified by sandwich enzyme-linked immunosorbent assay. The levels of CA2M present in sera of HIV-associated cardiac diseases were significantly higher than those of HIV without cardiac involvement and healthy sera. CA2M may act as a novel diagnostic marker to identify cardiac manifestations in HIV/AIDS patients. Publication Types: Research Support, Non-U.S. Gov ... Read More »
» Published in AIDS. 2006 Oct 3;20(15):1979-81.

11. Expanding research on the role of alcohol consumption and related risks in the prevention and treatment of HIV/AIDS.
Match Strength: 4.661

This article is a review of some of the major epidemiological, behavioral, biological, and integrative prevention research issues and priorities in the area of HIV/AIDS and alcohol consumption. Drinking alcohol increases both the risk for infection with HIV and related illnesses and the morbidity and mortality of patients who progress to AIDS. New and improved measurement procedures have helped in assessment of the complex patterns of alcohol use, identification of intervening explanatory mechanisms for risk behaviors and contexts, and determination of intervention outcomes. Both the direct ... Read More »
» Published in Subst Use Misuse. 2006;41(10-12):1465-507.

12. Postmortem findings and opportunistic infections in HIV-positive patients from a public hospital in Peru.
Match Strength: 4.423

There is a paucity of HIV autopsy data from South America and none that document the postmortem findings in patients with HIV/AIDS in Peru. The purpose of this autopsy study was to determine the spectrum of opportunistic infections and the causes of mortality in HIV-positive patients at a public hospital in Lima. Clinico-epidemiological information regarding HIV infection in Peru is also reviewed. Sixteen HIV-related hospital postmortems, performed between 1999 and 2004, were included in this retrospective analysis. The primary cause of death was established in 12 patients: one died of ... Read More »
» Published in Pathol Res Pract. 2006;202(11):767-75. Epub 2006 Sep 19.

13. Evidence-based HIV behavioral prevention from the perspective of the CDC's HIV/AIDS Prevention Research Synthesis Team.
Match Strength: 3.885

The evidence-based approach to health promotion and disease prevention is growing in many public health sectors, including HIV behavioral prevention. This approach is based on utilizing relevant and rigorous scientific evidence, most appropriately identified through a systematic research synthesis process. With regard to HIV behavioral prevention, this research synthesis process provides decision makers and prevention planners with the evidence base and recommendations they need to translate proven scientific research into practice. The Center for Disease Control and Prevention's HIV/AIDS ... Read More »
» Published in AIDS Educ Prev. 2006 Aug;18(4 Suppl A):21-31.

14. An introduction to the herpes viruses.
Match Strength: 3.880

The herpes viruses continue to affect patients worldwide. The use of immunosuppressant medications, the AIDS epidemic and crowded living conditions will continue to present a challenge to our health care system ... Read More »
» Published in Dent Assist. 2006 Jul-Aug;75(4):20-3; quiz 24-5.

15. Evidence-Based Health Benefits Management: Strategies to Optimize Antiretroviral Medication Adherence and Outcomes in HIV/AIDS.
Match Strength: 3.774

OBJECTIVE: To review how evidence-based principles can be applied to benefit design, specialty network management, and medication therapy management to successfully manage pharmaceutical benefits for patients infected with human immunodeficiency virus (HIV). SUMMARY: The most critical barrier to successfully managing HIV disease is suboptimal patient adherence to antiretroviral therapy. Managing HIV infection is unique in that the risk of treatment failure increases remarkably with even relatively minor lapses in patient adherence. The incremental cost of HIV treatment failure has been ... Read More »
» Published in J Manag Care Pharm. 2006 Sep;12(7 Suppl B):12-6.

16. Successful HIV Treatment: Lessons Learned.
Match Strength: 3.669

OBJECTIVE: To review current insights concerning treatment of human immunodeficiency virus (HIV). SUMMARY: The range of antiretroviral agents available for treating patients who have HIV/AIDS (acquired immunodeficiency syndrome) has expanded to 20 medications since the first, zidovudine, was approved in 1987. While the exact choice of drugs to use in treatment must be tailored to the patient, depending on safety and tolerance, the ultimate goal is durable suppression of the HIV virus. Highly active antiretroviral treatment (HAART) is the current standard of care and involves treating the ... Read More »
» Published in J Manag Care Pharm. 2006 Sep;12(7 Suppl B):6-11.

17. Supporting adherence to highly active antiretroviral therapy and protected sex among people living with HIV/AIDS: the role of patient-provider communication in Rio de Janeiro, Brazil.
Match Strength: 3.104

This exploratory study examined patient-provider communication dynamics regarding adherence to highly active antiretroviral therapy (HAART) and protective sexual behavior among people living with HIV/AIDS (PLWHA). We conducted 20 direct observations of routine consultations between PLWHA and care providers in two large public health clinics providing free HIV medications and clinical care to PLWHA in the greater Rio de Janeiro area of Brazil. Immediately after these observations, 20 semistructured in-depth interviews were conducted with observation participants regarding their communication ... Read More »
» Published in AIDS Patient Care STDS. 2006 Sep;20(9):637-48.

18. Emerging targets and novel strategies in the treatment of AIDS-related Kaposi's sarcoma: bidirectional translational science.
Match Strength: 3.004

Through the mentorship process, Dr. Arthur Pardee emphasized the critical importance of bidirectional translational research-not only advancing drug development from bench to bedside, but also bringing back precious clinical material to the laboratory to assess the biologic effects of therapeutic agents on their targets. This mini-review focuses on the signal transduction pathways of Kaposi's sarcoma (KS) and on how the knowledge of such pathways has led to the rational development of molecularly targeted pathogenesis-driven therapies. Acquired immune deficiency syndrome (AIDS) related-KS ... Read More »
» Published in J Cell Physiol. 2006 Dec;209(3):659-62.

19. Biophysical delivery of peptides: applicability for cancer therapy.
Match Strength: 2.886

There is a current trend towards evaluation of molecular agents for treatment of a variety of ailments, including cancer. One class of such biomolecules is proteins, and their shortened versions, peptides. Use of peptidic entities has been hindered by poor bioavailability in vivo and the high cost involved in mass-producing these macromolecular drugs. The need for localized delivery is being met with the development of various biophysical means, which include devices and aids, mainly transdermal and invasive implants. In addition, various cell-based delivery modalities, which include the use ... Read More »
» Published in Peptides. 2006 Dec;27(12):3479-88. Epub 2006 Sep 25.

20. Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates.
Match Strength: 2.763

Neutralizing antibody induction is a key feature of many effective vaccines and is the only immune response that has proven to be capable of completely blocking AIDS virus infection in animal models. Unfortunately, the extensive genetic variability and complex immune-evasion strategies of HIV-1 have thwarted all attempts to date at eliciting an effective neutralizing antibody response with candidate HIV-1 vaccine immunogens. Recent advances in our understanding of how these evasion strategies operate, coupled with growing progress in unravelling the structure and immunobiology of the viral ... Read More »
» Published in Expert Rev Vaccines. 2006 Aug;5(4):579-95.

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