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The effects of green tea ingestion over four weeks on atherosclerotic markers.

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BACKGROUND: The objective of this study was to evaluate the effects of green tea ingestion over four weeks on atherosclerotic biological markers.METHODS: After a one-week baseline period, 12 healthy male volunteers aged 28--42 years drank 600 mL of green tea daily for four weeks. Lipid profile, oxidized low-density lipoprotein (ox-LDL), total antioxidant capacity (TAC), C-reactive protein (CRP) and soluble cell adhesion molecules were measured at baseline and after two and four weeks ingestion of green tea.RESULTS: There was no significant change in the concentrations of lipid profile, TAC, CRP, soluble intercellular adhesion molecule-1 (sICAM-1), or soluble E-selectin after ingestion of green tea. The levels of ox-LDL and soluble vascular cell adhesion molecule-1 (sVCAM-1) were significantly decreased after four weeks of green tea ingestion (Wilcoxon signed rank test, P=0.006).CONCLUSIONS: The results of this study suggest an in vivo anti-oxidative effect for green tea and an influence of green tea on atherosclerotic biological markers. The effect of green tea seen on ox-LDL and sVCAM-1 provides a potential mechanism for the cardiovascular benefits of regular ingestion of green tea. Publication Types: Clinical Trial, Research Support, Non-U.S. Gov't

Keywords: four weeks, cell adhesion, adhesion molecule, lipid profile, biological markers, atherosclerotic biological, this study, ingestion, soluble, weeks, adhesion

Authored by Sung H, Min WK, Lee W, Chun S, Park H, Lee YW, Jang S, Lee DH. Department of Laboratory Medicine, Asan Medical Center and University of College of Medicine, 388-1 Pungnap-dong, Songpa-Gu, Seoul 138-736, South Korea.

Published in Ann Clin Biochem. 2005 Jul;42(Pt 4):292-7. The full report is available online. link   A subscription to the periodical may be required.

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