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Effect of long-term oral administration of green tea extract on weight gain and glucose tolerance in Zucker diabetic (ZDF) rats.

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There have been some claims that green tea reduces weight and lowers blood glucose in diabetes. Intraperitoneal injections of green tea catechins in diabetic rats have shown beneficial effects. To determine if oral administration of green tea would prevent development of diabetes, young Zucker diabetic rats were dosed with green tea extract containing 50-125 mg/kg of Epigallocatechin gallate (EGCG) starting at 7 weeks of age, before the appearance of excessive weight gain and glucose elevation. While there was a trend toward lower weight gain and average daily glucose, there was no statistically significant difference. Publication Types: Research Support, N.I.H., Extramural


Keywords: weight gain, diabetic rats, glucose, weight

Authored by Janle EM, Portocarrero C, Zhu Y, Zhou Q. Botanical Center in Vivo Care, 700 West State St, West Lafayette, IN, 47907, USA.

Published in J Herb Pharmacother. 2005;5(3):55-65. The full report is available online. link   A subscription to the periodical may be required.



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