Clinical characteristics and diabetes associated autoantibodies in patients with both type 1 diabetes mellitus and asthma.
OBJECTIVE: Type 1 diabetes mellitus (DM1) and asthma are mediated by opposite arms of the cellular immune system, namely T helper (Th)1 and Th2 CD4+ cells, respectively. It is not known whether their coexistence affects their clinical manifestations. METHODS: The number of asthma exacerbations, frequency of hypoglycemic events, HbA1c levels, diabetes associated autoantibody status and diabetes associated late complications were determined in three paired groups of patients (n = 11) matched by gender and age: DM1 and asthma, asthma only, and DM1 only. RESULTS: Patients with both diseases had a higher prevalence of hypoglycemic events per month compared to patients with DM1 only: 5.67 +/- 4.27 vs 1.45 +/- 2.06, respectively (p = 0.008). The co-existence of the two diseases did not modify the remaining clinical and laboratory parameters. CONCLUSION: Patients with both DM1 and asthma have similar clinical characteristics to patients with only one of these diseases apart from a higher rate of hypoglycemic events compared to patients with DM1 without asthma.
Keywords: patients with, hypoglycemic events, with both, diabetes associated, patients, asthma, events, diseases, hypoglycemic, clinical, diabetes
Authored by Rachmiel M, Bloch O, Bistritzer Z, Weintrob N, Ofan R, Bloch K, Vardi P, Rapoport MJ. Department of Pediatrics, Assaf Harofeh Medical Center, Zerifin, Israel.
Published in J Pediatr Endocrinol Metab. 2006 Aug;19(8):1001-6. The full report is available online. A subscription to the periodical may be required.
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